Details for: KLRC4

Gene ID: 8302

Symbol: KLRC4

Ensembl ID: ENSG00000183542

Description: killer cell lectin like receptor C4

Associated with

  • External side of plasma membrane
    (GO:0009897)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Stimulatory c-type lectin receptor signaling pathway
    (GO:0002223)
  • Transmembrane signaling receptor activity
    (GO:0004888)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 8.6237
    Cell Significance Index: 303.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 5.2000
    Cell Significance Index: 107.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.5514
    Cell Significance Index: 131.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.1016
    Cell Significance Index: 102.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0508
    Cell Significance Index: 44.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.6453
    Cell Significance Index: 52.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3846
    Cell Significance Index: 62.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1669
    Cell Significance Index: 222.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0053
    Cell Significance Index: 15.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7742
    Cell Significance Index: 76.5900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.6532
    Cell Significance Index: 6.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6145
    Cell Significance Index: 554.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5341
    Cell Significance Index: 11.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4016
    Cell Significance Index: 65.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3792
    Cell Significance Index: 41.2500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.3453
    Cell Significance Index: 3.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2142
    Cell Significance Index: 12.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2012
    Cell Significance Index: 13.9200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0921
    Cell Significance Index: 1.1900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0257
    Cell Significance Index: 0.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0110
    Cell Significance Index: 0.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0024
    Cell Significance Index: 0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0067
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0129
    Cell Significance Index: -3.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0132
    Cell Significance Index: -2.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0161
    Cell Significance Index: -2.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0175
    Cell Significance Index: -3.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0179
    Cell Significance Index: -2.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0200
    Cell Significance Index: -1.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0235
    Cell Significance Index: -2.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0259
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0282
    Cell Significance Index: -3.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0301
    Cell Significance Index: -1.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0307
    Cell Significance Index: -3.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0361
    Cell Significance Index: -3.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0390
    Cell Significance Index: -2.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0412
    Cell Significance Index: -1.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0425
    Cell Significance Index: -3.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0455
    Cell Significance Index: -2.1400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0485
    Cell Significance Index: -0.6600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0486
    Cell Significance Index: -0.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0525
    Cell Significance Index: -3.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0566
    Cell Significance Index: -2.9400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0612
    Cell Significance Index: -0.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0646
    Cell Significance Index: -1.5700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0698
    Cell Significance Index: -1.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0705
    Cell Significance Index: -2.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0732
    Cell Significance Index: -3.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0757
    Cell Significance Index: -2.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0819
    Cell Significance Index: -2.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0845
    Cell Significance Index: -2.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0848
    Cell Significance Index: -3.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0856
    Cell Significance Index: -2.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0931
    Cell Significance Index: -1.2700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1001
    Cell Significance Index: -0.8000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1008
    Cell Significance Index: -1.1900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1074
    Cell Significance Index: -1.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1079
    Cell Significance Index: -1.5500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1086
    Cell Significance Index: -1.0300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1135
    Cell Significance Index: -1.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1138
    Cell Significance Index: -2.6300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1142
    Cell Significance Index: -1.3800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1168
    Cell Significance Index: -1.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1172
    Cell Significance Index: -3.1300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1174
    Cell Significance Index: -1.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1176
    Cell Significance Index: -3.1500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1186
    Cell Significance Index: -1.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1187
    Cell Significance Index: -2.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1188
    Cell Significance Index: -2.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1190
    Cell Significance Index: -2.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1205
    Cell Significance Index: -3.5500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1209
    Cell Significance Index: -1.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1209
    Cell Significance Index: -3.0800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1211
    Cell Significance Index: -1.5800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1211
    Cell Significance Index: -1.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1213
    Cell Significance Index: -3.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1217
    Cell Significance Index: -3.1100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1218
    Cell Significance Index: -1.7300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1236
    Cell Significance Index: -2.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1253
    Cell Significance Index: -3.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1268
    Cell Significance Index: -2.7400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1296
    Cell Significance Index: -2.0800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1310
    Cell Significance Index: -1.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1346
    Cell Significance Index: -2.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1374
    Cell Significance Index: -3.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1402
    Cell Significance Index: -2.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1420
    Cell Significance Index: -2.8500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1423
    Cell Significance Index: -2.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1430
    Cell Significance Index: -2.7900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1450
    Cell Significance Index: -1.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1457
    Cell Significance Index: -2.8800
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1478
    Cell Significance Index: -1.8200
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1493
    Cell Significance Index: -1.6700
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.1501
    Cell Significance Index: -1.5900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1505
    Cell Significance Index: -2.4200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1507
    Cell Significance Index: -1.6200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1514
    Cell Significance Index: -2.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1533
    Cell Significance Index: -1.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Function:** KLRC4 is a stimulatory c-type lectin receptor that recognizes carbohydrate ligands on the surface of target cells, leading to the activation of NK cells and other immune cells. 2. **Cell Type Expression:** KLRC4 is expressed in a variety of cell types, including hematopoietic cells, epithelial cells of the large and small intestine, and neural cells of the cerebral cortex. 3. **Signaling Pathway:** KLRC4 activates the stimulatory c-type lectin receptor signaling pathway, which leads to the activation of downstream signaling molecules and the subsequent release of cytokines and other immune mediators. 4. **NKG2 Family Member:** KLRC4 is a member of the NKG2 family of receptors, which are known to play a crucial role in the regulation of immune responses, particularly in the context of NK cell activation. **Pathways and Functions:** 1. **Positive Regulation of NK Cell-Mediated Cytotoxicity:** KLRC4 has been shown to positively regulate NK cell-mediated cytotoxicity, suggesting its role in the modulation of immune responses. 2. **Stimulatory C-Type Lectin Receptor Signaling Pathway:** KLRC4 activates the stimulatory c-type lectin receptor signaling pathway, which leads to the activation of downstream signaling molecules and the subsequent release of cytokines and other immune mediators. 3. **Immune Cell Activation:** KLRC4 has been shown to activate various immune cells, including NK cells, T cells, and dendritic cells, leading to the activation of immune responses. 4. **Tumor Immune Evasion:** KLRC4 has been implicated in the immune evasion of tumors, suggesting its role in the modulation of immune responses in the context of cancer. **Clinical Significance:** 1. **Cancer Immunotherapy:** KLRC4 has been identified as a potential target for cancer immunotherapy, given its role in the modulation of immune responses and immune evasion of tumors. 2. **Inflammatory Diseases:** KLRC4 has been implicated in the pathogenesis of inflammatory diseases, such as inflammatory bowel disease (IBD), suggesting its role in the modulation of immune responses in these conditions. 3. **Neurological Disorders:** KLRC4 has been identified in the cerebral cortex of the brain, suggesting its role in the regulation of immune responses in the central nervous system and the pathogenesis of neurological disorders. 4. **Immunodeficiency Disorders:** KLRC4 has been implicated in the pathogenesis of immunodeficiency disorders, such as NK cell-related immunodeficiency diseases, suggesting its role in the regulation of immune responses in these conditions. In conclusion, KLRC4 is a critical receptor that plays a significant role in the regulation of immune responses, particularly in the context of NK cell activation and immune evasion of tumors. Further research is needed to fully elucidate the role of KLRC4 in human disease and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2444459623

Symbol: NKG2F_HUMAN

Name: NKG2-F type II integral membrane protein

UniProtKB Accession Codes:

O43908 O60851

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9394807

Title: Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes.

PubMed ID: 9394807

DOI: 10.1002/eji.1830271114

PubMed ID: 9598306

Title: Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.

PubMed ID: 9598306

DOI: 10.1006/geno.1997.5197

PubMed ID: 9683661

Title: The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.

PubMed ID: 9683661

DOI: 10.1007/s002510050420

PubMed ID: 11751968

Title: Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.

PubMed ID: 11751968

DOI: 10.4049/jimmunol.168.1.240

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 158
  • Mass: 18234
  • Checksum: 1AABC0E5ED26ACCC
  • Sequence:
    • MNKQRGTYSE VSLAQDPKRQ QRKLKGNKIS ISGTKQEIFQ VELNLQNASS DHQGNDKTYH 
CKGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPCIGVL EQNNFSLNRR MQKARHCGHC 
PEEWITYSNS CYYIGKERRT WEERVCWPVL RRTLICFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.