Details for: CDK10

Gene ID: 8558

Symbol: CDK10

Ensembl ID: ENSG00000185324

Description: cyclin dependent kinase 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.8880
    Cell Significance Index: -22.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.1015
    Cell Significance Index: -22.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.7621
    Cell Significance Index: -23.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.4771
    Cell Significance Index: -26.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.2264
    Cell Significance Index: -23.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.2684
    Cell Significance Index: -24.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9086
    Cell Significance Index: -23.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.6809
    Cell Significance Index: -20.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4672
    Cell Significance Index: -25.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8257
    Cell Significance Index: -12.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.3306
    Cell Significance Index: 379.0500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.1093
    Cell Significance Index: 33.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5452
    Cell Significance Index: 44.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5416
    Cell Significance Index: 69.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5061
    Cell Significance Index: 42.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2361
    Cell Significance Index: 245.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1907
    Cell Significance Index: 71.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1387
    Cell Significance Index: 228.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8676
    Cell Significance Index: 30.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8070
    Cell Significance Index: 55.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6934
    Cell Significance Index: 9.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5593
    Cell Significance Index: 8.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4772
    Cell Significance Index: 24.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4640
    Cell Significance Index: 12.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4543
    Cell Significance Index: 30.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4417
    Cell Significance Index: 43.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4372
    Cell Significance Index: 238.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4138
    Cell Significance Index: 148.4100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4058
    Cell Significance Index: 3.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3984
    Cell Significance Index: 359.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3976
    Cell Significance Index: 274.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3940
    Cell Significance Index: 54.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3354
    Cell Significance Index: 8.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3331
    Cell Significance Index: 63.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3164
    Cell Significance Index: 14.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2884
    Cell Significance Index: 51.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2413
    Cell Significance Index: 28.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2410
    Cell Significance Index: 15.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2059
    Cell Significance Index: 25.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1672
    Cell Significance Index: 4.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1616
    Cell Significance Index: 4.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1545
    Cell Significance Index: 5.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1503
    Cell Significance Index: 66.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1491
    Cell Significance Index: 3.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1454
    Cell Significance Index: 6.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1384
    Cell Significance Index: 2.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1157
    Cell Significance Index: 14.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1024
    Cell Significance Index: 6.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0987
    Cell Significance Index: 5.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0773
    Cell Significance Index: 0.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0627
    Cell Significance Index: 10.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0565
    Cell Significance Index: 2.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0468
    Cell Significance Index: 1.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0450
    Cell Significance Index: 1.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0330
    Cell Significance Index: 1.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0236
    Cell Significance Index: 1.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0165
    Cell Significance Index: 30.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0154
    Cell Significance Index: 0.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0134
    Cell Significance Index: 20.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0109
    Cell Significance Index: 20.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0099
    Cell Significance Index: 6.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0067
    Cell Significance Index: 0.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0065
    Cell Significance Index: 0.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -2.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0037
    Cell Significance Index: -0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0168
    Cell Significance Index: -12.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0229
    Cell Significance Index: -16.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0263
    Cell Significance Index: -0.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0314
    Cell Significance Index: -14.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0334
    Cell Significance Index: -4.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0334
    Cell Significance Index: -3.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0360
    Cell Significance Index: -20.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0368
    Cell Significance Index: -2.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0461
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0463
    Cell Significance Index: -28.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0775
    Cell Significance Index: -1.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0782
    Cell Significance Index: -22.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0805
    Cell Significance Index: -5.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1241
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1306
    Cell Significance Index: -27.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1547
    Cell Significance Index: -1.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1548
    Cell Significance Index: -18.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1593
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1596
    Cell Significance Index: -18.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1787
    Cell Significance Index: -2.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1867
    Cell Significance Index: -3.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2300
    Cell Significance Index: -23.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2679
    Cell Significance Index: -7.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2702
    Cell Significance Index: -7.9400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2869
    Cell Significance Index: -4.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2910
    Cell Significance Index: -23.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2972
    Cell Significance Index: -8.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3060
    Cell Significance Index: -7.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3337
    Cell Significance Index: -7.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3339
    Cell Significance Index: -20.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3482
    Cell Significance Index: -7.6300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4121
    Cell Significance Index: -6.2100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4158
    Cell Significance Index: -4.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDK10 is a member of the cyclin-dependent kinase family, which plays a crucial role in the regulation of the cell cycle. It is specifically involved in the G2/M phase transition, where it phosphorylates and activates key proteins to drive cell cycle progression. CDK10 exhibits a unique substrate specificity, phosphorylating proteins involved in actin cytoskeleton organization, mitotic cell cycle regulation, and protein-protein interactions. Notably, CDK10 is also implicated in the regulation of immune responses, particularly in the context of T-cell activation and proliferation. **Pathways and Functions:** CDK10 is involved in various cellular pathways, including: 1. **Cell Cycle Regulation:** CDK10 phosphorylates and activates proteins involved in the G2/M phase transition, driving cell cycle progression and ensuring proper cell division. 2. **Actin Cytoskeleton Organization:** CDK10 regulates actin cytoskeleton organization, which is crucial for cell migration, adhesion, and cytokinesis. 3. **Protein Phosphorylation:** CDK10 phosphorylates a wide range of proteins, including those involved in protein-protein interactions, transcriptional regulation, and signal transduction. 4. **Immune Regulation:** CDK10 is implicated in the regulation of T-cell activation, proliferation, and differentiation, highlighting its role in immune responses. **Significant Expression in Immune Cells:** CDK10 is highly expressed in immune cells, including: 1. **Pulmonary Interstitial Fibroblasts:** CDK10 is involved in the regulation of fibroblast function, which is critical in the context of pulmonary fibrosis. 2. **Corticothalamic-Projecting Glutamatergic Cortical Neurons:** CDK10 is required for the proper functioning of these neurons, which are involved in the regulation of motor functions and cognitive processes. 3. **Leydig Cells:** CDK10 regulates the function of these cells, which are involved in the production of testosterone. **Clinical Significance:** CDK10 dysregulation has been implicated in various diseases, including: 1. **Cancer:** CDK10 overexpression has been observed in certain types of cancer, including lung and breast cancer. 2. **Neurological Disorders:** CDK10 dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune-Mediated Diseases:** CDK10 plays a crucial role in the regulation of immune responses, and dysregulation of CDK10 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, CDK10 is a critical regulator of cellular processes, including cell cycle progression, actin cytoskeleton organization, and protein phosphorylation. Its significant expression in immune cells highlights its role in immune regulation and cellular proliferation. Further research is necessary to fully elucidate the functions of CDK10 and its implications in human disease.

Genular Protein ID: 3194894213

Symbol: CDK10_HUMAN

Name: Cyclin-dependent kinase 10

UniProtKB Accession Codes:

Q15131 A8K370 A8K8I6 A8MXU6 B3KQJ3 B7Z420 D3DX82 D3DX83 Q0VGZ7 Q15130 Q6PJC0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 4 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 24 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 7 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8208557

Title: PISSLRE, a human novel CDC2-related protein kinase.

PubMed ID: 8208557

PubMed ID: 8084611

Title: Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases.

PubMed ID: 8084611

PubMed ID: 10036189

Title: The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer.

PubMed ID: 10036189

DOI: 10.1006/geno.1998.5676

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 24218572

Title: CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.

PubMed ID: 24218572

DOI: 10.1073/pnas.1306814110

PubMed ID: 27104747

Title: STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.

PubMed ID: 27104747

DOI: 10.1080/15384101.2016.1147632

PubMed ID: 28886341

Title: CDK10 mutations in humans and mice cause severe growth retardation, spine malformations, and developmental delays.

PubMed ID: 28886341

DOI: 10.1016/j.ajhg.2017.08.003

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 360
  • Mass: 41038
  • Checksum: 25B28560961103F4
  • Sequence:
    • MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ 
TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 
EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA 
DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP 
GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL 
HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAT SEGQSKRCKP

Genular Protein ID: 4165885942

Symbol: B7Z537_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z537

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 386
  • Mass: 43821
  • Checksum: 4C793AE72E594DBE
  • Sequence:
    • MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ 
TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 
EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA 
DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP 
GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL 
HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAS WRICQHPSRR 
LRSSASCCRC SGASSICTRT SLSTGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.