Details for: RRP1

Gene ID: 8568

Symbol: RRP1

Ensembl ID: ENSG00000160214

Description: ribosomal RNA processing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 122.0545
    Cell Significance Index: -18.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.9694
    Cell Significance Index: -17.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.8734
    Cell Significance Index: -22.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.0946
    Cell Significance Index: -18.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.1435
    Cell Significance Index: -22.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.4346
    Cell Significance Index: -18.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.2634
    Cell Significance Index: -21.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6931
    Cell Significance Index: -17.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5270
    Cell Significance Index: -21.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3851
    Cell Significance Index: -5.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5270
    Cell Significance Index: 151.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5268
    Cell Significance Index: 248.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2401
    Cell Significance Index: 64.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1049
    Cell Significance Index: 66.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9645
    Cell Significance Index: 870.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7864
    Cell Significance Index: 21.4100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.6166
    Cell Significance Index: 1.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6165
    Cell Significance Index: 17.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6113
    Cell Significance Index: 78.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6108
    Cell Significance Index: 43.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5447
    Cell Significance Index: 15.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4994
    Cell Significance Index: 220.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4089
    Cell Significance Index: 11.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3925
    Cell Significance Index: 29.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3713
    Cell Significance Index: 202.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3470
    Cell Significance Index: 68.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3338
    Cell Significance Index: 17.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3271
    Cell Significance Index: 38.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3238
    Cell Significance Index: 3.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3132
    Cell Significance Index: 14.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3129
    Cell Significance Index: 42.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3000
    Cell Significance Index: 60.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2979
    Cell Significance Index: 36.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2914
    Cell Significance Index: 13.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2851
    Cell Significance Index: 19.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2784
    Cell Significance Index: 17.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2773
    Cell Significance Index: 50.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2730
    Cell Significance Index: 7.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2721
    Cell Significance Index: 188.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2606
    Cell Significance Index: 12.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2404
    Cell Significance Index: 8.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1217
    Cell Significance Index: 43.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1044
    Cell Significance Index: 13.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0930
    Cell Significance Index: 1.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0923
    Cell Significance Index: 5.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0899
    Cell Significance Index: 17.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0756
    Cell Significance Index: 1.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0324
    Cell Significance Index: 1.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0247
    Cell Significance Index: 0.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0096
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0024
    Cell Significance Index: 4.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0053
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0071
    Cell Significance Index: -1.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0104
    Cell Significance Index: -0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0110
    Cell Significance Index: -16.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0153
    Cell Significance Index: -11.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0171
    Cell Significance Index: -23.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0218
    Cell Significance Index: -13.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0233
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0282
    Cell Significance Index: -20.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0305
    Cell Significance Index: -0.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0313
    Cell Significance Index: -0.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0358
    Cell Significance Index: -0.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0369
    Cell Significance Index: -20.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0406
    Cell Significance Index: -25.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0408
    Cell Significance Index: -18.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0647
    Cell Significance Index: -18.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0689
    Cell Significance Index: -8.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0787
    Cell Significance Index: -0.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0822
    Cell Significance Index: -5.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1126
    Cell Significance Index: -12.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1153
    Cell Significance Index: -1.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1167
    Cell Significance Index: -1.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1192
    Cell Significance Index: -17.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1194
    Cell Significance Index: -25.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1555
    Cell Significance Index: -9.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1658
    Cell Significance Index: -4.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1803
    Cell Significance Index: -2.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1866
    Cell Significance Index: -14.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2030
    Cell Significance Index: -21.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2233
    Cell Significance Index: -12.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2276
    Cell Significance Index: -4.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2321
    Cell Significance Index: -18.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2583
    Cell Significance Index: -7.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2691
    Cell Significance Index: -16.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2883
    Cell Significance Index: -12.7500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2893
    Cell Significance Index: -2.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3504
    Cell Significance Index: -13.2700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3548
    Cell Significance Index: -7.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3727
    Cell Significance Index: -9.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3889
    Cell Significance Index: -5.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3959
    Cell Significance Index: -10.5900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4016
    Cell Significance Index: -3.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4057
    Cell Significance Index: -11.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4320
    Cell Significance Index: -7.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4618
    Cell Significance Index: -10.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4849
    Cell Significance Index: -5.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal RNA Processing:** RRP1 plays a pivotal role in the processing of rRNA, specifically in the nucleolus and cytosol. It is involved in the maturation of ribosomal subunits, ensuring the proper assembly and function of ribosomes. 2. **Cellular Expression:** RRP1 is expressed in various cell types, including proerythroblast, bladder urothelial cell, and intestinal crypt stem cell, indicating its involvement in cellular differentiation, growth, and maintenance. 3. **Protein Binding:** RRP1 interacts with various proteins, including other RRP1 homologs, ribosomal proteins, and RNA-binding proteins, regulating rRNA processing and ribosome assembly. **Pathways and Functions:** 1. **Chromatin Remodeling:** RRP1 is involved in chromatin remodeling, a process that regulates gene expression by altering chromatin structure and accessibility. 2. **Metabolic Pathways:** RRP1 is also implicated in metabolic pathways, including the metabolism of rRNA, which is essential for protein synthesis and cellular energy homeostasis. 3. **Nucleolus and Nucleus:** RRP1 is localized to the nucleolus and nucleus, where it regulates rRNA processing and ribosome assembly. 4. **Preribosome and Small Subunit Precursor:** RRP1 is involved in the assembly of the preribosome and small subunit precursor, crucial steps in ribosome biogenesis. **Clinical Significance:** 1. **Cancer:** Alterations in RRP1 expression have been implicated in various cancers, including bladder urothelial carcinoma and prostate cancer, suggesting its potential as a diagnostic biomarker or therapeutic target. 2. **Neurological Disorders:** RRP1 has been linked to neurological disorders, such as autism spectrum disorder and schizophrenia, where disruptions in ribosome biogenesis and rRNA processing may contribute to disease pathogenesis. 3. **Metabolic Diseases:** RRP1 may also play a role in metabolic diseases, including diabetes and metabolic syndrome, where impaired ribosome biogenesis and rRNA processing may contribute to disease progression. In conclusion, RRP1 is a critical gene involved in the regulation of ribosomal RNA processing, cellular differentiation, and metabolic homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying RRP1 function and its potential as a therapeutic target.

Genular Protein ID: 4005021214

Symbol: RRP1_HUMAN

Name: Ribosomal RNA processing protein 1 homolog A

UniProtKB Accession Codes:

P56182 Q9NST5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 4 Ensembl 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192856

Title: The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3.

PubMed ID: 9192856

DOI: 10.1006/geno.1997.4755

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10341208

Title: The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis.

PubMed ID: 10341208

DOI: 10.1242/jcs.112.12.1889

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 20926688

Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.

PubMed ID: 20926688

DOI: 10.1091/mbc.e10-04-0287

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21536856

Title: Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.

PubMed ID: 21536856

DOI: 10.1074/mcp.m110.006148

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26797129

Title: Substrate specificity of the HEMK2 protein glutamine methyltransferase and identification of novel substrates.

PubMed ID: 26797129

DOI: 10.1074/jbc.m115.711952

Sequence Information:

  • Length: 461
  • Mass: 52839
  • Checksum: C6F204EF4161AEAE
  • Sequence:
    • MVSRVQLPPE IQLAQRLAGN EQVTRDRAVR KLRKYIVART QRAAGGFTHD ELLKVWKGLF 
YCMWMQDKPL LQEELGRTIS QLVHAFQTTE AQHLFLQAFW QTMNREWTGI DRLRLDKFYM 
LMRMVLNESL KVLKMQGWEE RQIEELLELL MTEILHPSSQ APNGVKSHFI EIFLEELTKV 
GAEELTADQN LKFIDPFCRI AARTKDSLVL NNITRGIFET IVEQAPLAIE DLLNELDTQD 
EEVASDSDES SEGGERGDAL SQKRSEKPPA GSICRAEPEA GEEQAGDDRD SGGPVLQFDY 
EAVANRLFEM ASRQSTPSQN RKRLYKVIRK LQDLAGGIFP EDEIPEKACR RLLEGRRQKK 
TKKQKRLLRL QQERGKGEKE PPSPGMERKR SRRRGVGADP EARAEAGEQP GTAERALLRD 
QPRGRGQRGA RQRRRTPRPL TSARAKAANV QEPEKKKKRR E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.