Details for: PPM1D

Gene ID: 8493

Symbol: PPM1D

Ensembl ID: ENSG00000170836

Description: protein phosphatase, Mg2+/Mn2+ dependent 1D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 166.5753
    Cell Significance Index: -25.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.0688
    Cell Significance Index: -26.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 69.5234
    Cell Significance Index: -28.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.7805
    Cell Significance Index: -23.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.5706
    Cell Significance Index: -27.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.0040
    Cell Significance Index: -27.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3529
    Cell Significance Index: -25.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5026
    Cell Significance Index: -16.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9665
    Cell Significance Index: -27.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3446
    Cell Significance Index: 75.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1299
    Cell Significance Index: 30.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0803
    Cell Significance Index: 214.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0084
    Cell Significance Index: 99.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8645
    Cell Significance Index: 173.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7482
    Cell Significance Index: 675.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5684
    Cell Significance Index: 9.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5481
    Cell Significance Index: 89.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5370
    Cell Significance Index: 41.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5254
    Cell Significance Index: 57.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5084
    Cell Significance Index: 182.3700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4777
    Cell Significance Index: 6.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4385
    Cell Significance Index: 26.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3696
    Cell Significance Index: 9.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3252
    Cell Significance Index: 9.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3225
    Cell Significance Index: 8.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3202
    Cell Significance Index: 14.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2959
    Cell Significance Index: 6.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2381
    Cell Significance Index: 164.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2322
    Cell Significance Index: 10.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2255
    Cell Significance Index: 42.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2060
    Cell Significance Index: 12.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1936
    Cell Significance Index: 13.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1790
    Cell Significance Index: 6.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1775
    Cell Significance Index: 24.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1677
    Cell Significance Index: 20.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1214
    Cell Significance Index: 21.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1074
    Cell Significance Index: 7.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0957
    Cell Significance Index: 42.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0912
    Cell Significance Index: 1.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0695
    Cell Significance Index: 37.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0492
    Cell Significance Index: 1.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0481
    Cell Significance Index: 21.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0426
    Cell Significance Index: 1.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0370
    Cell Significance Index: 23.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0359
    Cell Significance Index: 67.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0233
    Cell Significance Index: 35.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0225
    Cell Significance Index: 30.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0202
    Cell Significance Index: 37.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0134
    Cell Significance Index: 1.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0059
    Cell Significance Index: 0.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0057
    Cell Significance Index: 0.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0017
    Cell Significance Index: -0.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0191
    Cell Significance Index: -2.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0286
    Cell Significance Index: -20.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0310
    Cell Significance Index: -23.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0342
    Cell Significance Index: -25.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0462
    Cell Significance Index: -26.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0489
    Cell Significance Index: -30.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0560
    Cell Significance Index: -3.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0751
    Cell Significance Index: -12.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0819
    Cell Significance Index: -23.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0870
    Cell Significance Index: -1.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0952
    Cell Significance Index: -4.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0979
    Cell Significance Index: -11.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0996
    Cell Significance Index: -12.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1045
    Cell Significance Index: -10.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1079
    Cell Significance Index: -6.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1291
    Cell Significance Index: -2.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1323
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1406
    Cell Significance Index: -29.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1542
    Cell Significance Index: -5.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1689
    Cell Significance Index: -7.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1767
    Cell Significance Index: -9.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1846
    Cell Significance Index: -21.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1981
    Cell Significance Index: -10.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2048
    Cell Significance Index: -6.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2084
    Cell Significance Index: -2.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2139
    Cell Significance Index: -22.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2142
    Cell Significance Index: -15.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2297
    Cell Significance Index: -17.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2439
    Cell Significance Index: -5.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2474
    Cell Significance Index: -6.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2846
    Cell Significance Index: -5.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3071
    Cell Significance Index: -15.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3178
    Cell Significance Index: -25.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3240
    Cell Significance Index: -4.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3321
    Cell Significance Index: -20.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3469
    Cell Significance Index: -18.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3497
    Cell Significance Index: -9.3700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3826
    Cell Significance Index: -2.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3923
    Cell Significance Index: -8.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4156
    Cell Significance Index: -6.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4186
    Cell Significance Index: -7.0100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4563
    Cell Significance Index: -5.6600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4767
    Cell Significance Index: -11.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4819
    Cell Significance Index: -6.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4873
    Cell Significance Index: -13.9700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4880
    Cell Significance Index: -5.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4980
    Cell Significance Index: -14.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/threonine phosphatase activity**: PPM1D is a dual-specificity phosphatase that dephosphorylates both serine and threonine residues on target proteins. 2. **Mg2+/Mn2+ dependent**: The enzyme requires magnesium or manganese ions to catalyze its phosphatase activity. 3. **Cellular localization**: PPM1D is expressed in multiple cell types, including germ cells, pulmonary interstitial fibroblasts, endothelial cells, and neurons. 4. **Signaling pathway regulation**: PPM1D is involved in various signaling pathways, including DNA damage response, cell cycle regulation, and gene expression. **Pathways and Functions:** 1. **DNA damage response**: PPM1D dephosphorylates and activates key proteins involved in DNA damage response, such as p53 and ATM. 2. **Cell cycle regulation**: PPM1D regulates the G2/M transition of the cell cycle by dephosphorylating and activating cyclin-dependent kinases. 3. **Gene expression**: PPM1D modulates gene expression by dephosphorylating and activating transcription factors, such as Runx2. 4. **Signal transduction by p53 class mediator**: PPM1D interacts with p53 and other p53-class mediators to regulate cell growth and survival. 5. **Metal ion binding**: PPM1D binds to metal ions, such as magnesium and manganese, which are required for its phosphatase activity. **Clinical Significance:** 1. **Cancer**: PPM1D is overexpressed in various cancers, including breast, lung, and colon cancer, and its dysregulation is associated with cancer progression and metastasis. 2. **Neurodegenerative disorders**: PPM1D is implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation leads to neuronal dysfunction and death. 3. **Metabolic disorders**: PPM1D is involved in glucose and lipid metabolism, and its dysregulation is associated with metabolic disorders, such as type 2 diabetes and obesity. 4. **Regenerative medicine**: PPM1D has potential applications in regenerative medicine, where its dysregulation is targeted to promote tissue repair and regeneration. In conclusion, PPM1D is a key regulator of cellular homeostasis and disease pathogenesis. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. Further research is needed to fully understand the role of PPM1D in human health and disease, and to explore its therapeutic potential.

Genular Protein ID: 1751694667

Symbol: PPM1D_HUMAN

Name: Protein phosphatase 1D

UniProtKB Accession Codes:

O15297 Q53XP4 Q6P991 Q8IVR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DNASU 1 DisGeNET 1 EC 3 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9177166

Title: Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.

PubMed ID: 9177166

DOI: 10.1073/pnas.94.12.6048

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15870257

Title: PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.

PubMed ID: 15870257

DOI: 10.1101/gad.1291305

PubMed ID: 16311512

Title: Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.

PubMed ID: 16311512

DOI: 10.1038/sj.cdd.4401801

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21283629

Title: LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).

PubMed ID: 21283629

DOI: 10.1371/journal.pone.0016427

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23242139

Title: Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer.

PubMed ID: 23242139

DOI: 10.1038/nature11725

PubMed ID: 28343630

Title: De novo truncating mutations in the last and penultimate exons of PPM1D cause an intellectual disability syndrome.

PubMed ID: 28343630

DOI: 10.1016/j.ajhg.2017.02.005

Sequence Information:

  • Length: 605
  • Mass: 66675
  • Checksum: E6C5884CF04008B7
  • Sequence:
    • MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPTAEEKPS PRRSLSQPLP PRPSPAALPG 
GEVSGKGPAV AAREARDPLP DAGASPAPSR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL 
WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII 
RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG 
VNRVVWKRPR LTHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT 
LDPQKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ 
RMLRADNTSA IVICISPEVD NQGNFTNEDE LYLNLTDSPS YNSQETCVMT PSPCSTPPVK 
SLEEDPWPRV NSKDHIPALV RSNAFSENFL EVSAEIAREN VQGVVIPSKD PEPLEENCAK 
ALTLRIHDSL NNSLPIGLVP TNSTNTVMDQ KNLKMSTPGQ MKAQEIERTP PTNFKRTLEE 
SNSGPLMKKH RRNGLSRSSG AQPASLPTTS QRKNSVKLTM RRRLRGQKKI GNPLLHQHRK 
TVCVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.