Details for: HAT1

Gene ID: 8520

Symbol: HAT1

Ensembl ID: ENSG00000128708

Description: histone acetyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 155.6782
    Cell Significance Index: -24.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.4120
    Cell Significance Index: -34.6000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 97.4638
    Cell Significance Index: -40.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.9420
    Cell Significance Index: -43.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.7339
    Cell Significance Index: -34.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.7445
    Cell Significance Index: -40.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 65.6014
    Cell Significance Index: -44.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.9628
    Cell Significance Index: -35.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.9436
    Cell Significance Index: -39.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5053
    Cell Significance Index: -33.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5549
    Cell Significance Index: -41.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2068
    Cell Significance Index: -20.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0939
    Cell Significance Index: -24.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9544
    Cell Significance Index: 135.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1852
    Cell Significance Index: 235.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9695
    Cell Significance Index: 26.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8662
    Cell Significance Index: 173.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8340
    Cell Significance Index: 62.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7565
    Cell Significance Index: 523.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7285
    Cell Significance Index: 93.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7026
    Cell Significance Index: 383.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6784
    Cell Significance Index: 93.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6743
    Cell Significance Index: 82.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6728
    Cell Significance Index: 297.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5393
    Cell Significance Index: 4.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5176
    Cell Significance Index: 84.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5176
    Cell Significance Index: 185.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5175
    Cell Significance Index: 93.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5063
    Cell Significance Index: 28.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5007
    Cell Significance Index: 59.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4504
    Cell Significance Index: 15.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4502
    Cell Significance Index: 31.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4347
    Cell Significance Index: 20.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4308
    Cell Significance Index: 12.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3706
    Cell Significance Index: 17.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3575
    Cell Significance Index: 18.5700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3509
    Cell Significance Index: 5.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3506
    Cell Significance Index: 22.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3072
    Cell Significance Index: 19.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3015
    Cell Significance Index: 57.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2243
    Cell Significance Index: 28.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1951
    Cell Significance Index: 5.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1603
    Cell Significance Index: 8.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1521
    Cell Significance Index: 4.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1233
    Cell Significance Index: 21.0600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.1148
    Cell Significance Index: 1.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1088
    Cell Significance Index: 3.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0693
    Cell Significance Index: 3.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0623
    Cell Significance Index: 117.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0394
    Cell Significance Index: 3.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0386
    Cell Significance Index: 0.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0235
    Cell Significance Index: 14.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0123
    Cell Significance Index: 22.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0109
    Cell Significance Index: 16.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -6.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0185
    Cell Significance Index: -25.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0189
    Cell Significance Index: -13.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0200
    Cell Significance Index: -12.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0213
    Cell Significance Index: -9.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0305
    Cell Significance Index: -4.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0322
    Cell Significance Index: -18.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0328
    Cell Significance Index: -24.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0457
    Cell Significance Index: -0.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0492
    Cell Significance Index: -1.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0559
    Cell Significance Index: -5.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0592
    Cell Significance Index: -1.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0639
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0959
    Cell Significance Index: -20.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1169
    Cell Significance Index: -6.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1221
    Cell Significance Index: -35.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1370
    Cell Significance Index: -15.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1373
    Cell Significance Index: -16.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1421
    Cell Significance Index: -3.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1791
    Cell Significance Index: -5.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1836
    Cell Significance Index: -4.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1902
    Cell Significance Index: -4.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2340
    Cell Significance Index: -5.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3050
    Cell Significance Index: -5.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3302
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3304
    Cell Significance Index: -37.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3530
    Cell Significance Index: -36.7600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3544
    Cell Significance Index: -2.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3694
    Cell Significance Index: -6.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4014
    Cell Significance Index: -4.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4175
    Cell Significance Index: -33.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4621
    Cell Significance Index: -20.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4911
    Cell Significance Index: -6.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5123
    Cell Significance Index: -19.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6178
    Cell Significance Index: -16.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6302
    Cell Significance Index: -12.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6759
    Cell Significance Index: -27.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7058
    Cell Significance Index: -43.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7136
    Cell Significance Index: -21.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7219
    Cell Significance Index: -23.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7283
    Cell Significance Index: -21.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7329
    Cell Significance Index: -16.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7563
    Cell Significance Index: -24.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7610
    Cell Significance Index: -26.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7633
    Cell Significance Index: -16.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7649
    Cell Significance Index: -24.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** HAT1 is a histone acetyltransferase, meaning it catalyzes the transfer of an acetyl group from acetyl-CoA to the lysine residue on histone proteins, leading to chromatin relaxation and increased gene transcription. 2. **Subcellular Localization:** HAT1 is primarily localized to the nucleus, where it interacts with histone proteins and other chromatin-associated factors. 3. **Cell Type-Specific Expression:** HAT1 is highly expressed in erythroid progenitor cells, male germ cells, and oogonial cells, suggesting its involvement in specific cellular processes, such as hematopoiesis and gametogenesis. 4. **Protein-Protein Interactions:** HAT1 interacts with various proteins, including histones, transcription factors, and chromatin-modifying enzymes, to regulate gene expression and chromatin structure. **Pathways and Functions:** 1. **Chromatin Remodeling:** HAT1 plays a key role in chromatin remodeling by acetylating histones, leading to increased accessibility of DNA to transcription factors and other regulatory proteins. 2. **Gene Transcription:** HAT1 regulates gene transcription by modifying chromatin structure and recruiting transcriptional co-activators and co-repressors. 3. **Cell Cycle Regulation:** HAT1 is involved in cell cycle regulation by controlling the expression of genes involved in DNA replication and cell division. 4. **Epigenetic Regulation:** HAT1 contributes to epigenetic regulation by modifying histones and influencing gene expression in response to environmental cues. **Clinical Significance:** 1. **Cancer:** HAT1 has been implicated in various cancers, including leukemia, lymphoma, and prostate cancer, where its overexpression is associated with tumorigenesis and poor prognosis. 2. **Neurological Disorders:** HAT1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation contributes to cognitive decline and motor dysfunction. 3. **Immunological Disorders:** HAT1 plays a role in immunological disorders, including autoimmune diseases and immunodeficiency syndromes, where its aberrant expression can lead to immune dysfunction. 4. **Reproductive Disorders:** HAT1 has been implicated in reproductive disorders, including infertility and miscarriage, where its dysregulation can affect gametogenesis and embryonic development. In conclusion, HAT1 is a multifunctional enzyme that plays a critical role in regulating gene expression, chromatin remodeling, and cell cycle progression. Its dysregulation has been implicated in various diseases, highlighting the importance of investigating its function and clinical significance in disease. Further research is needed to elucidate the mechanisms by which HAT1 regulates gene expression and to explore its therapeutic potential in treating diseases associated with its aberrant expression.

Genular Protein ID: 529819391

Symbol: HAT1_HUMAN

Name: Histone acetyltransferase type B catalytic subunit

UniProtKB Accession Codes:

O14929 Q49A44 Q53QF0 Q53SU4 Q6P594 Q8WWB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9427644

Title: Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.

PubMed ID: 9427644

DOI: 10.1016/s0960-9822(98)70040-5

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11585814

Title: Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase.

PubMed ID: 11585814

DOI: 10.1074/jbc.c100549200

PubMed ID: 12841681

Title: Quantitative real-time RT-PCR analysis of eight novel estrogen-regulated genes in breast cancer.

PubMed ID: 12841681

DOI: 10.1177/172460080301800205

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20148353

Title: Irradiation with heavy-ion particles changes the cellular distribution of human histone acetyltransferase HAT1.

PubMed ID: 20148353

DOI: 10.1007/s11010-010-0390-0

PubMed ID: 20953179

Title: The program for processing newly synthesized histones H3.1 and H4.

PubMed ID: 20953179

DOI: 10.1038/nsmb.1911

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23653357

Title: Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover.

PubMed ID: 23653357

DOI: 10.1074/jbc.m113.473199

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28143904

Title: AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.

PubMed ID: 28143904

DOI: 10.1126/scisignal.aaf7478

PubMed ID: 31695772

Title: HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome.

PubMed ID: 31695772

DOI: 10.7150/thno.37173

PubMed ID: 31278053

Title: HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding.

PubMed ID: 31278053

DOI: 10.1016/j.molcel.2019.05.034

PubMed ID: 32081014

Title: Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions.

PubMed ID: 32081014

DOI: 10.1021/acs.jproteome.9b00843

PubMed ID: 31812350

Title: Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.

PubMed ID: 31812350

DOI: 10.1016/j.molcel.2019.11.003

PubMed ID: 22615379

Title: Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1.

PubMed ID: 22615379

DOI: 10.1073/pnas.1114117109

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 419
  • Mass: 49541
  • Checksum: 72DE4146ACC40EF6
  • Sequence:
    • MAGFGAMEKF LVEYKSAVEK KLAEYKCNTN TAIELKLVRF PEDLENDIRT FFPEYTHQLF 
GDDETAFGYK GLKILLYYIA GSLSTMFRVE YASKVDENFD CVEADDVEGK IRQIIPPGFC 
TNTNDFLSLL EKEVDFKPFG TLLHTYSVLS PTGGENFTFQ IYKADMTCRG FREYHERLQT 
FLMWFIETAS FIDVDDERWH YFLVFEKYNK DGATLFATVG YMTVYNYYVY PDKTRPRVSQ 
MLILTPFQGQ GHGAQLLETV HRYYTEFPTV LDITAEDPSK SYVKLRDFVL VKLCQDLPCF 
SREKLMQGFN EDMVIEAQQK FKINKQHARR VYEILRLLVT DMSDAEQYRS YRLDIKRRLI 
SPYKKKQRDL AKMRKCLRPE ELTNQMNQIE ISMQHEQLEE SFQELVEDYR RVIERLAQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.