Details for: PDXK

Gene ID: 8566

Symbol: PDXK

Ensembl ID: ENSG00000160209

Description: pyridoxal kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 297.9841
    Cell Significance Index: -46.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 186.0880
    Cell Significance Index: -47.2000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 113.9405
    Cell Significance Index: -46.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.7393
    Cell Significance Index: -48.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 74.3902
    Cell Significance Index: -49.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.2171
    Cell Significance Index: -47.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.6736
    Cell Significance Index: -47.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.4222
    Cell Significance Index: -50.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1134
    Cell Significance Index: -47.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.9190
    Cell Significance Index: -19.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.6783
    Cell Significance Index: 254.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.3608
    Cell Significance Index: 32.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2767
    Cell Significance Index: 61.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2631
    Cell Significance Index: 105.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9123
    Cell Significance Index: 99.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8724
    Cell Significance Index: 112.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8039
    Cell Significance Index: 361.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3577
    Cell Significance Index: 269.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2906
    Cell Significance Index: 27.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2825
    Cell Significance Index: 700.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2646
    Cell Significance Index: 59.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2611
    Cell Significance Index: 155.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1700
    Cell Significance Index: 51.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1596
    Cell Significance Index: 1047.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1584
    Cell Significance Index: 30.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1470
    Cell Significance Index: 206.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1004
    Cell Significance Index: 31.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0980
    Cell Significance Index: 393.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9441
    Cell Significance Index: 35.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8546
    Cell Significance Index: 110.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8359
    Cell Significance Index: 23.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5921
    Cell Significance Index: 26.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5339
    Cell Significance Index: 236.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5264
    Cell Significance Index: 39.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5188
    Cell Significance Index: 36.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4998
    Cell Significance Index: 81.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4228
    Cell Significance Index: 12.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4143
    Cell Significance Index: 3.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3966
    Cell Significance Index: 54.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3820
    Cell Significance Index: 264.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3786
    Cell Significance Index: 64.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2226
    Cell Significance Index: 4.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1990
    Cell Significance Index: 37.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1716
    Cell Significance Index: 323.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1465
    Cell Significance Index: 107.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1429
    Cell Significance Index: 14.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1388
    Cell Significance Index: 10.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1010
    Cell Significance Index: 2.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0729
    Cell Significance Index: 4.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0607
    Cell Significance Index: 93.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0577
    Cell Significance Index: 43.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0550
    Cell Significance Index: 101.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0479
    Cell Significance Index: 6.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0213
    Cell Significance Index: 1.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0190
    Cell Significance Index: 25.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0119
    Cell Significance Index: 5.3800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0092
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0111
    Cell Significance Index: -7.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0113
    Cell Significance Index: -8.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0326
    Cell Significance Index: -0.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0386
    Cell Significance Index: -1.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0452
    Cell Significance Index: -3.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0486
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0507
    Cell Significance Index: -31.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0637
    Cell Significance Index: -35.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0829
    Cell Significance Index: -6.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1293
    Cell Significance Index: -27.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1418
    Cell Significance Index: -40.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1434
    Cell Significance Index: -16.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1439
    Cell Significance Index: -16.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1465
    Cell Significance Index: -4.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1804
    Cell Significance Index: -21.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2474
    Cell Significance Index: -35.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2839
    Cell Significance Index: -6.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3581
    Cell Significance Index: -22.5700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3629
    Cell Significance Index: -5.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4131
    Cell Significance Index: -43.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4153
    Cell Significance Index: -10.9200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4237
    Cell Significance Index: -48.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4418
    Cell Significance Index: -11.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5039
    Cell Significance Index: -28.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5425
    Cell Significance Index: -33.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6069
    Cell Significance Index: -21.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6271
    Cell Significance Index: -15.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6752
    Cell Significance Index: -43.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6865
    Cell Significance Index: -14.5700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.7560
    Cell Significance Index: -9.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7628
    Cell Significance Index: -24.4300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7859
    Cell Significance Index: -9.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7884
    Cell Significance Index: -13.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8003
    Cell Significance Index: -12.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8517
    Cell Significance Index: -25.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8914
    Cell Significance Index: -28.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9132
    Cell Significance Index: -26.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9667
    Cell Significance Index: -31.6500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9920
    Cell Significance Index: -12.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.9967
    Cell Significance Index: -15.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0025
    Cell Significance Index: -35.1200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.0141
    Cell Significance Index: -21.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.0341
    Cell Significance Index: -17.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDXK is a member of the kinase family and is involved in the phosphorylation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. The enzyme is highly specific, with a high affinity for PLP, and is capable of catalyzing the transfer of a phosphate group to PLP, resulting in the formation of pyridoxal phosphate. PDXK is highly expressed in various cell types, including immune cells, such as macrophages and epithelial cells, and is also found in tissues involved in nutrient metabolism, such as the salivary gland and kidney. **Pathways and Functions:** PDXK is involved in several key pathways, including: 1. **Vitamin B6 Metabolism:** PDXK plays a crucial role in the activation of vitamin B6 to its active form, pyridoxal phosphate, which is essential for various cellular processes, including neurotransmission, amino acid metabolism, and immune response. 2. **Innate Immunity:** PDXK is highly expressed in immune cells, such as macrophages and neutrophils, and is involved in the regulation of innate immune responses, including neutrophil degranulation and phagocytosis. 3. **Neutrophil Degranulation:** PDXK has been shown to regulate neutrophil degranulation, a critical process in the clearance of pathogens and the resolution of inflammation. 4. **Metabolism:** PDXK is involved in the metabolism of water-soluble vitamins, including vitamin B6, and is essential for maintaining cellular homeostasis. **Clinical Significance:** Dysregulation of PDXK has been implicated in various diseases, including: 1. **Immune Disorders:** PDXK dysfunction has been linked to various immune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Neurological Disorders:** PDXK has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. 3. **Cancer:** PDXK has been shown to play a role in cancer development and progression, particularly in the context of immune evasion and tumor metastasis. In conclusion, PDXK is a multifaceted enzyme involved in the activation of vitamin B6 and plays a crucial role in maintaining cellular homeostasis and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying PDXK's functions and its potential as a therapeutic target.

Genular Protein ID: 786017969

Symbol: PDXK_HUMAN

Name: Pyridoxal kinase

UniProtKB Accession Codes:

O00764 Q7Z2Y0 Q9BS02

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 32 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 3 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 2 RefSeq 6 Rhea 6 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9099727

Title: Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor.

PubMed ID: 9099727

DOI: 10.1074/jbc.272.16.10756

PubMed ID: 15154080

Title: Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis.

PubMed ID: 15154080

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10987144

Title: Human pyridoxal kinase: overexpression and properties of the recombinant enzyme.

PubMed ID: 10987144

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28716709

Title: Isolation and characterization of the 5'-flanking region of the human PDXK gene.

PubMed ID: 28716709

DOI: 10.1016/j.gene.2017.07.044

PubMed ID: 16600635

Title: Crystal structure of human pyridoxal kinase.

PubMed ID: 16600635

DOI: 10.1016/j.jsb.2006.02.008

PubMed ID: 17766369

Title: Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation.

PubMed ID: 17766369

DOI: 10.1110/ps.073022107

PubMed ID: 19351586

Title: Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase.

PubMed ID: 19351586

DOI: 10.1016/j.bbrc.2009.01.170

PubMed ID: 22879864

Title: Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition.

PubMed ID: 22879864

DOI: 10.1371/journal.pone.0040954

PubMed ID: 31187503

Title: PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation.

PubMed ID: 31187503

DOI: 10.1002/ana.25524

Sequence Information:

  • Length: 312
  • Mass: 35102
  • Checksum: 2DBDCAB5D8640569
  • Sequence:
    • MEEECRVLSI QSHVIRGYVG NRAATFPLQV LGFEIDAVNS VQFSNHTGYA HWKGQVLNSD 
ELQELYEGLR LNNMNKYDYV LTGYTRDKSF LAMVVDIVQE LKQQNPRLVY VCDPVLGDKW 
DGEGSMYVPE DLLPVYKEKV VPLADIITPN QFEAELLSGR KIHSQEEALR VMDMLHSMGP 
DTVVITSSDL PSPQGSNYLI VLGSQRRRNP AGSVVMERIR MDIRKVDAVF VGTGDLFAAM 
LLAWTHKHPN NLKVACEKTV STLHHVLQRT IQCAKAQAGE GVRPSPMQLE LRMVQSKRDI 
EDPEIVVQAT VL

Genular Protein ID: 1104097287

Symbol: F2Z2Y4_HUMAN

Name: N/A

UniProtKB Accession Codes:

F2Z2Y4

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 3 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 6 SMR 1 SUPFAM 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 272
  • Mass: 30638
  • Checksum: 9AA9476B9B16AC7E
  • Sequence:
    • MGRSRPPGYA HWKGQVLNSD ELQELYEGLR LNNMNKYDYV LTGYTRDKSF LAMVVDIVQE 
LKQQNPRLVY VCDPVLGDKW DGEGSMYVPE DLLPVYKEKV VPLADIITPN QFEAELLSGR 
KIHSQEEALR VMDMLHSMGP DTVVITSSDL PSPQGSNYLI VLGSQRRRNP AGSVVMERIR 
MDIRKVDAVF VGTGDLFAAM LLAWTHKHPN NLKVACEKTV STLHHVLQRT IQCAKAQAGE 
GVRPSPMQLE LRMVQSKRDI EDPEIVVQAT VL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.