Details for: NR4A3

Gene ID: 8013

Symbol: NR4A3

Ensembl ID: ENSG00000119508

Description: nuclear receptor subfamily 4 group A member 3

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Nuclear receptor transcription pathway
    (R-HSA-383280)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
    (R-HSA-8936459)
  • Transcriptional regulation by runx1
    (R-HSA-8878171)
  • Animal organ regeneration
    (GO:0031100)
  • Camp response element binding
    (GO:0035497)
  • Cellular respiration
    (GO:0045333)
  • Cellular response to catecholamine stimulus
    (GO:0071870)
  • Cellular response to corticotropin-releasing hormone stimulus
    (GO:0071376)
  • Cellular response to leptin stimulus
    (GO:0044320)
  • Chromatin
    (GO:0000785)
  • Common myeloid progenitor cell proliferation
    (GO:0035726)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Energy homeostasis
    (GO:0097009)
  • Fat cell differentiation
    (GO:0045444)
  • Gastrulation
    (GO:0007369)
  • Intracellular receptor signaling pathway
    (GO:0030522)
  • Intracellular signal transduction
    (GO:0035556)
  • Mast cell degranulation
    (GO:0043303)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear glucocorticoid receptor binding
    (GO:0035259)
  • Nuclear receptor activity
    (GO:0004879)
  • Nuclear steroid receptor activity
    (GO:0003707)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Platelet-derived growth factor receptor signaling pathway
    (GO:0048008)
  • Positive regulation of cardiac muscle hypertrophy
    (GO:0010613)
  • Positive regulation of d-glucose transmembrane transport
    (GO:0010828)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of feeding behavior
    (GO:2000253)
  • Positive regulation of mast cell activation by fc-epsilon receptor signaling pathway
    (GO:0038097)
  • Positive regulation of mast cell cytokine production
    (GO:0032765)
  • Positive regulation of monocyte aggregation
    (GO:1900625)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of smooth muscle cell proliferation
    (GO:0048660)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of type b pancreatic cell proliferation
    (GO:0061469)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Steroid hormone receptor signaling pathway
    (GO:0043401)
  • Transcription regulator complex
    (GO:0005667)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 155.4532
    Cell Significance Index: -24.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.2161
    Cell Significance Index: -23.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.0484
    Cell Significance Index: -19.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.6439
    Cell Significance Index: -24.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.6865
    Cell Significance Index: -23.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1505
    Cell Significance Index: -24.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.5015
    Cell Significance Index: 147.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7697
    Cell Significance Index: -14.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.8246
    Cell Significance Index: 35.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0568
    Cell Significance Index: -6.6900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.7950
    Cell Significance Index: 43.2400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.3254
    Cell Significance Index: 22.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3186
    Cell Significance Index: 101.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9197
    Cell Significance Index: 47.7800
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.6858
    Cell Significance Index: 5.2600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4795
    Cell Significance Index: 11.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3335
    Cell Significance Index: 628.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3070
    Cell Significance Index: 8.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2031
    Cell Significance Index: 9.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1719
    Cell Significance Index: 109.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1673
    Cell Significance Index: 75.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1417
    Cell Significance Index: 18.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1291
    Cell Significance Index: 25.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0903
    Cell Significance Index: 62.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0818
    Cell Significance Index: 10.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0703
    Cell Significance Index: 2.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0486
    Cell Significance Index: 7.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0473
    Cell Significance Index: 20.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0204
    Cell Significance Index: 3.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0200
    Cell Significance Index: 30.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0146
    Cell Significance Index: 2.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0109
    Cell Significance Index: 1.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0069
    Cell Significance Index: 3.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0006
    Cell Significance Index: -0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0093
    Cell Significance Index: -0.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0096
    Cell Significance Index: -1.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0143
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0188
    Cell Significance Index: -13.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0231
    Cell Significance Index: -8.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0241
    Cell Significance Index: -17.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0270
    Cell Significance Index: -20.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0414
    Cell Significance Index: -25.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0424
    Cell Significance Index: -23.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0537
    Cell Significance Index: -15.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0587
    Cell Significance Index: -6.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0936
    Cell Significance Index: -18.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0972
    Cell Significance Index: -9.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1065
    Cell Significance Index: -12.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1216
    Cell Significance Index: -25.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1311
    Cell Significance Index: -3.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1385
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1395
    Cell Significance Index: -23.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1451
    Cell Significance Index: -18.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1504
    Cell Significance Index: -9.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1507
    Cell Significance Index: -15.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1547
    Cell Significance Index: -16.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1687
    Cell Significance Index: -7.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1859
    Cell Significance Index: -12.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1971
    Cell Significance Index: -11.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1999
    Cell Significance Index: -5.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2012
    Cell Significance Index: -11.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2223
    Cell Significance Index: -25.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2266
    Cell Significance Index: -15.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2494
    Cell Significance Index: -6.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2548
    Cell Significance Index: -13.2700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2628
    Cell Significance Index: -4.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2714
    Cell Significance Index: -20.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2860
    Cell Significance Index: -9.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2909
    Cell Significance Index: -8.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3099
    Cell Significance Index: -8.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3138
    Cell Significance Index: -13.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3239
    Cell Significance Index: -14.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3360
    Cell Significance Index: -6.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3487
    Cell Significance Index: -14.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3573
    Cell Significance Index: -21.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3804
    Cell Significance Index: -23.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3926
    Cell Significance Index: -17.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4040
    Cell Significance Index: -21.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4079
    Cell Significance Index: -25.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4097
    Cell Significance Index: -10.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4099
    Cell Significance Index: -9.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4219
    Cell Significance Index: -3.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4244
    Cell Significance Index: -9.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4353
    Cell Significance Index: -15.9800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.4526
    Cell Significance Index: -4.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4587
    Cell Significance Index: -23.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4658
    Cell Significance Index: -17.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4710
    Cell Significance Index: -16.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4731
    Cell Significance Index: -7.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5131
    Cell Significance Index: -13.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5189
    Cell Significance Index: -16.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5339
    Cell Significance Index: -11.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5394
    Cell Significance Index: -17.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5473
    Cell Significance Index: -13.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5585
    Cell Significance Index: -11.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5642
    Cell Significance Index: -19.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6185
    Cell Significance Index: -21.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6311
    Cell Significance Index: -7.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** NR4A3 is a transcription factor that regulates the expression of target genes by binding to specific DNA sequences. 2. **Cellular Expression:** This gene is highly expressed in multiple cell types, including fibroblasts, epithelial cells, and neurons. 3. **Nuclear Receptor Superfamily:** NR4A3 is part of the nuclear receptor superfamily, which plays a crucial role in regulating gene expression in response to various stimuli. 4. **Steroid Hormone Mediated Signaling:** NR4A3 is involved in steroid hormone-mediated signaling pathways, which regulate various physiological processes, including energy homeostasis and cell growth. **Pathways and Functions:** 1. **Energy Homeostasis:** NR4A3 regulates the expression of genes involved in energy metabolism, including fatty acid oxidation and glucose transmembrane transport. 2. **Cell Proliferation and Differentiation:** This gene is involved in regulating cell proliferation and differentiation in various cell types, including epithelial cells and neurons. 3. **Inflammation and Immune Response:** NR4A3 regulates the expression of genes involved in inflammation and immune response, including the regulation of mast cell activation and cytokine production. 4. **Cardiac Muscle Hypertrophy:** This gene is involved in regulating cardiac muscle hypertrophy, which is a condition characterized by the enlargement of cardiac muscle cells. **Clinical Significance:** 1. **Cancer:** NR4A3 has been implicated in the development and progression of various cancers, including prostate cancer and breast cancer. 2. **Metabolic Disorders:** This gene is involved in regulating energy metabolism and has been implicated in the development of metabolic disorders, including obesity and type 2 diabetes. 3. **Neurological Disorders:** NR4A3 has been implicated in the development and progression of various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease:** This gene is involved in regulating cardiac muscle function and has been implicated in the development of cardiovascular disease, including cardiac hypertrophy and heart failure. In conclusion, the NR4A3 gene plays a crucial role in regulating various biological processes, including energy homeostasis, cell proliferation, and differentiation. Its dysregulation has been implicated in the development and progression of various diseases, including cancer, metabolic disorders, and neurological disorders. Further research is needed to fully understand the functional significance of NR4A3 and its role in human disease.

Genular Protein ID: 3494968504

Symbol: NR4A3_HUMAN

Name: Nuclear receptor subfamily 4 group A member 3

UniProtKB Accession Codes:

Q92570 A2A3I7 Q12935 Q14979 Q16420 Q4VXA8 Q4VXA9 Q9UEK2 Q9UEK3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 42 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 4 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8809112

Title: Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family.

PubMed ID: 8809112

DOI: 10.1016/0167-4781(96)00101-7

PubMed ID: 8614405

Title: The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor.

PubMed ID: 8614405

DOI: 10.1210/mend.9.12.8614405

PubMed ID: 8570200

Title: Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma.

PubMed ID: 8570200

PubMed ID: 8634690

Title: Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation.

PubMed ID: 8634690

DOI: 10.1093/hmg/4.12.2219

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 9573341

Title: Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA.

PubMed ID: 9573341

DOI: 10.1016/s0378-1119(98)00095-x

PubMed ID: 12543801

Title: The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas.

PubMed ID: 12543801

PubMed ID: 20558821

Title: Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis.

PubMed ID: 20558821

DOI: 10.1161/circresaha.110.222083

PubMed ID: 24022864

Title: 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3.

PubMed ID: 24022864

DOI: 10.1152/ajpendo.00169.2013

PubMed ID: 25852083

Title: DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1.

PubMed ID: 25852083

DOI: 10.1093/cvr/cvv126

Sequence Information:

  • Length: 626
  • Mass: 68230
  • Checksum: FB4A1AB7667D96F6
  • Sequence:
    • MPCVQAQYSP SPPGSSYAAQ TYSSEYTTEI MNPDYTKLTM DLGSTEITAT ATTSLPSIST 
FVEGYSSNYE LKPSCVYQMQ RPLIKVEEGR APSYHHHHHH HHHHHHHHQQ QHQQPSIPPA 
SSPEDEVLPS TSMYFKQSPP STPTTPAFPP QAGALWDEAL PSAPGCIAPG PLLDPPMKAV 
PTVAGARFPL FHFKPSPPHP PAPSPAGGHH LGYDPTAAAA LSLPLGAAAA AGSQAAALES 
HPYGLPLAKR AAPLAFPPLG LTPSPTASSL LGESPSLPSP PSRSSSSGEG TCAVCGDNAA 
CQHYGVRTCE GCKGFFKRTV QKNAKYVCLA NKNCPVDKRR RNRCQYCRFQ KCLSVGMVKE 
VVRTDSLKGR RGRLPSKPKS PLQQEPSQPS PPSPPICMMN ALVRALTDST PRDLDYSRYC 
PTDQAAAGTD AEHVQQFYNL LTASIDVSRS WAEKIPGFTD LPKEDQTLLI ESAFLELFVL 
RLSIRSNTAE DKFVFCNGLV LHRLQCLRGF GEWLDSIKDF SLNLQSLNLD IQALACLSAL 
SMITERHGLK EPKRVEELCN KITSSLKDHQ SKGQALEPTE SKVLGALVEL RKICTLGLQR 
IFYLKLEDLV SPPSIIDKLF LDTLPF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.