Details for: YARS1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 199.9418
Cell Significance Index: -31.1000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 118.7494
Cell Significance Index: -30.1200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 81.5880
Cell Significance Index: -33.6100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 79.3094
Cell Significance Index: -32.2200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 78.9414
Cell Significance Index: -37.2700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 70.6863
Cell Significance Index: -36.3600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 55.7508
Cell Significance Index: -37.4100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 33.9463
Cell Significance Index: -32.4100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 27.5030
Cell Significance Index: -33.9100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.8367
Cell Significance Index: -34.8700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.1129
Cell Significance Index: -11.1900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4278
Cell Significance Index: 286.4100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.3104
Cell Significance Index: 36.6200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.1969
Cell Significance Index: 52.9400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1317
Cell Significance Index: 1021.8200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.9937
Cell Significance Index: 37.6300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8210
Cell Significance Index: 89.3000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7925
Cell Significance Index: 284.2600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.7750
Cell Significance Index: 40.6900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7739
Cell Significance Index: 125.8700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7658
Cell Significance Index: 151.9800 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.7539
Cell Significance Index: 12.1000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.6509
Cell Significance Index: 16.7300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5779
Cell Significance Index: 15.4300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5550
Cell Significance Index: 16.3000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5066
Cell Significance Index: 14.6000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4989
Cell Significance Index: 58.8300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4673
Cell Significance Index: 323.2100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4417
Cell Significance Index: 33.9000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3972
Cell Significance Index: 71.6000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3664
Cell Significance Index: 200.1200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3559
Cell Significance Index: 24.6200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3345
Cell Significance Index: 41.1400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3023
Cell Significance Index: 19.5100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2705
Cell Significance Index: 12.7200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2257
Cell Significance Index: 31.0000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2163
Cell Significance Index: 36.9400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.2143
Cell Significance Index: 5.2300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2099
Cell Significance Index: 92.7900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2068
Cell Significance Index: 9.6400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2023
Cell Significance Index: 9.1700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1991
Cell Significance Index: 3.0000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1926
Cell Significance Index: 9.7300 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1658
Cell Significance Index: 21.4200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1154
Cell Significance Index: 21.9600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1103
Cell Significance Index: 10.9100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1037
Cell Significance Index: 6.9700 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.1028
Cell Significance Index: 3.2500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1013
Cell Significance Index: 5.2600 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.0915
Cell Significance Index: 1.1400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0906
Cell Significance Index: 2.5900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0889
Cell Significance Index: 2.4200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0709
Cell Significance Index: 4.4700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0610
Cell Significance Index: 4.5500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0592
Cell Significance Index: 111.4800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0426
Cell Significance Index: 57.9100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0395
Cell Significance Index: 72.8500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0362
Cell Significance Index: 27.4200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0356
Cell Significance Index: 54.8800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0341
Cell Significance Index: 0.7500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0261
Cell Significance Index: 16.5600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0242
Cell Significance Index: 0.4200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0074
Cell Significance Index: -3.3700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0091
Cell Significance Index: -0.5100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0094
Cell Significance Index: -0.2700 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0186
Cell Significance Index: -2.3900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0303
Cell Significance Index: -1.5800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0370
Cell Significance Index: -27.1400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0393
Cell Significance Index: -29.0900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0581
Cell Significance Index: -32.7800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0631
Cell Significance Index: -39.4300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0632
Cell Significance Index: -4.4700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0799
Cell Significance Index: -8.1600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0912
Cell Significance Index: -2.9200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1012
Cell Significance Index: -2.1600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1083
Cell Significance Index: -31.1500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1134
Cell Significance Index: -16.4800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1214
Cell Significance Index: -13.9100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1668
Cell Significance Index: -5.8600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1839
Cell Significance Index: -38.7300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1855
Cell Significance Index: -4.7400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2083
Cell Significance Index: -4.3200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2834
Cell Significance Index: -29.5100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2941
Cell Significance Index: -5.7400 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3060
Cell Significance Index: -2.5000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3284
Cell Significance Index: -4.4800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3594
Cell Significance Index: -6.0200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3664
Cell Significance Index: -9.6400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3717
Cell Significance Index: -7.7800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3755
Cell Significance Index: -6.3300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3960
Cell Significance Index: -13.7600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4016
Cell Significance Index: -24.6200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4178
Cell Significance Index: -33.0900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4485
Cell Significance Index: -2.7100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4899
Cell Significance Index: -5.8400 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.5068
Cell Significance Index: -7.2200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5211
Cell Significance Index: -11.2900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5781
Cell Significance Index: -12.2700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5937
Cell Significance Index: -15.8800 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.6020
Cell Significance Index: -3.9300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 308602254
Symbol: SYYC_HUMAN
Name: Tyrosine--tRNA ligase, cytoplasmic
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8552597
Title: Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria.
PubMed ID: 8552597
PubMed ID: 9162081
Title: Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine.
PubMed ID: 9162081
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22291016
Title: tRNA-controlled nuclear import of a human tRNA synthetase.
PubMed ID: 22291016
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 12427973
Title: Crystal structure of a human aminoacyl-tRNA synthetase cytokine.
PubMed ID: 12427973
PubMed ID: 14671330
Title: Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains.
PubMed ID: 14671330
PubMed ID: 25533949
Title: A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
PubMed ID: 25533949
DOI: 10.1038/nature14028
PubMed ID: 16429158
Title: Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy.
PubMed ID: 16429158
DOI: 10.1038/ng1727
PubMed ID: 24627108
Title: Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges.
PubMed ID: 24627108
PubMed ID: 27633801
Title: A novel multisystem disease associated with recessive mutations in the tyrosyl-tRNA synthetase (YARS) gene.
PubMed ID: 27633801
DOI: 10.1002/ajmg.a.37973
PubMed ID: 29232904
Title: An Expanded Multi-Organ Disease Phenotype Associated with Mutations in YARS.
PubMed ID: 29232904
DOI: 10.3390/genes8120381
PubMed ID: 30304524
Title: Homozygosity for a mutation affecting the catalytic domain of tyrosyl-tRNA synthetase (YARS) causes multisystem disease.
PubMed ID: 30304524
DOI: 10.1093/hmg/ddy344
PubMed ID: 36307205
Title: A missense, loss-of-function YARS1 variant in a patient with proximal-predominant motor neuropathy.
PubMed ID: 36307205
DOI: 10.1101/mcs.a006246
Sequence Information:
- Length: 528
- Mass: 59143
- Checksum: 00C7E88843905780
- Sequence:
MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV AYFVPMSKIA DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRVSYYENV IKAMLESIGV PLEKLKFIKG TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD AQFGGIDQRK IFTFAEKYLP ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED VKKKLKKAFC EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPM AKGPAKNSEP EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR TVVSGLVQFV PKEELQDRLV VVLCNLKPQK MRGVESQGML LCASIEGINR QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE LKPKKKVFEK LQADFKISEE CIAQWKQTNF MTKLGSISCK SLKGGNIS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.