Details for: YARS1

Gene ID: 8565

Symbol: YARS1

Ensembl ID: ENSG00000134684

Description: tyrosyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 199.9418
    Cell Significance Index: -31.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.7494
    Cell Significance Index: -30.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.5880
    Cell Significance Index: -33.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.3094
    Cell Significance Index: -32.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.9414
    Cell Significance Index: -37.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.6863
    Cell Significance Index: -36.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 55.7508
    Cell Significance Index: -37.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.9463
    Cell Significance Index: -32.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.5030
    Cell Significance Index: -33.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.8367
    Cell Significance Index: -34.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1129
    Cell Significance Index: -11.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4278
    Cell Significance Index: 286.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3104
    Cell Significance Index: 36.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1969
    Cell Significance Index: 52.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1317
    Cell Significance Index: 1021.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9937
    Cell Significance Index: 37.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8210
    Cell Significance Index: 89.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7925
    Cell Significance Index: 284.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7750
    Cell Significance Index: 40.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7739
    Cell Significance Index: 125.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7658
    Cell Significance Index: 151.9800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7539
    Cell Significance Index: 12.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6509
    Cell Significance Index: 16.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5779
    Cell Significance Index: 15.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5550
    Cell Significance Index: 16.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5066
    Cell Significance Index: 14.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4989
    Cell Significance Index: 58.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4673
    Cell Significance Index: 323.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4417
    Cell Significance Index: 33.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3972
    Cell Significance Index: 71.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3664
    Cell Significance Index: 200.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3559
    Cell Significance Index: 24.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3345
    Cell Significance Index: 41.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3023
    Cell Significance Index: 19.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2705
    Cell Significance Index: 12.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2257
    Cell Significance Index: 31.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2163
    Cell Significance Index: 36.9400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2143
    Cell Significance Index: 5.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2099
    Cell Significance Index: 92.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2068
    Cell Significance Index: 9.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2023
    Cell Significance Index: 9.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1991
    Cell Significance Index: 3.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1926
    Cell Significance Index: 9.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1658
    Cell Significance Index: 21.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1154
    Cell Significance Index: 21.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1103
    Cell Significance Index: 10.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1037
    Cell Significance Index: 6.9700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1028
    Cell Significance Index: 3.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1013
    Cell Significance Index: 5.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0915
    Cell Significance Index: 1.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0906
    Cell Significance Index: 2.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0889
    Cell Significance Index: 2.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0709
    Cell Significance Index: 4.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0610
    Cell Significance Index: 4.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0592
    Cell Significance Index: 111.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0426
    Cell Significance Index: 57.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0395
    Cell Significance Index: 72.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0362
    Cell Significance Index: 27.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0356
    Cell Significance Index: 54.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0341
    Cell Significance Index: 0.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0261
    Cell Significance Index: 16.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0242
    Cell Significance Index: 0.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0074
    Cell Significance Index: -3.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0091
    Cell Significance Index: -0.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0094
    Cell Significance Index: -0.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0186
    Cell Significance Index: -2.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0303
    Cell Significance Index: -1.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0370
    Cell Significance Index: -27.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0393
    Cell Significance Index: -29.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0581
    Cell Significance Index: -32.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0631
    Cell Significance Index: -39.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0632
    Cell Significance Index: -4.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0799
    Cell Significance Index: -8.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0912
    Cell Significance Index: -2.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1012
    Cell Significance Index: -2.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1083
    Cell Significance Index: -31.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1134
    Cell Significance Index: -16.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1214
    Cell Significance Index: -13.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1668
    Cell Significance Index: -5.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1839
    Cell Significance Index: -38.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1855
    Cell Significance Index: -4.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2083
    Cell Significance Index: -4.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2834
    Cell Significance Index: -29.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2941
    Cell Significance Index: -5.7400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3060
    Cell Significance Index: -2.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3284
    Cell Significance Index: -4.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3594
    Cell Significance Index: -6.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3664
    Cell Significance Index: -9.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3717
    Cell Significance Index: -7.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3755
    Cell Significance Index: -6.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3960
    Cell Significance Index: -13.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4016
    Cell Significance Index: -24.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4178
    Cell Significance Index: -33.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4485
    Cell Significance Index: -2.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4899
    Cell Significance Index: -5.8400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5068
    Cell Significance Index: -7.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5211
    Cell Significance Index: -11.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5781
    Cell Significance Index: -12.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5937
    Cell Significance Index: -15.8800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6020
    Cell Significance Index: -3.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** YARS1 is a cytosolic enzyme that catalyzes the aminoacylation of tyrosine-tRNA, a crucial step in the translation of mRNAs into proteins. The gene is highly expressed in cells involved in immune responses, neuronal function, and cellular metabolism. Its expression is also notable in cells that undergo rapid proliferation and differentiation, such as plasmablasts and L2/3-6 intratelencephalic projecting glutamatergic neurons. YARS1 has been implicated in various cellular processes, including apoptosis, response to starvation, and protein metabolism. **Pathways and Functions:** YARS1 is involved in several key pathways, including: 1. **Translation**: YARS1 is essential for the aminoacylation of tyrosine-tRNA, which is required for the translation of mRNAs into proteins. 2. **Protein binding**: YARS1 interacts with various proteins, including other tRNA synthetases, to regulate protein synthesis. 3. **Apoptotic process**: YARS1 has been implicated in the regulation of apoptosis, particularly in cells undergoing stress or starvation. 4. **Metabolism of proteins**: YARS1 is involved in the regulation of protein metabolism, including protein degradation and synthesis. **Clinical Significance:** Dysregulation of YARS1 has been implicated in various diseases, including: 1. **Neurological disorders**: Altered expression of YARS1 has been observed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: YARS1 has been implicated in the regulation of cell proliferation and differentiation in various cancers. 3. **Immune disorders**: Altered expression of YARS1 has been observed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Metabolic disorders**: YARS1 has been implicated in the regulation of glucose and lipid metabolism, particularly in the context of insulin resistance and type 2 diabetes. In conclusion, YARS1 is a critical gene that plays a pivotal role in protein synthesis and cellular regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the function and regulation of this gene in the context of human health and disease.

Genular Protein ID: 308602254

Symbol: SYYC_HUMAN

Name: Tyrosine--tRNA ligase, cytoplasmic

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8552597

Title: Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria.

PubMed ID: 8552597

DOI: 10.1073/pnas.93.1.166

PubMed ID: 9162081

Title: Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine.

PubMed ID: 9162081

DOI: 10.1074/jbc.272.22.14420

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22291016

Title: tRNA-controlled nuclear import of a human tRNA synthetase.

PubMed ID: 22291016

DOI: 10.1074/jbc.c111.325902

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 12427973

Title: Crystal structure of a human aminoacyl-tRNA synthetase cytokine.

PubMed ID: 12427973

DOI: 10.1073/pnas.242611799

PubMed ID: 14671330

Title: Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains.

PubMed ID: 14671330

DOI: 10.1073/pnas.2136794100

PubMed ID: 25533949

Title: A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.

PubMed ID: 25533949

DOI: 10.1038/nature14028

PubMed ID: 16429158

Title: Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy.

PubMed ID: 16429158

DOI: 10.1038/ng1727

PubMed ID: 24627108

Title: Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges.

PubMed ID: 24627108

DOI: 10.1007/s00415-014-7289-8

PubMed ID: 27633801

Title: A novel multisystem disease associated with recessive mutations in the tyrosyl-tRNA synthetase (YARS) gene.

PubMed ID: 27633801

DOI: 10.1002/ajmg.a.37973

PubMed ID: 29232904

Title: An Expanded Multi-Organ Disease Phenotype Associated with Mutations in YARS.

PubMed ID: 29232904

DOI: 10.3390/genes8120381

PubMed ID: 30304524

Title: Homozygosity for a mutation affecting the catalytic domain of tyrosyl-tRNA synthetase (YARS) causes multisystem disease.

PubMed ID: 30304524

DOI: 10.1093/hmg/ddy344

PubMed ID: 36307205

Title: A missense, loss-of-function YARS1 variant in a patient with proximal-predominant motor neuropathy.

PubMed ID: 36307205

DOI: 10.1101/mcs.a006246

Sequence Information:

  • Length: 528
  • Mass: 59143
  • Checksum: 00C7E88843905780
  • Sequence:
  • MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV AYFVPMSKIA 
    DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRVSYYENV IKAMLESIGV PLEKLKFIKG 
    TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD 
    AQFGGIDQRK IFTFAEKYLP ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED 
    VKKKLKKAFC EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA 
    AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPM AKGPAKNSEP 
    EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR TVVSGLVQFV PKEELQDRLV 
    VVLCNLKPQK MRGVESQGML LCASIEGINR QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE 
    LKPKKKVFEK LQADFKISEE CIAQWKQTNF MTKLGSISCK SLKGGNIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.