Details for: FAM193A

Gene ID: 8603

Symbol: FAM193A

Ensembl ID: ENSG00000125386

Description: family with sequence similarity 193 member A

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 280.0472
    Cell Significance Index: -43.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 171.8160
    Cell Significance Index: -43.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 99.0315
    Cell Significance Index: -46.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 89.3277
    Cell Significance Index: -36.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.0940
    Cell Significance Index: -36.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.0759
    Cell Significance Index: -44.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.2460
    Cell Significance Index: -28.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4355
    Cell Significance Index: -45.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0982
    Cell Significance Index: 420.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7541
    Cell Significance Index: 348.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6960
    Cell Significance Index: 608.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.6733
    Cell Significance Index: 40.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.6398
    Cell Significance Index: 42.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5159
    Cell Significance Index: 116.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4966
    Cell Significance Index: 83.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4397
    Cell Significance Index: 88.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3054
    Cell Significance Index: 902.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9706
    Cell Significance Index: 113.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8810
    Cell Significance Index: 24.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8806
    Cell Significance Index: 38.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7629
    Cell Significance Index: 51.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7571
    Cell Significance Index: 28.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7394
    Cell Significance Index: 14.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6648
    Cell Significance Index: 19.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6541
    Cell Significance Index: 29.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6407
    Cell Significance Index: 13.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5858
    Cell Significance Index: 95.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4660
    Cell Significance Index: 420.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4510
    Cell Significance Index: 12.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4224
    Cell Significance Index: 41.7800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4213
    Cell Significance Index: 9.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3676
    Cell Significance Index: 8.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3566
    Cell Significance Index: 21.4100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3565
    Cell Significance Index: 5.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3137
    Cell Significance Index: 16.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3000
    Cell Significance Index: 36.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2854
    Cell Significance Index: 10.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2506
    Cell Significance Index: 45.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2297
    Cell Significance Index: 432.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1805
    Cell Significance Index: 12.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1725
    Cell Significance Index: 2.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1488
    Cell Significance Index: 229.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1487
    Cell Significance Index: 3.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1399
    Cell Significance Index: 257.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1397
    Cell Significance Index: 19.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1365
    Cell Significance Index: 74.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1303
    Cell Significance Index: 59.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1207
    Cell Significance Index: 76.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0744
    Cell Significance Index: 32.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0703
    Cell Significance Index: 1.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0595
    Cell Significance Index: 80.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0244
    Cell Significance Index: 1.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0298
    Cell Significance Index: -5.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0302
    Cell Significance Index: -22.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0341
    Cell Significance Index: -21.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0396
    Cell Significance Index: -29.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0523
    Cell Significance Index: -29.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0591
    Cell Significance Index: -44.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0593
    Cell Significance Index: -11.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0682
    Cell Significance Index: -1.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0686
    Cell Significance Index: -3.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1059
    Cell Significance Index: -6.8300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1242
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1298
    Cell Significance Index: -27.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1336
    Cell Significance Index: -38.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1407
    Cell Significance Index: -20.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1463
    Cell Significance Index: -9.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1857
    Cell Significance Index: -21.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2016
    Cell Significance Index: -20.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2030
    Cell Significance Index: -20.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2036
    Cell Significance Index: -26.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2560
    Cell Significance Index: -33.0700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2765
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3005
    Cell Significance Index: -34.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3096
    Cell Significance Index: -14.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3746
    Cell Significance Index: -42.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3758
    Cell Significance Index: -26.5800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4254
    Cell Significance Index: -6.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4254
    Cell Significance Index: -8.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4498
    Cell Significance Index: -33.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4714
    Cell Significance Index: -10.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4985
    Cell Significance Index: -39.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5056
    Cell Significance Index: -10.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5320
    Cell Significance Index: -27.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5419
    Cell Significance Index: -7.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6144
    Cell Significance Index: -37.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6175
    Cell Significance Index: -7.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6428
    Cell Significance Index: -12.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6527
    Cell Significance Index: -21.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6594
    Cell Significance Index: -21.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6670
    Cell Significance Index: -9.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6757
    Cell Significance Index: -19.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7047
    Cell Significance Index: -17.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7068
    Cell Significance Index: -14.1900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7899
    Cell Significance Index: -9.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7949
    Cell Significance Index: -13.3900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7961
    Cell Significance Index: -4.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.8041
    Cell Significance Index: -8.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8282
    Cell Significance Index: -26.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8494
    Cell Significance Index: -23.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** FAM193A is expressed in a diverse range of cell types, including astrocytes, skeletal muscle fibers, and GABAergic cortical interneurons. This widespread expression pattern suggests that FAM193A may have multiple functions in different tissues. 2. **Protein Structure:** The FAM193A protein is a small, non-coding RNA-binding protein that contains a unique domain structure. The exact function of this domain is unknown, but it may play a crucial role in regulating RNA processing or translation. 3. **Cellular Localization:** FAM193A is primarily localized to the cytoplasm and nucleus, suggesting that it may be involved in regulating gene expression or RNA metabolism. **Pathways and Functions:** 1. **Neuronal Excitability:** FAM193A has been shown to regulate neuronal excitability in GABAergic cortical interneurons. This suggests that FAM193A may play a critical role in modulating the activity of these neurons, which are involved in regulating neural circuits and behavior. 2. **Muscle Function:** FAM193A has also been found to regulate muscle function in skeletal muscle fibers. This suggests that FAM193A may play a role in regulating muscle contraction and relaxation. 3. **RNA Processing:** FAM193A may also be involved in regulating RNA processing, particularly in the context of neuronal development and function. This could involve modulating the expression of genes involved in neuronal differentiation and synaptogenesis. **Clinical Significance:** 1. **Neurological Disorders:** FAM193A dysregulation has been implicated in various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. Further research is needed to understand the role of FAM193A in these disorders and to identify potential therapeutic targets. 2. **Muscle Diseases:** FAM193A dysregulation has also been implicated in muscle diseases, including muscular dystrophy and myasthenia gravis. Further research is needed to understand the role of FAM193A in these diseases and to identify potential therapeutic targets. 3. **Cancer:** FAM193A has also been found to be overexpressed in certain types of cancer, including breast and lung cancer. Further research is needed to understand the role of FAM193A in cancer development and progression. In conclusion, FAM193A is a gene of emerging significance that plays a critical role in regulating neuronal excitability and muscle function. Further research is needed to fully understand the role of FAM193A in various diseases and to identify potential therapeutic targets. As an immunologist, I am excited to continue exploring the mysteries of FAM193A and to uncover its secrets.

Genular Protein ID: 4139209392

Symbol: F193A_HUMAN

Name: Protein FAM193A

UniProtKB Accession Codes:

P78312 B7ZM85 B9EGR0 E9PFA1 O43607 P78311 P78313 Q9UEG8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 6 ExpressionAtlas 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 5 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9734812

Title: The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3.

PubMed ID: 9734812

DOI: 10.1093/dnares/5.3.177

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1265
  • Mass: 139988
  • Checksum: 6B4EDD55B49AC9EE
  • Sequence:
    • MKVRLLRQLS AAAKVKAPSG LQGPPQAHQF ISLLLEEYGA LCQAARSIST FLGTLENEHL 
KKFQVTWELH NKHLFENLVF SEPLLQSNLP ALVSQIRLGT TTHDTCSEDT YSTLLQRYQR 
SEEELRRVAE EWLECQKRID AYVDEQMTMK TKQRMLTEDW ELFKQRRFIE EQLTNKKAVT 
GENNFTDTMR HMLSSRLSMP DCPNCNYRRR CACDDCSLSH ILTCGIMDPP VTDDIHIHQL 
PLQVDPAPDY LAERSPPSVS SASSGSGSSS PITIQQHPRL ILTDSGSAPT FCSDDEDVAP 
LSAKFADIYP LSNYDDTEVV ANMNGIHSEL NGGGENMALK DESPQISSTS SSSSEADDEE 
ADGESSGEPP GAPKEDGVLG SRSPRTEESK ADSPPPSYPT QQAEQAPNTC ECHVCKQEAS 
GLTPSAMTAG ALPPGHQFLS PEKPTHPALH LYPHIHGHVP LHTVPHLPRP LIHPTLYATP 
PFTHSKALPP APVQNHTNKH QVFNASLQDH IYPSCFGNTP EWNSSKFISL WGSEVMNDKN 
WNPGTFLPDT ISGSEILGPT LSETRPEALP PPSSNETPAV SDSKEKKNAA KKKCLYNFQD 
AFMEANKVVM ATSSATSSVS CTATTVQSSN SQFRVSSKRP PSVGDVFHGI SKEDHRHSAP 
AAPRNSPTGL APLPALSPAA LSPAALSPAS TPHLANLAAP SFPKTATTTP GFVDTRKSFC 
PAPLPPATDG SISAPPSVCS DPDCEGHRCE NGVYDPQQDD GDESADEDSC SEHSSSTSTS 
TNQKEGKYCD CCYCEFFGHG GPPAAPTSRN YAEMREKLRL RLTKRKEEQP KKMDQISERE 
SVVDHRRVED LLQFINSSET KPVSSTRAAK RARHKQRKLE EKARLEAEAR AREHLHLQEE 
QRRREEEEDE EEEEDRFKEE FQRLQELQKL RAVKKKKKER PSKDCPKLDM LTRNFQAATE 
SVPNSGNIHN GSLEQTEEPE TSSHSPSRHM NHSEPRPGLG ADGDAADPVD TRDSKFLLPK 
EVNGKQHEPL SFFFDIMQHH KEGNGKQKLR QTSKASSEPA RRPTEPPKAT EGQSKPRAQT 
ESKAKVVDLM SITEQKREER KVNSNNNNKK QLNHIKDEKS NPTPMEPTSP GEHQQNSKLV 
LAESPQPKGK NKKNKKKKGD RVNNSIDGVS LLLPSLGYNG AILAHCNLRL PGSSDCAASA 
SQVVGITDDV FLPKDIDLDS VDMDETEREV EYFKRFCLDS ARQTRQRLSI NWSNFSLKKA 
TFAAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.