Details for: PPFIA3

Gene ID: 8541

Symbol: PPFIA3

Ensembl ID: ENSG00000177380

Description: PTPRF interacting protein alpha 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 118.4864
    Cell Significance Index: -18.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.9120
    Cell Significance Index: -18.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 27.9126
    Cell Significance Index: -18.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.8472
    Cell Significance Index: -15.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.0289
    Cell Significance Index: -18.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0963
    Cell Significance Index: -19.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7199
    Cell Significance Index: -18.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.3830
    Cell Significance Index: 235.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2343
    Cell Significance Index: -4.8900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3052
    Cell Significance Index: 10.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2359
    Cell Significance Index: 1115.9400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.1577
    Cell Significance Index: 2.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1457
    Cell Significance Index: 229.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.0965
    Cell Significance Index: 13.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9426
    Cell Significance Index: 42.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9145
    Cell Significance Index: 20.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8935
    Cell Significance Index: 12.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8913
    Cell Significance Index: 144.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7765
    Cell Significance Index: 278.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7005
    Cell Significance Index: 36.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6249
    Cell Significance Index: 18.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5848
    Cell Significance Index: 35.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5729
    Cell Significance Index: 36.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5526
    Cell Significance Index: 15.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4423
    Cell Significance Index: 7.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4366
    Cell Significance Index: 30.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3613
    Cell Significance Index: 249.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3391
    Cell Significance Index: 64.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3379
    Cell Significance Index: 7.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2778
    Cell Significance Index: 18.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2631
    Cell Significance Index: 30.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2623
    Cell Significance Index: 8.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2297
    Cell Significance Index: 6.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1711
    Cell Significance Index: 75.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1271
    Cell Significance Index: 4.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1188
    Cell Significance Index: 5.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0770
    Cell Significance Index: 1.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0526
    Cell Significance Index: 3.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0458
    Cell Significance Index: 0.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0419
    Cell Significance Index: 0.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0277
    Cell Significance Index: 1.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0265
    Cell Significance Index: 5.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0097
    Cell Significance Index: 1.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0019
    Cell Significance Index: 1.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0019
    Cell Significance Index: 3.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0012
    Cell Significance Index: -0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0059
    Cell Significance Index: -0.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0064
    Cell Significance Index: -8.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0083
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0125
    Cell Significance Index: -9.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0133
    Cell Significance Index: -9.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0224
    Cell Significance Index: -14.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0225
    Cell Significance Index: -10.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0229
    Cell Significance Index: -17.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0235
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0259
    Cell Significance Index: -3.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0261
    Cell Significance Index: -4.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0278
    Cell Significance Index: -15.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0318
    Cell Significance Index: -4.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0333
    Cell Significance Index: -20.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0347
    Cell Significance Index: -0.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0372
    Cell Significance Index: -2.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0513
    Cell Significance Index: -14.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0530
    Cell Significance Index: -2.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0768
    Cell Significance Index: -11.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0773
    Cell Significance Index: -7.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0880
    Cell Significance Index: -18.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0957
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0998
    Cell Significance Index: -11.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1098
    Cell Significance Index: -5.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1402
    Cell Significance Index: -6.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1409
    Cell Significance Index: -2.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1430
    Cell Significance Index: -3.4300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1432
    Cell Significance Index: -1.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1515
    Cell Significance Index: -2.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1562
    Cell Significance Index: -2.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1571
    Cell Significance Index: -12.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1620
    Cell Significance Index: -19.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1724
    Cell Significance Index: -17.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1727
    Cell Significance Index: -12.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1773
    Cell Significance Index: -6.1600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1826
    Cell Significance Index: -1.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1896
    Cell Significance Index: -2.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1989
    Cell Significance Index: -15.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2167
    Cell Significance Index: -4.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2272
    Cell Significance Index: -7.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2295
    Cell Significance Index: -2.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2305
    Cell Significance Index: -7.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2352
    Cell Significance Index: -14.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2458
    Cell Significance Index: -15.8600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2518
    Cell Significance Index: -2.8500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2569
    Cell Significance Index: -5.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2570
    Cell Significance Index: -7.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2800
    Cell Significance Index: -6.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2929
    Cell Significance Index: -10.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3004
    Cell Significance Index: -8.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3020
    Cell Significance Index: -7.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3079
    Cell Significance Index: -4.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPFIA3 is a protein that interacts with PTPRF (Receptor-type Tyrosine-Protein Phosphatase F), a receptor-type tyrosine phosphatase involved in the regulation of synaptic plasticity. The protein is primarily expressed in neural progenitor cells, GABAergic neurons, dopaminergic neurons, and kidney capillary endothelial cells. Its expression is also observed in immature innate lymphoid cells and specific types of glutamatergic neurons. **Pathways and Functions:** PPFIA3 plays a crucial role in various neurotransmitter release pathways, including: 1. **Acetylcholine neurotransmitter release cycle**: PPFIA3 interacts with PTPRF to regulate the release of acetylcholine, a neurotransmitter involved in muscle contraction and cognitive functions. 2. **Acrosomal vesicle**: PPFIA3 is involved in the regulation of acrosomal vesicle docking, a process essential for sperm capacitation and fertilization. 3. **Dopamine neurotransmitter release cycle**: PPFIA3 interacts with PTPRF to regulate the release of dopamine, a neurotransmitter involved in motor control, motivation, and reward processing. 4. **Glutamate neurotransmitter release cycle**: PPFIA3 is involved in the regulation of glutamate release, a neurotransmitter involved in excitatory synaptic transmission. 5. **Neurotransmitter release cycle**: PPFIA3 plays a general role in regulating neurotransmitter release, including serotonin, norepinephrine, and acetylcholine. **Functions:** The primary function of PPFIA3 is to regulate protein-protein interactions at synapses, which is essential for synaptic plasticity and neurotransmitter release. PPFIA3 also regulates short-term neuronal synaptic plasticity, a process involved in learning and memory. **Clinical Significance:** Dysregulation of PPFIA3 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: PPFIA3 is involved in the regulation of neural development and synaptic plasticity, making it a potential target for the treatment of neurodevelopmental disorders such as autism and schizophrenia. 2. **Neurodegenerative disorders**: PPFIA3 has been implicated in the regulation of neurotransmitter release and synaptic plasticity in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 3. **Mental health disorders**: PPFIA3 is involved in the regulation of neurotransmitter release and synaptic plasticity, making it a potential target for the treatment of mental health disorders such as depression and anxiety. In conclusion, PPFIA3 is a key player in neurotransmitter release and synaptic function, with implications for various neurological disorders. Further research is needed to fully elucidate the role of PPFIA3 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1327045312

Symbol: LIPA3_HUMAN

Name: Liprin-alpha-3

UniProtKB Accession Codes:

O75145 A8K142 Q3MJA0 Q9H8B5 Q9UEW4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9624153

Title: Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.

PubMed ID: 9624153

DOI: 10.1074/jbc.273.25.15611

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23124857

Title: Liprin alpha3: a putative estrogen regulated acrosomal protein.

PubMed ID: 23124857

DOI: 10.1007/s00418-012-1044-y

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1194
  • Mass: 133496
  • Checksum: 4DD92531AD8AE12D
  • Sequence:
    • MMCEVMPTIS EDGRRGSALG PDEAGGELER LMVTMLTERE RLLETLREAQ DGLATAQLRL 
RELGHEKDSL QRQLSIALPQ EFAALTKELN LCREQLLERE EEIAELKAER NNTRLLLEHL 
ECLVSRHERS LRMTVVKRQA QSPGGVSSEV EVLKALKSLF EHHKALDEKV RERLRMALER 
VAVLEEELEL SNQETLNLRE QLSRRRSGLE EPGKDGDGQT LANGLGPGGD SNRRTAELEE 
ALERQRAEVC QLRERLAVLC RQMSQLEEEL GTAHRELGKA EEANSKLQRD LKEALAQRED 
MEERITTLEK RYLSAQREAT SLHDANDKLE NELASKESLY RQSEEKSRQL AEWLDDAKQK 
LQQTLQKAET LPEIEAQLAQ RVAALNKAEE RHGNFEERLR QLEAQLEEKN QELQRARQRE 
KMNDDHNKRL SETVDKLLSE SNERLQLHLK ERMGALEEKN SLSEEIANMK KLQDELLLNK 
EQLLAEMERM QMEIDQLRGR PPSSYSRSLP GSALELRYSQ APTLPSGAHL DPYVAGSGRA 
GKRGRWSGVK EEPSKDWERS APAGSIPPPF PGELDGSDEE EAEGMFGAEL LSPSGQADVQ 
TLAIMLQEQL EAINKEIKLI QEEKETTEQR AEELESRVSS SGLDSLGRYR SSCSLPPSLT 
TSTLASPSPP SSGHSTPRLA PPSPAREGTD KANHVPKEEA GAPRGEGPAI PGDTPPPTPR 
SARLERMTQA LALQAGSLED GGPPRGSEGT PDSLHKAPKK KSIKSSIGRL FGKKEKGRMG 
PPGRDSSSLA GTPSDETLAT DPLGLAKLTG PGDKDRRNKR KHELLEEACR QGLPFAAWDG 
PTVVSWLELW VGMPAWYVAA CRANVKSGAI MANLSDTEIQ REIGISNPLH RLKLRLAIQE 
MVSLTSPSAP ASSRTSTGNV WMTHEEMESL TATTKPETKE ISWEQILAYG DMNHEWVGND 
WLPSLGLPQY RSYFMESLVD ARMLDHLNKK ELRGQLKMVD SFHRVSLHYG IMCLKRLNYD 
RKDLERRREE SQTQIRDVMV WSNERVMGWV SGLGLKEFAT NLTESGVHGA LLALDETFDY 
SDLALLLQIP TQNAQARQLL EKEFSNLISL GTDRRLDEDS AKSFSRSPSW RKMFREKDLR 
GVTPDSAEML PPNFRSAAAG ALGSPGLPLR KLQPEGQTSG SSRADGVSVR TYSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.