Details for: MADCAM1

Gene ID: 8174

Symbol: MADCAM1

Ensembl ID: ENSG00000099866

Description: mucosal vascular addressin cell adhesion molecule 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.7458
    Cell Significance Index: -6.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.2430
    Cell Significance Index: -6.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.6612
    Cell Significance Index: -6.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2333
    Cell Significance Index: 39.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8650
    Cell Significance Index: 18.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7086
    Cell Significance Index: 134.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4355
    Cell Significance Index: 9.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3872
    Cell Significance Index: 349.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3556
    Cell Significance Index: 22.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2674
    Cell Significance Index: 43.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2530
    Cell Significance Index: 27.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2328
    Cell Significance Index: 3.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1874
    Cell Significance Index: 11.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1755
    Cell Significance Index: 35.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1752
    Cell Significance Index: 9.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1658
    Cell Significance Index: 16.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1584
    Cell Significance Index: 7.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1338
    Cell Significance Index: 3.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1234
    Cell Significance Index: 24.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1217
    Cell Significance Index: 8.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1183
    Cell Significance Index: 1.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1012
    Cell Significance Index: 36.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0856
    Cell Significance Index: 3.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0717
    Cell Significance Index: 3.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0620
    Cell Significance Index: 38.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0591
    Cell Significance Index: 8.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0552
    Cell Significance Index: 0.6900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0510
    Cell Significance Index: 0.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0494
    Cell Significance Index: 1.3800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0480
    Cell Significance Index: 0.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0468
    Cell Significance Index: 0.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0443
    Cell Significance Index: 3.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0421
    Cell Significance Index: 2.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0398
    Cell Significance Index: 0.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0394
    Cell Significance Index: 7.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0238
    Cell Significance Index: 32.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0192
    Cell Significance Index: 36.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0176
    Cell Significance Index: 0.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0167
    Cell Significance Index: 25.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0145
    Cell Significance Index: 26.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0088
    Cell Significance Index: 0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0055
    Cell Significance Index: 3.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0004
    Cell Significance Index: 0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0004
    Cell Significance Index: 0.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0005
    Cell Significance Index: -0.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0032
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0079
    Cell Significance Index: -5.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0091
    Cell Significance Index: -6.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0112
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0114
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0134
    Cell Significance Index: -2.2900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0137
    Cell Significance Index: -0.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0154
    Cell Significance Index: -1.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0170
    Cell Significance Index: -4.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0174
    Cell Significance Index: -0.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0175
    Cell Significance Index: -2.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0201
    Cell Significance Index: -2.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0244
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0322
    Cell Significance Index: -3.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0330
    Cell Significance Index: -3.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0342
    Cell Significance Index: -0.4900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0345
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0364
    Cell Significance Index: -4.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0432
    Cell Significance Index: -5.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0499
    Cell Significance Index: -1.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0529
    Cell Significance Index: -6.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0538
    Cell Significance Index: -3.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0549
    Cell Significance Index: -2.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0569
    Cell Significance Index: -0.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0585
    Cell Significance Index: -1.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0596
    Cell Significance Index: -6.2100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0627
    Cell Significance Index: -0.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0632
    Cell Significance Index: -1.3100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0656
    Cell Significance Index: -0.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0664
    Cell Significance Index: -4.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0668
    Cell Significance Index: -4.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0686
    Cell Significance Index: -4.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0747
    Cell Significance Index: -1.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0846
    Cell Significance Index: -6.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0867
    Cell Significance Index: -2.0800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0869
    Cell Significance Index: -1.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0932
    Cell Significance Index: -6.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1041
    Cell Significance Index: -1.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1066
    Cell Significance Index: -5.0100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1105
    Cell Significance Index: -1.5700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1112
    Cell Significance Index: -1.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1157
    Cell Significance Index: -3.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1175
    Cell Significance Index: -6.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1311
    Cell Significance Index: -1.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1338
    Cell Significance Index: -4.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1348
    Cell Significance Index: -3.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1352
    Cell Significance Index: -2.8700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1369
    Cell Significance Index: -1.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1396
    Cell Significance Index: -3.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1428
    Cell Significance Index: -2.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1444
    Cell Significance Index: -5.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1484
    Cell Significance Index: -4.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface Expression:** MADCAM1 is expressed on the surface of various cell types, including endothelial cells, immune cells, epithelial cells, and neural cells. 2. **Adhesion Function:** MADCAM1 mediates cell-cell and cell-extracellular matrix interactions, facilitating leukocyte tethering, rolling, and migration. 3. **Signal Transduction:** MADCAM1 interacts with integrins and other adhesion molecules, triggering signaling pathways that regulate immune responses and cell migration. 4. **Regulatory Role:** MADCAM1 is involved in the regulation of immune responses, including the modulation of leukocyte migration, immune system activation, and the interaction between lymphoid and non-lymphoid cells. **Pathways and Functions:** 1. **Adaptive Immune System:** MADCAM1 plays a crucial role in the regulation of immune responses, including the activation of immune cells and the modulation of cytokine production. 2. **Cell-Matrix Adhesion:** MADCAM1 mediates cell-extracellular matrix interactions, influencing cell migration, proliferation, and differentiation. 3. **Integrin-Mediated Signaling:** MADCAM1 interacts with integrins, triggering signaling pathways that regulate cell migration, adhesion, and immune responses. 4. **Leukocyte Migration:** MADCAM1 is involved in the regulation of leukocyte migration, facilitating the movement of immune cells to sites of inflammation or infection. **Clinical Significance:** 1. **Inflammatory Diseases:** MADCAM1 has been implicated in the pathogenesis of inflammatory diseases, including atherosclerosis, rheumatoid arthritis, and inflammatory bowel disease. 2. **Cancer:** MADCAM1 has been associated with cancer progression and metastasis, highlighting its potential as a therapeutic target. 3. **Neurological Disorders:** MADCAM1 has been implicated in neurological disorders, including multiple sclerosis and Alzheimer's disease, suggesting its potential as a therapeutic target. 4. **Regenerative Medicine:** MADCAM1 has been shown to play a role in tissue homeostasis and regeneration, highlighting its potential as a therapeutic target for tissue repair and regeneration. In conclusion, MADCAM1 is a critical adhesion molecule that plays a pivotal role in immune response, cell adhesion, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and potential therapeutic applications.

Genular Protein ID: 4283974330

Symbol: MADCA_HUMAN

Name: Mucosal addressin cell adhesion molecule 1

UniProtKB Accession Codes:

Q13477 A5PKV4 B2RPL9 O60222 O75867 Q5UGI7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8989586

Title: Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts.

PubMed ID: 8989586

DOI: 10.1038/icb.1996.81

PubMed ID: 8609404

Title: Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences.

PubMed ID: 8609404

PubMed ID: 9162097

Title: Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene.

PubMed ID: 9162097

DOI: 10.1007/s002510050249

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9655832

Title: The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition.

PubMed ID: 9655832

DOI: 10.1016/s0969-2126(98)00080-x

PubMed ID: 11807247

Title: A reassessment of the MAdCAM-1 structure and its role in integrin recognition.

PubMed ID: 11807247

DOI: 10.1107/s0907444901020522

PubMed ID: 23297416

Title: Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop.

PubMed ID: 23297416

DOI: 10.1074/jbc.m112.413153

Sequence Information:

  • Length: 382
  • Mass: 40155
  • Checksum: 9DCA60C30BA61E62
  • Sequence:
    • MDFGLALLLA GLLGLLLGQS LQVKPLQVEP PEPVVAVALG ASRQLTCRLA CADRGASVQW 
RGLDTSLGAV QSDTGRSVLT VRNASLSAAG TRVCVGSCGG RTFQHTVQLL VYAFPDQLTV 
SPAALVPGDP EVACTAHKVT PVDPNALSFS LLVGGQELEG AQALGPEVQE EEEEPQGDED 
VLFRVTERWR LPPLGTPVPP ALYCQATMRL PGLELSHRQA IPVLHSPTSP EPPDTTSPES 
PDTTSPESPD TTSQEPPDTT SPEPPDKTSP EPAPQQGSTH TPRSPGSTRT RRPEISQAGP 
TQGEVIPTGS SKPAGDQLPA ALWTSSAVLG LLLLALPTYH LWKRCRHLAE DDTHPPASLR 
LLPQVSAWAG LRGTGQVGIS PS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.