Details for: CDK10
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 9.27rCSI 14.16%PRS 56.76
-
CSI 7.36rCSI 10.89%PRS 57.46
-
CSI 5rCSI 6.01%PRS 49.99
-
CSI 4.92rCSI 15.38%PRS 38.95
-
CSI 4.9rCSI 12.68%PRS 47.61
-
CSI 4.31rCSI 4.62%PRS 50.39
-
CSI 3.28rCSI 3.23%PRS 68.11
-
CSI 3.06rCSI 7.19%PRS 59.23
-
CSI 2.94rCSI 2.05%PRS 66.17
-
CSI 2.88rCSI 2.19%PRS 64.56
-
CSI 2.85rCSI 2.98%PRS 55.31
-
CSI 2.84rCSI 1.98%PRS 54.5
-
CSI 2.65rCSI 11.26%PRS 46.99
-
CSI 2.63rCSI 9.33%PRS 63.34
-
CSI 2.61rCSI 3.82%PRS 55.6
-
CSI 2.57rCSI 3.51%PRS 54.38
-
CSI 2.53rCSI 4.53%PRS 50.67
-
CSI 2.51rCSI 1.8%PRS 66.07
-
CSI 2.47rCSI 1.84%PRS 65.95
-
CSI 2.44rCSI 6.21%PRS 47.2
-
CSI 2.43rCSI 2.01%PRS 50.81
-
CSI 2.43rCSI 4.2%PRS 42.37
-
CSI 2.41rCSI 3.83%PRS 63.09
-
CSI 2.37rCSI 5.42%PRS 51.55
-
CSI 2.35rCSI 5.96%PRS 41.92
-
CSI 2.34rCSI 2.26%PRS 42.62
-
CSI 2.32rCSI 3.31%PRS 54.65
-
CSI 2.31rCSI 2.27%PRS 54.66
-
CSI 2.3rCSI 4.63%PRS 41.41
-
CSI 2.27rCSI 2.11%PRS 51.82
-
CSI 2.23rCSI 1.96%PRS 40.6
-
CSI 2.18rCSI 1.47%PRS 64.07
-
CSI 2.17rCSI 1.88%PRS 56.59
-
CSI 2.13rCSI 1.59%PRS 67.41
-
CSI 2.13rCSI 4.71%PRS 49.71
-
CSI 2.06rCSI 1.63%PRS 39.25
-
CSI 2rCSI 2.09%PRS 48.96
-
CSI 1.98rCSI 1.66%PRS 56.96
-
CSI 1.95rCSI 2.61%PRS 60.77
-
CSI 1.93rCSI 2.64%PRS 57.41
-
CSI 1.93rCSI 1.6%PRS 53.59
-
CSI 1.91rCSI 3.46%PRS 44.91
-
CSI 1.9rCSI 7.13%PRS 44.5
-
CSI 1.89rCSI 1.97%PRS 52.51
-
CSI 1.84rCSI 2.78%PRS 54.97
-
CSI 1.84rCSI 2.16%PRS 55.05
-
CSI 1.83rCSI 1.61%PRS 57.33
-
CSI 1.83rCSI 3.63%PRS 73.86
-
CSI 1.81rCSI 5.18%PRS 71.36
-
CSI 1.8rCSI 1.46%PRS 53.18
-
CSI 1.8rCSI 1.6%PRS 50.46
-
CSI 1.76rCSI 4.19%PRS 53.67
-
CSI 1.73rCSI 3.05%PRS 49.65
-
CSI 1.72rCSI 2.18%PRS 58.04
-
CSI 1.66rCSI 2.05%PRS 47.98
-
CSI 1.65rCSI 2.29%PRS 55.19
-
CSI 1.65rCSI 3.96%PRS 65.68
-
CSI 1.64rCSI 2.04%PRS 33.38
-
CSI 1.63rCSI 2.17%PRS 57.57
-
CSI 1.62rCSI 2.6%PRS 42.21
-
CSI 1.62rCSI 4.2%PRS 56.53
-
CSI 1.6rCSI 2.29%PRS 57.96
-
CSI 1.56rCSI 2.01%PRS 36.16
-
CSI 1.55rCSI 2.38%PRS 67.57
-
CSI 1.55rCSI 1.93%PRS 54.3
-
CSI 1.54rCSI 4.01%PRS 58.48
-
CSI 1.52rCSI 1.38%PRS 48.84
-
CSI 1.52rCSI 3.61%PRS 57.32
-
CSI 1.5rCSI 2.13%PRS 48.59
-
CSI 1.46rCSI 1.46%PRS 45.77
-
CSI 1.4rCSI 2.29%PRS 41.95
-
CSI 1.37rCSI 2.78%PRS 33.09
-
CSI 1.37rCSI 2.22%PRS 49.71
-
CSI 1.35rCSI 1.41%PRS 50.98
-
CSI 1.33rCSI 1.81%PRS 44.78
-
CSI 1.32rCSI 2.1%PRS 44.63
-
CSI 1.24rCSI 2.65%PRS 65.54
-
CSI 1.21rCSI 2.96%PRS 46.78
-
CSI 1.17rCSI 4.57%PRS 59.44
-
CSI 1.16rCSI 2.87%PRS 50
-
CSI 1.15rCSI 4.32%PRS 41.45
-
CSI 1.13rCSI 1.79%PRS 53.32
-
CSI 1.11rCSI 4.48%PRS 50.46
-
CSI 1.06rCSI 2.38%PRS 35.85
-
CSI 1.04rCSI 2.41%PRS 42.36
-
CSI 1.04rCSI 2.3%PRS 39.34
-
CSI 1.04rCSI 3.93%PRS 35.93
-
CSI 1.03rCSI 5.19%PRS 64.21
-
CSI 1.01rCSI 1.78%PRS 34.11
-
CSI 1rCSI 1.15%PRS 42.03
-
CSI 0.97rCSI 0.84%PRS 62.48
-
CSI 0.95rCSI 0.73%PRS 51.43
-
CSI 0.95rCSI 2.96%PRS 36.48
-
CSI 0.94rCSI 1.57%PRS 35.1
-
CSI 0.93rCSI 1.5%PRS 37.24
-
CSI 0.89rCSI 1.06%PRS 34.96
-
CSI 0.84rCSI 2.83%PRS 59.11
-
CSI 0.83rCSI 2.02%PRS 33.88
-
CSI 0.81rCSI 2.16%PRS 44.01
-
CSI 0.8rCSI 1.9%PRS 62.85
-
CSI 0.2rCSI 4.8%PRS 34.6%
-
CSI 0.2rCSI 1.4%PRS 36.6%
-
CSI 0.3rCSI 6.2%PRS 35.5%
-
CSI 0.3rCSI 1.6%PRS 62.5%
-
CSI 0.3rCSI 1.2%PRS 66.9%
-
CSI 0.4rCSI 1.5%PRS 33.8%
-
CSI 0.5rCSI 2.5%PRS 71.7%
-
CSI 0.5rCSI 2.4%PRS 73.0%
-
CSI 0.6rCSI 3.3%PRS 37.8%
-
CSI 0.6rCSI 1.0%PRS 48.5%
-
CSI 0.7rCSI 2.9%PRS 51.1%
-
CSI 0.7rCSI 1.1%PRS 49.9%
-
CSI 0.7rCSI 2.7%PRS 44.2%
-
CSI 0.8rCSI 1.8%PRS 49.6%
-
CSI 0.8rCSI 3.5%PRS 69.3%
-
CSI 0.8rCSI 1.9%PRS 62.9%
-
CSI 0.8rCSI 2.2%PRS 44.0%
-
CSI 0.8rCSI 2.0%PRS 33.9%
-
CSI 0.8rCSI 2.8%PRS 59.1%
-
CSI 0.9rCSI 1.1%PRS 35.0%
-
CSI 0.9rCSI 1.5%PRS 37.2%
-
CSI 0.9rCSI 1.6%PRS 35.1%
-
CSI 1.0rCSI 3.0%PRS 36.5%
-
CSI 1.0rCSI 0.7%PRS 51.4%
-
CSI 1.0rCSI 0.8%PRS 62.5%
-
CSI 1.0rCSI 1.2%PRS 42.0%
-
CSI 1.0rCSI 1.8%PRS 34.1%
-
CSI 1.0rCSI 5.2%PRS 64.2%
-
CSI 1.0rCSI 3.9%PRS 35.9%
-
CSI 1.0rCSI 2.3%PRS 39.3%
-
CSI 1.0rCSI 2.4%PRS 42.4%
-
CSI 1.1rCSI 2.4%PRS 35.9%
-
CSI 1.1rCSI 4.5%PRS 50.5%
-
CSI 1.1rCSI 1.8%PRS 53.3%
-
CSI 1.2rCSI 4.3%PRS 41.5%
-
CSI 1.2rCSI 2.9%PRS 50.0%
-
CSI 1.2rCSI 4.6%PRS 59.4%
-
CSI 1.2rCSI 3.0%PRS 46.8%
-
CSI 1.2rCSI 2.7%PRS 65.5%
-
CSI 1.3rCSI 2.1%PRS 44.6%
-
CSI 1.3rCSI 1.8%PRS 44.8%
-
CSI 1.4rCSI 1.4%PRS 51.0%
-
CSI 1.4rCSI 2.2%PRS 49.7%
-
CSI 1.4rCSI 2.8%PRS 33.1%
-
CSI 1.4rCSI 2.3%PRS 42.0%
-
CSI 1.5rCSI 1.5%PRS 45.8%
-
CSI 1.5rCSI 2.1%PRS 48.6%
-
CSI 1.5rCSI 3.6%PRS 57.3%
-
CSI 1.5rCSI 1.4%PRS 48.8%
-
CSI 1.5rCSI 4.0%PRS 58.5%
-
CSI 1.6rCSI 1.9%PRS 54.3%
-
CSI 1.6rCSI 2.4%PRS 67.6%
-
CSI 1.6rCSI 2.0%PRS 36.2%
-
CSI 1.6rCSI 2.3%PRS 58.0%
-
CSI 1.6rCSI 4.2%PRS 56.5%
-
CSI 1.6rCSI 2.6%PRS 42.2%
-
CSI 1.6rCSI 2.2%PRS 57.6%
-
CSI 1.6rCSI 2.0%PRS 33.4%
-
CSI 1.7rCSI 4.0%PRS 65.7%
-
CSI 1.7rCSI 2.3%PRS 55.2%
-
CSI 1.7rCSI 2.1%PRS 48.0%
-
CSI 1.7rCSI 2.2%PRS 58.0%
-
CSI 1.7rCSI 3.1%PRS 49.7%
-
CSI 1.8rCSI 4.2%PRS 53.7%
-
CSI 1.8rCSI 1.6%PRS 50.5%
-
CSI 1.8rCSI 1.5%PRS 53.2%
-
CSI 1.8rCSI 5.2%PRS 71.4%
-
CSI 1.8rCSI 3.6%PRS 73.9%
-
CSI 1.8rCSI 1.6%PRS 57.3%
-
CSI 1.8rCSI 2.2%PRS 55.1%
-
CSI 1.8rCSI 2.8%PRS 55.0%
-
CSI 1.9rCSI 2.0%PRS 52.5%
-
CSI 1.9rCSI 7.1%PRS 44.5%
-
CSI 1.9rCSI 3.5%PRS 44.9%
-
CSI 1.9rCSI 1.6%PRS 53.6%
-
CSI 1.9rCSI 2.6%PRS 57.4%
-
CSI 2.0rCSI 2.6%PRS 60.8%
-
CSI 2.0rCSI 1.7%PRS 57.0%
-
CSI 2.0rCSI 2.1%PRS 49.0%
-
CSI 2.1rCSI 1.6%PRS 39.3%
-
CSI 2.1rCSI 4.7%PRS 49.7%
-
CSI 2.1rCSI 1.6%PRS 67.4%
-
CSI 2.2rCSI 1.9%PRS 56.6%
-
CSI 2.2rCSI 1.5%PRS 64.1%
-
CSI 2.2rCSI 2.0%PRS 40.6%
-
CSI 2.3rCSI 2.1%PRS 51.8%
-
CSI 2.3rCSI 4.6%PRS 41.4%
-
CSI 2.3rCSI 2.3%PRS 54.7%
-
CSI 2.3rCSI 3.3%PRS 54.7%
-
CSI 2.3rCSI 2.3%PRS 42.6%
-
CSI 2.4rCSI 6.0%PRS 41.9%
-
CSI 2.4rCSI 5.4%PRS 51.6%
-
CSI 2.4rCSI 3.8%PRS 63.1%
-
CSI 2.4rCSI 4.2%PRS 42.4%
-
CSI 2.4rCSI 2.0%PRS 50.8%
-
CSI 2.4rCSI 6.2%PRS 47.2%
-
CSI 2.5rCSI 1.8%PRS 66.0%
-
CSI 2.5rCSI 1.8%PRS 66.1%
-
CSI 2.5rCSI 4.5%PRS 50.7%
-
CSI 2.6rCSI 3.5%PRS 54.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3194894213
Symbol: CDK10_HUMAN
Name: Cyclin-dependent kinase 10
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8208557
Title: PISSLRE, a human novel CDC2-related protein kinase.
PubMed ID: 8208557
PubMed ID: 8084611
Title: Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases.
PubMed ID: 8084611
PubMed ID: 10036189
Title: The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer.
PubMed ID: 10036189
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 24218572
Title: CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.
PubMed ID: 24218572
PubMed ID: 27104747
Title: STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.
PubMed ID: 27104747
PubMed ID: 28886341
Title: CDK10 mutations in humans and mice cause severe growth retardation, spine malformations, and developmental delays.
PubMed ID: 28886341
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 360
- Mass: 41038
- Checksum: 25B28560961103F4
- Sequence:
MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAT SEGQSKRCKP
Genular Protein ID: 4165885942
Symbol: B7Z537_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 386
- Mass: 43821
- Checksum: 4C793AE72E594DBE
- Sequence:
MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAS WRICQHPSRR LRSSASCCRC SGASSICTRT SLSTGT