Details for: CBX4

Gene ID: 8535

Symbol: CBX4

Ensembl ID: ENSG00000141582

Description: chromobox 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 129.4800
    Cell Significance Index: -20.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 77.4710
    Cell Significance Index: -19.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.2168
    Cell Significance Index: -21.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.8146
    Cell Significance Index: -17.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.7586
    Cell Significance Index: -21.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.5176
    Cell Significance Index: -21.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.1989
    Cell Significance Index: -18.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.5618
    Cell Significance Index: -20.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9325
    Cell Significance Index: -21.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2280
    Cell Significance Index: -20.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1051
    Cell Significance Index: -15.6800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.4706
    Cell Significance Index: 16.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9522
    Cell Significance Index: 26.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4715
    Cell Significance Index: 94.9400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.2736
    Cell Significance Index: 8.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1124
    Cell Significance Index: 50.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0893
    Cell Significance Index: 31.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0589
    Cell Significance Index: 956.1400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.9177
    Cell Significance Index: 9.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8524
    Cell Significance Index: 22.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7745
    Cell Significance Index: 84.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7639
    Cell Significance Index: 45.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7229
    Cell Significance Index: 37.5500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.7097
    Cell Significance Index: 5.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6952
    Cell Significance Index: 113.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6744
    Cell Significance Index: 14.6100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5792
    Cell Significance Index: 4.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5303
    Cell Significance Index: 33.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4909
    Cell Significance Index: 97.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4129
    Cell Significance Index: 74.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3924
    Cell Significance Index: 20.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3709
    Cell Significance Index: 45.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3572
    Cell Significance Index: 157.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3421
    Cell Significance Index: 15.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3323
    Cell Significance Index: 23.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3277
    Cell Significance Index: 8.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3190
    Cell Significance Index: 174.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2666
    Cell Significance Index: 50.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2630
    Cell Significance Index: 33.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2441
    Cell Significance Index: 2.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2275
    Cell Significance Index: 8.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2257
    Cell Significance Index: 30.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2153
    Cell Significance Index: 14.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2115
    Cell Significance Index: 42.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1868
    Cell Significance Index: 8.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1225
    Cell Significance Index: 13.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1039
    Cell Significance Index: 17.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0738
    Cell Significance Index: 1.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0716
    Cell Significance Index: 8.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0606
    Cell Significance Index: 21.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0502
    Cell Significance Index: 1.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0469
    Cell Significance Index: 4.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0174
    Cell Significance Index: 2.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0053
    Cell Significance Index: 3.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0018
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0068
    Cell Significance Index: -9.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0106
    Cell Significance Index: -19.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0111
    Cell Significance Index: -17.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0130
    Cell Significance Index: -8.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0203
    Cell Significance Index: -11.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0213
    Cell Significance Index: -13.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0263
    Cell Significance Index: -11.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0475
    Cell Significance Index: -1.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0499
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0528
    Cell Significance Index: -11.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0537
    Cell Significance Index: -5.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0575
    Cell Significance Index: -16.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0639
    Cell Significance Index: -8.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0699
    Cell Significance Index: -3.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0840
    Cell Significance Index: -0.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0925
    Cell Significance Index: -5.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0980
    Cell Significance Index: -14.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1042
    Cell Significance Index: -12.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1115
    Cell Significance Index: -8.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1159
    Cell Significance Index: -3.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1240
    Cell Significance Index: -3.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1463
    Cell Significance Index: -9.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1472
    Cell Significance Index: -3.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1493
    Cell Significance Index: -1.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1653
    Cell Significance Index: -4.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1860
    Cell Significance Index: -19.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1973
    Cell Significance Index: -4.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1974
    Cell Significance Index: -5.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2217
    Cell Significance Index: -17.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2562
    Cell Significance Index: -2.9100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2928
    Cell Significance Index: -4.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2949
    Cell Significance Index: -5.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3023
    Cell Significance Index: -13.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3041
    Cell Significance Index: -5.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3045
    Cell Significance Index: -8.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3198
    Cell Significance Index: -16.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3411
    Cell Significance Index: -5.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3464
    Cell Significance Index: -21.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3476
    Cell Significance Index: -8.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3562
    Cell Significance Index: -5.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3581
    Cell Significance Index: -13.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CBX4 is a histone-modifying enzyme that catalyzes the transfer of small ubiquitin-like modifier (SUMO) proteins to target proteins, thereby regulating their activity. The gene is primarily expressed in cells of hematopoietic origin, including cortical thymic epithelial cells, immature innate lymphoid cells, and early pro-B cells. CBX4 is also found in other cell types, such as glandular epithelial cells, cardiac muscle myoblasts, and cerebral cortex GABAergic interneurons. **Pathways and Functions:** CBX4 is involved in various cellular processes, including: 1. **Chromatin organization and regulation**: CBX4 modulates chromatin structure and function by interacting with histones and other chromatin-associated proteins. 2. **Transcriptional regulation**: CBX4 regulates gene expression by targeting transcription factors and co-factors for SUMOylation, thereby modulating their activity. 3. **Apoptosis and cell cycle regulation**: CBX4 negatively regulates apoptosis by inhibiting the activity of pro-apoptotic proteins. 4. **Stress response and cellular senescence**: CBX4 is involved in the regulation of cellular responses to stress and oxidative damage, promoting cellular senescence in damaged cells. 5. **DNA damage response and repair**: CBX4 interacts with proteins involved in DNA damage response and repair, modulating the activity of these proteins. **Clinical Significance:** Dysregulation of CBX4 has been implicated in various diseases, including: 1. **Cancer**: CBX4 is a tumor suppressor gene, and its dysregulation has been linked to tumorigenesis and cancer progression. 2. **Neurological disorders**: CBX4 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it regulates gene expression and cellular responses to stress. 3. **Autoimmune diseases**: CBX4 has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it regulates immune cell function and tolerance. 4. **Cardiovascular disease**: CBX4 has been implicated in cardiovascular disease, where it regulates cardiac cell function and response to stress. In conclusion, the CBX4 gene plays a critical role in regulating epigenetic and transcriptional processes, maintaining genome stability, and modulating cellular responses to stress and stimuli. Its dysregulation has been implicated in various diseases, highlighting the importance of CBX4 in human health and disease. Further research is needed to fully elucidate the mechanisms by which CBX4 regulates cellular processes and to explore its therapeutic potential in disease contexts.

Genular Protein ID: 1093004491

Symbol: CBX4_HUMAN

Name: E3 SUMO-protein ligase CBX4

UniProtKB Accession Codes:

O00257 B1PJR7 Q6TPI8 Q96C04

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 12 DIP 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9315667

Title: Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis.

PubMed ID: 9315667

DOI: 10.1128/mcb.17.10.6076

PubMed ID: 19266028

Title: Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.

PubMed ID: 19266028

DOI: 10.1371/journal.pgen.1000397

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9199346

Title: RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.

PubMed ID: 9199346

DOI: 10.1128/mcb.17.7.4105

PubMed ID: 12101246

Title: Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins.

PubMed ID: 12101246

DOI: 10.1128/mcb.22.15.5539-5553.2002

PubMed ID: 12167701

Title: The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

PubMed ID: 12167701

DOI: 10.1128/mcb.22.17.6070-6078.2002

PubMed ID: 12679040

Title: The polycomb protein Pc2 is a SUMO E3.

PubMed ID: 12679040

DOI: 10.1016/s0092-8674(03)00159-4

PubMed ID: 15592428

Title: Multiple activities contribute to Pc2 E3 function.

PubMed ID: 15592428

DOI: 10.1038/sj.emboj.7600506

PubMed ID: 16061479

Title: Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.

PubMed ID: 16061479

DOI: 10.1074/jbc.m504477200

PubMed ID: 17018294

Title: Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.

PubMed ID: 17018294

DOI: 10.1016/j.molcel.2006.08.004

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18927235

Title: Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences.

PubMed ID: 18927235

DOI: 10.1073/pnas.0805317105

PubMed ID: 19636380

Title: Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.

PubMed ID: 19636380

DOI: 10.1371/journal.pone.0006380

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21282530

Title: Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.

PubMed ID: 21282530

DOI: 10.1074/mcp.m110.002642

PubMed ID: 22467880

Title: Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling.

PubMed ID: 22467880

DOI: 10.1074/jbc.m111.336354

PubMed ID: 22825850

Title: DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation.

PubMed ID: 22825850

DOI: 10.1074/jbc.m112.390120

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27211601

Title: SUMO5, a novel poly-sumo isoform, regulates pml nuclear bodies.

PubMed ID: 27211601

DOI: 10.1038/srep26509

PubMed ID: 28839133

Title: USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components.

PubMed ID: 28839133

DOI: 10.1038/s41467-017-00301-4

PubMed ID: 28842558

Title: HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.

PubMed ID: 28842558

DOI: 10.1038/s41467-017-00476-w

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 560
  • Mass: 61368
  • Checksum: DF5C8C4C0CCB1F31
  • Sequence:
    • MELPAVGEHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNR 
ERQEQLMGYR KRGPKPKPLV VQVPTFARRS NVLTGLQDSS TDNRAKLDLG AQGKGQGHQY 
ELNSKKHHQY QPHSKERAGK PPPPGKSGKY YYQLNSKKHH PYQPDPKMYD LQYQGGHKEA 
PSPTCPDLGA KSHPPDKWAQ GAGAKGYLGA VKPLAGAAGA PGKGSEKGPP NGMMPAPKEA 
VTGNGIGGKM KIVKNKNKNG RIVIVMSKYM ENGMQAVKIK SGEVAEGEAR SPSHKKRAAD 
ERHPPADRTF KKAAGAEEKK VEAPPKRREE EVSGVSDPQP QDAGSRKLSP TKEAFGEQPL 
QLTTKPDLLA WDPARNTHPP SHHPHPHPHH HHHHHHHHHH AVGLNLSHVR KRCLSETHGE 
REPCKKRLTA RSISTPTCLG GSPAAERPAD LPPAAALPQP EVILLDSDLD EPIDLRCVKT 
RSEAGEPPSS LQVKPETPAS AAVAVAAAAA PTTTAEKPPA EAQDEPAESL SEFKPFFGNI 
IITDVTANCL TVTFKEYVTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.