Details for: FZD3

Gene ID: 7976

Symbol: FZD3

Ensembl ID: ENSG00000104290

Description: frizzled class receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 264.8747
    Cell Significance Index: -41.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 160.1461
    Cell Significance Index: -40.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.6265
    Cell Significance Index: -41.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.9976
    Cell Significance Index: -28.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.9877
    Cell Significance Index: -40.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5625
    Cell Significance Index: -41.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9249
    Cell Significance Index: -8.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.8155
    Cell Significance Index: 240.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.6444
    Cell Significance Index: 148.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4604
    Cell Significance Index: 493.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0749
    Cell Significance Index: 205.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.9496
    Cell Significance Index: 23.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8905
    Cell Significance Index: 71.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7756
    Cell Significance Index: 78.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4185
    Cell Significance Index: 34.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3717
    Cell Significance Index: 159.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3332
    Cell Significance Index: 478.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2806
    Cell Significance Index: 78.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0848
    Cell Significance Index: 979.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6392
    Cell Significance Index: 103.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6177
    Cell Significance Index: 67.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5495
    Cell Significance Index: 300.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5402
    Cell Significance Index: 36.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4485
    Cell Significance Index: 9.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4233
    Cell Significance Index: 25.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4215
    Cell Significance Index: 291.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3503
    Cell Significance Index: 63.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3168
    Cell Significance Index: 140.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2717
    Cell Significance Index: 12.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2572
    Cell Significance Index: 35.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2003
    Cell Significance Index: 39.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1873
    Cell Significance Index: 3.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1685
    Cell Significance Index: 28.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1667
    Cell Significance Index: 31.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1649
    Cell Significance Index: 20.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1489
    Cell Significance Index: 4.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1450
    Cell Significance Index: 7.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1349
    Cell Significance Index: 9.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1330
    Cell Significance Index: 4.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1180
    Cell Significance Index: 3.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0609
    Cell Significance Index: 1.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0175
    Cell Significance Index: 11.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0075
    Cell Significance Index: 14.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0080
    Cell Significance Index: -4.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0135
    Cell Significance Index: -24.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0162
    Cell Significance Index: -11.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0279
    Cell Significance Index: -37.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0377
    Cell Significance Index: -27.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0454
    Cell Significance Index: -2.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0509
    Cell Significance Index: -28.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0521
    Cell Significance Index: -39.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0851
    Cell Significance Index: -17.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1077
    Cell Significance Index: -30.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1194
    Cell Significance Index: -3.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1240
    Cell Significance Index: -6.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1311
    Cell Significance Index: -16.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1349
    Cell Significance Index: -3.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1445
    Cell Significance Index: -18.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1466
    Cell Significance Index: -21.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1705
    Cell Significance Index: -20.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1789
    Cell Significance Index: -20.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1992
    Cell Significance Index: -22.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2243
    Cell Significance Index: -17.2200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2293
    Cell Significance Index: -1.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2434
    Cell Significance Index: -5.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2788
    Cell Significance Index: -7.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2798
    Cell Significance Index: -19.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2849
    Cell Significance Index: -29.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2934
    Cell Significance Index: -13.7900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3455
    Cell Significance Index: -2.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3494
    Cell Significance Index: -11.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3769
    Cell Significance Index: -39.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3937
    Cell Significance Index: -7.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3985
    Cell Significance Index: -29.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4151
    Cell Significance Index: -9.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4208
    Cell Significance Index: -33.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4411
    Cell Significance Index: -14.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4811
    Cell Significance Index: -25.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5034
    Cell Significance Index: -8.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5096
    Cell Significance Index: -16.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5203
    Cell Significance Index: -31.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5386
    Cell Significance Index: -34.7500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5547
    Cell Significance Index: -7.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5914
    Cell Significance Index: -15.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6253
    Cell Significance Index: -8.9600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6324
    Cell Significance Index: -6.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6489
    Cell Significance Index: -16.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6618
    Cell Significance Index: -14.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7378
    Cell Significance Index: -21.7300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7444
    Cell Significance Index: -15.8000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.8131
    Cell Significance Index: -5.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8343
    Cell Significance Index: -22.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8448
    Cell Significance Index: -12.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8503
    Cell Significance Index: -17.0700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.8914
    Cell Significance Index: -8.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8946
    Cell Significance Index: -31.3400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.9403
    Cell Significance Index: -10.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FZD3 is a G protein-coupled receptor (GPCR) that belongs to the Frizzled family, characterized by the presence of a PDZ domain-binding motif. It is primarily expressed in neuronal cells, including neurons, astrocytes, and oligodendrocytes. FZD3 is identified by its high sequence homology with other Frizzled receptors and its ability to interact with Wnt proteins, thereby modulating their signaling activities. **Pathways and Functions:** FZD3 is integral to the Wnt signaling pathway, which is involved in various cellular processes, including: 1. **Canonical Wnt signaling pathway:** FZD3 interacts with β-catenin to regulate gene expression, promoting cell proliferation, differentiation, and survival. 2. **Non-canonical Wnt signaling pathway:** FZD3 is involved in the planar cell polarity (PCP) pathway, which regulates cell polarity, migration, and axon guidance. 3. **Ca2+ pathway:** FZD3 modulates Ca2+ signaling, influencing neuronal excitability and synaptic transmission. 4. **Cell proliferation and differentiation:** FZD3 regulates the proliferation and differentiation of neuronal cells, including neurons, astrocytes, and oligodendrocytes. **Clinical Significance:** Dysregulation of the Wnt signaling pathway, including FZD3, has been implicated in various neurological and immunological disorders, such as: 1. **Neurological disorders:** FZD3 has been linked to neurodevelopmental disorders, such as autism spectrum disorder (ASD), schizophrenia, and Parkinson's disease. 2. **Immunological disorders:** FZD3 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it regulates the immune response and tissue homeostasis. 3. **Cancer:** FZD3 has been identified as a tumor suppressor in certain cancers, including colorectal cancer and glioblastoma. In conclusion, FZD3 is a multifunctional receptor that plays a crucial role in regulating various cellular processes, including cell proliferation, differentiation, and migration. Its dysregulation has been implicated in various neurological and immunological disorders, highlighting the importance of further research into the mechanisms of FZD3-mediated signaling and its potential therapeutic applications.

Genular Protein ID: 2262981534

Symbol: FZD3_HUMAN

Name: Frizzled-3

UniProtKB Accession Codes:

Q9NPG1 A8K615

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10777673

Title: Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21.

PubMed ID: 10777673

DOI: 10.1006/bbrc.2000.2578

PubMed ID: 10873558

Title: Identification, gene structure and expression of human frizzled-3 (FZD3).

PubMed ID: 10873558

DOI: 10.1006/bbrc.2000.2882

PubMed ID: 11407985

Title: Characterization of mouse frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes.

PubMed ID: 11407985

DOI: 10.1046/j.1523-1747.2001.01336.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 22045688

Title: FZD6 is a novel gene for human neural tube defects.

PubMed ID: 22045688

DOI: 10.1002/humu.21643

Sequence Information:

  • Length: 666
  • Mass: 76263
  • Checksum: 46D7C46E21160215
  • Sequence:
    • MAMTWIVFSL WPLTVFMGHI GGHSLFSCEP ITLRMCQDLP YNTTFMPNLL NHYDQQTAAL 
AMEPFHPMVN LDCSRDFRPF LCALYAPICM EYGRVTLPCR RLCQRAYSEC SKLMEMFGVP 
WPEDMECSRF PDCDEPYPRL VDLNLAGEPT EGAPVAVQRD YGFWCPRELK IDPDLGYSFL 
HVRDCSPPCP NMYFRREELS FARYFIGLIS IICLSATLFT FLTFLIDVTR FRYPERPIIF 
YAVCYMMVSL IFFIGFLLED RVACNASIPA QYKASTVTQG SHNKACTMLF MILYFFTMAG 
SVWWVILTIT WFLAAVPKWG SEAIEKKALL FHASAWGIPG TLTIILLAMN KIEGDNISGV 
CFVGLYDVDA LRYFVLAPLC LYVVVGVSLL LAGIISLNRV RIEIPLEKEN QDKLVKFMIR 
IGVFSILYLV PLLVVIGCYF YEQAYRGIWE TTWIQERCRE YHIPCPYQVT QMSRPDLILF 
LMKYLMALIV GIPSVFWVGS KKTCFEWASF FHGRRKKEIV NESRQVLQEP DFAQSLLRDP 
NTPIIRKSRG TSTQGTSTHA SSTQLAMVDD QRSKAGSIHS KVSSYHGSLH RSRDGRYTPC 
SYRGMEERLP HGSMSRLTDH SRHSSSHRLN EQSRHSSIRD LSNNPMTHIT HGTSMNRVIE 
EDGTSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.