Gene PIAS1 - ENSG00000033800 | NCBI Gene ID: 8554

Details for: PIAS1

Gene ID: 8554

Symbol: PIAS1

Ensembl ID: ENSG00000033800

Description: protein inhibitor of activated STAT 1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Dna repair
(R-HSA-73894)
Formation of incision complex in gg-ner
(R-HSA-5696395)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Metabolism of proteins
(R-HSA-392499)
Nucleotide excision repair
(R-HSA-5696398)
Post-translational protein modification
(R-HSA-597592)
Regulation of ifng signaling
(R-HSA-877312)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Sumoylation of intracellular receptors
(R-HSA-4090294)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Sumoylation of transcription factors
(R-HSA-3232118)
Sumoylation of ubiquitinylation proteins
(R-HSA-3232142)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Dna-binding transcription factor binding
(GO:0140297)
Enzyme binding
(GO:0019899)
Fat cell differentiation
(GO:0045444)
G1/s transition of mitotic cell cycle
(GO:0000082)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear periphery
(GO:0034399)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pml body
(GO:0016605)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein localization to cell periphery
(GO:1904377)
Positive regulation of protein sumoylation
(GO:0033235)
Positive regulation of smooth muscle cell differentiation
(GO:0051152)
Protein-dna complex assembly
(GO:0065004)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein sumoylation
(GO:0016925)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of cell population proliferation
(GO:0042127)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Spermatogenesis
(GO:0007283)
Sumo ligase activity
(GO:0061665)
Sumo transferase activity
(GO:0019789)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Ubiquitin protein ligase binding
(GO:0031625)
Visual learning
(GO:0008542)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: anterior lens cell (CL0002223)
Fold Change: 3.9
Marker Score: 5239.5
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.57
Marker Score: 4318
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 3.19
Marker Score: 2098
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.17
Marker Score: 6965
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.01
Marker Score: 3469.5
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.99
Marker Score: 12521
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.89
Marker Score: 1435
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.76
Marker Score: 1444
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.73
Marker Score: 2419
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.68
Marker Score: 782.5
Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.67
Marker Score: 966
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.67
Marker Score: 11118
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.63
Marker Score: 58817
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.61
Marker Score: 1810
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.58
Marker Score: 2918
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.53
Marker Score: 800
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.51
Marker Score: 53638
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.45
Marker Score: 6144
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 2.36
Marker Score: 600
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.31
Marker Score: 4439
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.3
Marker Score: 1338
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.29
Marker Score: 86979.5
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.26
Marker Score: 2434.5
Cell Name: contractile cell (CL0000183)
Fold Change: 2.23
Marker Score: 1210
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.23
Marker Score: 10316
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.22
Marker Score: 39396
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.21
Marker Score: 44022.5
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.21
Marker Score: 1318
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.19
Marker Score: 1084
Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.18
Marker Score: 566
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.16
Marker Score: 1264
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.12
Marker Score: 16266
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.12
Marker Score: 31675
Cell Name: lactocyte (CL0002325)
Fold Change: 2.11
Marker Score: 33835
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.06
Marker Score: 76086
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.04
Marker Score: 2250
Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.02
Marker Score: 2517
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.01
Marker Score: 1058
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.01
Marker Score: 7755
Cell Name: lung goblet cell (CL1000143)
Fold Change: 2
Marker Score: 575
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.97
Marker Score: 10347
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.96
Marker Score: 1472
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.95
Marker Score: 1093
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.95
Marker Score: 119722
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.93
Marker Score: 8013
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.9
Marker Score: 709
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.89
Marker Score: 17754.5
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.89
Marker Score: 5381
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.87
Marker Score: 10071
Cell Name: granule cell (CL0000120)
Fold Change: 1.86
Marker Score: 14037.5
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.85
Marker Score: 4418
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.84
Marker Score: 1416
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.83
Marker Score: 2209
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.82
Marker Score: 1740
Cell Name: neuron (CL0000540)
Fold Change: 1.82
Marker Score: 7409
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.82
Marker Score: 18758
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.81
Marker Score: 17171
Cell Name: podocyte (CL0000653)
Fold Change: 1.8
Marker Score: 666
Cell Name: macroglial cell (CL0000126)
Fold Change: 1.79
Marker Score: 4125.5
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.77
Marker Score: 860
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.76
Marker Score: 739
Cell Name: fat cell (CL0000136)
Fold Change: 1.76
Marker Score: 983
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.75
Marker Score: 15070.5
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.74
Marker Score: 5850
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.74
Marker Score: 966
Cell Name: astrocyte (CL0000127)
Fold Change: 1.73
Marker Score: 1501
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.73
Marker Score: 2512
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.72
Marker Score: 586
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.68
Marker Score: 56593
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.67
Marker Score: 608
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.67
Marker Score: 1373
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.66
Marker Score: 5899
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.63
Marker Score: 2304
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.62
Marker Score: 1400
Cell Name: melanocyte (CL0000148)
Fold Change: 1.61
Marker Score: 652
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.59
Marker Score: 2672
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.59
Marker Score: 1701
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.57
Marker Score: 1036
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.57
Marker Score: 1667
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.53
Marker Score: 2366
Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.53
Marker Score: 736
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.52
Marker Score: 1392
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.51
Marker Score: 1808.5
Cell Name: keratocyte (CL0002363)
Fold Change: 1.49
Marker Score: 342
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.47
Marker Score: 352
Cell Name: blood cell (CL0000081)
Fold Change: 1.46
Marker Score: 16994
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.46
Marker Score: 335
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.46
Marker Score: 360
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.45
Marker Score: 1796
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.44
Marker Score: 458
Cell Name: pro-B cell (CL0000826)
Fold Change: 1.43
Marker Score: 1380
Cell Name: microglial cell (CL0000129)
Fold Change: 1.43
Marker Score: 2601
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.42
Marker Score: 1498
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.42
Marker Score: 1781.5
Cell Name: basal cell (CL0000646)
Fold Change: 1.4
Marker Score: 1810
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.4
Marker Score: 3804
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.39
Marker Score: 810
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.39
Marker Score: 8963
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.38
Marker Score: 762
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 1.38
Marker Score: 407

Hover over a box to see details here...

**Key Characteristics:** 1. **E3 SUMO-protein ligase activity**: PIAS1 possesses E3 SUMO-protein ligase activity, which enables it to catalyze the transfer of sumoylation units to target proteins. 2. **Specificity for STAT1**: PIAS1 is specifically involved in the regulation of STAT1, which is a critical transcription factor in the interferon signaling pathway. 3. **Inhibition of STAT1 activation**: PIAS1 inhibits the activation of STAT1, which modulates the immune response and prevents excessive inflammation. 4. **Regulation of various cellular processes**: PIAS1 is involved in the regulation of cell proliferation, differentiation, and survival, as well as the formation of incision complexes in GG-NER (Global Genome Nucleotide Excision Repair) and G1/S transition of the mitotic cell cycle. **Pathways and Functions:** 1. **Cytokine signaling in the immune system**: PIAS1 regulates the interferon signaling pathway by inhibiting the activation of STAT1, which is a key transcription factor in this pathway. 2. **DNA repair**: PIAS1 is involved in the regulation of GG-NER and G1/S transition of the mitotic cell cycle, which are critical processes in DNA repair and cell cycle regulation. 3. **Cell proliferation and differentiation**: PIAS1 regulates cell proliferation and differentiation by modulating the activity of transcription factors and signaling pathways. 4. **Apoptosis and transcriptional regulation**: PIAS1 regulates apoptosis and transcriptional regulation by modulating the activity of transcription factors and signaling pathways. **Clinical Significance:** 1. **Immunological disorders**: PIAS1 dysregulation has been implicated in various immunological disorders, including autoimmune diseases and cancer. 2. **Cancer**: PIAS1 has been shown to be overexpressed in certain types of cancer, including lung and colon cancer, and is associated with poor prognosis. 3. **Neurological disorders**: PIAS1 has been implicated in the regulation of neuroinflammation and is associated with various neurological disorders, including multiple sclerosis and Alzheimer's disease. 4. **Gene therapy**: PIAS1 has been identified as a potential target for gene therapy in the treatment of immunological disorders and cancer. In conclusion, PIAS1 is a critical regulator of the immune response and various cellular processes, and its dysregulation has been implicated in various immunological disorders and cancers. Further research is needed to fully understand the role of PIAS1 in regulating immune response and cellular processes, and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

E3 SUMO-protein ligase PIAS1

Genular Protein ID: 1855041927

Symbol: PIAS1_HUMAN

Name: E3 SUMO-protein ligase PIAS1

UniProtKB Accession Codes:

O75925 B2RB67 B3KSY9 C5J4B4 Q147X4 Q99751 Q9UN02

Database IDs:

Citations:

PubMed ID: 9724754

Title: Inhibition of Stat1-mediated gene activation by PIAS1.

PubMed ID: 9724754

DOI: 10.1073/pnas.95.18.10626

PubMed ID: 10628744

Title: Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis.

PubMed ID: 10628744

DOI: 10.1210/mend.14.1.0408

PubMed ID: 19906316

Title: Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.

PubMed ID: 19906316

DOI: 10.1186/1471-2164-10-518

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9177271

Title: Cloning and characterization of Gu/RH-II binding protein.

PubMed ID: 9177271

DOI: 10.1006/bbrc.1997.6642

PubMed ID: 11672422

Title: LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1.

PubMed ID: 11672422

DOI: 10.1042/0264-6021:3590485

PubMed ID: 11583632

Title: Involvement of PIAS1 in the sumoylation of tumor suppressor p53.

PubMed ID: 11583632

DOI: 10.1016/s1097-2765(01)00349-5

PubMed ID: 11439351

Title: Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.

PubMed ID: 11439351

DOI: 10.1038/sj.onc.1204489

PubMed ID: 12223491

Title: SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.

PubMed ID: 12223491

DOI: 10.1074/jbc.m208099200

PubMed ID: 12393906

Title: Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes.

PubMed ID: 12393906

DOI: 10.1074/jbc.m208319200

PubMed ID: 12356736

Title: Transcription factor Sp3 is silenced through SUMO modification by PIAS1.

PubMed ID: 12356736

DOI: 10.1093/emboj/cdf510

PubMed ID: 11867732

Title: Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity.

PubMed ID: 11867732

DOI: 10.1073/pnas.052559499

PubMed ID: 14701874

Title: SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.

PubMed ID: 14701874

DOI: 10.1101/gad.1153003

PubMed ID: 14500712

Title: PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation.

PubMed ID: 14500712

DOI: 10.1074/jbc.m308562200

PubMed ID: 15208321

Title: Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation.

PubMed ID: 15208321

DOI: 10.1074/jbc.m401753200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16600910

Title: PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.

PubMed ID: 16600910

DOI: 10.1101/gad.1392006

PubMed ID: 16617055

Title: Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation.

PubMed ID: 16617055

DOI: 10.1074/jbc.m513135200

PubMed ID: 17540171

Title: Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.

PubMed ID: 17540171

DOI: 10.1016/j.cell.2007.03.056

PubMed ID: 17369852

Title: SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.

PubMed ID: 17369852

DOI: 10.1038/sj.onc.1210387

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19136629

Title: PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.

PubMed ID: 19136629

DOI: 10.1101/gad.489409

PubMed ID: 21724836

Title: Retraction. PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.

PubMed ID: 21724836

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19557165

Title: Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery.

PubMed ID: 19557165

DOI: 10.1371/journal.ppat.1000493

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21965678

Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.

PubMed ID: 21965678

DOI: 10.1074/jbc.m111.267237

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27211601

Title: SUMO5, a novel poly-sumo isoform, regulates pml nuclear bodies.

PubMed ID: 27211601

DOI: 10.1038/srep26509

PubMed ID: 28842558

Title: HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.

PubMed ID: 28842558

DOI: 10.1038/s41467-017-00476-w

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29262325

Title: B Cell Receptor Activation and Chemical Induction Trigger Caspase-Mediated Cleavage of PIAS1 to Facilitate Epstein-Barr Virus Reactivation.

PubMed ID: 29262325

DOI: 10.1016/j.celrep.2017.11.071

PubMed ID: 15133049

Title: NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers.

PubMed ID: 15133049

DOI: 10.1074/jbc.m403561200

Sequence Information:

Length: 651
Mass: 71836
Checksum: AA69338221124119
Sequence:

MADSAELKQM VMSLRVSELQ VLLGYAGRNK HGRKHELLTK ALHLLKAGCS PAVQMKIKEL 
YRRRFPQKIM TPADLSIPNV HSSPMPATLS PSTIPQLTYD GHPASSPLLP VSLLGPKHEL 
ELPHLTSALH PVHPDIKLQK LPFYDLLDEL IKPTSLASDN SQRFRETCFA FALTPQQVQQ 
ISSSMDISGT KCDFTVQVQL RFCLSETSCP QEDHFPPNLC VKVNTKPCSL PGYLPPTKNG 
VEPKRPSRPI NITSLVRLST TVPNTIVVSW TAEIGRNYSM AVYLVKQLSS TVLLQRLRAK 
GIRNPDHSRA LIKEKLTADP DSEIATTSLR VSLLCPLGKM RLTIPCRALT CSHLQCFDAT 
LYIQMNEKKP TWVCPVCDKK APYEHLIIDG LFMEILKYCT DCDEIQFKED GTWAPMRSKK 
EVQEVSASYN GVDGCLSSTL EHQVASHHQS SNKNKKVEVI DLTIDSSSDE EEEEPSAKRT 
CPSLSPTSPL NNKGILSLPH QASPVSRTPS LPAVDTSYIN TSLIQDYRHP FHMTPMPYDL 
QGLDFFPFLS GDNQHYNTSL LAAAAAAVSD DQDLLHSSRF FPYTSSQMFL DQLSAGGSTS 
LPTTNGSSSG SNSSLVSSNS LRESHSHTVT NRSSTDTASI FGIIPDIISL D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: PIAS1

Associated with

Cells (max top 100)

Other Information

Inhibition of Stat1-mediated gene activation by PIAS1. PubMed ID: 9724754

Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis. PubMed ID: 10628744

Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site. PubMed ID: 19906316

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and characterization of Gu/RH-II binding protein. PubMed ID: 9177271

LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. PubMed ID: 11672422

Involvement of PIAS1 in the sumoylation of tumor suppressor p53. PubMed ID: 11583632

Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells. PubMed ID: 11439351

SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. PubMed ID: 12223491

Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. PubMed ID: 12393906

Transcription factor Sp3 is silenced through SUMO modification by PIAS1. PubMed ID: 12356736

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. PubMed ID: 11867732

SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. PubMed ID: 14701874

PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. PubMed ID: 14500712

Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation. PubMed ID: 15208321

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein. PubMed ID: 16600910

Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. PubMed ID: 16617055

Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity. PubMed ID: 17540171

SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1. PubMed ID: 17369852

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling. PubMed ID: 19136629

Retraction. PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling. PubMed ID: 21724836

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery. PubMed ID: 19557165

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. PubMed ID: 21965678

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

SUMO5, a novel poly-sumo isoform, regulates pml nuclear bodies. PubMed ID: 27211601

HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells. PubMed ID: 28842558

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

B Cell Receptor Activation and Chemical Induction Trigger Caspase-Mediated Cleavage of PIAS1 to Facilitate Epstein-Barr Virus Reactivation. PubMed ID: 29262325

NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers. PubMed ID: 15133049