Details for: SYMPK

Gene ID: 8189

Symbol: SYMPK

Ensembl ID: ENSG00000125755

Description: symplekin scaffold protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 221.2861
    Cell Significance Index: -34.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 129.0394
    Cell Significance Index: -32.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 77.4375
    Cell Significance Index: -36.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.9371
    Cell Significance Index: -30.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.6925
    Cell Significance Index: -34.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.3857
    Cell Significance Index: -30.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.3036
    Cell Significance Index: -36.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7442
    Cell Significance Index: -34.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2751
    Cell Significance Index: -36.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6990
    Cell Significance Index: -16.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3124
    Cell Significance Index: 263.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2082
    Cell Significance Index: 140.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1705
    Cell Significance Index: 232.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0418
    Cell Significance Index: 940.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9948
    Cell Significance Index: 108.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9661
    Cell Significance Index: 27.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9550
    Cell Significance Index: 26.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8500
    Cell Significance Index: 51.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8265
    Cell Significance Index: 296.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7775
    Cell Significance Index: 20.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6176
    Cell Significance Index: 61.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5807
    Cell Significance Index: 26.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5754
    Cell Significance Index: 44.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4915
    Cell Significance Index: 67.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4815
    Cell Significance Index: 33.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3611
    Cell Significance Index: 18.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3527
    Cell Significance Index: 63.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3206
    Cell Significance Index: 37.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3161
    Cell Significance Index: 172.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2849
    Cell Significance Index: 36.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2683
    Cell Significance Index: 32.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2633
    Cell Significance Index: 182.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2249
    Cell Significance Index: 12.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1834
    Cell Significance Index: 11.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1814
    Cell Significance Index: 11.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1799
    Cell Significance Index: 79.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1521
    Cell Significance Index: 7.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1299
    Cell Significance Index: 3.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1247
    Cell Significance Index: 5.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1225
    Cell Significance Index: 19.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1163
    Cell Significance Index: 218.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0869
    Cell Significance Index: 16.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0768
    Cell Significance Index: 1.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0732
    Cell Significance Index: 134.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0728
    Cell Significance Index: 112.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0559
    Cell Significance Index: 25.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0555
    Cell Significance Index: 2.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0494
    Cell Significance Index: 31.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0354
    Cell Significance Index: 0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0342
    Cell Significance Index: 2.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0275
    Cell Significance Index: 1.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0251
    Cell Significance Index: 34.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0006
    Cell Significance Index: 0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0147
    Cell Significance Index: -2.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0170
    Cell Significance Index: -0.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0178
    Cell Significance Index: -13.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0255
    Cell Significance Index: -19.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0307
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0375
    Cell Significance Index: -27.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0406
    Cell Significance Index: -6.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0564
    Cell Significance Index: -1.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0581
    Cell Significance Index: -3.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0591
    Cell Significance Index: -33.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0637
    Cell Significance Index: -6.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0655
    Cell Significance Index: -40.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0831
    Cell Significance Index: -1.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1075
    Cell Significance Index: -30.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1181
    Cell Significance Index: -2.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1182
    Cell Significance Index: -2.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1487
    Cell Significance Index: -10.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1624
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1794
    Cell Significance Index: -37.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2204
    Cell Significance Index: -7.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2245
    Cell Significance Index: -14.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2382
    Cell Significance Index: -27.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2581
    Cell Significance Index: -3.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2607
    Cell Significance Index: -27.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2855
    Cell Significance Index: -7.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3074
    Cell Significance Index: -6.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3635
    Cell Significance Index: -4.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3686
    Cell Significance Index: -12.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3715
    Cell Significance Index: -8.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3841
    Cell Significance Index: -30.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4330
    Cell Significance Index: -9.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4388
    Cell Significance Index: -26.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4408
    Cell Significance Index: -12.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4444
    Cell Significance Index: -12.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4897
    Cell Significance Index: -10.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5312
    Cell Significance Index: -13.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5366
    Cell Significance Index: -11.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5603
    Cell Significance Index: -3.3900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5672
    Cell Significance Index: -7.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5939
    Cell Significance Index: -8.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6090
    Cell Significance Index: -17.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6097
    Cell Significance Index: -15.2400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6204
    Cell Significance Index: -4.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6325
    Cell Significance Index: -11.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6422
    Cell Significance Index: -13.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6678
    Cell Significance Index: -19.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6820
    Cell Significance Index: -21.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Symplekin (SYMPK) is a scaffold protein that belongs to the symplekin family, which consists of two members, SYMPK and SINFED (SYMPK-interacting factor). SYMPK is a 12-kDa protein that contains a central coiled-coil domain, which allows it to interact with multiple proteins. Its expression is highly restricted to specific cell types, including neurons in the peripheral nervous system and cortical interneurons. SYMPK is also expressed in other cell types, such as ciliary muscle cells and GABAergic cortical interneurons. **Pathways and Functions:** Symplekin plays a crucial role in regulating various cellular processes, including: 1. **Cytoskeleton organization**: SYMPK interacts with actin and microtubule-associated proteins to modulate cytoskeleton dynamics and maintain cellular shape. 2. **Signaling pathways**: SYMPK interacts with numerous signaling molecules, including G-proteins, receptor tyrosine kinases, and transcription factors, to regulate cell adhesion, migration, and survival. 3. **Gene expression**: SYMPK regulates gene expression by interacting with RNA-binding proteins and transcription factors, which modulate mRNA stability, localization, and translation. 4. **RNA processing**: SYMPK interacts with RNA-binding proteins and cleavage factors to regulate mRNA processing, including splicing, capping, and polyadenylation. 5. **Cell adhesion**: SYMPK regulates cell adhesion by interacting with adhesion molecules, such as cadherins and integrins, to modulate cell-cell and cell-matrix interactions. **Clinical Significance:** Symplekin has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: SYMPK has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), where it may play a role in regulating cellular stress and survival pathways. 2. **Neurodevelopmental disorders**: SYMPK has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, where it may regulate synaptic plasticity and neuronal connectivity. 3. **Cancer**: SYMPK has been shown to regulate cell growth, migration, and invasion in various cancer types, including glioblastoma and breast cancer. In conclusion, Symplekin is a critical scaffold protein that regulates various cellular processes, including cytoskeleton organization, signaling pathways, gene expression, RNA processing, and cell adhesion. Its expression is highly restricted to specific cell types, including neurons in the peripheral nervous system and cortical interneurons, highlighting its importance in neuronal function and development. Further research is needed to elucidate the mechanisms by which SYMPK regulates cellular processes and its role in neurological disorders.

Genular Protein ID: 1344685189

Symbol: SYMPK_HUMAN

Name: Symplekin

UniProtKB Accession Codes:

Q92797 O00521 O00689 O00733 Q59GT5 Q8N2U5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9585442

Title: Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat.

PubMed ID: 9585442

DOI: 10.1007/s003359900804

PubMed ID: 9330635

Title: Chromosomal localization to 19q13.3, partial genomic structure and 5' cDNA sequence of the human symplekin gene.

PubMed ID: 9330635

DOI: 10.1007/bf02721375

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8769423

Title: Symplekin, a novel type of tight junction plaque protein.

PubMed ID: 8769423

DOI: 10.1083/jcb.134.4.1003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10669729

Title: Complex protein interactions within the human polyadenylation machinery identify a novel component.

PubMed ID: 10669729

DOI: 10.1128/mcb.20.5.1515-1525.2000

PubMed ID: 12006661

Title: Symplekin, a constitutive protein of karyo- and cytoplasmic particles involved in mRNA biogenesis in Xenopus laevis oocytes.

PubMed ID: 12006661

DOI: 10.1091/mbc.01-12-0567

PubMed ID: 14707147

Title: HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin.

PubMed ID: 14707147

DOI: 10.1074/jbc.m311719200

PubMed ID: 16230528

Title: Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs.

PubMed ID: 16230528

DOI: 10.1101/gad.1371105

PubMed ID: 18688255

Title: Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation.

PubMed ID: 18688255

DOI: 10.1038/embor.2008.146

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20861839

Title: Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.

PubMed ID: 20861839

DOI: 10.1038/nature09391

PubMed ID: 23070812

Title: An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.

PubMed ID: 23070812

DOI: 10.1101/gad.198853.112

Sequence Information:

  • Length: 1274
  • Mass: 141148
  • Checksum: D8AD9ABB0B25A688
  • Sequence:
    • MASGSGDSVT RRSVASQFFT QEEGPGIDGM TTSERVVDLL NQAALITNDS KITVLKQVQE 
LIINKDPTLL DNFLDEIIAF QADKSIEVRK FVIGFIEEAC KRDIELLLKL IANLNMLLRD 
ENVNVVKKAI LTMTQLYKVA LQWMVKSRVI SELQEACWDM VSAMAGDIIL LLDSDNDGIR 
THAIKFVEGL IVTLSPRMAD SEIPRRQEHD ISLDRIPRDH PYIQYNVLWE EGKAALEQLL 
KFMVHPAISS INLTTALGSL ANIARQRPMF MSEVIQAYET LHANLPPTLA KSQVSSVRKN 
LKLHLLSVLK HPASLEFQAQ ITTLLVDLGT PQAEIARNMP SSKDTRKRPR DDSDSTLKKM 
KLEPNLGEDD EDKDLEPGPS GTSKASAQIS GQSDTDITAE FLQPLLTPDN VANLVLISMV 
YLPEAMPASF QAIYTPVESA GTEAQIKHLA RLMATQMTAA GLGPGVEQTK QCKEEPKEEK 
VVKTESVLIK RRLSAQGQAI SVVGSLSSMS PLEEEAPQAK RRPEPIIPVT QPRLAGAGGR 
KKIFRLSDVL KPLTDAQVEA MKLGAVKRIL RAEKAVACSG AAQVRIKILA SLVTQFNSGL 
KAEVLSFILE DVRARLDLAF AWLYQEYNAY LAAGASGSLD KYEDCLIRLL SGLQEKPDQK 
DGIFTKVVLE APLITESALE VVRKYCEDES RTYLGMSTLR DLIFKRPSRQ FQYLHVLLDL 
SSHEKDKVRS QALLFIKRMY EKEQLREYVE KFALNYLQLL VHPNPPSVLF GADKDTEVAA 
PWTEETVKQC LYLYLALLPQ NHKLIHELAA VYTEAIADIK RTVLRVIEQP IRGMGMNSPE 
LLLLVENCPK GAETLVTRCL HSLTDKVPPS PELVKRVRDL YHKRLPDVRF LIPVLNGLEK 
KEVIQALPKL IKLNPIVVKE VFNRLLGTQH GEGNSALSPL NPGELLIALH NIDSVKCDMK 
SIIKATNLCF AERNVYTSEV LAVVMQQLME QSPLPMLLMR TVIQSLTMYP RLGGFVMNIL 
SRLIMKQVWK YPKVWEGFIK CCQRTKPQSF QVILQLPPQQ LGAVFDKCPE LREPLLAHVR 
SFTPHQQAHI PNSIMTILEA SGKQEPEAKE APAGPLEEDD LEPLTLAPAP APRPPQDLIG 
LRLAQEKALK RQLEEEQKLK PGGVGAPSSS SPSPSPSARP GPPPSEEAMD FREEGPECET 
PGIFISMDDD SGLTEAALLD SSLEGPLPKE TAAGGLTLKE ERSPQTLAPV GEDAMKTPSP 
AAEDAREPEA KGNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.