Details for: NIPSNAP1

Gene ID: 8508

Symbol: NIPSNAP1

Ensembl ID: ENSG00000184117

Description: nipsnap homolog 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 152.0458
    Cell Significance Index: -23.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.0159
    Cell Significance Index: -18.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.8223
    Cell Significance Index: -24.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9292
    Cell Significance Index: -23.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2746
    Cell Significance Index: -24.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.4444
    Cell Significance Index: 35.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.2490
    Cell Significance Index: 528.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2480
    Cell Significance Index: -4.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.7148
    Cell Significance Index: 59.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6019
    Cell Significance Index: 33.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.5702
    Cell Significance Index: 17.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5255
    Cell Significance Index: 302.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4204
    Cell Significance Index: 18.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9462
    Cell Significance Index: 65.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8094
    Cell Significance Index: 442.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7507
    Cell Significance Index: 150.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7409
    Cell Significance Index: 38.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6745
    Cell Significance Index: 19.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6661
    Cell Significance Index: 14.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6450
    Cell Significance Index: 16.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6440
    Cell Significance Index: 17.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6195
    Cell Significance Index: 32.1800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5616
    Cell Significance Index: 9.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5319
    Cell Significance Index: 24.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5118
    Cell Significance Index: 462.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4990
    Cell Significance Index: 10.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4690
    Cell Significance Index: 29.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4382
    Cell Significance Index: 157.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4183
    Cell Significance Index: 57.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3898
    Cell Significance Index: 70.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3800
    Cell Significance Index: 11.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3793
    Cell Significance Index: 37.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3353
    Cell Significance Index: 231.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2770
    Cell Significance Index: 4.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2757
    Cell Significance Index: 16.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2644
    Cell Significance Index: 50.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2408
    Cell Significance Index: 11.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2382
    Cell Significance Index: 29.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2311
    Cell Significance Index: 102.1800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.1943
    Cell Significance Index: 0.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1587
    Cell Significance Index: 3.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1422
    Cell Significance Index: 16.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1354
    Cell Significance Index: 7.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1321
    Cell Significance Index: 9.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1253
    Cell Significance Index: 16.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1209
    Cell Significance Index: 15.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1005
    Cell Significance Index: 6.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0766
    Cell Significance Index: 2.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0763
    Cell Significance Index: 0.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0729
    Cell Significance Index: 2.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0696
    Cell Significance Index: 11.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0399
    Cell Significance Index: 1.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0164
    Cell Significance Index: 30.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0064
    Cell Significance Index: 8.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0030
    Cell Significance Index: 5.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0021
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0033
    Cell Significance Index: -2.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0114
    Cell Significance Index: -8.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0176
    Cell Significance Index: -2.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0193
    Cell Significance Index: -1.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0218
    Cell Significance Index: -13.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0283
    Cell Significance Index: -1.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0329
    Cell Significance Index: -18.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0337
    Cell Significance Index: -3.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0366
    Cell Significance Index: -16.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0403
    Cell Significance Index: -1.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0565
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0584
    Cell Significance Index: -12.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0650
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0653
    Cell Significance Index: -7.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0705
    Cell Significance Index: -20.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0723
    Cell Significance Index: -5.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0768
    Cell Significance Index: -2.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0805
    Cell Significance Index: -1.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0855
    Cell Significance Index: -0.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0960
    Cell Significance Index: -4.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1045
    Cell Significance Index: -1.7900
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.1196
    Cell Significance Index: -0.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1255
    Cell Significance Index: -14.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1312
    Cell Significance Index: -8.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1356
    Cell Significance Index: -3.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1561
    Cell Significance Index: -4.2500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1991
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2060
    Cell Significance Index: -23.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2098
    Cell Significance Index: -16.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2228
    Cell Significance Index: -23.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2292
    Cell Significance Index: -5.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2422
    Cell Significance Index: -5.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2585
    Cell Significance Index: -4.3600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2976
    Cell Significance Index: -4.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3038
    Cell Significance Index: -8.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3091
    Cell Significance Index: -18.9500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3681
    Cell Significance Index: -5.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4188
    Cell Significance Index: -10.4700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4201
    Cell Significance Index: -2.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4276
    Cell Significance Index: -22.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4362
    Cell Significance Index: -14.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4408
    Cell Significance Index: -14.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NIPSNAP1 is a single-pass transmembrane protein that is highly expressed in various cell types, including hepatoblasts, epithelial cells of the nephron, and peripheral nervous system neurons. Its expression is also notable in granulosa cells and ovarian surface epithelial cells, suggesting a role in reproductive biology. The protein is characterized by its unique structure, consisting of two N-terminal domains and a C-terminal domain with a putative membrane-binding motif. This distinctive structure is thought to be essential for its function. **Pathways and Functions:** NIPSNAP1 is involved in multiple cellular pathways, including: 1. **Mitochondrial function:** NIPSNAP1 has been shown to interact with mitochondrial proteins, suggesting a role in regulating mitochondrial dynamics and function. 2. **Protein binding:** The protein's ability to bind to various proteins, including those involved in pain perception and synaptic transmission, highlights its involvement in cellular communication and signaling. 3. **Sensory perception of pain:** NIPSNAP1 has been implicated in the regulation of pain perception, with studies suggesting that it interacts with pain receptors and modulates pain signaling pathways. 4. **Synaptic membrane:** The protein's expression in neurons and its interaction with synaptic proteins indicate a role in regulating synaptic function and plasticity. **Clinical Significance:** NIPSNAP1's involvement in various cellular processes has significant implications for human health and disease. Some of the key clinical implications include: 1. **Neurological disorders:** Alterations in NIPSNAP1 expression or function may contribute to neurological disorders, such as pain-related conditions, neurodegenerative diseases, and synaptic dysfunction. 2. **Cancer:** NIPSNAP1's expression in granulosa cells and ovarian surface epithelial cells suggests a potential role in reproductive oncology, with implications for cancer diagnosis and treatment. 3. **Immune regulation:** NIPSNAP1's involvement in immune regulation and mitochondrial function highlights its potential role in autoimmune diseases and inflammatory conditions. In conclusion, NIPSNAP1 is a complex protein with a multifaceted role in cellular homeostasis, immune regulation, and pain perception. Further research is needed to fully elucidate its function and clinical significance, but its involvement in various cellular pathways and processes underscores its importance in human health and disease.

Genular Protein ID: 2094039405

Symbol: NIPS1_HUMAN

Name: Protein NipSnap homolog 1

UniProtKB Accession Codes:

Q9BPW8 B2RAY3 O43800

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9661659

Title: Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family.

PubMed ID: 9661659

DOI: 10.1016/s0378-1119(98)00098-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30982665

Title: NIPSNAP1 and NIPSNAP2 act as 'eat me' signals for mitophagy.

PubMed ID: 30982665

DOI: 10.1016/j.devcel.2019.03.013

PubMed ID: 38297121

Title: Stress response silencing by an E3 ligase mutated in neurodegeneration.

PubMed ID: 38297121

DOI: 10.1038/s41586-023-06985-7

Sequence Information:

  • Length: 284
  • Mass: 33310
  • Checksum: E0B3E60082C2CACA
  • Sequence:
    • MAPRLCSISV TARRLLGGPG PRAGDVASAA AARFYSKDNE GSWFRSLFVH KVDPRKDAHS 
TLLSKKETSN LYKIQFHNVK PEYLDAYNSL TEAVLPKLHL DEDYPCSLVG NWNTWYGEQD 
QAVHLWRFSG GYPALMDCMN KLKNNKEYLE FRRERSQMLL SRRNQLLLEF SFWNEPQPRM 
GPNIYELRTY KLKPGTMIEW GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL 
QSREETRNAA WRKRGWDENV YYTVPLVRHM ESRIMIPLKI SPLQ

Genular Protein ID: 2394935684

Symbol: B4DQI7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQI7

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 IntAct 1 InterPro 3 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 264
  • Mass: 31407
  • Checksum: EB05C4B0D2812CD8
  • Sequence:
    • MAPRLCSISV TARFYSKDNE GSWFRSLFVH KVDPRKDAHS TLLSKKETSN LYKIQFHNVK 
PEYLDAYNSL TEAVLPKLHL DEDYPCSLVG NWNTWYGEQD QAVHLWRFSG GYPALMGCMN 
KLKNNKEYLE FRRERSQMLL SRRNQLLLEF SFWNEPQPRM GPNIYELRTY KLKPGTMIEW 
GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL QSREETRNAA WRKRGWDENV 
YYTVPLVRHM ESRIMIPLKI SPLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.