Details for: USP11

Gene ID: 8237

Symbol: USP11

Ensembl ID: ENSG00000102226

Description: ubiquitin specific peptidase 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 264.2961
    Cell Significance Index: -41.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 148.5945
    Cell Significance Index: -37.6900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 95.4733
    Cell Significance Index: -39.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.3624
    Cell Significance Index: -42.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.3708
    Cell Significance Index: -33.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.4965
    Cell Significance Index: -33.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.3037
    Cell Significance Index: -42.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.4572
    Cell Significance Index: -36.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8412
    Cell Significance Index: -42.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8936
    Cell Significance Index: -10.7100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.2544
    Cell Significance Index: 68.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.8841
    Cell Significance Index: 203.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.2094
    Cell Significance Index: 17.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6920
    Cell Significance Index: 339.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4637
    Cell Significance Index: 525.0200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2380
    Cell Significance Index: 15.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1808
    Cell Significance Index: 1066.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0111
    Cell Significance Index: 27.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9521
    Cell Significance Index: 12.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7806
    Cell Significance Index: 47.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7531
    Cell Significance Index: 122.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7489
    Cell Significance Index: 96.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7232
    Cell Significance Index: 25.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7036
    Cell Significance Index: 45.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7004
    Cell Significance Index: 484.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6973
    Cell Significance Index: 75.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6833
    Cell Significance Index: 93.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6761
    Cell Significance Index: 121.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6501
    Cell Significance Index: 79.9400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6290
    Cell Significance Index: 8.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5644
    Cell Significance Index: 14.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5336
    Cell Significance Index: 33.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5213
    Cell Significance Index: 61.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5029
    Cell Significance Index: 12.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5022
    Cell Significance Index: 4.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3884
    Cell Significance Index: 212.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3734
    Cell Significance Index: 25.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3734
    Cell Significance Index: 19.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3501
    Cell Significance Index: 69.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3158
    Cell Significance Index: 6.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3065
    Cell Significance Index: 58.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2032
    Cell Significance Index: 89.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1652
    Cell Significance Index: 4.7600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1625
    Cell Significance Index: 2.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1300
    Cell Significance Index: 1.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0829
    Cell Significance Index: 1.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0770
    Cell Significance Index: 7.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0720
    Cell Significance Index: 2.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0651
    Cell Significance Index: 2.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0570
    Cell Significance Index: 107.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0549
    Cell Significance Index: 3.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0282
    Cell Significance Index: 0.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0167
    Cell Significance Index: 25.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0151
    Cell Significance Index: 11.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0123
    Cell Significance Index: 22.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0048
    Cell Significance Index: 3.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0102
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0187
    Cell Significance Index: -13.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0187
    Cell Significance Index: -3.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0207
    Cell Significance Index: -28.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0217
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0232
    Cell Significance Index: -14.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0373
    Cell Significance Index: -1.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0428
    Cell Significance Index: -32.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0443
    Cell Significance Index: -20.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0457
    Cell Significance Index: -6.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0509
    Cell Significance Index: -5.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0521
    Cell Significance Index: -29.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0862
    Cell Significance Index: -18.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1012
    Cell Significance Index: -2.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1031
    Cell Significance Index: -13.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1184
    Cell Significance Index: -34.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1199
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1670
    Cell Significance Index: -19.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1840
    Cell Significance Index: -8.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2019
    Cell Significance Index: -15.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2056
    Cell Significance Index: -15.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2452
    Cell Significance Index: -28.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2478
    Cell Significance Index: -28.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2526
    Cell Significance Index: -7.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3304
    Cell Significance Index: -15.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3386
    Cell Significance Index: -7.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3430
    Cell Significance Index: -7.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3622
    Cell Significance Index: -28.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3813
    Cell Significance Index: -39.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3831
    Cell Significance Index: -8.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3871
    Cell Significance Index: -27.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3953
    Cell Significance Index: -12.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4081
    Cell Significance Index: -6.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4228
    Cell Significance Index: -10.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4271
    Cell Significance Index: -11.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4428
    Cell Significance Index: -10.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5106
    Cell Significance Index: -10.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5912
    Cell Significance Index: -11.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5997
    Cell Significance Index: -36.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6494
    Cell Significance Index: -13.8300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.6562
    Cell Significance Index: -4.9600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.6727
    Cell Significance Index: -7.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7033
    Cell Significance Index: -15.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7046
    Cell Significance Index: -23.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cysteine-type deubiquitinase activity**: USP11 exhibits a high degree of specificity for the removal of ubiquitin from target proteins, a process essential for regulating protein activity and localization. 2. **Expression in neuronal cells**: USP11 is predominantly expressed in various neuronal cell types, including inhibitory interneurons, suggesting a specific role in regulating neural circuitry and behavior. 3. **Association with protein folding and degradation**: USP11 interacts with chaperonins and other proteins involved in protein folding, highlighting its importance in maintaining protein homeostasis. 4. **Regulation of neurotransmission**: USP11 modulates the activity of GABAergic interneurons, which are critical for regulating inhibitory neurotransmission, suggesting a role in maintaining neural circuitry and behavior. **Pathways and Functions:** 1. **Chaperonin-mediated protein folding**: USP11 interacts with chaperonins to facilitate protein folding, ensuring the proper assembly of proteins and preventing protein misfolding. 2. **Deubiquitination**: USP11 removes ubiquitin from target proteins, regulating their activity, localization, and degradation. 3. **Protein binding**: USP11 interacts with various proteins, including chaperonins, to regulate protein homeostasis and neurotransmission. 4. **Protein deubiquitination**: USP11 specifically removes ubiquitin from target proteins, modulating their activity and localization. **Clinical Significance:** Dysregulation of USP11 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: USP11 mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. 2. **Neurodegenerative diseases**: Alterations in USP11 expression and function have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Neurotransmitter regulation**: USP11 modulates GABAergic neurotransmission, suggesting a potential role in regulating inhibitory neurotransmission and maintaining neural circuitry. In conclusion, the USP11 gene plays a complex and multifaceted role in regulating protein homeostasis and neurotransmission in the nervous system. Further research is necessary to fully understand the mechanisms by which USP11 modulates protein activity and localization, as well as its clinical significance in various neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.