Details for: CASP10

Gene ID: 843

Symbol: CASP10

Ensembl ID: ENSG00000003400

Description: caspase 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.81
    Marker Score: 8066
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.31
    Marker Score: 784
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.1
    Marker Score: 1219
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1
    Marker Score: 1153
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2206
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71766
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47990
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.88
    Marker Score: 244
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4951
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.86
    Marker Score: 7511
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13216
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 271
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.81
    Marker Score: 212
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 460
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.76
    Marker Score: 1103
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.75
    Marker Score: 702
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.74
    Marker Score: 183
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 558
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 291.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.72
    Marker Score: 225
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.69
    Marker Score: 1023
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.69
    Marker Score: 589
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2855.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 621
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.67
    Marker Score: 3203
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.65
    Marker Score: 709
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.63
    Marker Score: 314
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.62
    Marker Score: 554
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.59
    Marker Score: 1622.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.57
    Marker Score: 2353
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.57
    Marker Score: 1143.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.56
    Marker Score: 749
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.56
    Marker Score: 244
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.56
    Marker Score: 379
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.55
    Marker Score: 500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.55
    Marker Score: 132
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.54
    Marker Score: 1680
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.53
    Marker Score: 590
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.52
    Marker Score: 1231
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.52
    Marker Score: 225
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.51
    Marker Score: 513
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5
    Marker Score: 27984
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.49
    Marker Score: 1435
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.49
    Marker Score: 1114
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.49
    Marker Score: 590
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.49
    Marker Score: 329
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.48
    Marker Score: 3088
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.47
    Marker Score: 322
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.47
    Marker Score: 321
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.47
    Marker Score: 505
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.46
    Marker Score: 3992
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.46
    Marker Score: 457
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.46
    Marker Score: 132
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 731
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.45
    Marker Score: 331
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.45
    Marker Score: 1087
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.45
    Marker Score: 192.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 118
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.44
    Marker Score: 476
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.44
    Marker Score: 328
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.44
    Marker Score: 5075
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.43
    Marker Score: 561
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 286
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.43
    Marker Score: 227
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.43
    Marker Score: 1073
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.42
    Marker Score: 826
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.42
    Marker Score: 731
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.42
    Marker Score: 146
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 238
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.42
    Marker Score: 447
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.42
    Marker Score: 174
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.41
    Marker Score: 786
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.41
    Marker Score: 422
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4
    Marker Score: 6492
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.4
    Marker Score: 723.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 370
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.38
    Marker Score: 85.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.38
    Marker Score: 494
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.38
    Marker Score: 1311
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.38
    Marker Score: 2286
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.38
    Marker Score: 143
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.38
    Marker Score: 92
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.38
    Marker Score: 157
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.38
    Marker Score: 88
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.37
    Marker Score: 380
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.37
    Marker Score: 530
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.37
    Marker Score: 938
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.37
    Marker Score: 230

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Other Information

**Key characteristics:** - CASP10 is a cysteine-type endopeptidase, which means it specifically cleaves proteins by breaking the peptide bond between specific amino acids. - It is highly expressed in various cell types, including retinal cone cells, cerebral cortex endothelial cells, corneal epithelial cells, and intestinal crypt stem cells. - It is involved in both physiological and pathological processes, including apoptosis, inflammation, and tissue remodeling. **Pathways and functions:** - CASP10 is involved in the regulation of apoptosis through the death receptor pathway. - It acts as a death effector protein, binding to and activating caspases-8 and -10, which are key regulators of apoptosis. - It also plays a role in the regulation of inflammation through the activation of the Nf-kb pathway. - It is involved in cell signaling pathways, such as the Fasl/CD95l pathway and the Trail pathway. - It regulates the transcription of various genes involved in apoptosis, cell cycle regulation, and inflammation. **Clinical significance:** - Mutations in CASP10 have been linked to several human diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. - Overexpression of CASP10 has been observed in various cancers, where it promotes cell survival and proliferation. - Targeting CASP10 has emerged as a promising therapeutic strategy for cancer and other diseases where it is overexpressed. **Conclusion:** CASP10 is a critical protein involved in both physiological and pathological processes in humans. Its involvement in apoptosis, inflammation, cell signaling, and gene expression makes it a potential target for therapeutic interventions in various diseases.

Genular Protein ID: 1978445111

Symbol: CASPA_HUMAN

Name: Caspase-10

UniProtKB Accession Codes:

Q92851 Q68HC0 Q6KF62 Q6KF63 Q8IUP5 Q8WYQ8 Q99845 Q9Y2U6 Q9Y2U7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 14 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 4 RefSeq 7 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8755496

Title: In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

PubMed ID: 8755496

DOI: 10.1073/pnas.93.15.7464

PubMed ID: 9045686

Title: Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling.

PubMed ID: 9045686

DOI: 10.1074/jbc.272.10.6578

PubMed ID: 10187817

Title: Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10.

PubMed ID: 10187817

DOI: 10.1074/jbc.274.15.10301

PubMed ID: 11161814

Title: Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.

PubMed ID: 11161814

DOI: 10.1006/geno.2000.6392

PubMed ID: 17822854

Title: Cloning and characterization of a novel caspase-10 isoform that activates NF-kappa B activity.

PubMed ID: 17822854

DOI: 10.1016/j.bbagen.2007.07.010

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8962078

Title: Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.

PubMed ID: 8962078

DOI: 10.1073/pnas.93.25.14486

PubMed ID: 11717445

Title: Caspase-10 is an initiator caspase in death receptor signaling.

PubMed ID: 11717445

DOI: 10.1073/pnas.241358198

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15069192

Title: Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.

PubMed ID: 15069192

DOI: 10.1073/pnas.0307459101

PubMed ID: 16916640

Title: Engineered hybrid dimers: tracking the activation pathway of caspase-7.

PubMed ID: 16916640

DOI: 10.1016/j.molcel.2006.06.020

PubMed ID: 19557502

Title: RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway.

PubMed ID: 19557502

DOI: 10.1007/s11010-009-0180-8

PubMed ID: 10412980

Title: Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.

PubMed ID: 10412980

DOI: 10.1016/s0092-8674(00)80605-4

PubMed ID: 12010812

Title: Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.

PubMed ID: 12010812

DOI: 10.1182/blood.v99.11.4094

PubMed ID: 11973654

Title: Inactivating mutations of the caspase-10 gene in gastric cancer.

PubMed ID: 11973654

DOI: 10.1038/sj.onc.1205394

PubMed ID: 16446975

Title: Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome.

PubMed ID: 16446975

DOI: 10.1007/s00439-006-0138-9

PubMed ID: 18563783

Title: Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma.

PubMed ID: 18563783

DOI: 10.1002/humu.20803

PubMed ID: 19900088

Title: Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas.

PubMed ID: 19900088

DOI: 10.1080/00313020903041143

PubMed ID: 20025484

Title: Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas.

PubMed ID: 20025484

DOI: 10.3109/00313020903434371

PubMed ID: 27378136

Title: Atypical presentation of autoimmune lymphoproliferative syndrome due to CASP10 mutation.

PubMed ID: 27378136

DOI: 10.1016/j.imlet.2016.07.001

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 521
  • Mass: 58951
  • Checksum: 840348AE602B8243
  • Sequence:
    • MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN 
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR 
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR 
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE 
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT 
MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S

Genular Protein ID: 623864150

Symbol: A0A0S2Z3Z5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3Z5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 Pfam 2 PhylomeDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 522
  • Mass: 58994
  • Checksum: 34847E07B3DFA688
  • Sequence:
    • MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN 
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR 
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR 
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE 
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRHEDILSIL 
TAVNDDVSRR VDKQGTKKQM PQPAFTLRKK LVFPVPLDAL SL

Genular Protein ID: 4048156791

Symbol: A0A0S2Z3G5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3G5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 Pfam 2 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 479
  • Mass: 54566
  • Checksum: 1467FD7A4EE003FF
  • Sequence:
    • MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPRA AVYRMNRNHR 
GLCVIVNNHS FTSLKDRQGT HKDAEILSHV FQWLGFTVHI HNNVTKVEME MVLQKQKCNP 
AHADGDCFVF CILTHGRFGA VYSSDEALIP IREIMSHFTA LQCPRLAEKP KLFFIQACQG 
EEIQPSVSIE ADALNPEQAP TSLQDSIPAE ADFLLGLATV PGYVSFRHVE EGSWYIQSLC 
NHLKKLVPRH EDILSILTAV NDDVSRRVDK QGTKKQMPQP AFTLRKKLVF PVPLDALSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.