Details for: CDK13

Gene ID: 8621

Symbol: CDK13

Ensembl ID: ENSG00000065883

Description: cyclin dependent kinase 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 532.8675
    Cell Significance Index: -82.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 317.0988
    Cell Significance Index: -80.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 163.6771
    Cell Significance Index: -66.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 152.8621
    Cell Significance Index: -78.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 125.0778
    Cell Significance Index: -83.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 69.7884
    Cell Significance Index: -66.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 67.9262
    Cell Significance Index: -83.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.4827
    Cell Significance Index: -78.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.6584
    Cell Significance Index: -81.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.2973
    Cell Significance Index: -84.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.7988
    Cell Significance Index: -45.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.8123
    Cell Significance Index: 327.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.7822
    Cell Significance Index: 156.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6786
    Cell Significance Index: 537.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.5301
    Cell Significance Index: 49.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.5203
    Cell Significance Index: 193.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5196
    Cell Significance Index: 500.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4908
    Cell Significance Index: 893.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1169
    Cell Significance Index: 59.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9285
    Cell Significance Index: 313.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7150
    Cell Significance Index: 75.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6953
    Cell Significance Index: 23.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6663
    Cell Significance Index: 63.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5692
    Cell Significance Index: 1085.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.5663
    Cell Significance Index: 105.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5430
    Cell Significance Index: 94.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.5289
    Cell Significance Index: 39.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1485
    Cell Significance Index: 74.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0336
    Cell Significance Index: 46.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0021
    Cell Significance Index: 180.6600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9932
    Cell Significance Index: 21.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9116
    Cell Significance Index: 112.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9088
    Cell Significance Index: 21.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8188
    Cell Significance Index: 739.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8141
    Cell Significance Index: 23.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6475
    Cell Significance Index: 38.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4927
    Cell Significance Index: 927.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4426
    Cell Significance Index: 11.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3805
    Cell Significance Index: 168.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3756
    Cell Significance Index: 44.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3530
    Cell Significance Index: 6.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3477
    Cell Significance Index: 220.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3369
    Cell Significance Index: 518.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3075
    Cell Significance Index: 567.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2988
    Cell Significance Index: 135.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2656
    Cell Significance Index: 7.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2356
    Cell Significance Index: 128.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2237
    Cell Significance Index: 30.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1438
    Cell Significance Index: 195.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1417
    Cell Significance Index: 8.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1385
    Cell Significance Index: 26.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1221
    Cell Significance Index: 4.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0169
    Cell Significance Index: -0.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0343
    Cell Significance Index: -1.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0367
    Cell Significance Index: -5.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0428
    Cell Significance Index: -7.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0446
    Cell Significance Index: -32.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0558
    Cell Significance Index: -41.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0795
    Cell Significance Index: -49.6400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0891
    Cell Significance Index: -1.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0959
    Cell Significance Index: -54.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1094
    Cell Significance Index: -82.8400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1557
    Cell Significance Index: -2.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1609
    Cell Significance Index: -16.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1691
    Cell Significance Index: -16.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1714
    Cell Significance Index: -21.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1802
    Cell Significance Index: -8.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2395
    Cell Significance Index: -11.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2397
    Cell Significance Index: -16.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2530
    Cell Significance Index: -72.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2678
    Cell Significance Index: -56.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3092
    Cell Significance Index: -39.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4445
    Cell Significance Index: -46.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4531
    Cell Significance Index: -6.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4624
    Cell Significance Index: -12.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5137
    Cell Significance Index: -58.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5605
    Cell Significance Index: -39.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6031
    Cell Significance Index: -44.9500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6036
    Cell Significance Index: -4.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6065
    Cell Significance Index: -13.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6894
    Cell Significance Index: -78.6900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7002
    Cell Significance Index: -8.6900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.8044
    Cell Significance Index: -7.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8305
    Cell Significance Index: -13.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8503
    Cell Significance Index: -18.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8724
    Cell Significance Index: -10.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8887
    Cell Significance Index: -19.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8914
    Cell Significance Index: -70.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9409
    Cell Significance Index: -25.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0127
    Cell Significance Index: -62.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.0384
    Cell Significance Index: -21.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.0528
    Cell Significance Index: -54.8400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.1728
    Cell Significance Index: -17.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1807
    Cell Significance Index: -61.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.3058
    Cell Significance Index: -31.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.3142
    Cell Significance Index: -7.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.3268
    Cell Significance Index: -28.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3344
    Cell Significance Index: -42.7400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.3521
    Cell Significance Index: -16.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.4028
    Cell Significance Index: -32.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDK13 is a member of the cyclin-dependent kinase (CDK) family, which is a group of serine/threonine kinases that play key roles in cell cycle regulation. CDK13 is unique in its ability to bind to specific cyclins, which regulate its activity and substrate specificity. The gene is characterized by its high expression levels in various cell types, including immune cells, and is involved in the regulation of stem cell differentiation, neutrophil degranulation, and DNA repair. CDK13 is also involved in the regulation of transcriptional elongation and positive regulation of transcription by RNA polymerase II. **Pathways and Functions** CDK13 is involved in several key pathways and functions, including: 1. **Cell Cycle Regulation**: CDK13 regulates the cell cycle by phosphorylating specific substrates, which are involved in the progression of the cell cycle. 2. **Transcriptional Control**: CDK13 regulates transcriptional elongation and positive regulation of transcription by RNA polymerase II, which is essential for the expression of genes involved in immune response and DNA repair. 3. **Immune Response**: CDK13 is involved in the regulation of immune response, including neutrophil degranulation and the regulation of stem cell differentiation. 4. **DNA Repair**: CDK13 is involved in the regulation of DNA repair, including the regulation of transcription of DNA repair genes. 5. **Stem Cell Differentiation**: CDK13 regulates stem cell differentiation, which is essential for the development and maintenance of various tissues and organs. **Clinical Significance** CDK13 has been implicated in several diseases, including: 1. **Cancer**: CDK13 dysregulation has been observed in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumorigenesis and chemotherapy resistance. 2. **Immune System Disorders**: CDK13 has been implicated in immune system disorders, including autoimmune diseases and immunodeficiency diseases, where it regulates immune response and cell differentiation. 3. **Neurological Disorders**: CDK13 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates neuronal function and survival. 4. **Regenerative Medicine**: CDK13 has been identified as a potential target for regenerative medicine, where it regulates stem cell differentiation and tissue repair. In conclusion, CDK13 is a critical regulator of various cellular processes, including cell cycle regulation, transcriptional control, and immune response. Its dysregulation has been implicated in several diseases, including cancer, immune system disorders, and neurological disorders. Further research is needed to fully understand the role of CDK13 in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 854954990

Symbol: CDK13_HUMAN

Name: Cyclin-dependent kinase 13

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11162436

Title: A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE.

PubMed ID: 11162436

DOI: 10.1006/bbrc.2000.4042

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 1731328

Title: Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis.

PubMed ID: 1731328

DOI: 10.1073/pnas.89.2.579

PubMed ID: 11347906

Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11347906

DOI: 10.1093/dnares/8.2.85

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16721827

Title: CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo.

PubMed ID: 16721827

DOI: 10.1002/jcb.20986

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18480452

Title: CDK13, a new potential human immunodeficiency virus type 1 inhibitory factor regulating viral mRNA splicing.

PubMed ID: 18480452

DOI: 10.1128/jvi.02543-07

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20952539

Title: CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.

PubMed ID: 20952539

DOI: 10.1101/gad.1968210

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21835166

Title: Genome-wide evaluation and discovery of vertebrate A-to-I RNA editing sites.

PubMed ID: 21835166

DOI: 10.1016/j.bbrc.2011.07.075

PubMed ID: 22012619

Title: The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

PubMed ID: 22012619

DOI: 10.1101/gad.16962311

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34696162

Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.

PubMed ID: 34696162

DOI: 10.3390/vaccines9101054

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 27479907

Title: Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.

PubMed ID: 27479907

DOI: 10.1038/ng.3627

PubMed ID: 28807008

Title: Phenotypic and molecular characterisation of CDK13-related congenital heart defects, dysmorphic facial features and intellectual developmental disorders.

PubMed ID: 28807008

DOI: 10.1186/s13073-017-0463-8

Sequence Information:

  • Length: 1512
  • Mass: 164923
  • Checksum: 3CA54A3585A2943D
  • Sequence:
  • MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF 
    LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG GRQKRRRGPR AGQEAEKRRV 
    FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGSGGS 
    PASSSGTQRR GEGSERRPRR DRRSSSGRSK ERHREHRRRD GQRGGSEASK SRSRHSHSGE 
    ERAEVAKSGS SSSSGGRRKS ASATSSSSSS RKDRDSKAHR SRTKSSKEPP SAYKEPPKAY 
    REDKTEPKAY RRRRSLSPLG GRDDSPVSHR ASQSLRSRKS PSPAGGGSSP YSRRLPRSPS 
    PYSRRRSPSY SRHSSYERGG DVSPSPYSSS SWRRSRSPYS PVLRRSGKSR SRSPYSSRHS 
    RSRSRHRLSR SRSRHSSISP STLTLKSSLA AELNKNKKAR AAEAARAAEA AKAAEATKAA 
    EAAAKAAKAS NTSTPTKGNT ETSASASQTN HVKDVKKIKI EHAPSPSSGG TLKNDKAKTK 
    PPLQVTKVEN NLIVDKATKK AVIVGKESKS AATKEESVSL KEKTKPLTPS IGAKEKEQHV 
    ALVTSTLPPL PLPPMLPEDK EADSLRGNIS VKAVKKEVEK KLRCLLADLP LPPELPGGDD 
    LSKSPEEKKT ATQLHSKRRP KICGPRYGET KEKDIDWGKR CVDKFDIIGI IGEGTYGQVY 
    KARDKDTGEM VALKKVRLDN EKEGFPITAI REIKILRQLT HQSIINMKEI VTDKEDALDF 
    KKDKGAFYLV FEYMDHDLMG LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC 
    SNILLNNRGQ IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC 
    GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM KPKKQYRRKL 
    REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD VEPSKMPPPD LPLWQDCHEL 
    WSKKRRRQKQ MGMTDDVSTI KAPRKDLSLG LDDSRTNTPQ GVLPSSQLKS QGSSNVAPVK 
    TGPGQHLNHS ELAILLNLLQ SKTSVNMADF VQVLNIKVNS ETQQQLNKIN LPAGILATGE 
    KQTDPSTPQQ ESSKPLGGIQ PSSQTIQPKV ETDAAQAAVQ SAFAVLLTQL IKAQQSKQKD 
    VLLEERENGS GHEASLQLRP PPEPSTPVSG QDDLIQHQDM RILELTPEPD RPRILPPDQR 
    PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA ALLQLLAQHQ PQDDPKREGG 
    IDYQAGDTYV STSDYKDNFG SSSFSSAPYV SNDGLGSSSA PPLERRSFIG NSDIQSLDNY 
    STASSHSGGP PQPSAFSESF PSSVAGYGDI YLNAGPMLFS GDKDHRFEYS HGPIAVLANS 
    SDPSTGPEST HPLPAKMHNY NYGGNLQENP SGPSLMHGQT WTSPAQGPGY SQGYRGHIST 
    STGRGRGRGL PY

Genular Protein ID: 3376425255

Symbol: Q9BVE2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 324
  • Mass: 37339
  • Checksum: 5433011D95D0F2CB
  • Sequence:
  • MLPEDKEADS LRGNISVKAV KKEVEKKLRC LLADLPLPPE LPGGDDLSKS PEEKKTATQL 
    HSKRRPKICG PRYGETKEKD IDWGKRCVDK FDIIGIIGEG TYGQVYKARD KDTGEMVALK 
    KVRLDNEKEG FPITAIREIK ILRQLTHQSI INMKEIVTDK EDALDFKKDK GAFYLVFEYM 
    DHDLMGLLES GLVHFNENHI KSFMRQLMEG LDYCHKKNFL HRDIKCSNIL LNNRGQIKLA 
    DFGLARLYSS EESRPYTNKV ITLWYRPPEL LLGEERYTPA IDVWSCGCIL GELFTKKPIF 
    QANQELAQLE LIRHEENEVS DKQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.