Details for: TKTL1

Gene ID: 8277

Symbol: TKTL1

Ensembl ID: ENSG00000007350

Description: transketolase like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 21.7943
    Cell Significance Index: -3.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.4441
    Cell Significance Index: -3.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.7495
    Cell Significance Index: -3.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6961
    Cell Significance Index: 10.7700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5562
    Cell Significance Index: 4.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4021
    Cell Significance Index: -0.8800
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.3705
    Cell Significance Index: 1.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3329
    Cell Significance Index: 8.9100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2643
    Cell Significance Index: 2.6500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.2410
    Cell Significance Index: 1.3700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.2406
    Cell Significance Index: 2.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1108
    Cell Significance Index: 19.9800
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.0637
    Cell Significance Index: 0.4000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0573
    Cell Significance Index: 1.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0400
    Cell Significance Index: 1.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0326
    Cell Significance Index: 1.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0110
    Cell Significance Index: 2.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0055
    Cell Significance Index: 0.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0020
    Cell Significance Index: 0.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0011
    Cell Significance Index: 1.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0005
    Cell Significance Index: 0.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0015
    Cell Significance Index: -0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0020
    Cell Significance Index: -0.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0032
    Cell Significance Index: -2.0100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0034
    Cell Significance Index: -0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0039
    Cell Significance Index: -2.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0041
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0045
    Cell Significance Index: -3.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0054
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0059
    Cell Significance Index: -3.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0061
    Cell Significance Index: -0.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0061
    Cell Significance Index: -3.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0102
    Cell Significance Index: -1.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0122
    Cell Significance Index: -1.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0130
    Cell Significance Index: -1.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0155
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0163
    Cell Significance Index: -3.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0214
    Cell Significance Index: -0.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0240
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0248
    Cell Significance Index: -2.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0297
    Cell Significance Index: -3.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0324
    Cell Significance Index: -3.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0328
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0356
    Cell Significance Index: -2.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0379
    Cell Significance Index: -0.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0381
    Cell Significance Index: -3.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0416
    Cell Significance Index: -2.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0454
    Cell Significance Index: -3.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0476
    Cell Significance Index: -2.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0524
    Cell Significance Index: -3.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0551
    Cell Significance Index: -3.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0567
    Cell Significance Index: -1.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0572
    Cell Significance Index: -2.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0595
    Cell Significance Index: -3.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0649
    Cell Significance Index: -2.8200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0688
    Cell Significance Index: -2.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0691
    Cell Significance Index: -3.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0692
    Cell Significance Index: -1.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0703
    Cell Significance Index: -3.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0728
    Cell Significance Index: -3.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0771
    Cell Significance Index: -0.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0776
    Cell Significance Index: -2.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0788
    Cell Significance Index: -2.7600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0812
    Cell Significance Index: -0.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0816
    Cell Significance Index: -2.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0845
    Cell Significance Index: -2.6900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0888
    Cell Significance Index: -1.0800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0889
    Cell Significance Index: -1.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0957
    Cell Significance Index: -2.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0979
    Cell Significance Index: -2.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0988
    Cell Significance Index: -0.8300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0989
    Cell Significance Index: -2.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0992
    Cell Significance Index: -2.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0995
    Cell Significance Index: -3.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1045
    Cell Significance Index: -4.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1046
    Cell Significance Index: -1.7500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1062
    Cell Significance Index: -2.1600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1066
    Cell Significance Index: -0.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1078
    Cell Significance Index: -3.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1090
    Cell Significance Index: -2.7200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1108
    Cell Significance Index: -1.3900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1112
    Cell Significance Index: -0.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1139
    Cell Significance Index: -2.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1147
    Cell Significance Index: -2.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1153
    Cell Significance Index: -3.0800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1156
    Cell Significance Index: -1.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1169
    Cell Significance Index: -3.3500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1176
    Cell Significance Index: -1.6500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1177
    Cell Significance Index: -1.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1195
    Cell Significance Index: -2.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1202
    Cell Significance Index: -3.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1226
    Cell Significance Index: -0.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1248
    Cell Significance Index: -4.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1269
    Cell Significance Index: -2.5100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1298
    Cell Significance Index: -2.7100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1302
    Cell Significance Index: -1.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural homology**: TKTL1 shares a high degree of structural similarity with transketolase, suggesting a conserved enzymatic function. 2. **Thiamine metabolic process involvement**: TKTL1 is involved in the thiamine pyrophosphate binding process, indicating its role in thiamine metabolism and energy production. 3. **Cytosolic localization**: TKTL1 is primarily localized in the cytosol, where it can interact with other enzymes and proteins to regulate metabolic pathways. 4. **Widespread expression**: TKTL1 is expressed in a variety of cell types, including those of the nervous system, immune system, and epithelial tissues. **Pathways and Functions:** 1. **Thiamine metabolic process**: TKTL1 is involved in the thiamine pyrophosphate binding process, which is essential for energy production and glucose metabolism. 2. **Glucose catabolic process**: TKTL1 contributes to the breakdown of glucose in the cytosol, regulating energy production and cellular metabolism. 3. **Metal ion binding**: TKTL1 may interact with metal ions, such as thiamine pyrophosphate, to regulate enzymatic activity and protein function. 4. **Transketolase activity**: Although TKTL1 lacks the enzymatic activity of transketolase, its structural homology suggests a potential role in regulating transketolase activity. **Clinical Significance:** 1. **Neurodegenerative diseases**: Dysregulation of thiamine metabolism has been implicated in various neurodegenerative diseases, such as Wernicke-Korsakoff syndrome and Alzheimer's disease. TKTL1 may play a role in maintaining thiamine homeostasis and preventing disease progression. 2. **Cancer**: Alterations in thiamine metabolism have been observed in various types of cancer, including colorectal and breast cancer. TKTL1 expression in cancer cells may contribute to tumorigenesis and metastasis. 3. **Immune system disorders**: TKTL1 expression in immune cells suggests its potential role in regulating immune function and responding to infections or autoimmune diseases. 4. **Developmental disorders**: TKTL1's expression in embryonic stem cells and neural progenitor cells highlights its involvement in tissue development and patterning. In conclusion, TKTL1 is a multifunctional enzyme involved in thiamine metabolism, glucose catabolism, and metal ion binding. Its widespread expression in various cell types and potential role in regulating enzymatic activity and protein function make it an important candidate for further study in the context of human disease.

Genular Protein ID: 3141423453

Symbol: TKTL1_HUMAN

Name: Transketolase-like protein 1

UniProtKB Accession Codes:

P51854 A8K896 Q5TYJ8 Q5TYJ9 Q8TC75

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 21 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 2 Rhea 2 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8838793

Title: Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes.

PubMed ID: 8838793

DOI: 10.1006/geno.1996.0124

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15991799

Title: Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer.

PubMed ID: 15991799

PubMed ID: 36074851

Title: Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals.

PubMed ID: 36074851

DOI: 10.1126/science.abl6422

Sequence Information:

  • Length: 596
  • Mass: 65333
  • Checksum: F492A902441E2A14
  • Sequence:
    • MADAEARAEF PEEARPDRGT LQVLQDMASR LRIHSIRATC STSSGHPTSC SSSSEIMSVL 
FFYIMRYKQS DPENPDNDRF VLAKRLSFVD VATGWLGQGL GVACGMAYTG KYFDRASYRV 
FCLMSDGESS EGSVWEAMAF ASYYSLDNLV AIFDVNRLGH SGALPAEHCI NIYQRRCEAF 
GWNTYVVDGR DVEALCQVFW QASQVKHKPT AVVAKTFKGR GTPSIEDAES WHAKPMPRER 
ADAIIKLIES QIQTSRNLDP QPPIEDSPEV NITDVRMTSP PDYRVGDKIA TRKACGLALA 
KLGYANNRVV VLDGDTRYST FSEIFNKEYP ERFIECFMAE QNMVSVALGC ASRGRTIAFA 
STFAAFLTRA FDHIRIGGLA ESNINIIGSH CGVSVGDDGA SQMALEDIAM FRTIPKCTIF 
YPTDAVSTEH AVALAANAKG MCFIRTTRPE TMVIYTPQER FEIGQAKVLR HCVSDKVTVI 
GAGITVYEAL AAADELSKQD IFIRVIDLFT IKPLDVATIV SSAKATEGRI ITVEDHYPQG 
GIGEAVCAAV SMDPDIQVHS LAVSGVPQSG KSEELLDMYG ISARHIIVAV KCMLLN

Genular Protein ID: 2451332577

Symbol: B7Z7I0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7I0

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 590
  • Mass: 64721
  • Checksum: 04E16F657675CB1F
  • Sequence:
    • MADAEARAEF PEEARPDRGT LQVLQDMASR LRIHSIRATC STSSGSSSEI MSVLFFYIMR 
YKQSDPENPD NDRFVLAKRL SFVDVATGWL GQGLGVACGM AYTGKYFDRA SYRVFCLMSD 
GESSEGSVWE AMAFASYYSL DNLVAIFDVN RLGHSGALPA EHCINIYQRR CEAFGWNTYV 
VDGRDVEALC QVFWQASQVK HKPTAVVAKT FKGRGTPSIE DAESWHAKPM PRERADAIIK 
LIESQIQTSR NLDPQPPIED SPEVNITDVR MTSPPDYRVG DKIATRKACG LALAKLGYAN 
NRVVVLDGDT RYSTFSEIFN KEYPERFIEC FMAEQNMVSV ALGCASRGRT IAFASTFAAF 
LTRAFDHIRI GGLAESNINI IGSHCGVSVG DDGASQMALE DIAMFRTIPK CTIFYPTDAV 
STEHAVALAA NAKGMCFIRT TRPETMVIYT PQERFEIGQA KVLRHCVSDK VTVIGAGITV 
YEALAAADEL SKQDIFIRVI DLFTIKPLDV ATIVSSAKAT EGRIITVEDH YPQGGIGEAV 
CAAVSMDPDI QVHSLAVSGV PQSGKSEELL DMYGISARHI IVAVKCMLLN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.