Details for: ELL

Gene ID: 8178

Symbol: ELL

Ensembl ID: ENSG00000105656

Description: elongation factor for RNA polymerase II

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 125.8798
    Cell Significance Index: -19.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.1663
    Cell Significance Index: -20.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.8355
    Cell Significance Index: -21.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6186
    Cell Significance Index: -20.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3443
    Cell Significance Index: -13.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3012
    Cell Significance Index: -16.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2762
    Cell Significance Index: -20.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8403
    Cell Significance Index: 49.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2585
    Cell Significance Index: 17.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9555
    Cell Significance Index: 24.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9395
    Cell Significance Index: 25.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7335
    Cell Significance Index: 145.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6288
    Cell Significance Index: 126.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6256
    Cell Significance Index: 32.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6014
    Cell Significance Index: 17.2400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5996
    Cell Significance Index: 14.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5782
    Cell Significance Index: 16.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5137
    Cell Significance Index: 11.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5083
    Cell Significance Index: 23.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4531
    Cell Significance Index: 49.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4526
    Cell Significance Index: 12.3200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.4403
    Cell Significance Index: 3.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4372
    Cell Significance Index: 26.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4325
    Cell Significance Index: 19.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3997
    Cell Significance Index: 65.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3758
    Cell Significance Index: 14.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3681
    Cell Significance Index: 132.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3503
    Cell Significance Index: 34.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3295
    Cell Significance Index: 25.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2563
    Cell Significance Index: 231.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2283
    Cell Significance Index: 15.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2138
    Cell Significance Index: 38.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1950
    Cell Significance Index: 134.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1821
    Cell Significance Index: 22.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1569
    Cell Significance Index: 21.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1083
    Cell Significance Index: 47.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1051
    Cell Significance Index: 4.9400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0982
    Cell Significance Index: 1.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0903
    Cell Significance Index: 49.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0804
    Cell Significance Index: 5.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0791
    Cell Significance Index: 10.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0719
    Cell Significance Index: 13.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0568
    Cell Significance Index: 2.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0424
    Cell Significance Index: 79.8300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0291
    Cell Significance Index: 0.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0286
    Cell Significance Index: 0.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0236
    Cell Significance Index: 2.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0221
    Cell Significance Index: 10.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0198
    Cell Significance Index: 12.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0184
    Cell Significance Index: 28.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0158
    Cell Significance Index: 2.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0134
    Cell Significance Index: 0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0097
    Cell Significance Index: 17.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0081
    Cell Significance Index: 11.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0030
    Cell Significance Index: 0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0214
    Cell Significance Index: -16.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0222
    Cell Significance Index: -16.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0282
    Cell Significance Index: -2.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0315
    Cell Significance Index: -17.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0322
    Cell Significance Index: -0.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0348
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0362
    Cell Significance Index: -22.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0400
    Cell Significance Index: -0.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0613
    Cell Significance Index: -17.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0671
    Cell Significance Index: -1.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0731
    Cell Significance Index: -10.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0771
    Cell Significance Index: -8.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0797
    Cell Significance Index: -5.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1043
    Cell Significance Index: -21.9700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1159
    Cell Significance Index: -1.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1163
    Cell Significance Index: -7.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1327
    Cell Significance Index: -15.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1331
    Cell Significance Index: -13.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1341
    Cell Significance Index: -8.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1383
    Cell Significance Index: -7.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1458
    Cell Significance Index: -9.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1622
    Cell Significance Index: -0.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1751
    Cell Significance Index: -3.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1828
    Cell Significance Index: -4.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2019
    Cell Significance Index: -5.4000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2122
    Cell Significance Index: -3.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2141
    Cell Significance Index: -3.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2343
    Cell Significance Index: -18.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2457
    Cell Significance Index: -12.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2491
    Cell Significance Index: -4.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2503
    Cell Significance Index: -12.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2624
    Cell Significance Index: -16.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2682
    Cell Significance Index: -2.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2945
    Cell Significance Index: -5.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3472
    Cell Significance Index: -9.1300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3500
    Cell Significance Index: -4.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3747
    Cell Significance Index: -12.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3785
    Cell Significance Index: -10.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3895
    Cell Significance Index: -11.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3962
    Cell Significance Index: -8.4100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3995
    Cell Significance Index: -8.0200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4054
    Cell Significance Index: -5.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4075
    Cell Significance Index: -14.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4242
    Cell Significance Index: -13.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Polymerase II Association:** ELL is a non-catalytic subunit of the RNAPII complex, which is responsible for transcribing approximately 80% of the human genome. 2. **Transcription Elongation Regulation:** ELL facilitates the elongation of RNAPII transcripts by interacting with other proteins, such as the positive transcription elongation factor b (P-TEFb) and the transcription factor TFIID. 3. **DNA Repair and Maintenance:** ELL has been implicated in the regulation of DNA repair pathways, including nucleotide excision repair (NER) and transcription-coupled NER (TC-NER). 4. **Immune Cell Function:** ELL is significantly expressed in immune cells, such as mononuclear cells, lymphoid lineage-restricted progenitor cells, and immature innate lymphoid cells, suggesting its involvement in immune regulation and function. **Pathways and Functions:** 1. **Transcription Elongation Pathway:** ELL interacts with RNAPII and other proteins to regulate transcription elongation, ensuring the accurate and efficient production of RNA transcripts. 2. **DNA Repair Pathway:** ELL is involved in the regulation of DNA repair pathways, including NER and TC-NER, which are essential for maintaining genome stability. 3. **Immune Response Pathway:** ELL is expressed in immune cells and has been implicated in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 4. **Cell Cycle Regulation:** ELL has been shown to regulate cell cycle progression by interacting with the cyclin-dependent kinase inhibitor p21. **Clinical Significance:** 1. **Cancer Association:** Alterations in ELL expression have been observed in various cancers, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis. 2. **Immune-Related Disorders:** ELL has been implicated in immune-related disorders, such as rheumatoid arthritis and multiple sclerosis, highlighting its importance in immune homeostasis. 3. **Neurological Disorders:** ELL has been shown to be involved in neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in neurodegenerative diseases. 4. **Gene Therapy:** ELL has been identified as a potential target for gene therapy, with the aim of regulating gene expression and immune function in various diseases. In conclusion, the ELL gene plays a critical role in regulating gene expression, immune function, and DNA repair. Its significance in various diseases, including cancer, immune-related disorders, and neurological disorders, underscores the importance of further research into the molecular mechanisms underlying ELL function.

Genular Protein ID: 4242270942

Symbol: ELL_HUMAN

Name: RNA polymerase II elongation factor ELL

UniProtKB Accession Codes:

P55199

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7991593

Title: Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.

PubMed ID: 7991593

DOI: 10.1073/pnas.91.25.12110

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8596958

Title: An RNA polymerase II elongation factor encoded by the human ELL gene.

PubMed ID: 8596958

DOI: 10.1126/science.271.5257.1873

PubMed ID: 11418481

Title: EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein.

PubMed ID: 11418481

DOI: 10.1182/blood.v98.1.201

PubMed ID: 12446457

Title: ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties.

PubMed ID: 12446457

DOI: 10.1182/blood-2002-06-1664

PubMed ID: 12686606

Title: ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia.

PubMed ID: 12686606

DOI: 10.1091/mbc.e02-07-0394

PubMed ID: 16006523

Title: ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL.

PubMed ID: 16006523

DOI: 10.1073/pnas.0503017102

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20471948

Title: HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.

PubMed ID: 20471948

DOI: 10.1016/j.molcel.2010.04.013

PubMed ID: 20159561

Title: AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

PubMed ID: 20159561

DOI: 10.1016/j.molcel.2010.01.026

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22195968

Title: The little elongation complex regulates small nuclear RNA transcription.

PubMed ID: 22195968

DOI: 10.1016/j.molcel.2011.12.008

PubMed ID: 22252557

Title: ELL facilitates RNA polymerase II pause site entry and release.

PubMed ID: 22252557

DOI: 10.1038/ncomms1652

PubMed ID: 22895430

Title: The super elongation complex (SEC) family in transcriptional control.

PubMed ID: 22895430

DOI: 10.1038/nrm3417

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23932780

Title: The little elongation complex functions at initiation and elongation phases of snRNA gene transcription.

PubMed ID: 23932780

DOI: 10.1016/j.molcel.2013.07.003

PubMed ID: 24413172

Title: A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II.

PubMed ID: 24413172

DOI: 10.1242/jcs.141788

Sequence Information:

  • Length: 621
  • Mass: 68265
  • Checksum: EB4A3F94CA8A411F
  • Sequence:
    • MAALKEDRSY GLSCGRVSDG SKVSVFHVKL TDSALRAFES YRARQDSVSL RPSIRFQGSQ 
GHISIPQPDC PAEARTFSFY LSNIGRDNPQ GSFDCIQQYV SSHGEVHLDC LGSIQDKITV 
CATDDSYQKA RQSMAQAEEE TRSRSAIVIK AGGRYLGKKV QFRKPAPGAT DAVPSRKRAT 
PINLASAIRK SGASAVSGGS GVSQRPFRDR VLHLLALRPY RKAELLLRLQ KDGLTQADKD 
ALDGLLQQVA NMSAKDGTCT LQDCMYKDVQ KDWPGYSEGD QQLLKRVLVR KLCQPQSTGS 
LLGDPAASSP PGERGRSASP PQKRLQPPDF IDPLANKKPR ISHFTQRAQP AVNGKLGVPN 
GREALLPTPG PPASTDTLSS STHLPPRLEP PRAHDPLADV SNDLGHSGRD CEHGEAAAPA 
PTVRLGLPLL TDCAQPSRPH GSPSRSKPKK KSKKHKDKER AAEDKPRAQL PDCAPATHAT 
PGAPADTPGL NGTCSVSSVP TSTSETPDYL LKYAAISSSE QRQSYKNDFN AEYSEYRDLH 
ARIERITRRF TQLDAQLRQL SQGSEEYETT RGQILQEYRK IKKTNTNYSQ EKHRCEYLHS 
KLAHIKRLIA EYDQRQLQAW P

Genular Protein ID: 1469255388

Symbol: U3KQ90_HUMAN

Name: N/A

UniProtKB Accession Codes:

U3KQ90

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 488
  • Mass: 53600
  • Checksum: 4EC28927F531E6E6
  • Sequence:
    • MAQAEEETRS RSAIVIKAGG RYLGKKVQFR KPAPGATDAV PSRKRATPIN LASAIRKSGA 
SAVSGGSGVS QRPFRDRVLH LLALRPYRKA ELLLRLQKDG LTQADKDALD GLLQQVANMS 
AKDGTCTLQD CMYKDVQKDW PGYSEGDQQL LKRVLVRKLC QPQSTGSLLG DPAASSPPGE 
RGRSASPPQK RLQPPDFIDP LANKKPRISH FTQRAQPAVN GKLGVPNGRE ALLPTPGPPA 
STDTLSSSTH LPPRLEPPRA HDPLADVSND LGHSGRDCEH GEAAAPAPTV RLGLPLLTDC 
AQPSRPHGSP SRSKPKKKSK KHKDKERAAE DKPRAQLPDC APATHATPGA PADTPGLNGT 
CSVSSVPTST SETPDYLLKY AAISSSEQRQ SYKNDFNAEY SEYRDLHARI ERITRRFTQL 
DAQLRQLSQG SEEYETTRGQ ILQEYRKIKK TNTNYSQEKH RCEYLHSKLA HIKRLIAEYD 
QRQLQAWP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.