Details for: EIF4EBP3

Gene ID: 8637

Symbol: EIF4EBP3

Ensembl ID: ENSG00000243056

Description: eukaryotic translation initiation factor 4E binding protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 37.6739
    Cell Significance Index: -5.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.7485
    Cell Significance Index: -5.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 13.8806
    Cell Significance Index: -7.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8055
    Cell Significance Index: -5.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 4.1462
    Cell Significance Index: 86.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5396
    Cell Significance Index: 25.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5370
    Cell Significance Index: 35.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.5129
    Cell Significance Index: -5.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8754
    Cell Significance Index: 95.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6819
    Cell Significance Index: 10.5500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.6558
    Cell Significance Index: 4.7100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5675
    Cell Significance Index: 4.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5475
    Cell Significance Index: 6.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4606
    Cell Significance Index: 31.8600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3498
    Cell Significance Index: 1.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3252
    Cell Significance Index: 6.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2770
    Cell Significance Index: 7.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2748
    Cell Significance Index: 49.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2568
    Cell Significance Index: 7.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2229
    Cell Significance Index: 27.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1710
    Cell Significance Index: 7.7500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.1503
    Cell Significance Index: 0.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1388
    Cell Significance Index: 2.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1168
    Cell Significance Index: 19.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1053
    Cell Significance Index: 20.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1011
    Cell Significance Index: 91.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0972
    Cell Significance Index: 2.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0967
    Cell Significance Index: 9.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0737
    Cell Significance Index: 9.4500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0667
    Cell Significance Index: 0.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0475
    Cell Significance Index: 1.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0408
    Cell Significance Index: 8.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0397
    Cell Significance Index: 1.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0375
    Cell Significance Index: 4.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0289
    Cell Significance Index: 3.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0265
    Cell Significance Index: 11.7300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0235
    Cell Significance Index: 0.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0227
    Cell Significance Index: 0.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0213
    Cell Significance Index: 0.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0200
    Cell Significance Index: 0.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0194
    Cell Significance Index: 1.4900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0187
    Cell Significance Index: 0.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0182
    Cell Significance Index: 0.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0160
    Cell Significance Index: 2.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0157
    Cell Significance Index: 0.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0123
    Cell Significance Index: 4.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0099
    Cell Significance Index: 0.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0074
    Cell Significance Index: 0.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0037
    Cell Significance Index: 2.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0037
    Cell Significance Index: 0.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0030
    Cell Significance Index: 0.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0020
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0034
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -6.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0041
    Cell Significance Index: -3.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0075
    Cell Significance Index: -1.0300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0080
    Cell Significance Index: -0.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0088
    Cell Significance Index: -4.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0101
    Cell Significance Index: -0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0102
    Cell Significance Index: -5.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0104
    Cell Significance Index: -6.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0143
    Cell Significance Index: -6.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0163
    Cell Significance Index: -1.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0237
    Cell Significance Index: -6.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0292
    Cell Significance Index: -6.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0316
    Cell Significance Index: -6.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0433
    Cell Significance Index: -1.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0451
    Cell Significance Index: -6.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0470
    Cell Significance Index: -2.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0473
    Cell Significance Index: -2.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0538
    Cell Significance Index: -1.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0677
    Cell Significance Index: -1.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0752
    Cell Significance Index: -4.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0802
    Cell Significance Index: -2.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0803
    Cell Significance Index: -4.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0811
    Cell Significance Index: -5.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0856
    Cell Significance Index: -6.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0943
    Cell Significance Index: -1.3500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0951
    Cell Significance Index: -1.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0963
    Cell Significance Index: -6.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0967
    Cell Significance Index: -6.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0993
    Cell Significance Index: -0.6000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0993
    Cell Significance Index: -0.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1133
    Cell Significance Index: -3.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1189
    Cell Significance Index: -5.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1221
    Cell Significance Index: -6.4100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1223
    Cell Significance Index: -1.6500
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: -0.1243
    Cell Significance Index: -0.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1267
    Cell Significance Index: -3.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1275
    Cell Significance Index: -4.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1362
    Cell Significance Index: -3.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1372
    Cell Significance Index: -4.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1450
    Cell Significance Index: -5.4900
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.1468
    Cell Significance Index: -1.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF4EBP3 is a phosphoprotein that binds to the eukaryotic translation initiation factor 4E (eIF4E), a key player in the initiation of protein synthesis. This binding inhibits the translation of certain mRNAs, including those involved in cell growth, proliferation, and immune responses. EIF4EBP3 is also a transcriptional co-repressor, which regulates the expression of target genes involved in immune cell development and function. **Pathways and Functions:** EIF4EBP3 is involved in several key pathways, including: 1. **Negative regulation of translational initiation**: EIF4EBP3 binds to eIF4E, inhibiting the translation of certain mRNAs, thereby regulating protein synthesis and cell growth. 2. **Eukaryotic translation initiation factor 4f complex**: EIF4EBP3 interacts with the eIF4f complex, which is essential for the recruitment of ribosomes to mRNA. 3. **Protein binding**: EIF4EBP3 interacts with various proteins, including eIF4E, eIF4A, and eIF3, to regulate protein synthesis and translation initiation. 4. **Translation repressor activity**: EIF4EBP3 inhibits the translation of specific mRNAs, including those involved in immune responses and cell growth. **Clinical Significance:** EIF4EBP3 plays a critical role in maintaining immune homeostasis and preventing excessive protein synthesis, which can contribute to various diseases, including: 1. **Cancer**: Dysregulation of EIF4EBP3 has been implicated in cancer development and progression, as it can lead to uncontrolled protein synthesis and cell proliferation. 2. **Autoimmune diseases**: EIF4EBP3 may play a role in the regulation of immune cell function and the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders**: EIF4EBP3 has been implicated in the regulation of synaptic plasticity and the development of neurological disorders, such as Alzheimer's disease and schizophrenia. 4. **Infectious diseases**: EIF4EBP3 may play a role in the regulation of immune responses to infections, including the development of sepsis and severe infections. In conclusion, EIF4EBP3 is a complex protein that plays a critical role in regulating protein synthesis and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2155201230

Symbol: 4EBP3_HUMAN

Name: Eukaryotic translation initiation factor 4E-binding protein 3

UniProtKB Accession Codes:

O60516

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9593750

Title: 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family.

PubMed ID: 9593750

DOI: 10.1074/jbc.273.22.14002

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22684010

Title: 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.

PubMed ID: 22684010

DOI: 10.1016/j.febslet.2012.05.059

Sequence Information:

  • Length: 100
  • Mass: 10873
  • Checksum: FD29A7F3829E546E
  • Sequence:
    • MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN SPIARTPPCC 
LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.