Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 429.5857
Cell Significance Index: -66.8200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 261.6666
Cell Significance Index: -66.3700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 149.2515
Cell Significance Index: -70.4700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 141.9790
Cell Significance Index: -57.6800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 127.5309
Cell Significance Index: -65.6000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 60.7912
Cell Significance Index: -58.0400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 56.0036
Cell Significance Index: -69.0500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 24.4936
Cell Significance Index: -65.6200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 17.8873
Cell Significance Index: -54.9400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.6290
Cell Significance Index: -69.5700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.5495
Cell Significance Index: -36.2200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.4266
Cell Significance Index: 236.9700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.0167
Cell Significance Index: 169.2800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.8084
Cell Significance Index: 2535.7700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4772
Cell Significance Index: 491.6100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.1886
Cell Significance Index: 439.0400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.8954
Cell Significance Index: 50.6100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.7900
Cell Significance Index: 194.7000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.7304
Cell Significance Index: 281.4400 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.3701
Cell Significance Index: 26.7400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.3664
Cell Significance Index: 490.1200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.3243
Cell Significance Index: 37.0100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2918
Cell Significance Index: 158.8400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2779
Cell Significance Index: 230.3700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.2644
Cell Significance Index: 32.5000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.1189
Cell Significance Index: 85.8600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.0865
Cell Significance Index: 66.7800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.8634
Cell Significance Index: 597.1900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7956
Cell Significance Index: 93.8200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7736
Cell Significance Index: 52.0200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7006
Cell Significance Index: 382.6100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6791
Cell Significance Index: 43.8200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6237
Cell Significance Index: 32.4900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5646
Cell Significance Index: 77.5300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4303
Cell Significance Index: 190.2600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4174
Cell Significance Index: 19.4600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3938
Cell Significance Index: 17.8500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3887
Cell Significance Index: 20.1900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.3553
Cell Significance Index: 8.5200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3495
Cell Significance Index: 10.0700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2820
Cell Significance Index: 6.1100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2677
Cell Significance Index: 504.0600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2506
Cell Significance Index: 159.1300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2408
Cell Significance Index: 23.8200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2092
Cell Significance Index: 9.8300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2056
Cell Significance Index: 39.1200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1801
Cell Significance Index: 81.7300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1447
Cell Significance Index: 6.4000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1390
Cell Significance Index: 256.4300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1313
Cell Significance Index: 2.2500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1234
Cell Significance Index: 3.3600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1226
Cell Significance Index: 20.9400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1161
Cell Significance Index: 178.6800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0969
Cell Significance Index: 3.6700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0877
Cell Significance Index: 3.0800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0623
Cell Significance Index: 84.6700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0563
Cell Significance Index: 0.3400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0255
Cell Significance Index: 0.2400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0124
Cell Significance Index: 1.6100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0052
Cell Significance Index: -3.8000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0366
Cell Significance Index: -27.1200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0572
Cell Significance Index: -32.2900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0638
Cell Significance Index: -39.8300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0665
Cell Significance Index: -50.3700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0809
Cell Significance Index: -5.1000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0914
Cell Significance Index: -6.8100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1292
Cell Significance Index: -16.5600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1322
Cell Significance Index: -9.3500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1762
Cell Significance Index: -37.1100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1968
Cell Significance Index: -28.6100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2120
Cell Significance Index: -61.0000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2550
Cell Significance Index: -5.4300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2632
Cell Significance Index: -7.5100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2718
Cell Significance Index: -31.1400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2892
Cell Significance Index: -29.5400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3185
Cell Significance Index: -8.5300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3374
Cell Significance Index: -39.3200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3474
Cell Significance Index: -4.7400 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4283
Cell Significance Index: -6.1600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4505
Cell Significance Index: -51.4200 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4526
Cell Significance Index: -6.5000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4760
Cell Significance Index: -49.5600 - Cell Name: peg cell (CL4033014)
Fold Change: -0.5168
Cell Significance Index: -11.9400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5187
Cell Significance Index: -14.8700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.5723
Cell Significance Index: -9.6400 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5981
Cell Significance Index: -12.7900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6284
Cell Significance Index: -49.7700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6737
Cell Significance Index: -16.8400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6797
Cell Significance Index: -10.0400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.7119
Cell Significance Index: -17.3700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8605
Cell Significance Index: -45.1800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.9196
Cell Significance Index: -15.3900 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.9378
Cell Significance Index: -9.4600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9673
Cell Significance Index: -30.9800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.0379
Cell Significance Index: -15.3200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.0498
Cell Significance Index: -36.4800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.0511
Cell Significance Index: -23.0200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.1119
Cell Significance Index: -68.1700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.2181
Cell Significance Index: -39.8800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.2321
Cell Significance Index: -39.2400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2187904982
Symbol: CUL3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9733711
Title: Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family.
PubMed ID: 9733711
PubMed ID: 9734811
Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9734811
PubMed ID: 9663463
Title: Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
PubMed ID: 9663463
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8681378
Title: cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
PubMed ID: 8681378
PubMed ID: 10500095
Title: Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.
PubMed ID: 10500095
PubMed ID: 11311237
Title: In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3.
PubMed ID: 11311237
PubMed ID: 10597293
Title: Covalent modification of all members of human cullin family proteins by NEDD8.
PubMed ID: 10597293
PubMed ID: 10230407
Title: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.
PubMed ID: 10230407
PubMed ID: 12609982
Title: TIP120A associates with cullins and modulates ubiquitin ligase activity.
PubMed ID: 12609982
PubMed ID: 14528312
Title: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
PubMed ID: 14528312
DOI: 10.1038/ncb1056
PubMed ID: 15983046
Title: Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
PubMed ID: 15983046
PubMed ID: 15897469
Title: Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.
PubMed ID: 15897469
PubMed ID: 16524876
Title: BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
PubMed ID: 16524876
PubMed ID: 15601839
Title: BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
PubMed ID: 15601839
PubMed ID: 17543862
Title: A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.
PubMed ID: 17543862
PubMed ID: 17254749
Title: Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells -- evidence for cullin dimerization.
PubMed ID: 17254749
PubMed ID: 17192413
Title: The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer.
PubMed ID: 17192413
PubMed ID: 18573101
Title: KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases.
PubMed ID: 18573101
PubMed ID: 18397884
Title: Regulation of TIP60 by ATF2 modulates ATM activation.
PubMed ID: 18397884
PubMed ID: 16006525
Title: Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.
PubMed ID: 16006525
PubMed ID: 19261606
Title: The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
PubMed ID: 19261606
PubMed ID: 19995937
Title: The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
PubMed ID: 19995937
PubMed ID: 20389280
Title: The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.
PubMed ID: 20389280
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22085717
Title: Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex.
PubMed ID: 22085717
PubMed ID: 21840486
Title: A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression.
PubMed ID: 21840486
PubMed ID: 21670212
Title: PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth.
PubMed ID: 21670212
PubMed ID: 22748208
Title: A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system.
PubMed ID: 22748208
PubMed ID: 23213400
Title: The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A.
PubMed ID: 23213400
DOI: 10.1242/bio.2011018
PubMed ID: 23135275
Title: Selective proteasomal degradation of the B'beta subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15.
PubMed ID: 23135275
PubMed ID: 22578813
Title: Translational homeostasis via the mRNA cap-binding protein, eIF4E.
PubMed ID: 22578813
PubMed ID: 22358839
Title: Ubiquitin-dependent regulation of COPII coat size and function.
PubMed ID: 22358839
DOI: 10.1038/nature10822
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23387299
Title: The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
PubMed ID: 23387299
DOI: 10.1042/bj20121903
PubMed ID: 23453970
Title: Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
PubMed ID: 23453970
PubMed ID: 24076655
Title: TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
PubMed ID: 24076655
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23455478
Title: Ubiquitylation-dependent localization of PLK1 in mitosis.
PubMed ID: 23455478
DOI: 10.1038/ncb2695
PubMed ID: 23776465
Title: Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification.
PubMed ID: 23776465
PubMed ID: 23576762
Title: Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
PubMed ID: 23576762
PubMed ID: 23201271
Title: Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.
PubMed ID: 23201271
PubMed ID: 24192928
Title: Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.
PubMed ID: 24192928
PubMed ID: 25349211
Title: SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).
PubMed ID: 25349211
PubMed ID: 24768539
Title: K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking.
PubMed ID: 24768539
PubMed ID: 25270598
Title: Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension.
PubMed ID: 25270598
DOI: 10.1038/ncomms6081
PubMed ID: 25684205
Title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
PubMed ID: 25684205
PubMed ID: 26399832
Title: Cell-fate determination by ubiquitin-dependent regulation of translation.
PubMed ID: 26399832
DOI: 10.1038/nature14978
PubMed ID: 27716508
Title: Regulation of the CUL3 ubiquitin ligase by a calcium-dependent co-adaptor.
PubMed ID: 27716508
PubMed ID: 27565346
Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.
PubMed ID: 27565346
PubMed ID: 27664236
Title: Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.
PubMed ID: 27664236
PubMed ID: 26906416
Title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
PubMed ID: 26906416
DOI: 10.1242/jcs.181784
PubMed ID: 27561354
Title: Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.
PubMed ID: 27561354
DOI: 10.1038/ncomms12628
PubMed ID: 27798626
Title: Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility.
PubMed ID: 27798626
DOI: 10.1038/ng.3701
PubMed ID: 27708159
Title: Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
PubMed ID: 27708159
PubMed ID: 28395323
Title: Defining the human sperm microtubulome: an integrated genomics approach.
PubMed ID: 28395323
PubMed ID: 29276004
Title: Missense variants in RHOBTB2 cause a developmental and epileptic encephalopathy in humans, and altered levels cause neurological defects in Drosophila.
PubMed ID: 29276004
PubMed ID: 29769719
Title: KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
PubMed ID: 29769719
PubMed ID: 33417871
Title: UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.
PubMed ID: 33417871
PubMed ID: 36997086
Title: The stem cell-supporting small molecule UM171 triggers Cul3-KBTBD4-mediated degradation of ELM2 domain-harboring proteins.
PubMed ID: 36997086
PubMed ID: 22632832
Title: Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.
PubMed ID: 22632832
PubMed ID: 23573258
Title: Crystal structure of KLHL3 in complex with Cullin3.
PubMed ID: 23573258
PubMed ID: 23349464
Title: Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases.
PubMed ID: 23349464
PubMed ID: 22266938
Title: Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
PubMed ID: 22266938
DOI: 10.1038/nature10814
PubMed ID: 25969726
Title: Integrated analysis of whole-exome sequencing and transcriptome profiling in males with autism spectrum disorders.
PubMed ID: 25969726
PubMed ID: 32341456
Title: De novo variants in CUL3 are associated with global developmental delays with or without infantile spasms.
PubMed ID: 32341456
PubMed ID: 33097317
Title: A novel stop-gain CUL3 mutation in a Japanese patient with autism spectrum disorder.
PubMed ID: 33097317
Sequence Information:
- Length: 768
- Mass: 88930
- Checksum: A1A02022480BF099
- Sequence:
MSNLSKGTGS RKDTKMRIRA FPMTMDEKYV NSIWDLLKNA IQEIQRKNNS GLSFEELYRN AYTMVLHKHG EKLYTGLREV VTEHLINKVR EDVLNSLNNN FLQTLNQAWN DHQTAMVMIR DILMYMDRVY VQQNNVENVY NLGLIIFRDQ VVRYGCIRDH LRQTLLDMIA RERKGEVVDR GAIRNACQML MILGLEGRSV YEEDFEAPFL EMSAEFFQME SQKFLAENSA SVYIKKVEAR INEEIERVMH CLDKSTEEPI VKVVERELIS KHMKTIVEME NSGLVHMLKN GKTEDLGCMY KLFSRVPNGL KTMCECMSSY LREQGKALVS EEGEGKNPVD YIQGLLDLKS RFDRFLLESF NNDRLFKQTI AGDFEYFLNL NSRSPEYLSL FIDDKLKKGV KGLTEQEVET ILDKAMVLFR FMQEKDVFER YYKQHLARRL LTNKSVSDDS EKNMISKLKT ECGCQFTSKL EGMFRDMSIS NTTMDEFRQH LQATGVSLGG VDLTVRVLTT GYWPTQSATP KCNIPPAPRH AFEIFRRFYL AKHSGRQLTL QHHMGSADLN ATFYGPVKKE DGSEVGVGGA QVTGSNTRKH ILQVSTFQMT ILMLFNNREK YTFEEIQQET DIPERELVRA LQSLACGKPT QRVLTKEPKS KEIENGHIFT VNDQFTSKLH RVKIQTVAAK QGESDPERKE TRQKVDDDRK HEIEAAIVRI MKSRKKMQHN VLVAEVTQQL KARFLPSPVV IKKRIEGLIE REYLARTPED RKVYTYVA
Genular Protein ID: 4159265071
Symbol: B7Z600_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 550
- Mass: 63310
- Checksum: 511659C88F9360D0
- Sequence:
MESQKFLAEN SASVYIKKVE ARINEEIERV MHCLDKSTEE PIVKVVEREL ISKHMKTIVE MENSGLVHML KNGKTEDLGC MYKLFSRVPN GLKTMCECMS SYLREQGKAL VSEEGEGKNP VDYIQGLLDL KSRFDRFLLE SFNNDRLFKQ TIAGDFEYFL NLNSRSPEYL SLFIDDKLKK GVKGLTEQEV ETILDKAMVL FRFMQEKDVF ERYYKQHLAR RLLTNKSVSD DSEKNMISKL KTECGCQFTS KLEGMFRDMS ISNTTMDEFR QHLQATGVSL GGVDLTVRVL TTGYWPTQSA TPKCNIPPAP RHAFEIFRRF YLAKHSGRQL TLQHHMGSAD LNATFYGPIK KEDGSEVGVG GAQVTGSNTR KHILQVSTFQ MTILMLFNNR EKYTFEEIQQ ETDIPERELV RALQSLACGK PTQRVLTKEP KSKEIENGHI FTVNDQFTSK LHRVKIQTVA AKQGESDPER KETRQKVDDD RKHEIEAAIV RIMKSRKKMQ HNVLVAEVTQ QLKARFLPSP VVIKKRIEGL IEREYLARTP EDRKVYTYVA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.