Details for: STAM

Gene ID: 8027

Symbol: STAM

Ensembl ID: ENSG00000136738

Description: signal transducing adaptor molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 175.3188
    Cell Significance Index: -27.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 121.9823
    Cell Significance Index: -30.9400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 84.0641
    Cell Significance Index: -34.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.0229
    Cell Significance Index: -35.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.5619
    Cell Significance Index: -28.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.7724
    Cell Significance Index: -28.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.8914
    Cell Significance Index: -30.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2851
    Cell Significance Index: -32.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5823
    Cell Significance Index: -26.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2633
    Cell Significance Index: -32.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5195
    Cell Significance Index: -12.0800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 5.5132
    Cell Significance Index: 90.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5294
    Cell Significance Index: 250.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3273
    Cell Significance Index: 266.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2638
    Cell Significance Index: 205.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0789
    Cell Significance Index: 974.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8705
    Cell Significance Index: 66.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7986
    Cell Significance Index: 86.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7447
    Cell Significance Index: 44.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6818
    Cell Significance Index: 38.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6597
    Cell Significance Index: 236.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6467
    Cell Significance Index: 39.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5855
    Cell Significance Index: 15.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5707
    Cell Significance Index: 113.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5224
    Cell Significance Index: 361.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4839
    Cell Significance Index: 13.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4579
    Cell Significance Index: 30.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4510
    Cell Significance Index: 13.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4185
    Cell Significance Index: 75.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3482
    Cell Significance Index: 24.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3473
    Cell Significance Index: 42.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3310
    Cell Significance Index: 9.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3000
    Cell Significance Index: 564.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2831
    Cell Significance Index: 6.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2499
    Cell Significance Index: 15.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2491
    Cell Significance Index: 12.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2423
    Cell Significance Index: 33.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2350
    Cell Significance Index: 128.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2265
    Cell Significance Index: 3.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2132
    Cell Significance Index: 4.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1589
    Cell Significance Index: 18.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1419
    Cell Significance Index: 2.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1366
    Cell Significance Index: 60.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0980
    Cell Significance Index: 1.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0801
    Cell Significance Index: 13.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0723
    Cell Significance Index: 3.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0563
    Cell Significance Index: 35.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0529
    Cell Significance Index: 2.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0524
    Cell Significance Index: 96.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0348
    Cell Significance Index: 53.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0302
    Cell Significance Index: 41.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0237
    Cell Significance Index: 1.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0133
    Cell Significance Index: 6.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0074
    Cell Significance Index: 0.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0113
    Cell Significance Index: -7.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0132
    Cell Significance Index: -2.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0170
    Cell Significance Index: -2.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0194
    Cell Significance Index: -14.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0205
    Cell Significance Index: -0.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0247
    Cell Significance Index: -18.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0398
    Cell Significance Index: -22.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0458
    Cell Significance Index: -5.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0517
    Cell Significance Index: -6.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0539
    Cell Significance Index: -0.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0657
    Cell Significance Index: -3.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0933
    Cell Significance Index: -19.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1051
    Cell Significance Index: -10.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1154
    Cell Significance Index: -33.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1350
    Cell Significance Index: -15.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1511
    Cell Significance Index: -19.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1654
    Cell Significance Index: -11.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1754
    Cell Significance Index: -2.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1806
    Cell Significance Index: -9.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1952
    Cell Significance Index: -4.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1996
    Cell Significance Index: -7.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2153
    Cell Significance Index: -22.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2177
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2297
    Cell Significance Index: -26.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2459
    Cell Significance Index: -12.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2474
    Cell Significance Index: -7.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2607
    Cell Significance Index: -19.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2711
    Cell Significance Index: -17.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2863
    Cell Significance Index: -6.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2928
    Cell Significance Index: -7.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3423
    Cell Significance Index: -27.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3557
    Cell Significance Index: -7.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3579
    Cell Significance Index: -7.6500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3860
    Cell Significance Index: -8.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4018
    Cell Significance Index: -11.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4041
    Cell Significance Index: -6.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4293
    Cell Significance Index: -13.7500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4450
    Cell Significance Index: -5.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4479
    Cell Significance Index: -22.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4550
    Cell Significance Index: -7.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5036
    Cell Significance Index: -13.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5108
    Cell Significance Index: -10.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5269
    Cell Significance Index: -16.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5396
    Cell Significance Index: -18.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** STAM is a member of the adaptor protein family, which bridges signaling receptors with downstream effector molecules, facilitating the transmission of cellular signals. The STAM protein has several key characteristics: 1. **Adaptor function**: STAM acts as a scaffold protein, recruiting and interacting with multiple signaling molecules, including receptor tyrosine kinases, G-protein coupled receptors, and small GTPases. 2. **Phosphatidylinositol binding**: STAM contains a phosphatidylinositol (PI) binding motif, which allows it to interact with phospholipids and regulate membrane trafficking. 3. **Ubiquitin binding**: STAM binds to ubiquitin-like proteins, influencing protein degradation and sorting. 4. **Endosomal sorting**: STAM is involved in the sorting of proteins to endosomes and lysosomes, regulating protein degradation and recycling. **Pathways and Functions** STAM participates in numerous signaling pathways, including: 1. **Receptor tyrosine kinase signaling**: STAM interacts with receptor tyrosine kinases, such as EGFR and MET, influencing their activation and downstream signaling. 2. **G-protein coupled receptor signaling**: STAM interacts with G-protein coupled receptors, modulating their signaling and downstream effects. 3. **Small GTPase signaling**: STAM interacts with small GTPases, such as Rho and Miro, influencing their activation and downstream effects. 4. **Endosomal sorting and protein degradation**: STAM regulates the sorting of proteins to endosomes and lysosomes, influencing protein degradation and recycling. 5. **Exosomal secretion**: STAM is involved in the regulation of exosomal secretion, influencing the release of signaling molecules. **Clinical Significance** Dysregulation of STAM has been implicated in various diseases, including: 1. **Cancer**: STAM is overexpressed in certain types of cancer, including lung, breast, and colon cancer. 2. **Neurodegenerative diseases**: STAM has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Infectious diseases**: STAM plays a role in the entry of pathogens, such as Listeria monocytogenes, into host cells. 4. **Metabolic disorders**: STAM is involved in the regulation of glucose and lipid metabolism, influencing the development of metabolic disorders, such as type 2 diabetes. In summary, STAM is a multifunctional adaptor protein that plays a critical role in various cellular processes, including signal transduction, protein transport, and endocytosis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding STAM's functions and regulation in normal and pathological conditions.

Genular Protein ID: 88492392

Symbol: STAM1_HUMAN

Name: Signal transducing adapter molecule 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8780729

Title: Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.

PubMed ID: 8780729

DOI: 10.1006/bbrc.1996.1290

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11687594

Title: Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.

PubMed ID: 11687594

DOI: 10.1074/jbc.m109992200

PubMed ID: 9407053

Title: Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth.

PubMed ID: 9407053

DOI: 10.1074/jbc.272.52.32785

PubMed ID: 10383417

Title: Possible involvement of a novel STAM-associated molecule 'AMSH' in intracellular signal transduction mediated by cytokines.

PubMed ID: 10383417

DOI: 10.1074/jbc.274.27.19129

PubMed ID: 12551915

Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.

PubMed ID: 12551915

DOI: 10.1074/jbc.m210843200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 20494825

Title: Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.

PubMed ID: 20494825

DOI: 10.1016/j.cellsig.2010.05.004

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23166352

Title: Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking.

PubMed ID: 23166352

DOI: 10.1083/jcb.201204137

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24790097

Title: The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.

PubMed ID: 24790097

DOI: 10.1091/mbc.e13-10-0612

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29742433

Title: TIM-1 Ubiquitination Mediates Dengue Virus Entry.

PubMed ID: 29742433

DOI: 10.1016/j.celrep.2018.04.013

PubMed ID: 19278655

Title: Hybrid structural model of the complete human ESCRT-0 complex.

PubMed ID: 19278655

DOI: 10.1016/j.str.2009.01.012

PubMed ID: 20150893

Title: VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo.

PubMed ID: 20150893

DOI: 10.1038/emboj.2010.6

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 540
  • Mass: 59180
  • Checksum: 8D6F07FAE538F36F
  • Sequence:
  • MPLFATNPFD QDVEKATSEM NTAEDWGLIL DICDKVGQSR TGPKDCLRSI MRRVNHKDPH 
    VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSNVLNKG HPKVCEKLKA LMVEWTDEFK 
    NDPQLSLISA MIKNLKEQGV TFPAIGSQAA EQAKASPALV AKDPGTVANK KEEEDLAKAI 
    ELSLKEQRQQ STTLSTLYPS TSSLLTNHQH EGRKVRAIYD FEAAEDNELT FKAGEIITVL 
    DDSDPNWWKG ETHQGIGLFP SNFVTADLTA EPEMIKTEKK TVQFSDDVQV ETIEPEPEPA 
    FIDEDKMDQL LQMLQSTDPS DDQPDLPELL HLEAMCHQMG PLIDEKLEDI DRKHSELSEL 
    NVKVMEALSL YTKLMNEDPM YSMYAKLQNQ PYYMQSSGVS GSQVYAGPPP SGAYLVAGNA 
    QMSHLQSYSL PPEQLSSLSQ AVVPPSANPA LPSQQTQAAY PNTMVSSVQG NTYPSQAPVY 
    SPPPAATAAA ATADVTLYQN AGPNMPQVPN YNLTSSTLPQ PGGSQQPPQP QQPYSQKALL

Genular Protein ID: 4175465425

Symbol: B4DZT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 429
  • Mass: 46912
  • Checksum: 8CB84C76D6D0A625
  • Sequence:
  • MVEWTDEFKN DPQLSLISAM IKNLKEQGVT FPAIGSQAAE QAKASPALVA KDPGTVANKK 
    EEEDLAKAIE LSLKEQRQQS TTLSTLYPST SSLLTNHQHE GRKVRAIYDF EAAEDNELTF 
    KAGEIITVLD DSDPNWWKGE THQGIGLFPS NFVTADLTAE PEMIKTEKKT VQFSDDVQVE 
    TIEPEPEPAF IDEDKMDQLL QMLQSTDPSD DQPDLPELLH LEAMCHQMGP LIDEKLEDID 
    RKHSELSELN VKVMEALSLY TKLMNEDPMY SMYAKLQNQP YYMQSSGVSG SQVYAGPPPS 
    GAYLVAGNAQ MSHLQSYSLP PEQLSSLSQA VVPPSANPAL PSQQTQAAYP NTMVSSVQGN 
    TYPSQAPVYS PPPAATAAAA TADVTLYQNA GPNMPQVPNY NLTSSTLPQP GGSQQPPQPQ 
    QPYSQKALL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.