H2AC20 | ENSG00000184260 | NCBI 8338

Details for: H2AC20

Gene ID: 8338

Symbol: H2AC20

Ensembl ID: ENSG00000184260

Description: H2A clustered histone 20

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 55.5110
Cell Significance Index: -14.0800
Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 36.0024
Cell Significance Index: -5.6000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 34.8794
Cell Significance Index: -14.1700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 32.7964
Cell Significance Index: -16.8700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.9769
Cell Significance Index: -16.0000
Cell Name: thymocyte (CL0000893)
Fold Change: 4.5935
Cell Significance Index: 58.0400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.2397
Cell Significance Index: -16.7300
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.6755
Cell Significance Index: 16.8000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.1824
Cell Significance Index: 76.2800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.0751
Cell Significance Index: 30.9800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.0267
Cell Significance Index: 46.5400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8933
Cell Significance Index: 53.6300
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.7641
Cell Significance Index: 8.1300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7362
Cell Significance Index: 80.0800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7360
Cell Significance Index: 72.8100
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.6024
Cell Significance Index: 9.3200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5837
Cell Significance Index: 30.3200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5511
Cell Significance Index: 89.6300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5226
Cell Significance Index: 7.1300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4513
Cell Significance Index: 53.2200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4341
Cell Significance Index: 11.8200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4182
Cell Significance Index: 9.0600
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.4181
Cell Significance Index: 10.6800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.4147
Cell Significance Index: 6.2500
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.3822
Cell Significance Index: 3.9900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3683
Cell Significance Index: 25.4700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3607
Cell Significance Index: 18.7900
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.3511
Cell Significance Index: 3.6400
Cell Name: peg cell (CL4033014)
Fold Change: 0.3259
Cell Significance Index: 7.5300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3004
Cell Significance Index: 7.5100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2920
Cell Significance Index: 129.1200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2720
Cell Significance Index: 19.2400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2679
Cell Significance Index: 146.3000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2530
Cell Significance Index: 45.6200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2058
Cell Significance Index: 7.2300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1999
Cell Significance Index: 12.6000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1896
Cell Significance Index: 10.6400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1685
Cell Significance Index: 23.1400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1586
Cell Significance Index: 5.0800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1510
Cell Significance Index: 18.5700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.1371
Cell Significance Index: 1.4900
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1297
Cell Significance Index: 1.8200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1048
Cell Significance Index: 19.9500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1046
Cell Significance Index: 2.1900
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.0985
Cell Significance Index: 0.5600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0889
Cell Significance Index: 11.4000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0869
Cell Significance Index: 17.2500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0563
Cell Significance Index: 2.6300
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.0512
Cell Significance Index: 0.4300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0314
Cell Significance Index: 23.0500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.0250
Cell Significance Index: 1.9800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0221
Cell Significance Index: 0.4700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0148
Cell Significance Index: 2.5200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0041
Cell Significance Index: -7.8100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0070
Cell Significance Index: -0.3500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0086
Cell Significance Index: -0.2300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0103
Cell Significance Index: -18.9500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0117
Cell Significance Index: -18.0200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0135
Cell Significance Index: -18.3800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0138
Cell Significance Index: -0.6500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0138
Cell Significance Index: -0.5700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0169
Cell Significance Index: -12.7900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0182
Cell Significance Index: -0.5100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0192
Cell Significance Index: -12.1900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0199
Cell Significance Index: -14.7700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0270
Cell Significance Index: -15.2000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0297
Cell Significance Index: -13.5000
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0311
Cell Significance Index: -0.2400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0354
Cell Significance Index: -4.0500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0362
Cell Significance Index: -22.5800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0379
Cell Significance Index: -13.5800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0511
Cell Significance Index: -0.5800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0687
Cell Significance Index: -8.8800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0734
Cell Significance Index: -7.5000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0755
Cell Significance Index: -15.1400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0970
Cell Significance Index: -20.4300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0980
Cell Significance Index: -14.2500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1183
Cell Significance Index: -8.8200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1207
Cell Significance Index: -2.0200
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.1265
Cell Significance Index: -0.9200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1432
Cell Significance Index: -3.8300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1517
Cell Significance Index: -15.8000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1711
Cell Significance Index: -10.4900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1964
Cell Significance Index: -4.0800
Cell Name: decidual cell (CL2000002)
Fold Change: -0.1970
Cell Significance Index: -3.1600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1975
Cell Significance Index: -3.6500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1989
Cell Significance Index: -2.9800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2019
Cell Significance Index: -15.4900
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.2021
Cell Significance Index: -1.9700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2135
Cell Significance Index: -11.2100
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2416
Cell Significance Index: -2.8800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2544
Cell Significance Index: -7.4700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2649
Cell Significance Index: -6.8100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2990
Cell Significance Index: -10.3900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2997
Cell Significance Index: -7.8800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3072
Cell Significance Index: -8.8100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3287
Cell Significance Index: -2.6800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3290
Cell Significance Index: -9.6900
Cell Name: keratocyte (CL0002363)
Fold Change: -0.3599
Cell Significance Index: -5.7100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4264
Cell Significance Index: -18.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** H2AC20 is a histone protein that belongs to the H2A family, which consists of five subunits (H2A1, H2A2, H2A3, H2A4, and H2A5). H2AC20 is characterized by its ability to bind to DNA and its role in regulating gene expression. It is also involved in the assembly of the pre-replicative complex and the origin of replication, suggesting its importance in DNA replication and cell cycle regulation. **Pathways and Functions** H2AC20 is involved in various cellular pathways, including: 1. **Gene transcription**: H2AC20 plays a role in regulating gene expression by binding to specific DNA sequences and influencing the recruitment of transcriptional machinery. 2. **DNA repair**: H2AC20 is involved in the repair of DNA damage, particularly in the base-excision repair pathway. 3. **Cell cycle regulation**: H2AC20 is required for the proper progression of the cell cycle, particularly in the G2/M phase. 4. **Chromatin modifications**: H2AC20 is involved in the assembly of chromatin-modifying enzymes, such as histone acetyltransferases (Hats) and histone deacetylases (Hdacs). 5. **Transcriptional regulation**: H2AC20 interacts with transcription factors, such as Notch and Runx1, to regulate gene expression. **Clinical Significance** H2AC20 has been implicated in various diseases, including: 1. **Cancer**: H2AC20 is overexpressed in certain types of cancer, such as breast and lung cancer, suggesting its role in tumorigenesis. 2. **Infectious diseases**: H2AC20 has been shown to play a role in the regulation of gene expression in response to viral infections, such as HIV. 3. **Autoimmune diseases**: H2AC20 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Aging and senescence**: H2AC20 is involved in the regulation of cellular senescence and the senescence-associated secretory phenotype (SASP). In conclusion, H2AC20 is a multifunctional protein that plays a crucial role in various cellular processes, including gene transcription, DNA repair, and cell cycle regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2A type 2-C

Genular Protein ID: 1926418092

Symbol: H2A2C_HUMAN

Name: Histone H2A type 2-C

UniProtKB Accession Codes:

Q16777 Q6DRA7 Q8IUE5

Database IDs:

Citations:

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 15527963

Title: Functional characterization of a human histone gene cluster duplication.

PubMed ID: 15527963

DOI: 10.1016/j.gene.2004.07.036

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1469070

Title: A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing.

PubMed ID: 1469070

DOI: 10.1002/jcb.240500406

PubMed ID: 15078818

Title: Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.

PubMed ID: 15078818

DOI: 10.1101/gad.1184604

PubMed ID: 15010469

Title: Phosphorylation of histone H2A inhibits transcription on chromatin templates.

PubMed ID: 15010469

DOI: 10.1074/jbc.m400099200

PubMed ID: 15386022

Title: Role of histone H2A ubiquitination in Polycomb silencing.

PubMed ID: 15386022

DOI: 10.1038/nature02985

PubMed ID: 15823041

Title: Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes.

PubMed ID: 15823041

DOI: 10.1021/bi047505c

PubMed ID: 16359901

Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

PubMed ID: 16359901

DOI: 10.1016/j.molcel.2005.12.002

PubMed ID: 16702407

Title: DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

PubMed ID: 16702407

DOI: 10.1101/gad.373706

PubMed ID: 16457589

Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

PubMed ID: 16457589

DOI: 10.1021/pr050269n

PubMed ID: 16319397

Title: Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry.

PubMed ID: 16319397

DOI: 10.1074/mcp.m500288-mcp200

PubMed ID: 18001824

Title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

PubMed ID: 18001824

DOI: 10.1016/j.cell.2007.09.040

PubMed ID: 18001825

Title: RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

PubMed ID: 18001825

DOI: 10.1016/j.cell.2007.09.041

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19203578

Title: The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

PubMed ID: 19203578

DOI: 10.1016/j.cell.2008.12.042

PubMed ID: 19203579

Title: RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

PubMed ID: 19203579

DOI: 10.1016/j.cell.2008.12.041

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 22980979

Title: RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling.

PubMed ID: 22980979

DOI: 10.1016/j.cell.2012.08.005

PubMed ID: 22713238

Title: A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase.

PubMed ID: 22713238

DOI: 10.4161/cc.20919

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 24140421

Title: VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.

PubMed ID: 24140421

DOI: 10.1016/j.molcel.2013.09.017

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 24352239

Title: Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

PubMed ID: 24352239

DOI: 10.1038/nature12819

PubMed ID: 25470042

Title: TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.

PubMed ID: 25470042

DOI: 10.1038/nature13955

PubMed ID: 27083998

Title: USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.

PubMed ID: 27083998

DOI: 10.1101/gad.271841.115

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

Sequence Information:

Length: 129
Mass: 13988
Checksum: 358AE20D1C531724
Sequence:

MSGRGKQGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YMAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK 
TESHKAKSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H2AC20

Associated with

Cells (max top 100)

Other Information

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

Functional characterization of a human histone gene cluster duplication. PubMed ID: 15527963

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing. PubMed ID: 1469070

Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. PubMed ID: 15078818

Phosphorylation of histone H2A inhibits transcription on chromatin templates. PubMed ID: 15010469

Role of histone H2A ubiquitination in Polycomb silencing. PubMed ID: 15386022

Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. PubMed ID: 15823041

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. PubMed ID: 16359901

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. PubMed ID: 16702407

Precise characterization of human histones in the H2A gene family by top down mass spectrometry. PubMed ID: 16457589

Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry. PubMed ID: 16319397

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. PubMed ID: 18001824

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. PubMed ID: 18001825

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. PubMed ID: 19203578

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. PubMed ID: 19203579

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. PubMed ID: 22980979

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. PubMed ID: 22713238

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. PubMed ID: 24140421

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. PubMed ID: 24352239

TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. PubMed ID: 25470042

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response. PubMed ID: 27083998

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297