Details for: NUMB
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 413.0631
Cell Significance Index: -64.2500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 249.0899
Cell Significance Index: -63.1800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 164.6326
Cell Significance Index: -67.8200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 145.0471
Cell Significance Index: -68.4800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 143.3083
Cell Significance Index: -58.2200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 127.0837
Cell Significance Index: -65.3700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 102.2470
Cell Significance Index: -68.6100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 61.1474
Cell Significance Index: -58.3800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 53.7164
Cell Significance Index: -66.2300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 23.3530
Cell Significance Index: -51.1100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 23.3084
Cell Significance Index: -62.4400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 21.1056
Cell Significance Index: -64.8300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 16.9081
Cell Significance Index: -66.7200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 3.2623
Cell Significance Index: 46.9200 - Cell Name: preadipocyte (CL0002334)
Fold Change: 3.1301
Cell Significance Index: 61.0900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4487
Cell Significance Index: 485.9500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.4040
Cell Significance Index: 482.2400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.0422
Cell Significance Index: 51.0500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.7735
Cell Significance Index: 99.5200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2030
Cell Significance Index: 92.3200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.1703
Cell Significance Index: 60.9600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1608
Cell Significance Index: 69.6900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1322
Cell Significance Index: 184.1500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.1285
Cell Significance Index: 75.8800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.1084
Cell Significance Index: 766.6400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1035
Cell Significance Index: 395.8000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.0941
Cell Significance Index: 30.5800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.9465
Cell Significance Index: 41.8700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9102
Cell Significance Index: 19.7200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.8940
Cell Significance Index: 1683.2700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.8886
Cell Significance Index: 33.6500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.6384
Cell Significance Index: 11.8000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6030
Cell Significance Index: 108.7100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5762
Cell Significance Index: 70.8500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.5319
Cell Significance Index: 15.1800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5176
Cell Significance Index: 51.2000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4629
Cell Significance Index: 252.7800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.4452
Cell Significance Index: 7.5000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3709
Cell Significance Index: 70.5900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3508
Cell Significance Index: 15.9000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3421
Cell Significance Index: 16.0800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3290
Cell Significance Index: 9.4800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3158
Cell Significance Index: 200.5400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2911
Cell Significance Index: 39.9700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2822
Cell Significance Index: 18.2100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2411
Cell Significance Index: 106.5900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1794
Cell Significance Index: 6.3100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1707
Cell Significance Index: 7.9600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1682
Cell Significance Index: 76.3200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1631
Cell Significance Index: 300.7300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1548
Cell Significance Index: 210.5200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1359
Cell Significance Index: 209.2000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1295
Cell Significance Index: 2.2200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1125
Cell Significance Index: 0.6800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0482
Cell Significance Index: 43.5100 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.0219
Cell Significance Index: 0.3200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0192
Cell Significance Index: 3.2700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0060
Cell Significance Index: 0.7100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0041
Cell Significance Index: 0.1100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0295
Cell Significance Index: -21.8600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0349
Cell Significance Index: -21.7800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0367
Cell Significance Index: -4.7400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0449
Cell Significance Index: -32.9500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0616
Cell Significance Index: -46.6200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0937
Cell Significance Index: -52.8600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1102
Cell Significance Index: -11.2600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1430
Cell Significance Index: -18.3300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2009
Cell Significance Index: -29.2000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2043
Cell Significance Index: -58.7900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2242
Cell Significance Index: -47.2300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2373
Cell Significance Index: -27.6600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2649
Cell Significance Index: -13.9100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2854
Cell Significance Index: -21.2700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2869
Cell Significance Index: -6.1100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2939
Cell Significance Index: -30.6100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3193
Cell Significance Index: -36.5800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3309
Cell Significance Index: -17.1900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3403
Cell Significance Index: -7.2700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.4248
Cell Significance Index: -46.2100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5534
Cell Significance Index: -17.7300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5603
Cell Significance Index: -39.6300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5680
Cell Significance Index: -64.8400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5688
Cell Significance Index: -6.7800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.5703
Cell Significance Index: -9.5400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6362
Cell Significance Index: -8.6800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.6531
Cell Significance Index: -9.6400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.6628
Cell Significance Index: -19.0000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7173
Cell Significance Index: -45.2100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7519
Cell Significance Index: -59.5500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.8659
Cell Significance Index: -23.5700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.9634
Cell Significance Index: -25.8200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.0390
Cell Significance Index: -15.3400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.0403
Cell Significance Index: -34.0600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.0425
Cell Significance Index: -64.0800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.0452
Cell Significance Index: -33.2900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0768
Cell Significance Index: -66.0200 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -1.0795
Cell Significance Index: -10.8900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.1191
Cell Significance Index: -10.3100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.1381
Cell Significance Index: -24.9200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.1479
Cell Significance Index: -39.8900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4054339534
Symbol: NUMB_HUMAN
Name: Protein numb homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9303539
Title: Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.
PubMed ID: 9303539
PubMed ID: 10468633
Title: Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage.
PubMed ID: 10468633
PubMed ID: 21486681
Title: Characterization and role of NUMB in the human extravillous trophopblast.
PubMed ID: 21486681
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7596406
Title: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
PubMed ID: 7596406
DOI: 10.1038/375754a0
PubMed ID: 11752454
Title: Siah-1 binds and regulates the function of Numb.
PubMed ID: 11752454
PubMed ID: 12775724
Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.
PubMed ID: 12775724
PubMed ID: 14670962
Title: A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division.
PubMed ID: 14670962
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18657069
Title: AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis.
PubMed ID: 18657069
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 651
- Mass: 70804
- Checksum: 5B590BE49A74FCF2
- Sequence:
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.