Details for: CUL3
Gene ID: 8452
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CUL3
Ensembl ID: ENSG00000036257
Description: cullin 3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 29.92rCSI 50.22%PRS 11.73
-
CSI 24.33rCSI 59.12%PRS 11.5
-
CSI 19.51rCSI 31.37%PRS 12.77
-
CSI 17.57rCSI 54.91%PRS 12.49
-
CSI 17.08rCSI 26.08%PRS 19.97
-
CSI 15.67rCSI 56.4%PRS 11.02
-
CSI 11.91rCSI 13.98%PRS 22.92
-
CSI 11.77rCSI 20.79%PRS 11.66
-
CSI 10.86rCSI 19.43%PRS 18.38
-
CSI 10.84rCSI 23.75%PRS 26.53
-
CSI 10.68rCSI 28.79%PRS 25.69
-
CSI 10.16rCSI 22.44%PRS 14.21
-
CSI 10.02rCSI 49.37%PRS 26.87
-
CSI 9.97rCSI 37.69%PRS 12.05
-
CSI 9.78rCSI 57.57%PRS 12.26
-
CSI 9.44rCSI 8.71%PRS 20.53
-
CSI 9.34rCSI 23.63%PRS 24.54
-
CSI 9.06rCSI 31.02%PRS 17.21
-
CSI 7.58rCSI 19.23%PRS 15.05
-
CSI 7.31rCSI 22.88%PRS 13.46
-
CSI 7.29rCSI 36.26%PRS 21.56
-
CSI 7.01rCSI 26.26%PRS 16.75
-
CSI 6.98rCSI 8.34%PRS 11.51
-
CSI 5.85rCSI 5.28%PRS 17.84
-
CSI 5.75rCSI 9.08%PRS 19.93
-
CSI 5.66rCSI 8.69%PRS 23.67
-
CSI 5.54rCSI 29.07%PRS 33.89
-
CSI 5.34rCSI 39.24%PRS 11.63
-
CSI 5.06rCSI 13.2%PRS 30.27
-
CSI 4.87rCSI 10.31%PRS 39.42
-
CSI 4.76rCSI 10.88%PRS 19.28
-
CSI 4.41rCSI 5.49%PRS 27.99
-
CSI 4.39rCSI 3.52%PRS 35.26
-
CSI 4.31rCSI 13.97%PRS 23.92
-
CSI 4.1rCSI 33.37%PRS 19.96
-
CSI 4.1rCSI 7%PRS 39.75
-
CSI 4.08rCSI 8.46%PRS 19.77
-
CSI 3.98rCSI 7.89%PRS 47.38
-
CSI 3.94rCSI 3.26%PRS 20.1
-
CSI 3.93rCSI 6.01%PRS 25.59
-
CSI 3.86rCSI 18.09%PRS 39.49
-
CSI 3.86rCSI 5.36%PRS 20.26
-
CSI 3.76rCSI 24.96%PRS 21.16
-
CSI 3.73rCSI 2.82%PRS 27.18
-
CSI 3.7rCSI 7.51%PRS 10.05
-
CSI 3.7rCSI 5.9%PRS 17.01
-
CSI 3.62rCSI 27.22%PRS 36.04
-
CSI 3.55rCSI 15.81%PRS 50.12
-
CSI 3.44rCSI 9.84%PRS 34.86
-
CSI 3.41rCSI 7.94%PRS 39.12
-
CSI 3.38rCSI 48.02%PRS 15.06
-
CSI 3.34rCSI 18.28%PRS 30.91
-
CSI 3.33rCSI 12.93%PRS 26.95
-
CSI 3.31rCSI 8.81%PRS 16.86
-
CSI 3.29rCSI 78.8%PRS 10.08
-
CSI 3.26rCSI 2.58%PRS 13.63
-
CSI 3.23rCSI 4.97%PRS 27.21
-
CSI 3.2rCSI 4.28%PRS 25.79
-
CSI 3.19rCSI 6.09%PRS 31.33
-
CSI 3.19rCSI 76.97%PRS 11.03
-
CSI 3.03rCSI 3.12%PRS 32.16
-
CSI 3.02rCSI 20.59%PRS 20.75
-
CSI 3.01rCSI 70.15%PRS 36.78
-
CSI 3.01rCSI 3.74%PRS 10.94
-
CSI 2.98rCSI 3.44%PRS 17.36
-
CSI 2.9rCSI 5.28%PRS 16.74
-
CSI 2.88rCSI 3.93%PRS 21.99
-
CSI 2.83rCSI 7.5%PRS 31.5
-
CSI 2.76rCSI 56.15%PRS 17.01
-
CSI 2.69rCSI 54.76%PRS 15.96
-
CSI 2.68rCSI 3.44%PRS 19.15
-
CSI 2.66rCSI 6.88%PRS 18.48
-
CSI 2.6rCSI 7.68%PRS 23.89
-
CSI 2.54rCSI 4.18%PRS 23.33
-
CSI 2.53rCSI 2.21%PRS 26.42
-
CSI 2.52rCSI 1.9%PRS 21.03
-
CSI 2.51rCSI 5.8%PRS 16.01
-
CSI 2.49rCSI 2.4%PRS 39.94
-
CSI 2.48rCSI 6.96%PRS 30.69
-
CSI 2.47rCSI 2.12%PRS 32.54
-
CSI 2.45rCSI 3.15%PRS 12.29
-
CSI 2.43rCSI 3.71%PRS 22.66
-
CSI 2.4rCSI 3.53%PRS 18.27
-
CSI 2.4rCSI 7.4%PRS 29.65
-
CSI 2.39rCSI 7.09%PRS 27.89
-
CSI 2.39rCSI 5.25%PRS 22.4
-
CSI 2.38rCSI 4.72%PRS 20.86
-
CSI 2.37rCSI 1.4%PRS 27.71
-
CSI 2.36rCSI 4.46%PRS 25.02
-
CSI 2.35rCSI 15.06%PRS 30.56
-
CSI 2.31rCSI 2.94%PRS 23.07
-
CSI 2.3rCSI 5.39%PRS 28.56
-
CSI 2.27rCSI 3.15%PRS 28.02
-
CSI 2.24rCSI 3.88%PRS 15.12
-
CSI 2.24rCSI 1.56%PRS 23.7
-
CSI 2.23rCSI 10.67%PRS 24.49
-
CSI 2.2rCSI 3.16%PRS 26.84
-
CSI 2.12rCSI 2.63%PRS 21.12
-
CSI 2.09rCSI 2.19%PRS 18.51
-
CSI 2.09rCSI 1.61%PRS 18.36
-
CSI -1.3rCSI -6.8%PRS 34.9%
-
CSI -0.7rCSI -0.7%PRS 34.0%
-
CSI -0.6rCSI -2.4%PRS 12.4%
-
CSI -0.2rCSI -0.3%PRS 24.5%
-
CSI 0.0rCSI 0.2%PRS 38.2%
-
CSI 0.0rCSI 0.3%PRS 35.2%
-
CSI 0.1rCSI 0.3%PRS 36.3%
-
CSI 0.1rCSI 0.5%PRS 29.1%
-
CSI 0.1rCSI 2.6%PRS 53.1%
-
CSI 0.1rCSI 0.2%PRS 32.1%
-
CSI 0.1rCSI 0.1%PRS 23.2%
-
CSI 0.1rCSI 0.7%PRS 29.8%
-
CSI 0.2rCSI 4.5%PRS 43.2%
-
CSI 0.2rCSI 0.4%PRS 18.4%
-
CSI 0.2rCSI 3.6%PRS 47.2%
-
CSI 0.2rCSI 0.6%PRS 20.0%
-
CSI 0.2rCSI 1.0%PRS 28.1%
-
CSI 0.3rCSI 0.4%PRS 25.5%
-
CSI 0.3rCSI 1.7%PRS 15.5%
-
CSI 0.3rCSI 0.2%PRS 27.2%
-
CSI 0.3rCSI 1.8%PRS 29.4%
-
CSI 0.3rCSI 0.2%PRS 35.1%
-
CSI 0.3rCSI 0.7%PRS 31.5%
-
CSI 0.3rCSI 1.1%PRS 31.5%
-
CSI 0.3rCSI 0.7%PRS 13.7%
-
CSI 0.4rCSI 2.6%PRS 20.1%
-
CSI 0.4rCSI 1.9%PRS 23.3%
-
CSI 0.4rCSI 1.7%PRS 19.5%
-
CSI 0.4rCSI 3.4%PRS 13.4%
-
CSI 0.4rCSI 0.5%PRS 22.9%
-
CSI 0.4rCSI 0.5%PRS 14.6%
-
CSI 0.4rCSI 0.6%PRS 22.6%
-
CSI 0.4rCSI 1.3%PRS 20.8%
-
CSI 0.4rCSI 0.4%PRS 16.9%
-
CSI 0.4rCSI 0.5%PRS 19.4%
-
CSI 0.4rCSI 4.8%PRS 23.0%
-
CSI 0.4rCSI 0.4%PRS 20.0%
-
CSI 0.4rCSI 0.6%PRS 21.0%
-
CSI 0.4rCSI 0.9%PRS 29.5%
-
CSI 0.5rCSI 0.4%PRS 19.9%
-
CSI 0.5rCSI 0.7%PRS 18.5%
-
CSI 0.5rCSI 3.9%PRS 21.2%
-
CSI 0.5rCSI 1.9%PRS 33.9%
-
CSI 0.5rCSI 0.6%PRS 34.3%
-
CSI 0.5rCSI 0.7%PRS 30.0%
-
CSI 0.5rCSI 3.6%PRS 20.7%
-
CSI 0.5rCSI 1.4%PRS 29.5%
-
CSI 0.5rCSI 1.4%PRS 32.5%
-
CSI 0.5rCSI 0.7%PRS 19.8%
-
CSI 0.5rCSI 2.3%PRS 17.6%
-
CSI 0.5rCSI 0.7%PRS 21.7%
-
CSI 0.5rCSI 2.5%PRS 48.8%
-
CSI 0.5rCSI 1.3%PRS 31.4%
-
CSI 0.6rCSI 1.6%PRS 44.9%
-
CSI 0.6rCSI 2.4%PRS 36.4%
-
CSI 0.6rCSI 0.8%PRS 22.7%
-
CSI 0.6rCSI 3.5%PRS 48.3%
-
CSI 0.6rCSI 2.0%PRS 57.5%
-
CSI 0.6rCSI 0.8%PRS 27.3%
-
CSI 0.6rCSI 1.0%PRS 26.0%
-
CSI 0.6rCSI 1.7%PRS 15.2%
-
CSI 0.6rCSI 2.3%PRS 32.6%
-
CSI 0.6rCSI 1.6%PRS 18.3%
-
CSI 0.6rCSI 1.4%PRS 38.4%
-
CSI 0.6rCSI 0.6%PRS 30.2%
-
CSI 0.6rCSI 3.3%PRS 33.4%
-
CSI 0.6rCSI 0.5%PRS 23.6%
-
CSI 0.6rCSI 3.3%PRS 38.4%
-
CSI 0.7rCSI 3.9%PRS 10.9%
-
CSI 0.7rCSI 1.3%PRS 44.1%
-
CSI 0.7rCSI 1.6%PRS 23.0%
-
CSI 0.7rCSI 2.8%PRS 6.6%
-
CSI 0.7rCSI 2.3%PRS 51.1%
-
CSI 0.7rCSI 2.8%PRS 38.8%
-
CSI 0.7rCSI 0.5%PRS 29.3%
-
CSI 0.7rCSI 1.2%PRS 15.3%
-
CSI 0.8rCSI 1.5%PRS 20.3%
-
CSI 0.8rCSI 11.9%PRS 17.5%
-
CSI 0.8rCSI 2.0%PRS 23.7%
-
CSI 0.8rCSI 1.8%PRS 29.6%
-
CSI 0.8rCSI 0.7%PRS 20.8%
-
CSI 0.8rCSI 1.2%PRS 31.0%
-
CSI 0.8rCSI 1.0%PRS 17.4%
-
CSI 0.8rCSI 2.1%PRS 25.7%
-
CSI 0.8rCSI 7.7%PRS 50.4%
-
CSI 0.9rCSI 1.9%PRS 20.5%
-
CSI 0.9rCSI 2.4%PRS 18.5%
-
CSI 0.9rCSI 1.2%PRS 18.4%
-
CSI 0.9rCSI 4.9%PRS 49.3%
-
CSI 0.9rCSI 1.7%PRS 41.7%
-
CSI 0.9rCSI 4.2%PRS 21.3%
-
CSI 0.9rCSI 2.7%PRS 18.9%
-
CSI 0.9rCSI 3.3%PRS 33.9%
-
CSI 0.9rCSI 2.3%PRS 18.3%
-
CSI 0.9rCSI 1.5%PRS 15.2%
-
CSI 1.0rCSI 1.0%PRS 23.4%
-
CSI 1.0rCSI 7.3%PRS 21.4%
-
CSI 1.0rCSI 1.4%PRS 22.3%
-
CSI 1.0rCSI 1.1%PRS 22.4%
-
CSI 1.0rCSI 1.2%PRS 25.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2187904982
Symbol: CUL3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9733711
Title: Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family.
PubMed ID: 9733711
PubMed ID: 9734811
Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9734811
PubMed ID: 9663463
Title: Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
PubMed ID: 9663463
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8681378
Title: cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
PubMed ID: 8681378
PubMed ID: 10500095
Title: Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.
PubMed ID: 10500095
PubMed ID: 11311237
Title: In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3.
PubMed ID: 11311237
PubMed ID: 10597293
Title: Covalent modification of all members of human cullin family proteins by NEDD8.
PubMed ID: 10597293
PubMed ID: 10230407
Title: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.
PubMed ID: 10230407
PubMed ID: 12609982
Title: TIP120A associates with cullins and modulates ubiquitin ligase activity.
PubMed ID: 12609982
PubMed ID: 14528312
Title: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
PubMed ID: 14528312
DOI: 10.1038/ncb1056
PubMed ID: 15983046
Title: Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
PubMed ID: 15983046
PubMed ID: 15897469
Title: Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.
PubMed ID: 15897469
PubMed ID: 16524876
Title: BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
PubMed ID: 16524876
PubMed ID: 15601839
Title: BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
PubMed ID: 15601839
PubMed ID: 17543862
Title: A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.
PubMed ID: 17543862
PubMed ID: 17254749
Title: Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells -- evidence for cullin dimerization.
PubMed ID: 17254749
PubMed ID: 17192413
Title: The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer.
PubMed ID: 17192413
PubMed ID: 18573101
Title: KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases.
PubMed ID: 18573101
PubMed ID: 18397884
Title: Regulation of TIP60 by ATF2 modulates ATM activation.
PubMed ID: 18397884
PubMed ID: 16006525
Title: Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.
PubMed ID: 16006525
PubMed ID: 19261606
Title: The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
PubMed ID: 19261606
PubMed ID: 19995937
Title: The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
PubMed ID: 19995937
PubMed ID: 20389280
Title: The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.
PubMed ID: 20389280
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22085717
Title: Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex.
PubMed ID: 22085717
PubMed ID: 21840486
Title: A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression.
PubMed ID: 21840486
PubMed ID: 21670212
Title: PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth.
PubMed ID: 21670212
PubMed ID: 22748208
Title: A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system.
PubMed ID: 22748208
PubMed ID: 23213400
Title: The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A.
PubMed ID: 23213400
DOI: 10.1242/bio.2011018
PubMed ID: 23135275
Title: Selective proteasomal degradation of the B'beta subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15.
PubMed ID: 23135275
PubMed ID: 22578813
Title: Translational homeostasis via the mRNA cap-binding protein, eIF4E.
PubMed ID: 22578813
PubMed ID: 22358839
Title: Ubiquitin-dependent regulation of COPII coat size and function.
PubMed ID: 22358839
DOI: 10.1038/nature10822
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23387299
Title: The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
PubMed ID: 23387299
DOI: 10.1042/bj20121903
PubMed ID: 23453970
Title: Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
PubMed ID: 23453970
PubMed ID: 24076655
Title: TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
PubMed ID: 24076655
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23455478
Title: Ubiquitylation-dependent localization of PLK1 in mitosis.
PubMed ID: 23455478
DOI: 10.1038/ncb2695
PubMed ID: 23776465
Title: Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification.
PubMed ID: 23776465
PubMed ID: 23576762
Title: Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
PubMed ID: 23576762
PubMed ID: 23201271
Title: Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.
PubMed ID: 23201271
PubMed ID: 24192928
Title: Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.
PubMed ID: 24192928
PubMed ID: 25349211
Title: SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).
PubMed ID: 25349211
PubMed ID: 24768539
Title: K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking.
PubMed ID: 24768539
PubMed ID: 25270598
Title: Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension.
PubMed ID: 25270598
DOI: 10.1038/ncomms6081
PubMed ID: 25684205
Title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
PubMed ID: 25684205
PubMed ID: 26399832
Title: Cell-fate determination by ubiquitin-dependent regulation of translation.
PubMed ID: 26399832
DOI: 10.1038/nature14978
PubMed ID: 27716508
Title: Regulation of the CUL3 ubiquitin ligase by a calcium-dependent co-adaptor.
PubMed ID: 27716508
PubMed ID: 27565346
Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.
PubMed ID: 27565346
PubMed ID: 27664236
Title: Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.
PubMed ID: 27664236
PubMed ID: 26906416
Title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
PubMed ID: 26906416
DOI: 10.1242/jcs.181784
PubMed ID: 27561354
Title: Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.
PubMed ID: 27561354
DOI: 10.1038/ncomms12628
PubMed ID: 27798626
Title: Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility.
PubMed ID: 27798626
DOI: 10.1038/ng.3701
PubMed ID: 27708159
Title: Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
PubMed ID: 27708159
PubMed ID: 28395323
Title: Defining the human sperm microtubulome: an integrated genomics approach.
PubMed ID: 28395323
PubMed ID: 29276004
Title: Missense variants in RHOBTB2 cause a developmental and epileptic encephalopathy in humans, and altered levels cause neurological defects in Drosophila.
PubMed ID: 29276004
PubMed ID: 29769719
Title: KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
PubMed ID: 29769719
PubMed ID: 33417871
Title: UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.
PubMed ID: 33417871
PubMed ID: 36997086
Title: The stem cell-supporting small molecule UM171 triggers Cul3-KBTBD4-mediated degradation of ELM2 domain-harboring proteins.
PubMed ID: 36997086
PubMed ID: 22632832
Title: Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.
PubMed ID: 22632832
PubMed ID: 23573258
Title: Crystal structure of KLHL3 in complex with Cullin3.
PubMed ID: 23573258
PubMed ID: 23349464
Title: Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases.
PubMed ID: 23349464
PubMed ID: 22266938
Title: Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
PubMed ID: 22266938
DOI: 10.1038/nature10814
PubMed ID: 25969726
Title: Integrated analysis of whole-exome sequencing and transcriptome profiling in males with autism spectrum disorders.
PubMed ID: 25969726
PubMed ID: 32341456
Title: De novo variants in CUL3 are associated with global developmental delays with or without infantile spasms.
PubMed ID: 32341456
PubMed ID: 33097317
Title: A novel stop-gain CUL3 mutation in a Japanese patient with autism spectrum disorder.
PubMed ID: 33097317
Sequence Information:
- Length: 768
- Mass: 88930
- Checksum: A1A02022480BF099
- Sequence:
MSNLSKGTGS RKDTKMRIRA FPMTMDEKYV NSIWDLLKNA IQEIQRKNNS GLSFEELYRN AYTMVLHKHG EKLYTGLREV VTEHLINKVR EDVLNSLNNN FLQTLNQAWN DHQTAMVMIR DILMYMDRVY VQQNNVENVY NLGLIIFRDQ VVRYGCIRDH LRQTLLDMIA RERKGEVVDR GAIRNACQML MILGLEGRSV YEEDFEAPFL EMSAEFFQME SQKFLAENSA SVYIKKVEAR INEEIERVMH CLDKSTEEPI VKVVERELIS KHMKTIVEME NSGLVHMLKN GKTEDLGCMY KLFSRVPNGL KTMCECMSSY LREQGKALVS EEGEGKNPVD YIQGLLDLKS RFDRFLLESF NNDRLFKQTI AGDFEYFLNL NSRSPEYLSL FIDDKLKKGV KGLTEQEVET ILDKAMVLFR FMQEKDVFER YYKQHLARRL LTNKSVSDDS EKNMISKLKT ECGCQFTSKL EGMFRDMSIS NTTMDEFRQH LQATGVSLGG VDLTVRVLTT GYWPTQSATP KCNIPPAPRH AFEIFRRFYL AKHSGRQLTL QHHMGSADLN ATFYGPVKKE DGSEVGVGGA QVTGSNTRKH ILQVSTFQMT ILMLFNNREK YTFEEIQQET DIPERELVRA LQSLACGKPT QRVLTKEPKS KEIENGHIFT VNDQFTSKLH RVKIQTVAAK QGESDPERKE TRQKVDDDRK HEIEAAIVRI MKSRKKMQHN VLVAEVTQQL KARFLPSPVV IKKRIEGLIE REYLARTPED RKVYTYVA
Genular Protein ID: 4159265071
Symbol: B7Z600_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 550
- Mass: 63310
- Checksum: 511659C88F9360D0
- Sequence:
MESQKFLAEN SASVYIKKVE ARINEEIERV MHCLDKSTEE PIVKVVEREL ISKHMKTIVE MENSGLVHML KNGKTEDLGC MYKLFSRVPN GLKTMCECMS SYLREQGKAL VSEEGEGKNP VDYIQGLLDL KSRFDRFLLE SFNNDRLFKQ TIAGDFEYFL NLNSRSPEYL SLFIDDKLKK GVKGLTEQEV ETILDKAMVL FRFMQEKDVF ERYYKQHLAR RLLTNKSVSD DSEKNMISKL KTECGCQFTS KLEGMFRDMS ISNTTMDEFR QHLQATGVSL GGVDLTVRVL TTGYWPTQSA TPKCNIPPAP RHAFEIFRRF YLAKHSGRQL TLQHHMGSAD LNATFYGPIK KEDGSEVGVG GAQVTGSNTR KHILQVSTFQ MTILMLFNNR EKYTFEEIQQ ETDIPERELV RALQSLACGK PTQRVLTKEP KSKEIENGHI FTVNDQFTSK LHRVKIQTVA AKQGESDPER KETRQKVDDD RKHEIEAAIV RIMKSRKKMQ HNVLVAEVTQ QLKARFLPSP VVIKKRIEGL IEREYLARTP EDRKVYTYVA