Details for: PKP4
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 49.06rCSI 61.03%PRS 52.43
-
CSI 43.32rCSI 72.72%PRS 54.45
-
CSI 38.73rCSI 49.93%PRS 55.75
-
CSI 38.7rCSI 62.24%PRS 56.21
-
CSI 38.12rCSI 54.03%PRS 69.43
-
CSI 37.26rCSI 65.8%PRS 53.56
-
CSI 35.26rCSI 60.99%PRS 63.66
-
CSI 31.79rCSI 37.97%PRS 54.31
-
CSI 28.51rCSI 69.3%PRS 52.68
-
CSI 25.13rCSI 40.09%PRS 64.77
-
CSI 25.07rCSI 24.13%PRS 72.69
-
CSI 25.05rCSI 54.35%PRS 60.56
-
CSI 23.54rCSI 73.57%PRS 56.22
-
CSI 23.4rCSI 73.19%PRS 58.68
-
CSI 21.53rCSI 53.29%PRS 72.28
-
CSI 20.45rCSI 48.91%PRS 59.68
-
CSI 20.06rCSI 32.03%PRS 76.92
-
CSI 19.92rCSI 23.01%PRS 65.32
-
CSI 19.73rCSI 45.02%PRS 64.33
-
CSI 19.58rCSI 29.91%PRS 73.68
-
CSI 19.5rCSI 73.69%PRS 54.9
-
CSI 19.36rCSI 69.66%PRS 52.53
-
CSI 18.39rCSI 69.39%PRS 56.33
-
CSI 18.33rCSI 48.98%PRS 64.11
-
CSI 18.32rCSI 36.79%PRS 62.57
-
CSI 18.12rCSI 45.95%PRS 62.93
-
CSI 17.65rCSI 47.01%PRS 60.93
-
CSI 17.43rCSI 24.21%PRS 71.72
-
CSI 17.33rCSI 56.95%PRS 59.42
-
CSI 17.33rCSI 38.13%PRS 56.28
-
CSI 15.65rCSI 13.12%PRS 76.41
-
CSI 15.65rCSI 28.44%PRS 64.13
-
CSI 15.37rCSI 27.5%PRS 72.44
-
CSI 15.2rCSI 44.92%PRS 62.65
-
CSI 14.39rCSI 37.99%PRS 81.17
-
CSI 14.36rCSI 35.06%PRS 66.03
-
CSI 14.23rCSI 22.63%PRS 65.75
-
CSI 13.75rCSI 25.75%PRS 61.04
-
CSI 13.57rCSI 28.15%PRS 70.07
-
CSI 13.5rCSI 17.34%PRS 63.81
-
CSI 13.32rCSI 9.86%PRS 66.02
-
CSI 13.22rCSI 19.39%PRS 83.57
-
CSI 13.17rCSI 21.57%PRS 62.19
-
CSI 13.12rCSI 12.65%PRS 65.31
-
CSI 12.69rCSI 22.25%PRS 65.83
-
CSI 12.63rCSI 33.51%PRS 80.89
-
CSI 12.48rCSI 32.43%PRS 75.07
-
CSI 12.47rCSI 13.01%PRS 72.85
-
CSI 12.43rCSI 13.33%PRS 73.69
-
CSI 12.37rCSI 46.34%PRS 65.15
-
CSI 12.23rCSI 34.76%PRS 69.62
-
CSI 12.08rCSI 71.16%PRS 55.41
-
CSI 11.97rCSI 21.51%PRS 66.22
-
CSI 11.85rCSI 9.37%PRS 60.64
-
CSI 11.61rCSI 23.56%PRS 51.3
-
CSI 11.29rCSI 38.67%PRS 60.31
-
CSI 11.19rCSI 25.83%PRS 61.07
-
CSI 11.17rCSI 17.97%PRS 62.66
-
CSI 11.12rCSI 28.98%PRS 73.52
-
CSI 10.77rCSI 43.89%PRS 65.58
-
CSI 10.37rCSI 15.65%PRS 78.27
-
CSI 10.36rCSI 16.79%PRS 68.73
-
CSI 10.15rCSI 51.11%PRS 71.41
-
CSI 9.52rCSI 24.09%PRS 79.37
-
CSI 9.42rCSI 11.72%PRS 74.51
-
CSI 9.39rCSI 8.25%PRS 61.51
-
CSI 9.38rCSI 24.26%PRS 68.1
-
CSI 9.21rCSI 19.49%PRS 86.47
-
CSI 8.97rCSI 20.1%PRS 55.04
-
CSI 8.85rCSI 65.09%PRS 59.94
-
CSI 8.77rCSI 12.89%PRS 65.97
-
CSI 8.58rCSI 18.96%PRS 58.8
-
CSI 8.52rCSI 7.93%PRS 73.95
-
CSI 8.44rCSI 11.69%PRS 71.72
-
CSI 8.23rCSI 24.43%PRS 82.36
-
CSI 8.09rCSI 38.77%PRS 73.02
-
CSI 8.05rCSI 56.92%PRS 65.87
-
CSI 7.96rCSI 10.65%PRS 72.55
-
CSI 7.93rCSI 9.2%PRS 78.66
-
CSI 7.81rCSI 17.2%PRS 77.24
-
CSI 7.64rCSI 19.92%PRS 73.39
-
CSI 7.45rCSI 40.76%PRS 70.42
-
CSI 7.39rCSI 28.75%PRS 74.62
-
CSI 7.32rCSI 16.73%PRS 73.79
-
CSI 7.32rCSI 40.93%PRS 76.66
-
CSI 7.17rCSI 14.73%PRS 61.33
-
CSI 7.01rCSI 31.17%PRS 73.43
-
CSI 7.01rCSI 46.53%PRS 68.8
-
CSI 6.86rCSI 16.09%PRS 74.68
-
CSI 6.76rCSI 29.69%PRS 68.86
-
CSI 6.74rCSI 7.91%PRS 75.12
-
CSI 6.67rCSI 26.9%PRS 72.42
-
CSI 6.64rCSI 17.31%PRS 68.81
-
CSI 6.53rCSI 40.81%PRS 64.68
-
CSI 6.44rCSI 55.53%PRS 60.22
-
CSI 6.4rCSI 7.01%PRS 75.93
-
CSI 6.35rCSI 19.55%PRS 78.79
-
CSI 6.32rCSI 35.73%PRS 58.55
-
CSI 6.26rCSI 36.99%PRS 66.03
-
CSI 6.16rCSI 16.99%PRS 68.05
-
CSI 0.3rCSI 7.6%PRS 84.8%
-
CSI 0.8rCSI 2.0%PRS 66.7%
-
CSI 0.8rCSI 4.2%PRS 82.3%
-
CSI 0.8rCSI 3.3%PRS 81.1%
-
CSI 0.9rCSI 18.9%PRS 91.8%
-
CSI 0.9rCSI 1.8%PRS 76.4%
-
CSI 1.0rCSI 7.0%PRS 84.4%
-
CSI 1.1rCSI 4.3%PRS 83.9%
-
CSI 1.1rCSI 7.4%PRS 82.3%
-
CSI 1.2rCSI 2.8%PRS 78.1%
-
CSI 1.2rCSI 4.0%PRS 71.6%
-
CSI 1.3rCSI 1.0%PRS 75.3%
-
CSI 1.3rCSI 1.8%PRS 76.9%
-
CSI 1.3rCSI 3.2%PRS 75.0%
-
CSI 1.3rCSI 3.8%PRS 82.1%
-
CSI 1.5rCSI 5.5%PRS 63.5%
-
CSI 1.5rCSI 8.0%PRS 80.4%
-
CSI 1.5rCSI 2.9%PRS 86.8%
-
CSI 1.6rCSI 7.0%PRS 83.8%
-
CSI 1.6rCSI 2.4%PRS 85.4%
-
CSI 1.7rCSI 10.6%PRS 71.8%
-
CSI 1.7rCSI 4.3%PRS 83.2%
-
CSI 1.7rCSI 3.6%PRS 82.5%
-
CSI 1.7rCSI 11.5%PRS 67.2%
-
CSI 1.7rCSI 3.1%PRS 85.5%
-
CSI 1.7rCSI 6.1%PRS 79.1%
-
CSI 1.8rCSI 2.5%PRS 62.5%
-
CSI 1.8rCSI 1.8%PRS 76.5%
-
CSI 1.9rCSI 4.8%PRS 70.8%
-
CSI 1.9rCSI 17.6%PRS 77.7%
-
CSI 1.9rCSI 7.5%PRS 84.2%
-
CSI 2.0rCSI 11.1%PRS 84.5%
-
CSI 2.1rCSI 2.7%PRS 77.0%
-
CSI 2.2rCSI 10.8%PRS 68.7%
-
CSI 2.2rCSI 18.4%PRS 62.6%
-
CSI 2.2rCSI 31.4%PRS 63.9%
-
CSI 2.3rCSI 11.1%PRS 82.5%
-
CSI 2.3rCSI 12.1%PRS 75.9%
-
CSI 2.3rCSI 47.2%PRS 63.0%
-
CSI 2.4rCSI 56.2%PRS 87.7%
-
CSI 2.4rCSI 3.9%PRS 82.8%
-
CSI 2.5rCSI 7.1%PRS 68.7%
-
CSI 2.6rCSI 51.9%PRS 64.3%
-
CSI 2.7rCSI 20.0%PRS 65.2%
-
CSI 2.7rCSI 23.7%PRS 61.4%
-
CSI 2.7rCSI 1.9%PRS 76.2%
-
CSI 2.8rCSI 4.0%PRS 67.9%
-
CSI 2.8rCSI 7.8%PRS 82.1%
-
CSI 2.9rCSI 3.8%PRS 79.2%
-
CSI 3.0rCSI 71.3%PRS 53.8%
-
CSI 3.0rCSI 71.5%PRS 53.2%
-
CSI 3.1rCSI 7.0%PRS 67.9%
-
CSI 3.3rCSI 29.2%PRS 84.3%
-
CSI 3.3rCSI 2.6%PRS 88.7%
-
CSI 3.4rCSI 4.2%PRS 83.1%
-
CSI 3.4rCSI 48.5%PRS 80.2%
-
CSI 3.4rCSI 17.9%PRS 65.7%
-
CSI 3.5rCSI 2.8%PRS 75.2%
-
CSI 3.5rCSI 27.5%PRS 68.1%
-
CSI 3.6rCSI 9.7%PRS 79.1%
-
CSI 3.6rCSI 22.8%PRS 55.2%
-
CSI 4.0rCSI 6.2%PRS 77.4%
-
CSI 4.1rCSI 43.0%PRS 70.2%
-
CSI 4.1rCSI 42.1%PRS 67.4%
-
CSI 4.1rCSI 4.7%PRS 64.5%
-
CSI 4.1rCSI 13.1%PRS 70.2%
-
CSI 4.1rCSI 13.3%PRS 70.6%
-
CSI 4.3rCSI 4.6%PRS 80.0%
-
CSI 4.4rCSI 6.4%PRS 78.1%
-
CSI 4.4rCSI 6.5%PRS 77.9%
-
CSI 4.4rCSI 20.7%PRS 66.5%
-
CSI 4.5rCSI 19.9%PRS 56.9%
-
CSI 4.5rCSI 4.5%PRS 66.7%
-
CSI 4.5rCSI 13.1%PRS 62.2%
-
CSI 4.5rCSI 6.2%PRS 65.2%
-
CSI 4.6rCSI 7.2%PRS 75.1%
-
CSI 4.6rCSI 27.4%PRS 76.9%
-
CSI 4.6rCSI 4.4%PRS 72.3%
-
CSI 4.7rCSI 7.7%PRS 78.1%
-
CSI 4.7rCSI 22.6%PRS 70.5%
-
CSI 4.9rCSI 4.0%PRS 73.4%
-
CSI 4.9rCSI 5.1%PRS 78.2%
-
CSI 4.9rCSI 7.5%PRS 81.6%
-
CSI 5.0rCSI 43.1%PRS 68.8%
-
CSI 5.0rCSI 16.8%PRS 57.3%
-
CSI 5.1rCSI 14.9%PRS 72.0%
-
CSI 5.1rCSI 11.2%PRS 79.5%
-
CSI 5.2rCSI 33.2%PRS 80.7%
-
CSI 5.3rCSI 10.9%PRS 71.8%
-
CSI 5.4rCSI 38.2%PRS 72.3%
-
CSI 5.4rCSI 4.8%PRS 71.0%
-
CSI 5.4rCSI 31.0%PRS 70.6%
-
CSI 5.4rCSI 8.1%PRS 73.7%
-
CSI 5.5rCSI 14.6%PRS 87.5%
-
CSI 5.6rCSI 39.9%PRS 65.0%
-
CSI 5.6rCSI 8.7%PRS 78.6%
-
CSI 5.7rCSI 65.2%PRS 63.1%
-
CSI 5.8rCSI 13.4%PRS 81.3%
-
CSI 5.8rCSI 10.2%PRS 69.2%
-
CSI 6.0rCSI 11.9%PRS 69.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 697327569
Symbol: PKP4_HUMAN
Name: Plakophilin-4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8937994
Title: Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins.
PubMed ID: 8937994
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17115030
Title: The armadillo protein p0071 regulates Rho signalling during cytokinesis.
PubMed ID: 17115030
DOI: 10.1038/ncb1504
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19706687
Title: PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells.
PubMed ID: 19706687
DOI: 10.1242/jcs.046854
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25009281
Title: DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.
PubMed ID: 25009281
PubMed ID: 29034528
Title: Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF.
PubMed ID: 29034528
DOI: 10.1111/ced.13214
PubMed ID: 30479852
Title: Subclinical oral involvement in patients with endemic pemphigus foliaceus.
PubMed ID: 30479852
DOI: 10.5826/dpc.0804a02
Sequence Information:
- Length: 1192
- Mass: 131868
- Checksum: 48EA1579E323E019
- Sequence:
MPAPEQASLV EEGQPQTRQE AASTGPGMEP ETTATTILAS VKEQELQFQR LTRELEVERQ IVASQLERCR LGAESPSIAS TSSTEKSFPW RSTDVPNTGV SKPRVSDAVQ PNNYLIRTEP EQGTLYSPEQ TSLHESEGSL GNSRSSTQMN SYSDSGYQEA GSFHNSQNVS KADNRQQHSF IGSTNNHVVR NSRAEGQTLV QPSVANRAMR RVSSVPSRAQ SPSYVISTGV SPSRGSLRTS LGSGFGSPSV TDPRPLNPSA YSSTTLPAAR AASPYSQRPA SPTAIRRIGS VTSRQTSNPN GPTPQYQTTA RVGSPLTLTD AQTRVASPSQ GQVGSSSPKR SGMTAVPQHL GPSLQRTVHD MEQFGQQQYD IYERMVPPRP DSLTGLRSSY ASQHSQLGQD LRSAVSPDLH ITPIYEGRTY YSPVYRSPNH GTVELQGSQT ALYRTGSVGI GNLQRTSSQR STLTYQRNNY ALNTTATYAE PYRPIQYRVQ ECNYNRLQHA VPADDGTTRS PSIDSIQKDP REFAWRDPEL PEVIHMLQHQ FPSVQANAAA YLQHLCFGDN KVKMEVCRLG GIKHLVDLLD HRVLEVQKNA CGALRNLVFG KSTDENKIAM KNVGGIPALL RLLRKSIDAE VRELVTGVLW NLSSCDAVKM TIIRDALSTL TNTVIVPHSG WNNSSFDDDH KIKFQTSLVL RNTTGCLRNL SSAGEEARKQ MRSCEGLVDS LLYVIHTCVN TSDYDSKTVE NCVCTLRNLS YRLELEVPQA RLLGLNELDD LLGKESPSKD SEPSCWGKKK KKKKRTPQED QWDGVGPIPG LSKSPKGVEM LWHPSVVKPY LTLLAESSNP ATLEGSAGSL QNLSAGNWKF AAYIRAAVRK EKGLPILVEL LRMDNDRVVS SVATALRNMA LDVRNKELIG KYAMRDLVNR LPGGNGPSVL SDETMAAICC ALHEVTSKNM ENAKALADSG GIEKLVNITK GRGDRSSLKV VKAAAQVLNT LWQYRDLRSI YKKDGWNQNH FITPVSTLER DRFKSHPSLS TTNQQMSPII QSVGSTSSSP ALLGIRDPRS EYDRTQPPMQ YYNSQGDATH KGLYPGSSKP SPIYISSYSS PAREQNRRLQ HQQLYYSQDD SNRKNFDAYR LYLQSPHSYE DPYFDDRVHF PASTDYSTQY GLKSTTNYVD FYSTKRPSYR AEQYPGSPDS WV