Details for: EIF3J

Gene ID: 8669

Symbol: EIF3J

Ensembl ID: ENSG00000104131

Description: eukaryotic translation initiation factor 3 subunit J

Associated with

  • Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
    (R-HSA-72662)
  • Cap-dependent translation initiation
    (R-HSA-72737)
  • Eukaryotic translation initiation
    (R-HSA-72613)
  • Formation of a pool of free 40s subunits
    (R-HSA-72689)
  • Formation of the ternary complex, and subsequently, the 43s complex
    (R-HSA-72695)
  • Gtp hydrolysis and joining of the 60s ribosomal subunit
    (R-HSA-72706)
  • L13a-mediated translational silencing of ceruloplasmin expression
    (R-HSA-156827)
  • Metabolism of proteins
    (R-HSA-392499)
  • Ribosomal scanning and start codon recognition
    (R-HSA-72702)
  • Translation
    (R-HSA-72766)
  • Translation initiation complex formation
    (R-HSA-72649)
  • Cytosol
    (GO:0005829)
  • Eukaryotic 43s preinitiation complex
    (GO:0016282)
  • Eukaryotic 48s preinitiation complex
    (GO:0033290)
  • Eukaryotic translation initiation factor 3 complex
    (GO:0005852)
  • Formation of cytoplasmic translation initiation complex
    (GO:0001732)
  • Identical protein binding
    (GO:0042802)
  • Protein binding
    (GO:0005515)
  • Translational initiation
    (GO:0006413)
  • Translation initiation factor activity
    (GO:0003743)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 335.7062
    Cell Significance Index: -52.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 222.5960
    Cell Significance Index: -56.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 180.1928
    Cell Significance Index: -74.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 147.5888
    Cell Significance Index: -69.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 143.5052
    Cell Significance Index: -58.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 129.3583
    Cell Significance Index: -66.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.3045
    Cell Significance Index: -58.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.4154
    Cell Significance Index: -62.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.5170
    Cell Significance Index: -60.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.2451
    Cell Significance Index: -68.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.5176
    Cell Significance Index: -44.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.8935
    Cell Significance Index: -26.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1437
    Cell Significance Index: 100.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8367
    Cell Significance Index: 331.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8043
    Cell Significance Index: 221.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7572
    Cell Significance Index: 79.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7254
    Cell Significance Index: 280.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6564
    Cell Significance Index: 214.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6368
    Cell Significance Index: 43.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6353
    Cell Significance Index: 324.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6165
    Cell Significance Index: 44.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3220
    Cell Significance Index: 98.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2874
    Cell Significance Index: 91.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2504
    Cell Significance Index: 58.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1762
    Cell Significance Index: 520.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1514
    Cell Significance Index: 158.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1075
    Cell Significance Index: 604.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0667
    Cell Significance Index: 963.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0107
    Cell Significance Index: 202.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8705
    Cell Significance Index: 148.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8427
    Cell Significance Index: 54.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8037
    Cell Significance Index: 23.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7945
    Cell Significance Index: 41.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5985
    Cell Significance Index: 76.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5000
    Cell Significance Index: 54.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4438
    Cell Significance Index: 159.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3860
    Cell Significance Index: 3.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3636
    Cell Significance Index: 7.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3514
    Cell Significance Index: 9.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3384
    Cell Significance Index: 11.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3002
    Cell Significance Index: 207.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2757
    Cell Significance Index: 32.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2249
    Cell Significance Index: 3.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1888
    Cell Significance Index: 14.4900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1486
    Cell Significance Index: 1.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1459
    Cell Significance Index: 5.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1391
    Cell Significance Index: 1.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1388
    Cell Significance Index: 8.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1219
    Cell Significance Index: 2.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1185
    Cell Significance Index: 11.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0947
    Cell Significance Index: 4.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0908
    Cell Significance Index: 2.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0495
    Cell Significance Index: 9.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0372
    Cell Significance Index: 70.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0178
    Cell Significance Index: 13.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0095
    Cell Significance Index: 6.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0023
    Cell Significance Index: 3.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0017
    Cell Significance Index: 3.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0116
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0211
    Cell Significance Index: -13.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0225
    Cell Significance Index: -30.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0475
    Cell Significance Index: -29.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0678
    Cell Significance Index: -38.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0696
    Cell Significance Index: -1.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0726
    Cell Significance Index: -32.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0963
    Cell Significance Index: -2.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1053
    Cell Significance Index: -10.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1449
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1535
    Cell Significance Index: -32.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1859
    Cell Significance Index: -21.3000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1885
    Cell Significance Index: -1.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1975
    Cell Significance Index: -23.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2011
    Cell Significance Index: -57.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2527
    Cell Significance Index: -36.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2545
    Cell Significance Index: -14.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2792
    Cell Significance Index: -17.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3606
    Cell Significance Index: -4.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3677
    Cell Significance Index: -22.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4668
    Cell Significance Index: -11.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5027
    Cell Significance Index: -57.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5473
    Cell Significance Index: -43.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5551
    Cell Significance Index: -14.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5633
    Cell Significance Index: -15.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5672
    Cell Significance Index: -38.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5913
    Cell Significance Index: -30.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6019
    Cell Significance Index: -62.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6104
    Cell Significance Index: -15.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6909
    Cell Significance Index: -17.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7297
    Cell Significance Index: -50.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8206
    Cell Significance Index: -24.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8338
    Cell Significance Index: -36.8800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.8479
    Cell Significance Index: -6.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9043
    Cell Significance Index: -10.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9443
    Cell Significance Index: -18.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9606
    Cell Significance Index: -30.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0103
    Cell Significance Index: -61.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0270
    Cell Significance Index: -22.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0368
    Cell Significance Index: -39.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.2254
    Cell Significance Index: -28.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF3J is a conserved protein that belongs to the eIF3 complex, which is essential for the initiation of translation in eukaryotic cells. It is composed of multiple subunits, each with distinct functions. EIF3J is specifically involved in the formation of the ternary complex, which is a critical step in the initiation of translation. The protein exhibits identical protein binding properties, allowing it to interact with various factors involved in translation initiation. **Pathways and Functions:** EIF3J is involved in several key pathways, including: 1. **Cap-dependent translation initiation:** EIF3J plays a crucial role in the activation of mRNA upon binding of the cap-binding complex and eIFs. 2. **Formation of the 40S preinitiation complex:** EIF3J is essential for the formation of the 40S ribosomal subunit, which is a critical component of the translation initiation complex. 3. **GTP hydrolysis and joining of the 60S ribosomal subunit:** EIF3J participates in the hydrolysis of GTP and the joining of the 60S ribosomal subunit, which completes the assembly of the translation initiation complex. 4. **Metabolism of proteins:** EIF3J is involved in the regulation of protein synthesis, which is essential for various cellular processes, including growth, differentiation, and survival. **Clinical Significance:** EIF3J has been implicated in various diseases, including: 1. **Ceruloplasmin-related disorders:** EIF3J has been shown to be involved in the translational silencing of ceruloplasmin expression, which is associated with certain genetic disorders. 2. **Protein metabolism disorders:** EIF3J has been linked to disorders related to protein metabolism, such as muscular dystrophy and neurodegenerative diseases. 3. **Cancer:** EIF3J has been implicated in the regulation of protein synthesis in cancer cells, which can contribute to tumor growth and progression. 4. **Infectious diseases:** EIF3J has been shown to play a role in the regulation of protein synthesis in response to infection, which can impact the host's ability to combat pathogens. **Significantly Expressed Cells:** EIF3J is highly expressed in various cell types, including: 1. **Skeletal muscle satellite stem cells** 2. **Basal cells of prostate epithelium** 3. **Acinar cells of salivary gland** 4. **Glandular epithelial cells** 5. **Fibroblasts of mammary gland** 6. **Epithelial cells of esophagus** 7. **Erythroid progenitor cells** 8. **Stratified epithelial cells** 9. **Bladder urothelial cells** 10. **Progenitor cells of mammary luminal epithelium** In conclusion, EIF3J plays a crucial role in the regulation of protein synthesis in eukaryotic cells. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and regulation. Further research is needed to elucidate the mechanisms by which EIF3J influences protein synthesis and its role in disease pathology.

Genular Protein ID: 1111201746

Symbol: EIF3J_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75822 B4DUI3 F5H425 Q9BUD2 Q9H8Q2 Q9UI65

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9822659

Title: Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3.

PubMed ID: 9822659

DOI: 10.1074/jbc.273.48.31901

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14519125

Title: Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3.

PubMed ID: 14519125

DOI: 10.1046/j.1432-1033.2003.03807.x

PubMed ID: 14688252

Title: The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro.

PubMed ID: 14688252

DOI: 10.1074/jbc.m312745200

PubMed ID: 15703437

Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.

PubMed ID: 15703437

DOI: 10.1261/rna.7215305

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16766523

Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

PubMed ID: 16766523

DOI: 10.1074/jbc.m605418200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17190833

Title: Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit.

PubMed ID: 17190833

DOI: 10.1074/jbc.m610860200

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17588516

Title: eIF3j is located in the decoding center of the human 40S ribosomal subunit.

PubMed ID: 17588516

DOI: 10.1016/j.molcel.2007.05.019

PubMed ID: 17322308

Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

PubMed ID: 17322308

DOI: 10.1074/mcp.m600399-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18599441

Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

PubMed ID: 18599441

DOI: 10.1073/pnas.0801313105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25849773

Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

PubMed ID: 25849773

DOI: 10.1038/nature14267

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27462815

Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

PubMed ID: 27462815

DOI: 10.1038/nature18954

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16322461

Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.

PubMed ID: 16322461

DOI: 10.1126/science.1118977

Sequence Information:

  • Length: 258
  • Mass: 29062
  • Checksum: 83624235424445AA
  • Sequence:
    • MAAAAAAAGD SDSWDADAFS VEDPVRKVGG GGTAGGDRWE GEDEDEDVKD NWDDDDDEKK 
EEAEVKPEVK ISEKKKIAEK IKEKERQQKK RQEEIKKRLE EPEEPKVLTP EEQLADKLRL 
KKLQEESDLE LAKETFGVNN AVYGIDAMNP SSRDDFTEFG KLLKDKITQY EKSLYYASFL 
EVLVRDVCIS LEIDDLKKIT NSLTVLCSEK QKQEKQSKAK KKKKGVVPGG GLKATMKDDL 
ADYGGYDGGY VQDYEDFM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.