H2AC14 | ENSG00000276368 | NCBI 8331

Details for: H2AC14

Gene ID: 8331

Symbol: H2AC14

Ensembl ID: ENSG00000276368

Description: H2A clustered histone 14

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: thymocyte (CL0000893)
Fold Change: 1.2695
Cell Significance Index: 16.0400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.8705
Cell Significance Index: 18.5400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4552
Cell Significance Index: 45.0300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.4364
Cell Significance Index: 6.2500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3663
Cell Significance Index: 59.5700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3626
Cell Significance Index: 39.4400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3364
Cell Significance Index: 64.0200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2352
Cell Significance Index: 14.1200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2224
Cell Significance Index: 26.2300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.1739
Cell Significance Index: 1.8900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1281
Cell Significance Index: 3.6900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1201
Cell Significance Index: 1.8100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.1155
Cell Significance Index: 2.4000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1095
Cell Significance Index: 98.8600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1041
Cell Significance Index: 2.1800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1016
Cell Significance Index: 3.5700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0988
Cell Significance Index: 6.3800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0975
Cell Significance Index: 6.7400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0924
Cell Significance Index: 4.1900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0674
Cell Significance Index: 2.1600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0433
Cell Significance Index: 1.2100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0383
Cell Significance Index: 0.8300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0347
Cell Significance Index: 18.9700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0212
Cell Significance Index: 0.5300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0175
Cell Significance Index: 0.9100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0057
Cell Significance Index: 2.5100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0008
Cell Significance Index: -0.6200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0029
Cell Significance Index: -0.6100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0031
Cell Significance Index: -5.8300
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0039
Cell Significance Index: -0.1700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0080
Cell Significance Index: -6.0900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0087
Cell Significance Index: -0.0900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0088
Cell Significance Index: -1.1300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0101
Cell Significance Index: -1.7200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0109
Cell Significance Index: -0.6700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0148
Cell Significance Index: -8.3300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0201
Cell Significance Index: -3.6200
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0217
Cell Significance Index: -4.3100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0231
Cell Significance Index: -4.6400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0280
Cell Significance Index: -3.8400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0311
Cell Significance Index: -3.8200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0348
Cell Significance Index: -1.9500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0373
Cell Significance Index: -1.7400
Cell Name: salivary gland cell (CL0009005)
Fold Change: -0.0411
Cell Significance Index: -0.5100
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0458
Cell Significance Index: -0.5800
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0504
Cell Significance Index: -0.5700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0516
Cell Significance Index: -5.2700
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0533
Cell Significance Index: -0.7400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0537
Cell Significance Index: -1.3400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0538
Cell Significance Index: -1.4700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0580
Cell Significance Index: -0.9700
Cell Name: paneth cell (CL0000510)
Fold Change: -0.0764
Cell Significance Index: -0.7900
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0788
Cell Significance Index: -1.1200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0853
Cell Significance Index: -2.5100
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.0886
Cell Significance Index: -1.0600
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1027
Cell Significance Index: -1.7700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1080
Cell Significance Index: -8.2900
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1091
Cell Significance Index: -1.5300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1102
Cell Significance Index: -5.1800
Cell Name: tendon cell (CL0000388)
Fold Change: -0.1103
Cell Significance Index: -1.5000
Cell Name: myoblast (CL0000056)
Fold Change: -0.1119
Cell Significance Index: -1.1000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1227
Cell Significance Index: -6.4400
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1235
Cell Significance Index: -2.4100
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1261
Cell Significance Index: -1.7700
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.1296
Cell Significance Index: -0.8600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1300
Cell Significance Index: -3.3200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1312
Cell Significance Index: -4.5600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1326
Cell Significance Index: -1.5100
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.1335
Cell Significance Index: -1.8000
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.1349
Cell Significance Index: -1.8000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1362
Cell Significance Index: -3.3000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1451
Cell Significance Index: -3.8800
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.1486
Cell Significance Index: -1.7200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1515
Cell Significance Index: -3.8600
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1588
Cell Significance Index: -1.3500
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1624
Cell Significance Index: -4.2700
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: -0.1624
Cell Significance Index: -1.7200
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.1670
Cell Significance Index: -1.6100
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.1703
Cell Significance Index: -1.6600
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.1703
Cell Significance Index: -1.1100
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1821
Cell Significance Index: -2.6100
Cell Name: group 3 innate lymphoid cell, human (CL0001078)
Fold Change: -0.1911
Cell Significance Index: -1.7900
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1919
Cell Significance Index: -2.5100
Cell Name: peptic cell (CL0000155)
Fold Change: -0.1947
Cell Significance Index: -1.7300
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1949
Cell Significance Index: -3.8100
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.1954
Cell Significance Index: -2.0400
Cell Name: immature NK T cell (CL0000914)
Fold Change: -0.1992
Cell Significance Index: -2.5500
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2048
Cell Significance Index: -1.7200
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.2049
Cell Significance Index: -2.1200
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.2083
Cell Significance Index: -3.3500
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.2087
Cell Significance Index: -2.6500
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.2099
Cell Significance Index: -3.0600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2100
Cell Significance Index: -6.0200
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.2102
Cell Significance Index: -1.6200
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.2104
Cell Significance Index: -2.8900
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.2116
Cell Significance Index: -2.6800
Cell Name: chondroblast (CL0000058)
Fold Change: -0.2249
Cell Significance Index: -1.3200
Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.2269
Cell Significance Index: -1.3900
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2338
Cell Significance Index: -5.8400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2379
Cell Significance Index: -7.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** H2AC14 is a histone H2A variant that exhibits distinct characteristics compared to other H2A histones. It is primarily expressed in cells that undergo rapid proliferation, such as immune cells and stem cells. H2AC14 has been shown to be involved in the regulation of gene expression, particularly in the context of cell cycle progression and DNA damage response. It also plays a role in the assembly of the pre-replicative complex and the origin of replication. **Pathways and Functions** H2AC14 is involved in various cellular pathways, including: 1. **Cell Cycle Regulation**: H2AC14 is required for the proper assembly of the pre-replicative complex and the origin of replication, ensuring accurate DNA replication and cell cycle progression. 2. **DNA Damage Response**: H2AC14 is involved in the recognition and response to DNA damage, particularly in the context of base excision repair and nucleotide excision repair. 3. **Gene Silencing**: H2AC14 can act as a histone variant to silence gene expression by recruiting chromatin-modifying enzymes, such as histone deacetylases (Hdacs) and histone acetyltransferases (Hats). 4. **Immune Response**: H2AC14 is expressed in immune cells and plays a role in the regulation of gene expression in response to viral infections and other immune stimuli. 5. **Stem Cell Maintenance**: H2AC14 is involved in the maintenance of stem cell pluripotency and self-renewal, particularly in the context of intestinal stem cells. **Clinical Significance** Dysregulation of H2AC14 has been implicated in several diseases, including: 1. **Cancer**: Altered expression of H2AC14 has been observed in various types of cancer, including leukemia, lymphoma, and breast cancer. 2. **Neurodegenerative Diseases**: H2AC14 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Autoimmune Diseases**: H2AC14 has been shown to be involved in the regulation of immune responses in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Stem Cell Disorders**: Dysregulation of H2AC14 has been implicated in stem cell disorders, such as leukemia and lymphoma. In conclusion, H2AC14 is a histone variant that plays a critical role in chromatin structure and function, particularly in the context of cell cycle regulation, DNA damage response, and gene silencing. Its dysregulation has been implicated in various diseases, highlighting the importance of H2AC14 in maintaining cellular homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2A type 1-J

Genular Protein ID: 1332267895

Symbol: H2A1J_HUMAN

Name: Histone H2A type 1-J

UniProtKB Accession Codes:

Q99878 A2RUU6 Q5JXQ5

Database IDs:

Citations:

PubMed ID: 9439656

Title: The human histone gene cluster at the D6S105 locus.

PubMed ID: 9439656

DOI: 10.1007/s004390050630

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15078818

Title: Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.

PubMed ID: 15078818

DOI: 10.1101/gad.1184604

PubMed ID: 15010469

Title: Phosphorylation of histone H2A inhibits transcription on chromatin templates.

PubMed ID: 15010469

DOI: 10.1074/jbc.m400099200

PubMed ID: 15386022

Title: Role of histone H2A ubiquitination in Polycomb silencing.

PubMed ID: 15386022

DOI: 10.1038/nature02985

PubMed ID: 15823041

Title: Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes.

PubMed ID: 15823041

DOI: 10.1021/bi047505c

PubMed ID: 16359901

Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

PubMed ID: 16359901

DOI: 10.1016/j.molcel.2005.12.002

PubMed ID: 16702407

Title: DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

PubMed ID: 16702407

DOI: 10.1101/gad.373706

PubMed ID: 16457589

Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

PubMed ID: 16457589

DOI: 10.1021/pr050269n

PubMed ID: 16319397

Title: Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry.

PubMed ID: 16319397

DOI: 10.1074/mcp.m500288-mcp200

PubMed ID: 18001824

Title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

PubMed ID: 18001824

DOI: 10.1016/j.cell.2007.09.040

PubMed ID: 18001825

Title: RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

PubMed ID: 18001825

DOI: 10.1016/j.cell.2007.09.041

PubMed ID: 19203578

Title: The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

PubMed ID: 19203578

DOI: 10.1016/j.cell.2008.12.042

PubMed ID: 19203579

Title: RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

PubMed ID: 19203579

DOI: 10.1016/j.cell.2008.12.041

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 22980979

Title: RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling.

PubMed ID: 22980979

DOI: 10.1016/j.cell.2012.08.005

PubMed ID: 22713238

Title: A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase.

PubMed ID: 22713238

DOI: 10.4161/cc.20919

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 24140421

Title: VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.

PubMed ID: 24140421

DOI: 10.1016/j.molcel.2013.09.017

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 24352239

Title: Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

PubMed ID: 24352239

DOI: 10.1038/nature12819

PubMed ID: 25470042

Title: TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.

PubMed ID: 25470042

DOI: 10.1038/nature13955

PubMed ID: 27083998

Title: USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.

PubMed ID: 27083998

DOI: 10.1101/gad.271841.115

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

Sequence Information:

Length: 128
Mass: 13936
Checksum: 638BE3FE8256343E
Sequence:

MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK 
TESHHKTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H2AC14

Associated with

Cells (max top 100)

Other Information

The human histone gene cluster at the D6S105 locus. PubMed ID: 9439656

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. PubMed ID: 15078818

Phosphorylation of histone H2A inhibits transcription on chromatin templates. PubMed ID: 15010469

Role of histone H2A ubiquitination in Polycomb silencing. PubMed ID: 15386022

Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. PubMed ID: 15823041

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. PubMed ID: 16359901

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. PubMed ID: 16702407

Precise characterization of human histones in the H2A gene family by top down mass spectrometry. PubMed ID: 16457589

Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry. PubMed ID: 16319397

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. PubMed ID: 18001824

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. PubMed ID: 18001825

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. PubMed ID: 19203578

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. PubMed ID: 19203579

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. PubMed ID: 22980979

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. PubMed ID: 22713238

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. PubMed ID: 24140421

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. PubMed ID: 24352239

TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. PubMed ID: 25470042

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response. PubMed ID: 27083998

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297