Gene CAT - ENSG00000121691 | NCBI Gene ID: 847

Details for: CAT

Gene ID: 847

Symbol: CAT

Ensembl ID: ENSG00000121691

Description: catalase

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Peroxisomal protein import
(R-HSA-9033241)
Protein localization
(R-HSA-9609507)
Rna polymerase ii transcription
(R-HSA-73857)
Aerobic respiration
(GO:0009060)
Aminoacylase activity
(GO:0004046)
Antioxidant activity
(GO:0016209)
Catalase activity
(GO:0004096)
Catalase complex
(GO:0062151)
Cellular detoxification of hydrogen peroxide
(GO:0061692)
Cellular response to growth factor stimulus
(GO:0071363)
Cholesterol metabolic process
(GO:0008203)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Focal adhesion
(GO:0005925)
Heme binding
(GO:0020037)
Hemoglobin metabolic process
(GO:0020027)
Hydrogen peroxide catabolic process
(GO:0042744)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Nadp binding
(GO:0050661)
Negative regulation of apoptotic process
(GO:0043066)
Osteoblast differentiation
(GO:0001649)
Oxidoreductase activity, acting on peroxide as acceptor
(GO:0016684)
Peroxisomal matrix
(GO:0005782)
Peroxisomal membrane
(GO:0005778)
Peroxisome
(GO:0005777)
Positive regulation of cell division
(GO:0051781)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein-containing complex
(GO:0032991)
Protein homodimerization activity
(GO:0042803)
Response to activity
(GO:0014823)
Response to cadmium ion
(GO:0046686)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to fatty acid
(GO:0070542)
Response to hydrogen peroxide
(GO:0042542)
Response to hyperoxia
(GO:0055093)
Response to hypoxia
(GO:0001666)
Response to inactivity
(GO:0014854)
Response to insulin
(GO:0032868)
Response to l-ascorbic acid
(GO:0033591)
Response to lead ion
(GO:0010288)
Response to light intensity
(GO:0009642)
Response to ozone
(GO:0010193)
Response to phenylpropanoid
(GO:0080184)
Response to reactive oxygen species
(GO:0000302)
Response to vitamin a
(GO:0033189)
Response to vitamin e
(GO:0033197)
Response to xenobiotic stimulus
(GO:0009410)
Secretory granule lumen
(GO:0034774)
Triglyceride metabolic process
(GO:0006641)
Ureteric bud development
(GO:0001657)
Uv protection
(GO:0009650)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.63
Marker Score: 2743
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.44
Marker Score: 10004
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.21
Marker Score: 1598
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.18
Marker Score: 22131
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.15
Marker Score: 2590
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.11
Marker Score: 2137
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.07
Marker Score: 3330
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.05
Marker Score: 13390
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.05
Marker Score: 3401
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.04
Marker Score: 2461
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.03
Marker Score: 6644
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.02
Marker Score: 51669
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.96
Marker Score: 2890
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.96
Marker Score: 6954
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.94
Marker Score: 623
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.87
Marker Score: 16205
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.85
Marker Score: 1252
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.83
Marker Score: 4609
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.81
Marker Score: 633
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.78
Marker Score: 4773
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.76
Marker Score: 4015
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.76
Marker Score: 788
Cell Name: blood cell (CL0000081)
Fold Change: 1.75
Marker Score: 20379
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.75
Marker Score: 2787
Cell Name: fat cell (CL0000136)
Fold Change: 1.74
Marker Score: 974
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.73
Marker Score: 2079
Cell Name: lactocyte (CL0002325)
Fold Change: 1.72
Marker Score: 27598
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.71
Marker Score: 943
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 1.7
Marker Score: 1283
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.69
Marker Score: 10897
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.65
Marker Score: 1649
Cell Name: promyelocyte (CL0000836)
Fold Change: 1.62
Marker Score: 801
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.61
Marker Score: 8650
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.59
Marker Score: 35517
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.58
Marker Score: 6578.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.57
Marker Score: 2734
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.55
Marker Score: 86861
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.55
Marker Score: 752
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 1.55
Marker Score: 824.5
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.54
Marker Score: 6653
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.53
Marker Score: 1652
Cell Name: decidual cell (CL2000002)
Fold Change: 1.53
Marker Score: 6592
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.52
Marker Score: 2957
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.52
Marker Score: 5957
Cell Name: enterocyte (CL0000584)
Fold Change: 1.52
Marker Score: 7274
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.51
Marker Score: 1566
Cell Name: stem cell (CL0000034)
Fold Change: 1.46
Marker Score: 3467
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.46
Marker Score: 3078
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.45
Marker Score: 3933
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.41
Marker Score: 1439
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.4
Marker Score: 1603.5
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.4
Marker Score: 2663
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.4
Marker Score: 526
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.39
Marker Score: 481
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.38
Marker Score: 482.5
Cell Name: keratocyte (CL0002363)
Fold Change: 1.36
Marker Score: 312
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.35
Marker Score: 4248
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.33
Marker Score: 731
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.31
Marker Score: 1394
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.31
Marker Score: 257
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.31
Marker Score: 45258.5
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.3
Marker Score: 616
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.29
Marker Score: 1369
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.28
Marker Score: 885
Cell Name: erythroblast (CL0000765)
Fold Change: 1.28
Marker Score: 798
Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.27
Marker Score: 1501
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.27
Marker Score: 2879
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.27
Marker Score: 667
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.26
Marker Score: 513
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.26
Marker Score: 26794
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.25
Marker Score: 1179
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.25
Marker Score: 4297
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.25
Marker Score: 4623
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.25
Marker Score: 1144
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.24
Marker Score: 516
Cell Name: kidney cell (CL1000497)
Fold Change: 1.24
Marker Score: 825
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.23
Marker Score: 309
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.23
Marker Score: 599
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.22
Marker Score: 2935
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.21
Marker Score: 454
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.2
Marker Score: 820
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.2
Marker Score: 1697
Cell Name: myelocyte (CL0002193)
Fold Change: 1.2
Marker Score: 517
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.19
Marker Score: 295
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.19
Marker Score: 7614
Cell Name: mature B cell (CL0000785)
Fold Change: 1.19
Marker Score: 870
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.19
Marker Score: 13350
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.18
Marker Score: 553
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 1.18
Marker Score: 538
Cell Name: precursor cell (CL0011115)
Fold Change: 1.17
Marker Score: 285
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.17
Marker Score: 3027
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.17
Marker Score: 2909
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.17
Marker Score: 370
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.16
Marker Score: 278
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.16
Marker Score: 270
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.16
Marker Score: 7037
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.16
Marker Score: 436
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.15
Marker Score: 672
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.13
Marker Score: 889
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.13
Marker Score: 1202

Hover over a box to see details here...

**Key characteristics:** * Catalase is a protein with a molecular weight of approximately 125,000 Da. * It is found in both soluble and membrane-bound forms. * Catalase is regulated by a variety of factors, including calcium, pH, and reactive oxygen species. * It is an important regulator of the immune response. **Pathways and functions:** * Catalase helps to protect cells from damage caused by ROS by catalyzing the conversion of H2O2 into H2O and O2. * It also helps to regulate inflammation and cell death. * Catalase is involved in the detoxification of reactive oxygen species, including hydrogen peroxide, hydroxyl radicals, and peroxides. * It is also involved in the regulation of immune responses. **Clinical significance:** * Mutations in the CAT gene have been linked to a number of human diseases, including sickle cell anemia, hemolytic anemia, and amyotrophic lateral sclerosis. * Catalase inhibitors are being developed as potential treatments for these diseases. **Additional notes:** * Catalase is a highly conserved protein that is found in all eukaryotic cells. * It is a key regulator of the immune response. * It is a target for a variety of drugs, including paracetamol (Tylenol).

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Catalase

Genular Protein ID: 3147539547

Symbol: CATA_HUMAN

Name: Catalase

UniProtKB Accession Codes:

P04040 A8K6C0 B2RCZ9 D3DR07 Q2M1U4 Q4VXX5 Q9BWT9 Q9UC85

Database IDs:

Citations:

PubMed ID: 3755525

Title: Isolation and characterization of the human catalase gene.

PubMed ID: 3755525

DOI: 10.1093/nar/14.13.5321

PubMed ID: 3755526

Title: cDNA sequence coding for human kidney catalase.

PubMed ID: 3755526

PubMed ID: 11728823

Title: Transduction of human catalase mediated by an HIV-1 TAT protein basic domain and arginine-rich peptides into mammalian cells.

PubMed ID: 11728823

DOI: 10.1016/s0891-5849(01)00734-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8282800

Title: Vulnerability of the human airway epithelium to hyperoxia. Constitutive expression of the catalase gene in human bronchial epithelial cells despite oxidant stress.

PubMed ID: 8282800

DOI: 10.1172/jci116959

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7882369

Title: A human erythrocyte-derived growth-promoting factor with a wide target cell spectrum: identification as catalase.

PubMed ID: 7882369

PubMed ID: 6548744

Title: Isolation of human fibroblast catalase cDNA clones. Sequence of clones derived from spliced and unspliced mRNA.

PubMed ID: 6548744

DOI: 10.1016/s0021-9258(18)89819-2

PubMed ID: 2308162

Title: Molecular analysis of human acatalasemia. Identification of a splicing mutation.

PubMed ID: 2308162

DOI: 10.1016/0022-2836(90)90359-t

PubMed ID: 8769411

Title: Targeting of human catalase to peroxisomes is dependent upon a novel COOH-terminal peroxisomal targeting sequence.

PubMed ID: 8769411

DOI: 10.1083/jcb.134.4.849

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21976670

Title: PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.

PubMed ID: 21976670

DOI: 10.1074/jbc.m111.287201

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10666617

Title: Structure of human erythrocyte catalase.

PubMed ID: 10666617

DOI: 10.1107/s0907444999015930

PubMed ID: 10656833

Title: Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.

PubMed ID: 10656833

DOI: 10.1006/jmbi.1999.3458

PubMed ID: 11134921

Title: Structure of tetragonal crystals of human erythrocyte catalase.

PubMed ID: 11134921

DOI: 10.1107/s0907444900013767

Sequence Information:

Length: 527
Mass: 59756
Checksum: 7BAA2394D124ED20
Sequence:

MADSRDPASD QMQHWKEQRA AQKADVLTTG AGNPVGDKLN VITVGPRGPL LVQDVVFTDE 
MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF EHIGKKTPIA VRFSTVAGES 
GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDPIL FPSFIHSQKR NPQTHLKDPD 
MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ 
GIKNLSVEDA ARLSQEDPDY GIRDLFNAIA TGKYPSWTFY IQVMTFNQAE TFPFNPFDLT 
KVWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEASPDKM LQGRLFAYPD 
THRHRLGPNY LHIPVNCPYR ARVANYQRDG PMCMQDNQGG APNYYPNSFG APEQQPSALE 
HSIQYSGEVR RFNTANDDNV TQVRAFYVNV LNEEQRKRLC ENIAGHLKDA QIFIQKKAVK 
NFTEVHPDYG SHIQALLDKY NAEKPKNAIH TFVQSGSHLA AREKANL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CAT

Associated with

Cells (max top 100)

Other Information

Isolation and characterization of the human catalase gene. PubMed ID: 3755525

cDNA sequence coding for human kidney catalase. PubMed ID: 3755526

Transduction of human catalase mediated by an HIV-1 TAT protein basic domain and arginine-rich peptides into mammalian cells. PubMed ID: 11728823

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Vulnerability of the human airway epithelium to hyperoxia. Constitutive expression of the catalase gene in human bronchial epithelial cells despite oxidant stress. PubMed ID: 8282800

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

A human erythrocyte-derived growth-promoting factor with a wide target cell spectrum: identification as catalase. PubMed ID: 7882369

Isolation of human fibroblast catalase cDNA clones. Sequence of clones derived from spliced and unspliced mRNA. PubMed ID: 6548744

Molecular analysis of human acatalasemia. Identification of a splicing mutation. PubMed ID: 2308162

Targeting of human catalase to peroxisomes is dependent upon a novel COOH-terminal peroxisomal targeting sequence. PubMed ID: 8769411

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14. PubMed ID: 21976670

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structure of human erythrocyte catalase. PubMed ID: 10666617

Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism. PubMed ID: 10656833

Structure of tetragonal crystals of human erythrocyte catalase. PubMed ID: 11134921