H3C8 | ENSG00000273983 | NCBI 8355

Details for: H3C8

Gene ID: 8355

Symbol: H3C8

Ensembl ID: ENSG00000273983

Description: H3 clustered histone 8

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-7 signaling
(R-HSA-1266695)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Chromatin organization
(GO:0006325)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Nucleosome assembly
(GO:0006334)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: ileal goblet cell (CL1000326)
Fold Change: 8.5169
Cell Significance Index: -5.7200
Cell Name: thymocyte (CL0000893)
Fold Change: 1.5164
Cell Significance Index: 19.1600
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.3463
Cell Significance Index: 9.2600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.2297
Cell Significance Index: 25.5100
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.9699
Cell Significance Index: 10.0400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7865
Cell Significance Index: 22.6600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.6535
Cell Significance Index: 20.9300
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.5764
Cell Significance Index: 8.0900
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.5682
Cell Significance Index: 3.2300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4727
Cell Significance Index: 46.7700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4373
Cell Significance Index: 19.8200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4133
Cell Significance Index: 44.9600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3653
Cell Significance Index: 69.5200
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.2861
Cell Significance Index: 2.0800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2783
Cell Significance Index: 7.4500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2726
Cell Significance Index: 32.1500
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.2254
Cell Significance Index: 2.2300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2170
Cell Significance Index: 35.3000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1714
Cell Significance Index: 10.2900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1684
Cell Significance Index: 152.0400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1429
Cell Significance Index: 9.8900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1374
Cell Significance Index: 2.0700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1147
Cell Significance Index: 4.0300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0595
Cell Significance Index: 1.2900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0540
Cell Significance Index: 1.3500
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0539
Cell Significance Index: 1.3500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0369
Cell Significance Index: 7.3300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0289
Cell Significance Index: 15.7800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0216
Cell Significance Index: 0.4600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0091
Cell Significance Index: 4.0300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0066
Cell Significance Index: 0.4000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0002
Cell Significance Index: 0.0300
Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.0002
Cell Significance Index: 0.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0008
Cell Significance Index: -0.5900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0032
Cell Significance Index: -0.5500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0038
Cell Significance Index: -0.4400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0046
Cell Significance Index: -0.0500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0076
Cell Significance Index: -0.1600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0078
Cell Significance Index: -5.9200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0115
Cell Significance Index: -1.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0155
Cell Significance Index: -5.5500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0175
Cell Significance Index: -0.9800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0177
Cell Significance Index: -1.1400
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0254
Cell Significance Index: -0.4400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0312
Cell Significance Index: -3.8400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0314
Cell Significance Index: -14.2700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0315
Cell Significance Index: -0.8400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0316
Cell Significance Index: -4.3400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0357
Cell Significance Index: -7.1700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0359
Cell Significance Index: -1.0000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0377
Cell Significance Index: -1.9600
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.0426
Cell Significance Index: -0.4300
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0459
Cell Significance Index: -0.5800
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0555
Cell Significance Index: -0.7700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0591
Cell Significance Index: -1.5100
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0742
Cell Significance Index: -0.9400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0883
Cell Significance Index: -3.0700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0900
Cell Significance Index: -6.9100
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.0968
Cell Significance Index: -0.8800
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0998
Cell Significance Index: -1.1300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1031
Cell Significance Index: -1.7300
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1036
Cell Significance Index: -2.5100
Cell Name: tendon cell (CL0000388)
Fold Change: -0.1206
Cell Significance Index: -1.6400
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1295
Cell Significance Index: -1.8800
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1341
Cell Significance Index: -1.1400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1364
Cell Significance Index: -6.4100
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.1402
Cell Significance Index: -1.5900
Cell Name: rod bipolar cell (CL0000751)
Fold Change: -0.1422
Cell Significance Index: -1.6300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1454
Cell Significance Index: -4.7600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1467
Cell Significance Index: -4.3200
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1512
Cell Significance Index: -2.3400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1528
Cell Significance Index: -5.6100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1536
Cell Significance Index: -7.1600
Cell Name: myoblast (CL0000056)
Fold Change: -0.1577
Cell Significance Index: -1.5500
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1635
Cell Significance Index: -0.9700
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.1712
Cell Significance Index: -1.6500
Cell Name: muscle cell (CL0000187)
Fold Change: -0.1735
Cell Significance Index: -1.6600
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1909
Cell Significance Index: -5.0200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1915
Cell Significance Index: -6.1000
Cell Name: macroglial cell (CL0000126)
Fold Change: -0.1935
Cell Significance Index: -2.2400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1955
Cell Significance Index: -6.8500
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1975
Cell Significance Index: -2.8300
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2127
Cell Significance Index: -5.4200
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.2191
Cell Significance Index: -2.2100
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2286
Cell Significance Index: -2.9900
Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.2302
Cell Significance Index: -1.4100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2332
Cell Significance Index: -4.5600
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2416
Cell Significance Index: -6.0400
Cell Name: germ cell (CL0000586)
Fold Change: -0.2443
Cell Significance Index: -1.8500
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.2470
Cell Significance Index: -1.6700
Cell Name: peridermal cell (CL0000078)
Fold Change: -0.2517
Cell Significance Index: -1.5700
Cell Name: chondroblast (CL0000058)
Fold Change: -0.2555
Cell Significance Index: -1.5000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2567
Cell Significance Index: -5.6200
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: -0.2612
Cell Significance Index: -2.0300
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: -0.2694
Cell Significance Index: -2.9200
Cell Name: salivary gland cell (CL0009005)
Fold Change: -0.2698
Cell Significance Index: -3.3500
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2729
Cell Significance Index: -4.4200
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.2740
Cell Significance Index: -3.8000
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.2754
Cell Significance Index: -3.0000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2770
Cell Significance Index: -4.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Histone H3 family member**: H3C8 is a member of the histone H3 family, which plays a critical role in chromatin structure and gene expression. 2. **Clustered chromatin organization**: H3C8 is characterized by its clustered chromatin organization, which allows for efficient transcriptional regulation and chromatin remodeling. 3. **High expression levels**: H3C8 is highly expressed in various cell types, including thymocytes, lymphoid lineage restricted progenitor cells, hepatocytes, goblet cells, and intestinal epithelial cells. 4. **Regulation of gene expression**: H3C8 is involved in regulating gene expression through various mechanisms, including transcriptional activation, repression, and chromatin remodeling. **Pathways and Functions** 1. **Transcriptional regulation**: H3C8 is involved in regulating gene expression through its interaction with transcription factors, RNA polymerase, and chromatin remodeling complexes. 2. **Chromatin organization**: H3C8 plays a crucial role in maintaining chromatin structure and organization, which is essential for efficient transcriptional regulation and gene expression. 3. **DNA replication**: H3C8 is involved in regulating DNA replication and cell cycle progression, particularly during the G2/M phase. 4. **Cell cycle regulation**: H3C8 is required for proper cell cycle progression, including mitosis and cytokinesis. 5. **Immune system**: H3C8 is expressed in immune cells, including thymocytes and lymphoid lineage restricted progenitor cells, and plays a role in regulating immune responses. 6. **Developmental biology**: H3C8 is involved in regulating developmental processes, including embryogenesis, cell differentiation, and tissue development. 7. **Cancer**: H3C8 has been implicated in cancer development and progression, particularly in the context of viral infections and epigenetic regulation. **Clinical Significance** 1. **Cancer therapy**: H3C8 has been identified as a potential target for cancer therapy, particularly in the context of viral infections and epigenetic regulation. 2. **Autoimmune diseases**: H3C8 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, due to its role in regulating immune responses. 3. **Neurological disorders**: H3C8 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, due to its role in regulating gene expression and chromatin organization. 4. **Viral infections**: H3C8 has been identified as a key regulator of viral infections, including HIV and HCMV, due to its role in regulating gene expression and chromatin organization. 5. **Epigenetic regulation**: H3C8 has been implicated in epigenetic regulation, particularly in the context of DNA methylation and histone modification. In conclusion, the H3C8 gene plays a critical role in regulating gene expression, chromatin organization, and cell cycle progression. Its expression is significantly altered during different developmental stages, cell differentiation, and in response to various stimuli. Understanding the functions and clinical significance of H3C8 has important implications for the development of novel therapeutic strategies for various diseases, including cancer, autoimmune diseases, and neurological disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.