Details for: CDC14A
Gene ID: 8556
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CDC14A
Ensembl ID: ENSG00000079335
Description: cell division cycle 14A
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 18.64rCSI 82.81%PRS 71.83
-
CSI 8.75rCSI 22.18%PRS 61.22
-
CSI 7.76rCSI 6.27%PRS 81.78
-
CSI 7.43rCSI 8.58%PRS 63.86
-
CSI 6.35rCSI 9.57%PRS 76.76
-
CSI 6.3rCSI 4.9%PRS 87.51
-
CSI 6.29rCSI 13.78%PRS 78.29
-
CSI 5.82rCSI 12.89%PRS 70.31
-
CSI 5.64rCSI 16.04%PRS 68.28
-
CSI 5.45rCSI 3.79%PRS 82.97
-
CSI 5.39rCSI 4.47%PRS 73.92
-
CSI 5.17rCSI 20.2%PRS 48.66
-
CSI 5.09rCSI 3.85%PRS 84.7
-
CSI 4.85rCSI 19.57%PRS 70.77
-
CSI 4.78rCSI 14.94%PRS 54.53
-
CSI 4.64rCSI 7.4%PRS 63.23
-
CSI 4.62rCSI 6.34%PRS 88.81
-
CSI 4.48rCSI 3.64%PRS 71.58
-
CSI 4.38rCSI 6.08%PRS 70.03
-
CSI 4.16rCSI 4.46%PRS 72.08
-
CSI 4.15rCSI 9.3%PRS 53.33
-
CSI 4.13rCSI 7.5%PRS 84.51
-
CSI 4.01rCSI 3.05%PRS 84.21
-
CSI 3.95rCSI 9.79%PRS 70.5
-
CSI 3.73rCSI 2.6%PRS 85.86
-
CSI 3.69rCSI 7.61%PRS 70.77
-
CSI 3.62rCSI 4.65%PRS 62.62
-
CSI 3.62rCSI 14.11%PRS 89.21
-
CSI 3.55rCSI 11.35%PRS 68.64
-
CSI 3.5rCSI 2.83%PRS 73.52
-
CSI 3.42rCSI 7.09%PRS 68.51
-
CSI 3.27rCSI 2.3%PRS 87.25
-
CSI 3.26rCSI 5.15%PRS 73.49
-
CSI 3.1rCSI 2.46%PRS 90.27
-
CSI 3.08rCSI 2.3%PRS 85.46
-
CSI 3rCSI 2.15%PRS 84.95
-
CSI 2.96rCSI 7.71%PRS 72.09
-
CSI 2.95rCSI 4.86%PRS 76.67
-
CSI 2.95rCSI 5.63%PRS 83.67
-
CSI 2.94rCSI 2.89%PRS 86.04
-
CSI 2.89rCSI 2.68%PRS 88.21
-
CSI 2.77rCSI 4.79%PRS 62.06
-
CSI 2.69rCSI 2.12%PRS 58.88
-
CSI 2.64rCSI 6.03%PRS 72.24
-
CSI 2.58rCSI 10.98%PRS 63.87
-
CSI 2.58rCSI 2.26%PRS 79.93
-
CSI 2.57rCSI 7.08%PRS 66.43
-
CSI 2.51rCSI 2.95%PRS 86.35
-
CSI 2.5rCSI 2.15%PRS 78.99
-
CSI 2.44rCSI 1.83%PRS 77.46
-
CSI 2.43rCSI 1.63%PRS 84.67
-
CSI 2.42rCSI 2.41%PRS 65.1
-
CSI 2.42rCSI 4.36%PRS 89.3
-
CSI 2.42rCSI 4.26%PRS 67.55
-
CSI 2.33rCSI 11.5%PRS 81.44
-
CSI 2.33rCSI 11.16%PRS 71.35
-
CSI 2.31rCSI 8.64%PRS 63.47
-
CSI 2.3rCSI 3.15%PRS 63.71
-
CSI 2.21rCSI 10.6%PRS 69.16
-
CSI 2.2rCSI 2.63%PRS 88.43
-
CSI 2.18rCSI 1.29%PRS 87.67
-
CSI 2.17rCSI 4.79%PRS 75.73
-
CSI 2.14rCSI 4.35%PRS 49.7
-
CSI 2.12rCSI 4.83%PRS 62.87
-
CSI 2.11rCSI 1.86%PRS 59.7
-
CSI 2.07rCSI 3.62%PRS 64.08
-
CSI 2.05rCSI 5.45%PRS 80.25
-
CSI 2.04rCSI 4.98%PRS 64.63
-
CSI 2.03rCSI 3.11%PRS 72.13
-
CSI 2.03rCSI 1.57%PRS 73.54
-
CSI 2.01rCSI 2.97%PRS 76.22
-
CSI 1.98rCSI 2.8%PRS 67.71
-
CSI 1.94rCSI 2.03%PRS 68.54
-
CSI 1.9rCSI 1.87%PRS 88.24
-
CSI 1.83rCSI 3.13%PRS 86.6
-
CSI 1.75rCSI 2.78%PRS 64.18
-
CSI 1.74rCSI 1.57%PRS 68.83
-
CSI 1.63rCSI 2.67%PRS 60.49
-
CSI 1.61rCSI 3.84%PRS 71.83
-
CSI 1.61rCSI 4.16%PRS 66.48
-
CSI 1.59rCSI 1.98%PRS 73.16
-
CSI 1.59rCSI 2.57%PRS 67.18
-
CSI 1.56rCSI 1.81%PRS 77
-
CSI 1.55rCSI 2.11%PRS 81.5
-
CSI 1.54rCSI 8.88%PRS 69.11
-
CSI 1.53rCSI 1.91%PRS 81.95
-
CSI 1.53rCSI 3.95%PRS 91.52
-
CSI 1.52rCSI 1.38%PRS 84.9
-
CSI 1.51rCSI 1.75%PRS 62.66
-
CSI 1.49rCSI 2.28%PRS 80.27
-
CSI 1.47rCSI 2.37%PRS 60.87
-
CSI 1.44rCSI 2.3%PRS 75.65
-
CSI 1.43rCSI 3.71%PRS 73.71
-
CSI 1.4rCSI 2.54%PRS 62.79
-
CSI 1.37rCSI 1.86%PRS 91.47
-
CSI 1.37rCSI 3.68%PRS 77.76
-
CSI 1.35rCSI 2.7%PRS 85.91
-
CSI 1.35rCSI 1.96%PRS 85.94
-
CSI 1.29rCSI 1.56%PRS 78.54
-
CSI 1.26rCSI 1.8%PRS 60.96
-
CSI 0.2rCSI 1.1%PRS 78.5%
-
CSI 0.4rCSI 2.4%PRS 92.7%
-
CSI 0.5rCSI 1.8%PRS 62.0%
-
CSI 0.6rCSI 1.9%PRS 69.1%
-
CSI 0.7rCSI 3.6%PRS 74.8%
-
CSI 0.7rCSI 2.4%PRS 77.9%
-
CSI 0.7rCSI 5.7%PRS 65.1%
-
CSI 0.7rCSI 2.0%PRS 67.2%
-
CSI 0.7rCSI 3.2%PRS 60.6%
-
CSI 0.9rCSI 1.9%PRS 66.5%
-
CSI 0.9rCSI 4.8%PRS 79.1%
-
CSI 1.0rCSI 2.6%PRS 62.5%
-
CSI 1.0rCSI 2.1%PRS 85.7%
-
CSI 1.0rCSI 5.5%PRS 81.2%
-
CSI 1.1rCSI 2.6%PRS 77.0%
-
CSI 1.1rCSI 3.3%PRS 89.4%
-
CSI 1.2rCSI 1.6%PRS 73.7%
-
CSI 1.2rCSI 2.2%PRS 81.4%
-
CSI 1.2rCSI 2.6%PRS 82.1%
-
CSI 1.2rCSI 5.0%PRS 82.6%
-
CSI 1.3rCSI 1.8%PRS 61.0%
-
CSI 1.3rCSI 1.6%PRS 78.5%
-
CSI 1.4rCSI 2.0%PRS 85.9%
-
CSI 1.4rCSI 2.7%PRS 85.9%
-
CSI 1.4rCSI 3.7%PRS 77.8%
-
CSI 1.4rCSI 1.9%PRS 91.5%
-
CSI 1.4rCSI 2.5%PRS 62.8%
-
CSI 1.4rCSI 3.7%PRS 73.7%
-
CSI 1.4rCSI 2.3%PRS 75.7%
-
CSI 1.5rCSI 2.4%PRS 60.9%
-
CSI 1.5rCSI 2.3%PRS 80.3%
-
CSI 1.5rCSI 1.8%PRS 62.7%
-
CSI 1.5rCSI 1.4%PRS 84.9%
-
CSI 1.5rCSI 4.0%PRS 91.5%
-
CSI 1.5rCSI 1.9%PRS 82.0%
-
CSI 1.5rCSI 8.9%PRS 69.1%
-
CSI 1.6rCSI 2.1%PRS 81.5%
-
CSI 1.6rCSI 1.8%PRS 77.0%
-
CSI 1.6rCSI 2.6%PRS 67.2%
-
CSI 1.6rCSI 2.0%PRS 73.2%
-
CSI 1.6rCSI 4.2%PRS 66.5%
-
CSI 1.6rCSI 3.8%PRS 71.8%
-
CSI 1.6rCSI 2.7%PRS 60.5%
-
CSI 1.7rCSI 1.6%PRS 68.8%
-
CSI 1.8rCSI 2.8%PRS 64.2%
-
CSI 1.8rCSI 3.1%PRS 86.6%
-
CSI 1.9rCSI 1.9%PRS 88.2%
-
CSI 1.9rCSI 2.0%PRS 68.5%
-
CSI 2.0rCSI 2.8%PRS 67.7%
-
CSI 2.0rCSI 3.0%PRS 76.2%
-
CSI 2.0rCSI 1.6%PRS 73.5%
-
CSI 2.0rCSI 3.1%PRS 72.1%
-
CSI 2.0rCSI 5.0%PRS 64.6%
-
CSI 2.1rCSI 5.5%PRS 80.3%
-
CSI 2.1rCSI 3.6%PRS 64.1%
-
CSI 2.1rCSI 1.9%PRS 59.7%
-
CSI 2.1rCSI 4.8%PRS 62.9%
-
CSI 2.1rCSI 4.4%PRS 49.7%
-
CSI 2.2rCSI 4.8%PRS 75.7%
-
CSI 2.2rCSI 1.3%PRS 87.7%
-
CSI 2.2rCSI 2.6%PRS 88.4%
-
CSI 2.2rCSI 10.6%PRS 69.2%
-
CSI 2.3rCSI 3.2%PRS 63.7%
-
CSI 2.3rCSI 8.6%PRS 63.5%
-
CSI 2.3rCSI 11.2%PRS 71.4%
-
CSI 2.3rCSI 11.5%PRS 81.4%
-
CSI 2.4rCSI 4.3%PRS 67.6%
-
CSI 2.4rCSI 4.4%PRS 89.3%
-
CSI 2.4rCSI 2.4%PRS 65.1%
-
CSI 2.4rCSI 1.6%PRS 84.7%
-
CSI 2.4rCSI 1.8%PRS 77.5%
-
CSI 2.5rCSI 2.2%PRS 79.0%
-
CSI 2.5rCSI 3.0%PRS 86.4%
-
CSI 2.6rCSI 7.1%PRS 66.4%
-
CSI 2.6rCSI 2.3%PRS 79.9%
-
CSI 2.6rCSI 11.0%PRS 63.9%
-
CSI 2.6rCSI 6.0%PRS 72.2%
-
CSI 2.7rCSI 2.1%PRS 58.9%
-
CSI 2.8rCSI 4.8%PRS 62.1%
-
CSI 2.9rCSI 2.7%PRS 88.2%
-
CSI 2.9rCSI 2.9%PRS 86.0%
-
CSI 3.0rCSI 5.6%PRS 83.7%
-
CSI 3.0rCSI 4.9%PRS 76.7%
-
CSI 3.0rCSI 7.7%PRS 72.1%
-
CSI 3.0rCSI 2.2%PRS 85.0%
-
CSI 3.1rCSI 2.3%PRS 85.5%
-
CSI 3.1rCSI 2.5%PRS 90.3%
-
CSI 3.3rCSI 5.2%PRS 73.5%
-
CSI 3.3rCSI 2.3%PRS 87.3%
-
CSI 3.4rCSI 7.1%PRS 68.5%
-
CSI 3.5rCSI 2.8%PRS 73.5%
-
CSI 3.6rCSI 11.4%PRS 68.6%
-
CSI 3.6rCSI 14.1%PRS 89.2%
-
CSI 3.6rCSI 4.7%PRS 62.6%
-
CSI 3.7rCSI 7.6%PRS 70.8%
-
CSI 3.7rCSI 2.6%PRS 85.9%
-
CSI 4.0rCSI 9.8%PRS 70.5%
-
CSI 4.0rCSI 3.1%PRS 84.2%
-
CSI 4.1rCSI 7.5%PRS 84.5%
-
CSI 4.2rCSI 9.3%PRS 53.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 612316906
Symbol: CC14A_HUMAN
Name: Dual specificity protein phosphatase CDC14A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9367992
Title: A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.
PubMed ID: 9367992
PubMed ID: 10409437
Title: Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene.
PubMed ID: 10409437
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11598127
Title: Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a.
PubMed ID: 11598127
PubMed ID: 12134069
Title: Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.
PubMed ID: 12134069
PubMed ID: 11901424
Title: Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.
PubMed ID: 11901424
DOI: 10.1038/ncb777
PubMed ID: 15263015
Title: Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2.
PubMed ID: 15263015
PubMed ID: 17488717
Title: Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation.
PubMed ID: 17488717
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 27259055
Title: Mutations in CDC14A, encoding a protein phosphatase involved in hair cell ciliogenesis, cause autosomal-recessive severe to profound deafness.
PubMed ID: 27259055
PubMed ID: 29293958
Title: CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
PubMed ID: 29293958
DOI: 10.1093/hmg/ddx440
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 594
- Mass: 66574
- Checksum: D5552E2BAEEA84DF
- Sequence:
MAAESGELIG ACEFMKDRLY FATLRNRPKS TVNTHYFSID EELVYENFYA DFGPLNLAMV YRYCCKLNKK LKSYSLSRKK IVHYTCFDQR KRANAAFLIG AYAVIYLKKT PEEAYRALLS GSNPPYLPFR DASFGNCTYN LTILDCLQGI RKGLQHGFFD FETFDVDEYE HYERVENGDF NWIVPGKFLA FSGPHPKSKI ENGYPLHAPE AYFPYFKKHN VTAVVRLNKK IYEAKRFTDA GFEHYDLFFI DGSTPSDNIV RRFLNICENT EGAIAVHCKA GLGRTGTLIA CYVMKHYRFT HAEIIAWIRI CRPGSIIGPQ QHFLEEKQAS LWVQGDIFRS KLKNRPSSEG SINKILSGLD DMSIGGNLSK TQNMERFGED NLEDDDVEMK NGITQGDKLR ALKSQRQPRT SPSCAFRSDD TKGHPRAVSQ PFRLSSSLQG SAVTLKTSKM ALSPSATAKR INRTSLSSGA TVRSFSINSR LASSLGNLNA ATDDPENKKT SSSSKAGFTA SPFTNLLNGS SQPTTRNYPE LNNNQYNRSS NSNGGNLNSP PGPHSAKTEE HTTILRPSYT GLSSSSARFL SRSIPSLQSE YVHY
Genular Protein ID: 2846841378
Symbol: B4DY86_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 565
- Mass: 62816
- Checksum: E914AB0B84A6C7C2
- Sequence:
MVYRYCCKLN KKLKSYSLSR KKIVHYTCFD QRKRANAAFL IGAYAVIYLK KTPEEAYRAL LSGSNPPYLP FRDASFGNCT YNLTILDCLQ GIRKGLQHGF FDFETFDVDE YEHYERVENG DFNWIVPGKF LAFSGPHPKS KIENGYPLHA PEAYFPYFKK HNVTAVVRLN KKIYEAKRFT DAGFEHYDLF FIDGSTPSDN IVRRFLNICE NTEGAIAVHC KAGLGRTGTL IACYVMKHYR FTHAEIIAWI RICRPGSIIG PQQHFLEEKQ ASLWVQGDIF RSKLKNRPSN EGGINKILSG LDDMSIGGNL SKTQNMGRFG EDNLEDDDVE MKNGITQGDK LRALKSQRQP RTSPSCAFRS DDTKGHPRAV SQPFRLSSSL QGSAVTLKTS KMALSPSATA KRINRTSLSS GATVRSFSIN SRLASSLGNL NAATDDPENK KTSSSSKAGF TASPFTNLLN GSSQPTTRNY PELNNNQYNR SSNSNGGNLN SPPGPHSAKT EEHTTILRPS YTGLSSSSAR FLSRSIPVSA QTPPPGPQNP ECNFCALPSQ PRLPPKKFNS AKEAF
Genular Protein ID: 2064504910
Symbol: Q59EF4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 530
- Mass: 58905
- Checksum: F54BF28550AAF8B3
- Sequence:
CQLCKKAGSS SLSRKKIVHY TCFDQRKRAN AAFLIGAYAV IYLKKTPEEA YRALLSGSNP PYLPFRDASF GNCTYNLTIL DCLQGIRKGL QHGFFDFETF DVDEYEHYER VENGDFNWIV PGKFLAFSGP HPKSKIENGY PLHAPEAYFP YFKKHNVTAV VRLNKKIYEA KRFTDAGFEH YDLFFIDGST PSDNIVRRFL NICENTEGAI AVHCKAGLGR TGTLIACYVM KHYRFTHAEI IAWIRICRPG SIIGPQQHFL EEKQASLWVQ GDIFRSKLKN RPSSEGSINK ILSGLDDMSI GGNLSKTQNM ERFGEDNLED DDVEMKNGIT QGDKLRALKS QRQPRTSPSC AFRSDDTKGH PRAVSQPFRL SSSLQGSAVT LKTSKMALSP SATAKRINRT SLSSGATVRS FSINSRLASS LGNLNAATDD PENKKTSSSS KAGFTASPFT NLLNGSSQPT TRNYPELNNN QYNRSSNSNG GNLNSPPGPH SAKTEEHTTI LRPSYTGLSS SSARFLSRSI PSLQSEYVHY
Genular Protein ID: 205191801
Symbol: A0A0U1RQX7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
Sequence Information:
- Length: 565
- Mass: 62891
- Checksum: E09A5ACEBE63A3CB
- Sequence:
MVYRYCCKLN KKLKSYSLSR KKIVHYTCFD QRKRANAAFL IGAYAVIYLK KTPEEAYRAL LSGSNPPYLP FRDASFGNCT YNLTILDCLQ GIRKGLQHGF FDFETFDVDE YEHYERVENG DFNWIVPGKF LAFSGPHPKS KIENGYPLHA PEAYFPYFKK HNVTAVVRLN KKIYEAKRFT DAGFEHYDLF FIDGSTPSDN IVRRFLNICE NTEGAIAVHC KAGLGRTGTL IACYVMKHYR FTHAEIIAWI RICRPGSIIG PQQHFLEEKQ ASLWVQGDIF RSKLKNRPSS EGSINKILSG LDDMSIGGNL SKTQNMERFG EDNLEDDDVE MKNGITQGDK LRALKSQRQP RTSPSCAFRS DDTKGHPRAV SQPFRLSSSL QGSAVTLKTS KMALSPSATA KRINRTSLSS GATVRSFSIN SRLASSLGNL NAATDDPENK KTSSSSKAGF TASPFTNLLN GSSQPTTRNY PELNNNQYNR SSNSNGGNLN SPPGPHSAKT EEHTTILRPS YTGLSSSSAR FLSRSIPVSA QTPPPGPQNP ECNFCALPSQ PRLPPKKFNS AKEAF