Details for: DGKE

Gene ID: 8526

Symbol: DGKE

Ensembl ID: ENSG00000153933

Description: diacylglycerol kinase epsilon

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 154.5531
    Cell Significance Index: -24.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.7216
    Cell Significance Index: -22.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.6033
    Cell Significance Index: -24.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.1009
    Cell Significance Index: -24.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1859
    Cell Significance Index: -24.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.1567
    Cell Significance Index: -18.9100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.9410
    Cell Significance Index: 38.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5120
    Cell Significance Index: -9.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.0722
    Cell Significance Index: 193.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7437
    Cell Significance Index: 349.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4105
    Cell Significance Index: 62.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3991
    Cell Significance Index: 52.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1702
    Cell Significance Index: 419.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1420
    Cell Significance Index: 112.9700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.0688
    Cell Significance Index: 22.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8282
    Cell Significance Index: 53.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7082
    Cell Significance Index: 47.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6266
    Cell Significance Index: 17.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6049
    Cell Significance Index: 8.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5747
    Cell Significance Index: 93.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5636
    Cell Significance Index: 13.0200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.5279
    Cell Significance Index: 4.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5208
    Cell Significance Index: 56.6500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4870
    Cell Significance Index: 6.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4311
    Cell Significance Index: 298.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3318
    Cell Significance Index: 9.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3220
    Cell Significance Index: 19.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3172
    Cell Significance Index: 19.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2966
    Cell Significance Index: 8.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2414
    Cell Significance Index: 10.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2338
    Cell Significance Index: 5.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2326
    Cell Significance Index: 16.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2148
    Cell Significance Index: 38.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1983
    Cell Significance Index: 10.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1948
    Cell Significance Index: 10.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1573
    Cell Significance Index: 19.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1562
    Cell Significance Index: 4.5000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1456
    Cell Significance Index: 1.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1381
    Cell Significance Index: 75.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1303
    Cell Significance Index: 117.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1257
    Cell Significance Index: 23.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0887
    Cell Significance Index: 1.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0675
    Cell Significance Index: 1.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0618
    Cell Significance Index: 8.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0603
    Cell Significance Index: 2.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0495
    Cell Significance Index: 0.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0486
    Cell Significance Index: 21.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0362
    Cell Significance Index: 68.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0323
    Cell Significance Index: 0.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0245
    Cell Significance Index: 4.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0191
    Cell Significance Index: 12.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0166
    Cell Significance Index: 25.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0117
    Cell Significance Index: 5.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0063
    Cell Significance Index: 11.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0090
    Cell Significance Index: -5.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0092
    Cell Significance Index: -12.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0112
    Cell Significance Index: -2.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0142
    Cell Significance Index: -8.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0178
    Cell Significance Index: -13.0700
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0218
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0314
    Cell Significance Index: -0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0328
    Cell Significance Index: -24.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0351
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0396
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0538
    Cell Significance Index: -11.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0588
    Cell Significance Index: -7.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0594
    Cell Significance Index: -1.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0694
    Cell Significance Index: -19.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0770
    Cell Significance Index: -11.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1050
    Cell Significance Index: -12.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1206
    Cell Significance Index: -14.2200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1239
    Cell Significance Index: -1.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1274
    Cell Significance Index: -9.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1423
    Cell Significance Index: -14.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1527
    Cell Significance Index: -8.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1629
    Cell Significance Index: -21.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1634
    Cell Significance Index: -4.8000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1651
    Cell Significance Index: -2.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1669
    Cell Significance Index: -3.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1683
    Cell Significance Index: -3.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1770
    Cell Significance Index: -2.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1889
    Cell Significance Index: -19.6700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2032
    Cell Significance Index: -2.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2099
    Cell Significance Index: -16.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2167
    Cell Significance Index: -4.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2253
    Cell Significance Index: -10.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2465
    Cell Significance Index: -3.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2634
    Cell Significance Index: -12.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2719
    Cell Significance Index: -16.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2725
    Cell Significance Index: -20.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2776
    Cell Significance Index: -6.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2815
    Cell Significance Index: -9.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2821
    Cell Significance Index: -22.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2941
    Cell Significance Index: -6.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2960
    Cell Significance Index: -9.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3049
    Cell Significance Index: -4.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3102
    Cell Significance Index: -9.8800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3173
    Cell Significance Index: -2.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3285
    Cell Significance Index: -17.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** DGKE is a diacylglycerol kinase that phosphorylates diacylglycerol to produce phosphatidic acid, thereby activating PKC. 2. **Cellular Localization:** DGKE is primarily localized in the cytosol and plasma membrane, where it regulates signaling pathways in response to various stimuli. 3. **Signaling Pathways:** DGKE modulates GPCR downstream signaling, glutamatergic synapse formation, and platelet activation, among other pathways. 4. **Regulation:** DGKE is regulated by ATP binding and metal ion binding, which modulate its enzymatic activity. **Pathways and Functions:** DGKE plays a critical role in various signaling pathways, including: 1. **GPCR Signaling:** DGKE modulates the activity of GPCRs, which are key receptors involved in the regulation of immune and neurological functions. 2. **Glutamatergic Synapse Formation:** DGKE regulates the formation of glutamatergic synapses, which are essential for neuronal communication and learning. 3. **Platelet Activation:** DGKE modulates platelet activation and aggregation, which are critical for hemostasis and thrombosis. 4. **Immune Response:** DGKE regulates the immune response by modulating the activity of immune cells, such as neutrophils and macrophages. **Clinical Significance:** 1. **Neurological Disorders:** DGKE dysregulation has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Immune System Dysregulation:** DGKE dysregulation has been linked to immune system disorders, including autoimmune diseases and inflammatory conditions. 3. **Cancer:** DGKE has been implicated in cancer development and progression, particularly in the regulation of cell proliferation and survival. 4. **Thrombotic Disorders:** DGKE dysregulation has been linked to thrombotic disorders, including deep vein thrombosis and pulmonary embolism. In conclusion, DGKE is a multifunctional enzyme that plays a critical role in regulating various signaling pathways in the immune system and the nervous system. Its dysregulation has been implicated in various diseases, including neurological disorders, immune system dysregulation, cancer, and thrombotic disorders. Further research is needed to fully understand the mechanisms of DGKE and its clinical significance.

Genular Protein ID: 2214369132

Symbol: DGKE_HUMAN

Name: Diacylglycerol kinase epsilon

UniProtKB Accession Codes:

P52429 Q8TBM4 Q9UKQ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 40 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 16 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626589

Title: Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates.

PubMed ID: 8626589

DOI: 10.1074/jbc.271.17.10230

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10571048

Title: Characterization of the human diacylglycerol kinase epsilon gene and its assessment as a candidate for inherited retinitis pigmentosa.

PubMed ID: 10571048

DOI: 10.1016/s0378-1119(99)00345-5

PubMed ID: 15544348

Title: The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol.

PubMed ID: 15544348

DOI: 10.1021/bi0484724

PubMed ID: 18004883

Title: Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase.

PubMed ID: 18004883

DOI: 10.1021/bi701584v

PubMed ID: 19744926

Title: Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol.

PubMed ID: 19744926

DOI: 10.1074/jbc.m109.050617

PubMed ID: 22108654

Title: Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle.

PubMed ID: 22108654

DOI: 10.1016/j.febslet.2011.11.016

PubMed ID: 21477596

Title: Study of arachidonoyl specificity in two enzymes of the PI cycle.

PubMed ID: 21477596

DOI: 10.1016/j.jmb.2011.03.071

PubMed ID: 23949095

Title: Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.

PubMed ID: 23949095

DOI: 10.1159/000351849

PubMed ID: 23274426

Title: DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN.

PubMed ID: 23274426

DOI: 10.1681/asn.2012090903

PubMed ID: 23542698

Title: Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome.

PubMed ID: 23542698

DOI: 10.1038/ng.2590

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 567
  • Mass: 63927
  • Checksum: BC334AD15FB4D0B4
  • Sequence:
    • MEAERRPAPG SPSEGLFADG HLILWTLCSV LLPVFITFWC SLQRSRRQLH RRDIFRKSKH 
GWRDTDLFSQ PTYCCVCAQH ILQGAFCDCC GLRVDEGCLR KADKRFQCKE IMLKNDTKVL 
DAMPHHWIRG NVPLCSYCMV CKQQCGCQPK LCDYRCIWCQ KTVHDECMKN SLKNEKCDFG 
EFKNLIIPPS YLTSINQMRK DKKTDYEVLA SKLGKQWTPL IILANSRSGT NMGEGLLGEF 
RILLNPVQVF DVTKTPPIKA LQLCTLLPYY SARVLVCGGD GTVGWVLDAV DDMKIKGQEK 
YIPQVAVLPL GTGNDLSNTL GWGTGYAGEI PVAQVLRNVM EADGIKLDRW KVQVTNKGYY 
NLRKPKEFTM NNYFSVGPDA LMALNFHAHR EKAPSLFSSR ILNKAVYLFY GTKDCLVQEC 
KDLNKKVELE LDGERVALPS LEGIIVLNIG YWGGGCRLWE GMGDETYPLA RHDDGLLEVV 
GVYGSFHCAQ IQVKLANPFR IGQAHTVRLI LKCSMMPMQV DGEPWAQGPC TVTITHKTHA 
MMLYFSGEQT DDDISSTSDQ EDIKATE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.