Details for: CDC14A

Gene ID: 8556

Symbol: CDC14A

Ensembl ID: ENSG00000079335

Description: cell division cycle 14A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 144.3310
    Cell Significance Index: -22.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.2234
    Cell Significance Index: -21.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.8903
    Cell Significance Index: -22.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.4607
    Cell Significance Index: -20.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.6079
    Cell Significance Index: -20.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.4435
    Cell Significance Index: -22.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7728
    Cell Significance Index: -19.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.0034
    Cell Significance Index: -21.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4106
    Cell Significance Index: -19.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8058
    Cell Significance Index: -22.9100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.2303
    Cell Significance Index: 19.9300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.1089
    Cell Significance Index: 29.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.9583
    Cell Significance Index: 41.8600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.7586
    Cell Significance Index: 28.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6580
    Cell Significance Index: 93.0400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2788
    Cell Significance Index: 7.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1536
    Cell Significance Index: 22.5200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0916
    Cell Significance Index: 16.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.0221
    Cell Significance Index: 14.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.9774
    Cell Significance Index: 142.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8821
    Cell Significance Index: 22.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7763
    Cell Significance Index: 154.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5831
    Cell Significance Index: 63.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5823
    Cell Significance Index: 369.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5614
    Cell Significance Index: 29.2400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.5610
    Cell Significance Index: 4.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5567
    Cell Significance Index: 90.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5399
    Cell Significance Index: 32.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4160
    Cell Significance Index: 31.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3839
    Cell Significance Index: 44.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3530
    Cell Significance Index: 16.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3315
    Cell Significance Index: 299.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3195
    Cell Significance Index: 22.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3173
    Cell Significance Index: 16.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2865
    Cell Significance Index: 18.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2828
    Cell Significance Index: 532.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2375
    Cell Significance Index: 1.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1661
    Cell Significance Index: 16.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1392
    Cell Significance Index: 4.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1346
    Cell Significance Index: 24.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0912
    Cell Significance Index: 17.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0699
    Cell Significance Index: 48.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0545
    Cell Significance Index: 6.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0443
    Cell Significance Index: 20.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0441
    Cell Significance Index: 67.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0412
    Cell Significance Index: 76.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0361
    Cell Significance Index: 19.7400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0278
    Cell Significance Index: 0.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0179
    Cell Significance Index: 0.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0159
    Cell Significance Index: 7.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0065
    Cell Significance Index: 0.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0096
    Cell Significance Index: -1.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0114
    Cell Significance Index: -1.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0141
    Cell Significance Index: -19.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0232
    Cell Significance Index: -17.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0248
    Cell Significance Index: -18.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0250
    Cell Significance Index: -5.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0306
    Cell Significance Index: -23.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0331
    Cell Significance Index: -18.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0382
    Cell Significance Index: -13.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0394
    Cell Significance Index: -24.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0464
    Cell Significance Index: -1.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0539
    Cell Significance Index: -1.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0578
    Cell Significance Index: -3.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0624
    Cell Significance Index: -17.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0649
    Cell Significance Index: -11.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1110
    Cell Significance Index: -23.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1209
    Cell Significance Index: -12.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1248
    Cell Significance Index: -12.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1252
    Cell Significance Index: -14.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1334
    Cell Significance Index: -9.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1344
    Cell Significance Index: -15.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1419
    Cell Significance Index: -6.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1488
    Cell Significance Index: -3.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1534
    Cell Significance Index: -19.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1550
    Cell Significance Index: -3.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1660
    Cell Significance Index: -4.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1751
    Cell Significance Index: -10.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1852
    Cell Significance Index: -5.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2161
    Cell Significance Index: -13.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2336
    Cell Significance Index: -1.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2400
    Cell Significance Index: -6.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2456
    Cell Significance Index: -17.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2474
    Cell Significance Index: -6.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2670
    Cell Significance Index: -21.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2737
    Cell Significance Index: -17.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3281
    Cell Significance Index: -22.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3443
    Cell Significance Index: -16.0600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3812
    Cell Significance Index: -5.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3968
    Cell Significance Index: -10.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4187
    Cell Significance Index: -18.5200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.4388
    Cell Significance Index: -4.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4390
    Cell Significance Index: -23.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4555
    Cell Significance Index: -14.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4599
    Cell Significance Index: -15.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4655
    Cell Significance Index: -15.2400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.4663
    Cell Significance Index: -4.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4796
    Cell Significance Index: -7.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4860
    Cell Significance Index: -4.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Dual-Specificity Phosphatase**: CDC14A is a dual-specificity protein phosphatase, capable of dephosphorylating both serine/threonine and tyrosine residues on target proteins. 2. **Cell Cycle Regulation**: CDC14A plays a critical role in regulating the cell cycle, particularly in the transition from mitosis to cytokinesis. 3. **Dephosphorylation and Degradation**: CDC14A is involved in the dephosphorylation and degradation of key cell cycle regulators, such as APC and CDH1. 4. **High Expression in Specific Cell Types**: CDC14A is highly expressed in various cell types, including astrocytes, non-pigmented ciliary epithelial cells, and epithelial cells of the prostate and kidney. **Pathways and Functions** 1. **Apc/C-Mediated Degradation**: CDC14A is involved in the degradation of APC, a key regulator of the cell cycle, through dephosphorylation and ubiquitination. 2. **Cell Cycle**: CDC14A regulates the cell cycle, particularly in the transition from mitosis to cytokinesis. 3. **Mitotic Spindle**: CDC14A is involved in the organization of the mitotic spindle, ensuring proper chromosome segregation. 4. **Cytokinesis**: CDC14A regulates the transition from mitosis to cytokinesis, ensuring proper cell division. 5. **Signal Transduction**: CDC14A is involved in signal transduction pathways, including MAPK6/MAPK4 signaling cascades. **Clinical Significance** 1. **Cancer**: Abnormal expression or function of CDC14A has been implicated in several types of cancer, including prostate and breast cancer. 2. **Neurological Disorders**: CDC14A has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Kidney Disease**: CDC14A has been implicated in kidney disease, including diabetic nephropathy and kidney failure. 4. **Astrocyte Function**: CDC14A is highly expressed in astrocytes, and abnormal expression or function of CDC14A has been implicated in astrocyte dysfunction and neurological disorders. In conclusion, CDC14A is a crucial regulator of the cell cycle, particularly in the transition from mitosis to cytokinesis. Abnormal expression or function of CDC14A has been implicated in several diseases, including cancer, neurological disorders, and kidney disease. Further research is needed to fully understand the role of CDC14A in human disease and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 612316906

Symbol: CC14A_HUMAN

Name: Dual specificity protein phosphatase CDC14A

UniProtKB Accession Codes:

Q9UNH5 A6MA65 B1AQ14 B1AQ15 O43171 O60727 O60728 Q52LH9 Q8IXX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 5 EMBL 14 Ensembl 4 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 Rhea 9 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9367992

Title: A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.

PubMed ID: 9367992

DOI: 10.1074/jbc.272.47.29403

PubMed ID: 10409437

Title: Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene.

PubMed ID: 10409437

DOI: 10.1006/geno.1999.5863

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11598127

Title: Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a.

PubMed ID: 11598127

DOI: 10.1074/jbc.m108126200

PubMed ID: 12134069

Title: Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.

PubMed ID: 12134069

DOI: 10.1091/mbc.01-11-0535

PubMed ID: 11901424

Title: Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.

PubMed ID: 11901424

DOI: 10.1038/ncb777

PubMed ID: 15263015

Title: Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2.

PubMed ID: 15263015

DOI: 10.1083/jcb.200403084

PubMed ID: 17488717

Title: Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation.

PubMed ID: 17488717

DOI: 10.1074/jbc.m702990200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27259055

Title: Mutations in CDC14A, encoding a protein phosphatase involved in hair cell ciliogenesis, cause autosomal-recessive severe to profound deafness.

PubMed ID: 27259055

DOI: 10.1016/j.ajhg.2016.04.015

PubMed ID: 29293958

Title: CDC14A phosphatase is essential for hearing and male fertility in mouse and human.

PubMed ID: 29293958

DOI: 10.1093/hmg/ddx440

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 594
  • Mass: 66574
  • Checksum: D5552E2BAEEA84DF
  • Sequence:
    • MAAESGELIG ACEFMKDRLY FATLRNRPKS TVNTHYFSID EELVYENFYA DFGPLNLAMV 
YRYCCKLNKK LKSYSLSRKK IVHYTCFDQR KRANAAFLIG AYAVIYLKKT PEEAYRALLS 
GSNPPYLPFR DASFGNCTYN LTILDCLQGI RKGLQHGFFD FETFDVDEYE HYERVENGDF 
NWIVPGKFLA FSGPHPKSKI ENGYPLHAPE AYFPYFKKHN VTAVVRLNKK IYEAKRFTDA 
GFEHYDLFFI DGSTPSDNIV RRFLNICENT EGAIAVHCKA GLGRTGTLIA CYVMKHYRFT 
HAEIIAWIRI CRPGSIIGPQ QHFLEEKQAS LWVQGDIFRS KLKNRPSSEG SINKILSGLD 
DMSIGGNLSK TQNMERFGED NLEDDDVEMK NGITQGDKLR ALKSQRQPRT SPSCAFRSDD 
TKGHPRAVSQ PFRLSSSLQG SAVTLKTSKM ALSPSATAKR INRTSLSSGA TVRSFSINSR 
LASSLGNLNA ATDDPENKKT SSSSKAGFTA SPFTNLLNGS SQPTTRNYPE LNNNQYNRSS 
NSNGGNLNSP PGPHSAKTEE HTTILRPSYT GLSSSSARFL SRSIPSLQSE YVHY

Genular Protein ID: 2846841378

Symbol: B4DY86_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DY86

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 8 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 11 Gene3D 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 565
  • Mass: 62816
  • Checksum: E914AB0B84A6C7C2
  • Sequence:
    • MVYRYCCKLN KKLKSYSLSR KKIVHYTCFD QRKRANAAFL IGAYAVIYLK KTPEEAYRAL 
LSGSNPPYLP FRDASFGNCT YNLTILDCLQ GIRKGLQHGF FDFETFDVDE YEHYERVENG 
DFNWIVPGKF LAFSGPHPKS KIENGYPLHA PEAYFPYFKK HNVTAVVRLN KKIYEAKRFT 
DAGFEHYDLF FIDGSTPSDN IVRRFLNICE NTEGAIAVHC KAGLGRTGTL IACYVMKHYR 
FTHAEIIAWI RICRPGSIIG PQQHFLEEKQ ASLWVQGDIF RSKLKNRPSN EGGINKILSG 
LDDMSIGGNL SKTQNMGRFG EDNLEDDDVE MKNGITQGDK LRALKSQRQP RTSPSCAFRS 
DDTKGHPRAV SQPFRLSSSL QGSAVTLKTS KMALSPSATA KRINRTSLSS GATVRSFSIN 
SRLASSLGNL NAATDDPENK KTSSSSKAGF TASPFTNLLN GSSQPTTRNY PELNNNQYNR 
SSNSNGGNLN SPPGPHSAKT EEHTTILRPS YTGLSSSSAR FLSRSIPVSA QTPPPGPQNP 
ECNFCALPSQ PRLPPKKFNS AKEAF

Genular Protein ID: 2064504910

Symbol: Q59EF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EF4

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 8 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 11 Gene3D 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 530
  • Mass: 58905
  • Checksum: F54BF28550AAF8B3
  • Sequence:
    • CQLCKKAGSS SLSRKKIVHY TCFDQRKRAN AAFLIGAYAV IYLKKTPEEA YRALLSGSNP 
PYLPFRDASF GNCTYNLTIL DCLQGIRKGL QHGFFDFETF DVDEYEHYER VENGDFNWIV 
PGKFLAFSGP HPKSKIENGY PLHAPEAYFP YFKKHNVTAV VRLNKKIYEA KRFTDAGFEH 
YDLFFIDGST PSDNIVRRFL NICENTEGAI AVHCKAGLGR TGTLIACYVM KHYRFTHAEI 
IAWIRICRPG SIIGPQQHFL EEKQASLWVQ GDIFRSKLKN RPSSEGSINK ILSGLDDMSI 
GGNLSKTQNM ERFGEDNLED DDVEMKNGIT QGDKLRALKS QRQPRTSPSC AFRSDDTKGH 
PRAVSQPFRL SSSLQGSAVT LKTSKMALSP SATAKRINRT SLSSGATVRS FSINSRLASS 
LGNLNAATDD PENKKTSSSS KAGFTASPFT NLLNGSSQPT TRNYPELNNN QYNRSSNSNG 
GNLNSPPGPH SAKTEEHTTI LRPSYTGLSS SSARFLSRSI PSLQSEYVHY

Genular Protein ID: 205191801

Symbol: A0A0U1RQX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0U1RQX7

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 565
  • Mass: 62891
  • Checksum: E09A5ACEBE63A3CB
  • Sequence:
    • MVYRYCCKLN KKLKSYSLSR KKIVHYTCFD QRKRANAAFL IGAYAVIYLK KTPEEAYRAL 
LSGSNPPYLP FRDASFGNCT YNLTILDCLQ GIRKGLQHGF FDFETFDVDE YEHYERVENG 
DFNWIVPGKF LAFSGPHPKS KIENGYPLHA PEAYFPYFKK HNVTAVVRLN KKIYEAKRFT 
DAGFEHYDLF FIDGSTPSDN IVRRFLNICE NTEGAIAVHC KAGLGRTGTL IACYVMKHYR 
FTHAEIIAWI RICRPGSIIG PQQHFLEEKQ ASLWVQGDIF RSKLKNRPSS EGSINKILSG 
LDDMSIGGNL SKTQNMERFG EDNLEDDDVE MKNGITQGDK LRALKSQRQP RTSPSCAFRS 
DDTKGHPRAV SQPFRLSSSL QGSAVTLKTS KMALSPSATA KRINRTSLSS GATVRSFSIN 
SRLASSLGNL NAATDDPENK KTSSSSKAGF TASPFTNLLN GSSQPTTRNY PELNNNQYNR 
SSNSNGGNLN SPPGPHSAKT EEHTTILRPS YTGLSSSSAR FLSRSIPVSA QTPPPGPQNP 
ECNFCALPSQ PRLPPKKFNS AKEAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.