Details for: PDE5A

Gene ID: 8654

Symbol: PDE5A

Ensembl ID: ENSG00000138735

Description: phosphodiesterase 5A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 304.4774
    Cell Significance Index: -47.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 186.6794
    Cell Significance Index: -47.3500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 99.0421
    Cell Significance Index: -46.7600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 96.5414
    Cell Significance Index: -39.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 91.5267
    Cell Significance Index: -47.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 69.9381
    Cell Significance Index: -46.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.0948
    Cell Significance Index: -39.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.4118
    Cell Significance Index: -47.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.0019
    Cell Significance Index: -47.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5685
    Cell Significance Index: -23.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.4187
    Cell Significance Index: 113.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 4.2341
    Cell Significance Index: 72.5600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.9333
    Cell Significance Index: 26.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.5263
    Cell Significance Index: 29.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.2291
    Cell Significance Index: 137.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.1726
    Cell Significance Index: 82.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1495
    Cell Significance Index: 431.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.0840
    Cell Significance Index: 49.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8892
    Cell Significance Index: 106.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.8724
    Cell Significance Index: 82.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6676
    Cell Significance Index: 164.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5899
    Cell Significance Index: 31.0300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.4587
    Cell Significance Index: 31.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3177
    Cell Significance Index: 1189.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3067
    Cell Significance Index: 259.3200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.3064
    Cell Significance Index: 16.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.2622
    Cell Significance Index: 131.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.1163
    Cell Significance Index: 506.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0919
    Cell Significance Index: 73.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0578
    Cell Significance Index: 379.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8351
    Cell Significance Index: 135.8300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8038
    Cell Significance Index: 9.9700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7968
    Cell Significance Index: 11.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7591
    Cell Significance Index: 82.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7494
    Cell Significance Index: 57.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.6497
    Cell Significance Index: 1000.2400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6107
    Cell Significance Index: 8.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6033
    Cell Significance Index: 15.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.5893
    Cell Significance Index: 1086.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5845
    Cell Significance Index: 404.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5108
    Cell Significance Index: 961.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4418
    Cell Significance Index: 26.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4343
    Cell Significance Index: 9.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3504
    Cell Significance Index: 476.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3446
    Cell Significance Index: 15.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3289
    Cell Significance Index: 9.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2936
    Cell Significance Index: 20.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1867
    Cell Significance Index: 21.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1857
    Cell Significance Index: 5.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1686
    Cell Significance Index: 107.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1280
    Cell Significance Index: 16.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1187
    Cell Significance Index: 4.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1144
    Cell Significance Index: 21.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0913
    Cell Significance Index: 2.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0610
    Cell Significance Index: 10.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0532
    Cell Significance Index: 23.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0109
    Cell Significance Index: -1.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0149
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0230
    Cell Significance Index: -17.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0403
    Cell Significance Index: -25.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0492
    Cell Significance Index: -27.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0558
    Cell Significance Index: -40.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0620
    Cell Significance Index: -33.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0678
    Cell Significance Index: -51.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0773
    Cell Significance Index: -10.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0993
    Cell Significance Index: -16.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1051
    Cell Significance Index: -15.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1152
    Cell Significance Index: -14.1700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1191
    Cell Significance Index: -1.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1220
    Cell Significance Index: -35.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1378
    Cell Significance Index: -29.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2694
    Cell Significance Index: -19.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3017
    Cell Significance Index: -30.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3159
    Cell Significance Index: -19.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3258
    Cell Significance Index: -42.0900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3375
    Cell Significance Index: -4.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3691
    Cell Significance Index: -17.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3846
    Cell Significance Index: -43.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4061
    Cell Significance Index: -47.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4474
    Cell Significance Index: -14.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4829
    Cell Significance Index: -22.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4897
    Cell Significance Index: -10.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5496
    Cell Significance Index: -28.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5523
    Cell Significance Index: -43.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5708
    Cell Significance Index: -29.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5840
    Cell Significance Index: -36.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5913
    Cell Significance Index: -44.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5939
    Cell Significance Index: -14.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6460
    Cell Significance Index: -13.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6523
    Cell Significance Index: -9.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6628
    Cell Significance Index: -21.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6659
    Cell Significance Index: -21.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7406
    Cell Significance Index: -38.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7412
    Cell Significance Index: -47.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7559
    Cell Significance Index: -15.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8152
    Cell Significance Index: -16.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8168
    Cell Significance Index: -23.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8771
    Cell Significance Index: -18.3600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9113
    Cell Significance Index: -18.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9123
    Cell Significance Index: -31.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Catalytic activity:** PDE5A is a phosphodiesterase enzyme that hydrolyzes cGMP, thereby regulating its levels and activity in the cell. 2. **cGMP binding:** PDE5A exhibits high affinity for cGMP, allowing it to specifically degrade this second messenger and modulate its downstream signaling pathways. 3. **Cellular localization:** PDE5A is expressed in various cell types, including smooth muscle cells, skeletal muscle fibers, and immune cells, such as T cells and macrophages. 4. **Regulatory mechanisms:** PDE5A is negatively regulated by nitric oxide (NO), which stimulates guanylate cyclase to produce cGMP, thereby activating PDE5A and promoting the breakdown of cGMP. **Pathways and Functions:** 1. **Nitric oxide-mediated signaling:** PDE5A is a key component of the nitric oxide-mediated signaling pathway, which regulates vascular tone, smooth muscle contraction, and immune responses. 2. **Cardiovascular function:** PDE5A plays a crucial role in regulating cardiac muscle contraction, relaxation, and hypertrophy, highlighting its importance in cardiovascular health. 3. **Immune regulation:** PDE5A modulates T cell proliferation and negatively regulates immune responses, suggesting its involvement in immune homeostasis. 4. **Smooth muscle contraction:** PDE5A is essential for regulating smooth muscle contraction, which is critical for maintaining blood pressure and blood flow. **Clinical Significance:** 1. **Cardiovascular diseases:** Abnormalities in PDE5A expression and function have been implicated in various cardiovascular diseases, including hypertension, heart failure, and atherosclerosis. 2. **Impotence and erectile dysfunction:** PDE5A inhibitors, such as sildenafil, have been used to treat erectile dysfunction by increasing cGMP levels and promoting smooth muscle relaxation. 3. **Immune disorders:** Dysregulation of PDE5A has been linked to immune disorders, including autoimmune diseases and cancer. 4. **Cancer therapy:** PDE5A has been identified as a potential target for cancer therapy, as its inhibition can modulate tumor growth and metastasis. In conclusion, PDE5A is a multifunctional enzyme that plays a critical role in regulating various physiological processes, including immune responses, cardiovascular function, and smooth muscle contraction. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1396798320

Symbol: PDE5A_HUMAN

Name: cGMP-binding cGMP-specific phosphodiesterase

UniProtKB Accession Codes:

O76074 A0AV69 A8K2C4 O75026 O75887 Q86UI0 Q86V66 Q9Y6Z6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 18 DrugCentral 1 EC 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 44 PDBsum 44 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9714779

Title: Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.

PubMed ID: 9714779

DOI: 10.1016/s0378-1119(98)00303-5

PubMed ID: 9716380

Title: Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene.

PubMed ID: 9716380

DOI: 10.1046/j.1432-1327.1998.2550391.x

PubMed ID: 9642111

Title: Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase.

PubMed ID: 9642111

DOI: 10.1006/bbrc.1998.8769

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10393044

Title: Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells.

PubMed ID: 10393044

PubMed ID: 11723116

Title: Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells.

PubMed ID: 11723116

DOI: 10.1074/jbc.m106562200

PubMed ID: 25799991

Title: Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.

PubMed ID: 25799991

DOI: 10.1038/nature14332

PubMed ID: 15260978

Title: A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases.

PubMed ID: 15260978

DOI: 10.1016/j.molcel.2004.07.005

PubMed ID: 12955149

Title: Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules.

PubMed ID: 12955149

DOI: 10.1038/nature01914

Sequence Information:

  • Length: 875
  • Mass: 99985
  • Checksum: 9E30C6C182F13388
  • Sequence:
    • MERAGPSFGQ QRQQQQPQQQ KQQQRDQDSV EAWLDDHWDF TFSYFVRKAT REMVNAWFAE 
RVHTIPVCKE GIRGHTESCS CPLQQSPRAD NSAPGTPTRK ISASEFDRPL RPIVVKDSEG 
TVSFLSDSEK KEQMPLTPPR FDHDEGDQCS RLLELVKDIS SHLDVTALCH KIFLHIHGLI 
SADRYSLFLV CEDSSNDKFL ISRLFDVAEG STLEEVSNNC IRLEWNKGIV GHVAALGEPL 
NIKDAYEDPR FNAEVDQITG YKTQSILCMP IKNHREEVVG VAQAINKKSG NGGTFTEKDE 
KDFAAYLAFC GIVLHNAQLY ETSLLENKRN QVLLDLASLI FEEQQSLEVI LKKIAATIIS 
FMQVQKCTIF IVDEDCSDSF SSVFHMECEE LEKSSDTLTR EHDANKINYM YAQYVKNTME 
PLNIPDVSKD KRFPWTTENT GNVNQQCIRS LLCTPIKNGK KNKVIGVCQL VNKMEENTGK 
VKPFNRNDEQ FLEAFVIFCG LGIQNTQMYE AVERAMAKQM VTLEVLSYHA SAAEEETREL 
QSLAAAVVPS AQTLKITDFS FSDFELSDLE TALCTIRMFT DLNLVQNFQM KHEVLCRWIL 
SVKKNYRKNV AYHNWRHAFN TAQCMFAALK AGKIQNKLTD LEILALLIAA LSHDLDHRGV 
NNSYIQRSEH PLAQLYCHSI MEHHHFDQCL MILNSPGNQI LSGLSIEEYK TTLKIIKQAI 
LATDLALYIK RRGEFFELIR KNQFNLEDPH QKELFLAMLM TACDLSAITK PWPIQQRIAE 
LVATEFFDQG DRERKELNIE PTDLMNREKK NKIPSMQVGF IDAICLQLYE ALTHVSEDCF 
PLLDGCRKNR QKWQALAEQQ EKMLINGESG QAKRN

Genular Protein ID: 1295609741

Symbol: G5E9C5_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E9C5

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 7 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 823
  • Mass: 93630
  • Checksum: 4FFF1C345A9CED09
  • Sequence:
    • MVNAWFAERV HTIPVCKEGI RGHTESCSCP LQQSPRADNS APGTPTRKIS ASEFDRPLRP 
IVVKDSEGTV SFLSDSEKKE QMPLTPPRFD HDEGDQCSRL LELVKDISSH LDVTALCHKI 
FLHIHGLISA DRYSLFLVCE DSSNDKFLIS RLFDVAEGST LEEVSNNCIR LEWNKGIVGH 
VAALGEPLNI KDAYEDPRFN AEVDQITGYK TQSILCMPIK NHREEVVGVA QAINKKSGNG 
GTFTEKDEKD FAAYLAFCGI VLHNAQLYET SLLENKRNQV LLDLASLIFE EQQSLEVILK 
KIAATIISFM QVQKCTIFIV DEDCSDSFSS VFHMECEELE KSSDTLTREH DANKINYMYA 
QYVKNTMEPL NIPDVSKDKR FPWTTENTGN VNQQCIRSLL CTPIKNGKKN KVIGVCQLVN 
KMEENTGKVK PFNRNDEQFL EAFVIFCGLG IQNTQMYEAV ERAMAKQMVT LEVLSYHASA 
AEEETRELQS LAAAVVPSAQ TLKITDFSFS DFELSDLETA LCTIRMFTDL NLVQNFQMKH 
EVLCRWILSV KKNYRKNVAY HNWRHAFNTA QCMFAALKAG KIQNKLTDLE ILALLIAALS 
HDLDHRGVNN SYIQRSEHPL AQLYCHSIME HHHFDQCLMI LNSPGNQILS GLSIEEYKTT 
LKIIKQAILA TDLALYIKRR GEFFELIRKN QFNLEDPHQK ELFLAMLMTA CDLSAITKPW 
PIQQRIAELV ATEFFDQGDR ERKELNIEPT DLMNREKKNK IPSMQVGFID AICLQLYEAL 
THVSEDCFPL LDGCRKNRQK WQALAEQQEK MLINGESGQA KRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.