Details for: CGGBP1

Gene ID: 8545

Symbol: CGGBP1

Ensembl ID: ENSG00000163320

Description: CGG triplet repeat binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 362.9812
    Cell Significance Index: -56.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 226.9722
    Cell Significance Index: -57.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 139.5566
    Cell Significance Index: -57.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 132.1796
    Cell Significance Index: -62.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 127.8255
    Cell Significance Index: -51.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 115.4096
    Cell Significance Index: -59.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.0305
    Cell Significance Index: -52.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.5452
    Cell Significance Index: -62.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.1466
    Cell Significance Index: -53.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.2086
    Cell Significance Index: -63.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.2518
    Cell Significance Index: -33.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.6510
    Cell Significance Index: -45.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.6684
    Cell Significance Index: 18.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1436
    Cell Significance Index: 120.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7193
    Cell Significance Index: 341.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6339
    Cell Significance Index: 100.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6044
    Cell Significance Index: 83.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3745
    Cell Significance Index: 149.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3301
    Cell Significance Index: 266.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1358
    Cell Significance Index: 68.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9852
    Cell Significance Index: 121.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9293
    Cell Significance Index: 25.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9242
    Cell Significance Index: 166.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8503
    Cell Significance Index: 22.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7795
    Cell Significance Index: 107.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7280
    Cell Significance Index: 46.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7162
    Cell Significance Index: 91.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7037
    Cell Significance Index: 54.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6734
    Cell Significance Index: 16.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6435
    Cell Significance Index: 12.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6422
    Cell Significance Index: 29.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6403
    Cell Significance Index: 44.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6232
    Cell Significance Index: 17.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6207
    Cell Significance Index: 73.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6164
    Cell Significance Index: 8.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5975
    Cell Significance Index: 27.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5772
    Cell Significance Index: 207.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5638
    Cell Significance Index: 307.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5637
    Cell Significance Index: 19.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5401
    Cell Significance Index: 13.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4521
    Cell Significance Index: 12.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3904
    Cell Significance Index: 172.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3711
    Cell Significance Index: 10.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3624
    Cell Significance Index: 68.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3013
    Cell Significance Index: 14.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2483
    Cell Significance Index: 382.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2405
    Cell Significance Index: 327.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2223
    Cell Significance Index: 2.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2049
    Cell Significance Index: 5.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1711
    Cell Significance Index: 322.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1685
    Cell Significance Index: 2.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1545
    Cell Significance Index: 139.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1489
    Cell Significance Index: 274.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1486
    Cell Significance Index: 3.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1301
    Cell Significance Index: 2.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1171
    Cell Significance Index: 8.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0921
    Cell Significance Index: 58.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0914
    Cell Significance Index: 15.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0845
    Cell Significance Index: 13.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0275
    Cell Significance Index: 0.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0158
    Cell Significance Index: 7.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0071
    Cell Significance Index: 0.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0033
    Cell Significance Index: -0.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0159
    Cell Significance Index: -11.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0165
    Cell Significance Index: -10.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0180
    Cell Significance Index: -13.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0295
    Cell Significance Index: -21.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0371
    Cell Significance Index: -28.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0568
    Cell Significance Index: -0.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0624
    Cell Significance Index: -8.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0690
    Cell Significance Index: -38.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1189
    Cell Significance Index: -12.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1239
    Cell Significance Index: -8.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1345
    Cell Significance Index: -9.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1568
    Cell Significance Index: -33.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1654
    Cell Significance Index: -47.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1848
    Cell Significance Index: -26.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2028
    Cell Significance Index: -10.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2098
    Cell Significance Index: -6.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2457
    Cell Significance Index: -5.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2792
    Cell Significance Index: -4.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2882
    Cell Significance Index: -28.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3225
    Cell Significance Index: -36.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3538
    Cell Significance Index: -41.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4080
    Cell Significance Index: -2.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4207
    Cell Significance Index: -18.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4257
    Cell Significance Index: -8.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4639
    Cell Significance Index: -52.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4747
    Cell Significance Index: -49.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4816
    Cell Significance Index: -7.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4975
    Cell Significance Index: -9.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5669
    Cell Significance Index: -21.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5707
    Cell Significance Index: -18.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5773
    Cell Significance Index: -45.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7082
    Cell Significance Index: -20.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7181
    Cell Significance Index: -18.3500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8394
    Cell Significance Index: -6.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8650
    Cell Significance Index: -53.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9864
    Cell Significance Index: -26.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0235
    Cell Significance Index: -26.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **CGG Triplet Repeat Motif:** The CGGBP1 gene contains a CGG triplet repeat motif, which is a common feature of genes involved in transcriptional regulation and DNA binding. 2. **DNA Binding:** The CGGBP1 protein has been shown to bind to DNA, suggesting its involvement in transcriptional regulation. 3. **Transcriptional Regulation:** The CGGBP1 gene is involved in the regulation of gene expression, particularly in the context of transcriptional repression. 4. **Cellular Differentiation:** The CGGBP1 gene is highly expressed in various cell types, including skeletal muscle fibroblasts, cardiac neurons, and fat cells, suggesting its involvement in cellular differentiation. **Pathways and Functions:** 1. **Epigenetic Regulation of Gene Expression:** The CGGBP1 gene is involved in the regulation of gene expression through epigenetic mechanisms, such as DNA methylation and histone modification. 2. **Negative Regulation of Transcription by RNA Polymerase II:** The CGGBP1 gene has been shown to inhibit the activity of RNA polymerase II, a key enzyme involved in transcriptional elongation. 3. **Protein Binding:** The CGGBP1 protein has been shown to bind to various proteins, including transcription factors and chromatin-modifying enzymes, suggesting its involvement in protein-protein interactions. 4. **Nucleoplasm and Nucleus:** The CGGBP1 gene is localized to the nucleus and nucleoplasm, suggesting its involvement in nuclear processes. **Clinical Significance:** 1. **Neuropathic Disorders:** The CGGBP1 gene has been implicated in the pathogenesis of various neuropathic disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Cancer:** The CGGBP1 gene has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis. 3. **Metabolic Disorders:** The CGGBP1 gene has been implicated in the regulation of glucose metabolism and lipid metabolism, suggesting its potential role in the development of metabolic disorders. 4. **Neurodevelopmental Disorders:** The CGGBP1 gene has been implicated in the development of neurodevelopmental disorders, including autism spectrum disorder (ASD) and schizophrenia. In conclusion, the CGGBP1 gene is a fascinating example of a gene involved in transcriptional regulation and cellular differentiation. Its clinical significance extends to various neuropathic disorders, cancer, metabolic disorders, and neurodevelopmental disorders, highlighting the importance of further research into the mechanisms of this gene.

Genular Protein ID: 1555592923

Symbol: CGBP1_HUMAN

Name: CGG triplet repeat-binding protein 1

UniProtKB Accession Codes:

Q9UFW8 D3DU38 O15183

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9201980

Title: Rapid protein sequencing by tandem mass spectrometry and cDNA cloning of p20-CGGBP. A novel protein that binds to the unstable triplet repeat 5'-d(CGG)n-3' in the human FMR1 gene.

PubMed ID: 9201980

DOI: 10.1074/jbc.272.27.16761

PubMed ID: 14667814

Title: Gene structure and expression of the 5'-(CGG)(n)-3'-binding protein (CGGBP1).

PubMed ID: 14667814

DOI: 10.1016/s0888-7543(03)00212-x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 167
  • Mass: 18820
  • Checksum: 1AF69CDB885BB8AD
  • Sequence:
    • MERFVVTAPP ARNRSKTALY VTPLDRVTEF GGELHEDGGK LFCTSCNVVL NHVRKSAISD 
HLKSKTHTKR KAEFEEQNVR KKQRPLTASL QCNSTAQTEK VSVIQDFVKM CLEANIPLEK 
ADHPAVRAFL SRHVKNGGSI PKSDQLRRAY LPDGYENENQ LLNSQDC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.