Details for: NUMB

Gene ID: 8650

Symbol: NUMB

Ensembl ID: ENSG00000133961

Description: NUMB endocytic adaptor protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 413.0631
    Cell Significance Index: -64.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 249.0899
    Cell Significance Index: -63.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 164.6326
    Cell Significance Index: -67.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 145.0471
    Cell Significance Index: -68.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 143.3083
    Cell Significance Index: -58.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 127.0837
    Cell Significance Index: -65.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 102.2470
    Cell Significance Index: -68.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.1474
    Cell Significance Index: -58.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.7164
    Cell Significance Index: -66.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.3530
    Cell Significance Index: -51.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.3084
    Cell Significance Index: -62.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.1056
    Cell Significance Index: -64.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.9081
    Cell Significance Index: -66.7200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.2623
    Cell Significance Index: 46.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.1301
    Cell Significance Index: 61.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4487
    Cell Significance Index: 485.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4040
    Cell Significance Index: 482.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.0422
    Cell Significance Index: 51.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7735
    Cell Significance Index: 99.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2030
    Cell Significance Index: 92.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1703
    Cell Significance Index: 60.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1608
    Cell Significance Index: 69.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1322
    Cell Significance Index: 184.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1285
    Cell Significance Index: 75.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1084
    Cell Significance Index: 766.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1035
    Cell Significance Index: 395.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0941
    Cell Significance Index: 30.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9465
    Cell Significance Index: 41.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9102
    Cell Significance Index: 19.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8940
    Cell Significance Index: 1683.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8886
    Cell Significance Index: 33.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6384
    Cell Significance Index: 11.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6030
    Cell Significance Index: 108.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5762
    Cell Significance Index: 70.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5319
    Cell Significance Index: 15.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5176
    Cell Significance Index: 51.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4629
    Cell Significance Index: 252.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4452
    Cell Significance Index: 7.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3709
    Cell Significance Index: 70.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3508
    Cell Significance Index: 15.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3421
    Cell Significance Index: 16.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3290
    Cell Significance Index: 9.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3158
    Cell Significance Index: 200.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2911
    Cell Significance Index: 39.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2822
    Cell Significance Index: 18.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2411
    Cell Significance Index: 106.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1794
    Cell Significance Index: 6.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1707
    Cell Significance Index: 7.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1682
    Cell Significance Index: 76.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1631
    Cell Significance Index: 300.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1548
    Cell Significance Index: 210.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1359
    Cell Significance Index: 209.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1295
    Cell Significance Index: 2.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1125
    Cell Significance Index: 0.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0482
    Cell Significance Index: 43.5100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0219
    Cell Significance Index: 0.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0192
    Cell Significance Index: 3.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0060
    Cell Significance Index: 0.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0041
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0295
    Cell Significance Index: -21.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0349
    Cell Significance Index: -21.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0367
    Cell Significance Index: -4.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0449
    Cell Significance Index: -32.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0616
    Cell Significance Index: -46.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0937
    Cell Significance Index: -52.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1102
    Cell Significance Index: -11.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1430
    Cell Significance Index: -18.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2009
    Cell Significance Index: -29.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2043
    Cell Significance Index: -58.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2242
    Cell Significance Index: -47.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2373
    Cell Significance Index: -27.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2649
    Cell Significance Index: -13.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2854
    Cell Significance Index: -21.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2869
    Cell Significance Index: -6.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2939
    Cell Significance Index: -30.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3193
    Cell Significance Index: -36.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3309
    Cell Significance Index: -17.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3403
    Cell Significance Index: -7.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4248
    Cell Significance Index: -46.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5534
    Cell Significance Index: -17.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5603
    Cell Significance Index: -39.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5680
    Cell Significance Index: -64.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5688
    Cell Significance Index: -6.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5703
    Cell Significance Index: -9.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6362
    Cell Significance Index: -8.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6531
    Cell Significance Index: -9.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6628
    Cell Significance Index: -19.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7173
    Cell Significance Index: -45.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7519
    Cell Significance Index: -59.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8659
    Cell Significance Index: -23.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9634
    Cell Significance Index: -25.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.0390
    Cell Significance Index: -15.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0403
    Cell Significance Index: -34.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0425
    Cell Significance Index: -64.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0452
    Cell Significance Index: -33.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0768
    Cell Significance Index: -66.0200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -1.0795
    Cell Significance Index: -10.8900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1191
    Cell Significance Index: -10.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.1381
    Cell Significance Index: -24.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1479
    Cell Significance Index: -39.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NUMB is a multifunctional protein that exhibits a unique structure, comprising two distinct domains: the N-terminal domain and the C-terminal domain. The N-terminal domain interacts with Notch receptors, while the C-terminal domain interacts with various signaling molecules, including beta-catenin and alpha-catenin. This dual functionality enables NUMB to regulate multiple signaling pathways, including the Notch and Wnt/β-catenin pathways. Furthermore, NUMB has been shown to interact with other proteins, such as L1CAM and alpha-integrin, which are crucial for cell adhesion and migration. **Pathways and Functions:** NUMB's role in various signaling pathways is a hallmark of its multifunctionality. The Notch signaling pathway, which involves NUMB's interaction with Notch receptors, is essential for cell fate determination, cell migration, and differentiation. The Wnt/β-catenin pathway, which NUMB also regulates, plays a crucial role in cell proliferation, differentiation, and survival. Additionally, NUMB has been implicated in the regulation of protein localization to the plasma membrane, cell migration, and neurogenesis. Its interactions with L1CAM and alpha-integrin enable NUMB to modulate cell adhesion and migration, which are critical processes in immune cell function. **Clinical Significance:** NUMB's involvement in various signaling pathways makes it an attractive target for therapeutic interventions in immunological disorders. For instance, NUMB's role in regulating the Notch signaling pathway has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Additionally, NUMB's involvement in neurogenesis and cell migration has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. Furthermore, NUMB's interaction with L1CAM has been shown to play a crucial role in the development of the blood-brain barrier, which is essential for maintaining immune homeostasis in the central nervous system. **Significantly Expressed Cells:** The expression of NUMB in various cell types highlights its broad involvement in immunological processes. Mature microglial cells, astrocytes, and ciliary muscle cells express NUMB, suggesting its role in immune cell function, neuroprotection, and smooth muscle regulation. The expression of NUMB in renal alpha-intercalated cells and vascular leptomeningeal cells further underscores its involvement in renal and vascular homeostasis. **Conclusion:** NUMB, an endocytic adaptor protein, plays a multifaceted role in various cellular processes, including signaling pathways, cell migration, and neurogenesis. Its involvement in immunological disorders, such as autoimmune diseases and neurological disorders, highlights the need for further research into the mechanisms underlying NUMB's functions. As an expert immunologist, it is essential to continue exploring the intricacies of NUMB and its implications in immunology, with the ultimate goal of developing novel therapeutic strategies for immune-related diseases.

Genular Protein ID: 4054339534

Symbol: NUMB_HUMAN

Name: Protein numb homolog

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9303539

Title: Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.

PubMed ID: 9303539

DOI: 10.1101/gad.11.17.2239

PubMed ID: 10468633

Title: Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage.

PubMed ID: 10468633

DOI: 10.1073/pnas.96.18.10472

PubMed ID: 21486681

Title: Characterization and role of NUMB in the human extravillous trophopblast.

PubMed ID: 21486681

DOI: 10.1016/j.placenta.2011.03.008

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7596406

Title: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

PubMed ID: 7596406

DOI: 10.1038/375754a0

PubMed ID: 11752454

Title: Siah-1 binds and regulates the function of Numb.

PubMed ID: 11752454

DOI: 10.1073/pnas.261571998

PubMed ID: 12775724

Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.

PubMed ID: 12775724

DOI: 10.1074/jbc.m302191200

PubMed ID: 14670962

Title: A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division.

PubMed ID: 14670962

DOI: 10.1074/jbc.m311733200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18657069

Title: AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis.

PubMed ID: 18657069

DOI: 10.1111/j.1600-0854.2008.00790.x

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 651
  • Mass: 70804
  • Checksum: 5B590BE49A74FCF2
  • Sequence:
  • MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED 
    AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD 
    RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA 
    TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS 
    SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE 
    LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ 
    SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS 
    SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS 
    PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG 
    TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA 
    DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.