Details for: CASP10

Gene ID: 843

Symbol: CASP10

Ensembl ID: ENSG00000003400

Description: caspase 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.2251
    Cell Significance Index: -8.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.0549
    Cell Significance Index: -6.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.5719
    Cell Significance Index: -9.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 19.9461
    Cell Significance Index: -10.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 15.1262
    Cell Significance Index: -10.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.6937
    Cell Significance Index: -9.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.2428
    Cell Significance Index: -8.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9775
    Cell Significance Index: -8.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6881
    Cell Significance Index: -9.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.7739
    Cell Significance Index: -8.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.3289
    Cell Significance Index: -9.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0987
    Cell Significance Index: 399.3900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.5477
    Cell Significance Index: 22.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4074
    Cell Significance Index: 30.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0275
    Cell Significance Index: 53.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9480
    Cell Significance Index: 855.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9429
    Cell Significance Index: 48.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9212
    Cell Significance Index: 107.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9062
    Cell Significance Index: 26.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9025
    Cell Significance Index: 179.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8210
    Cell Significance Index: 89.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7415
    Cell Significance Index: 11.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5838
    Cell Significance Index: 94.9600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5134
    Cell Significance Index: 8.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4984
    Cell Significance Index: 22.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4718
    Cell Significance Index: 32.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4434
    Cell Significance Index: 4.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3517
    Cell Significance Index: 6.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3204
    Cell Significance Index: 3.6400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3028
    Cell Significance Index: 4.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2706
    Cell Significance Index: 26.7700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2501
    Cell Significance Index: 3.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2431
    Cell Significance Index: 6.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2429
    Cell Significance Index: 8.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2259
    Cell Significance Index: 4.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1771
    Cell Significance Index: 1.0700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1602
    Cell Significance Index: 2.5700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1365
    Cell Significance Index: 0.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1192
    Cell Significance Index: 7.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1164
    Cell Significance Index: 2.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0938
    Cell Significance Index: 51.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0727
    Cell Significance Index: 1.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0685
    Cell Significance Index: 8.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0491
    Cell Significance Index: 8.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0394
    Cell Significance Index: 4.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0199
    Cell Significance Index: 8.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0116
    Cell Significance Index: 0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0095
    Cell Significance Index: 1.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0020
    Cell Significance Index: 1.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0016
    Cell Significance Index: -1.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0036
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0040
    Cell Significance Index: -2.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0075
    Cell Significance Index: -0.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0087
    Cell Significance Index: -3.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0098
    Cell Significance Index: -7.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0118
    Cell Significance Index: -2.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0120
    Cell Significance Index: -0.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0125
    Cell Significance Index: -0.3200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0159
    Cell Significance Index: -0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0160
    Cell Significance Index: -3.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0197
    Cell Significance Index: -8.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0197
    Cell Significance Index: -5.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0249
    Cell Significance Index: -0.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0267
    Cell Significance Index: -2.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0284
    Cell Significance Index: -0.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0420
    Cell Significance Index: -6.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0523
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0548
    Cell Significance Index: -6.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0625
    Cell Significance Index: -3.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0655
    Cell Significance Index: -8.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0757
    Cell Significance Index: -2.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0792
    Cell Significance Index: -5.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0795
    Cell Significance Index: -9.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0795
    Cell Significance Index: -10.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0837
    Cell Significance Index: -8.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0893
    Cell Significance Index: -6.8600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0927
    Cell Significance Index: -0.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0989
    Cell Significance Index: -6.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1078
    Cell Significance Index: -6.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1155
    Cell Significance Index: -5.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1168
    Cell Significance Index: -9.2500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1178
    Cell Significance Index: -1.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1218
    Cell Significance Index: -8.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1299
    Cell Significance Index: -3.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1367
    Cell Significance Index: -10.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1395
    Cell Significance Index: -2.4700
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.1481
    Cell Significance Index: -1.6600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1549
    Cell Significance Index: -2.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1622
    Cell Significance Index: -9.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1659
    Cell Significance Index: -9.3100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1688
    Cell Significance Index: -7.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1882
    Cell Significance Index: -9.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1974
    Cell Significance Index: -8.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Caspase 10 exhibits several key characteristics that distinguish it from other caspases: 1. **Specificity for death receptors**: Caspase 10 is specifically activated by the death receptor signaling complex, which includes Fas-associated death domain (FADD) and receptor-interacting protein 1 (RIP-1). 2. **Involvement in extrinsic apoptosis**: Caspase 10 is a key player in the extrinsic apoptotic signaling pathway, where cell surface death receptors induce apoptosis. 3. **Homodimerization**: Caspase 10 forms homodimers, which are essential for its activation and subsequent cleavage of downstream substrates. 4. **Inhibition by FLICE-like inhibitory protein (FLIP)**: Caspase 10 is inhibited by FLIP, a protein that blocks the activation of caspase 10 by FADD and RIP-1. **Pathways and Functions** Caspase 10 is involved in several signaling pathways, including: 1. **Apoptotic process**: Caspase 10 is a key player in the extrinsic apoptotic signaling pathway, where cell surface death receptors induce apoptosis. 2. **Cd95 death-inducing signaling complex**: Caspase 10 is activated by the Cd95 death-inducing signaling complex, which includes FADD and RIP-1. 3. **Cysteine-type endopeptidase activity**: Caspase 10 exhibits cysteine-type endopeptidase activity, which is essential for its activation and subsequent cleavage of downstream substrates. 4. **Immune system**: Caspase 10 is highly expressed in immune cells, including natural killer cells and T cells, and plays a crucial role in regulating immune responses. **Clinical Significance** Caspase 10 has been implicated in various diseases, including: 1. **Autoimmune disorders**: Dysfunction of caspase 10 has been linked to autoimmune disorders, such as rheumatoid arthritis and systemic lupus erythematosus. 2. **Cancer**: Caspase 10 has been implicated in cancer development and progression, particularly in solid tumors. 3. **Neurological disorders**: Caspase 10 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Inflammatory disorders**: Caspase 10 has been implicated in inflammatory disorders, such as atherosclerosis and sepsis. In summary, caspase 10 is a crucial regulator of apoptosis and immune responses, and its dysfunction has been implicated in various diseases. Further research is needed to fully understand the role of caspase 10 in human disease and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 1978445111

Symbol: CASPA_HUMAN

Name: Caspase-10

UniProtKB Accession Codes:

Q92851 Q68HC0 Q6KF62 Q6KF63 Q8IUP5 Q8WYQ8 Q99845 Q9Y2U6 Q9Y2U7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 14 Ensembl 7 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 4 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8755496

Title: In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

PubMed ID: 8755496

DOI: 10.1073/pnas.93.15.7464

PubMed ID: 9045686

Title: Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling.

PubMed ID: 9045686

DOI: 10.1074/jbc.272.10.6578

PubMed ID: 10187817

Title: Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10.

PubMed ID: 10187817

DOI: 10.1074/jbc.274.15.10301

PubMed ID: 11161814

Title: Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.

PubMed ID: 11161814

DOI: 10.1006/geno.2000.6392

PubMed ID: 17822854

Title: Cloning and characterization of a novel caspase-10 isoform that activates NF-kappa B activity.

PubMed ID: 17822854

DOI: 10.1016/j.bbagen.2007.07.010

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8962078

Title: Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.

PubMed ID: 8962078

DOI: 10.1073/pnas.93.25.14486

PubMed ID: 11717445

Title: Caspase-10 is an initiator caspase in death receptor signaling.

PubMed ID: 11717445

DOI: 10.1073/pnas.241358198

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15069192

Title: Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.

PubMed ID: 15069192

DOI: 10.1073/pnas.0307459101

PubMed ID: 16916640

Title: Engineered hybrid dimers: tracking the activation pathway of caspase-7.

PubMed ID: 16916640

DOI: 10.1016/j.molcel.2006.06.020

PubMed ID: 19557502

Title: RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway.

PubMed ID: 19557502

DOI: 10.1007/s11010-009-0180-8

PubMed ID: 10412980

Title: Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.

PubMed ID: 10412980

DOI: 10.1016/s0092-8674(00)80605-4

PubMed ID: 12010812

Title: Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.

PubMed ID: 12010812

DOI: 10.1182/blood.v99.11.4094

PubMed ID: 11973654

Title: Inactivating mutations of the caspase-10 gene in gastric cancer.

PubMed ID: 11973654

DOI: 10.1038/sj.onc.1205394

PubMed ID: 16446975

Title: Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome.

PubMed ID: 16446975

DOI: 10.1007/s00439-006-0138-9

PubMed ID: 18563783

Title: Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma.

PubMed ID: 18563783

DOI: 10.1002/humu.20803

PubMed ID: 19900088

Title: Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas.

PubMed ID: 19900088

DOI: 10.1080/00313020903041143

PubMed ID: 20025484

Title: Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas.

PubMed ID: 20025484

DOI: 10.3109/00313020903434371

PubMed ID: 27378136

Title: Atypical presentation of autoimmune lymphoproliferative syndrome due to CASP10 mutation.

PubMed ID: 27378136

DOI: 10.1016/j.imlet.2016.07.001

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 521
  • Mass: 58951
  • Checksum: 840348AE602B8243
  • Sequence:
    • MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN 
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR 
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR 
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE 
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT 
MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S

Genular Protein ID: 4048156791

Symbol: A0A0S2Z3G5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3G5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 4 Gene3D 2 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 Pfam 2 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 479
  • Mass: 54566
  • Checksum: 1467FD7A4EE003FF
  • Sequence:
    • MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPRA AVYRMNRNHR 
GLCVIVNNHS FTSLKDRQGT HKDAEILSHV FQWLGFTVHI HNNVTKVEME MVLQKQKCNP 
AHADGDCFVF CILTHGRFGA VYSSDEALIP IREIMSHFTA LQCPRLAEKP KLFFIQACQG 
EEIQPSVSIE ADALNPEQAP TSLQDSIPAE ADFLLGLATV PGYVSFRHVE EGSWYIQSLC 
NHLKKLVPRH EDILSILTAV NDDVSRRVDK QGTKKQMPQP AFTLRKKLVF PVPLDALSL

Genular Protein ID: 623864150

Symbol: A0A0S2Z3Z5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3Z5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 4 Gene3D 2 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 Pfam 2 PhylomeDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 522
  • Mass: 58994
  • Checksum: 34847E07B3DFA688
  • Sequence:
    • MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN 
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR 
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR 
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE 
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRHEDILSIL 
TAVNDDVSRR VDKQGTKKQM PQPAFTLRKK LVFPVPLDAL SL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.