Details for: VAMP4

Gene ID: 8674

Symbol: VAMP4

Ensembl ID: ENSG00000117533

Description: vesicle associated membrane protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 135.0733
    Cell Significance Index: -21.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.8723
    Cell Significance Index: -21.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.7602
    Cell Significance Index: -25.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.2053
    Cell Significance Index: -19.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.3248
    Cell Significance Index: -22.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.1261
    Cell Significance Index: -20.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.2975
    Cell Significance Index: -22.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2829
    Cell Significance Index: -19.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3846
    Cell Significance Index: -19.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8818
    Cell Significance Index: -23.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0665
    Cell Significance Index: -8.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2477
    Cell Significance Index: 1126.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9189
    Cell Significance Index: 184.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9101
    Cell Significance Index: 26.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7873
    Cell Significance Index: 128.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4247
    Cell Significance Index: 29.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4218
    Cell Significance Index: 151.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3721
    Cell Significance Index: 257.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3613
    Cell Significance Index: 15.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3433
    Cell Significance Index: 13.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2801
    Cell Significance Index: 13.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2379
    Cell Significance Index: 42.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2289
    Cell Significance Index: 45.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2136
    Cell Significance Index: 14.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2129
    Cell Significance Index: 5.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1976
    Cell Significance Index: 4.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1901
    Cell Significance Index: 103.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1842
    Cell Significance Index: 18.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1816
    Cell Significance Index: 22.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1681
    Cell Significance Index: 10.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1641
    Cell Significance Index: 72.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1349
    Cell Significance Index: 207.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1252
    Cell Significance Index: 8.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1076
    Cell Significance Index: 198.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0973
    Cell Significance Index: 13.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0798
    Cell Significance Index: 6.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0769
    Cell Significance Index: 14.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0658
    Cell Significance Index: 8.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0637
    Cell Significance Index: 10.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0587
    Cell Significance Index: 2.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0571
    Cell Significance Index: 3.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0506
    Cell Significance Index: 32.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0454
    Cell Significance Index: 5.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0428
    Cell Significance Index: 80.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0422
    Cell Significance Index: 2.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0365
    Cell Significance Index: 49.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0228
    Cell Significance Index: 10.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0220
    Cell Significance Index: 0.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0149
    Cell Significance Index: 0.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0038
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0095
    Cell Significance Index: -7.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0108
    Cell Significance Index: -1.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0148
    Cell Significance Index: -8.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0173
    Cell Significance Index: -12.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0195
    Cell Significance Index: -14.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0325
    Cell Significance Index: -0.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0340
    Cell Significance Index: -0.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0465
    Cell Significance Index: -1.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0473
    Cell Significance Index: -0.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0499
    Cell Significance Index: -5.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0557
    Cell Significance Index: -11.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0608
    Cell Significance Index: -4.3000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0613
    Cell Significance Index: -0.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0635
    Cell Significance Index: -2.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0673
    Cell Significance Index: -19.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0703
    Cell Significance Index: -8.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0798
    Cell Significance Index: -2.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0878
    Cell Significance Index: -10.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0916
    Cell Significance Index: -1.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0963
    Cell Significance Index: -12.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0977
    Cell Significance Index: -5.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0989
    Cell Significance Index: -7.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1012
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1033
    Cell Significance Index: -11.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1276
    Cell Significance Index: -3.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1510
    Cell Significance Index: -4.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1592
    Cell Significance Index: -8.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1825
    Cell Significance Index: -19.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2030
    Cell Significance Index: -5.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2045
    Cell Significance Index: -2.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2402
    Cell Significance Index: -4.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2496
    Cell Significance Index: -19.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2500
    Cell Significance Index: -6.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2636
    Cell Significance Index: -6.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2851
    Cell Significance Index: -5.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3064
    Cell Significance Index: -18.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3579
    Cell Significance Index: -9.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3650
    Cell Significance Index: -11.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3779
    Cell Significance Index: -7.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3786
    Cell Significance Index: -13.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4008
    Cell Significance Index: -10.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4016
    Cell Significance Index: -3.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4074
    Cell Significance Index: -8.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4198
    Cell Significance Index: -13.3700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4203
    Cell Significance Index: -6.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4306
    Cell Significance Index: -6.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4340
    Cell Significance Index: -11.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4405
    Cell Significance Index: -9.3500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4549
    Cell Significance Index: -6.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** VAMP4 is a small, membrane-associated protein with a molecular weight of approximately 18 kDa. It belongs to the VAMP family, characterized by its ability to form a SNARE complex with other proteins, such as SNAP-25 and syntaxin. 2. **Expression:** VAMP4 is expressed in a wide range of cells, including immune cells (e.g., CD4-positive T cells, CD45RO-positive T cells), neurons (e.g., L2/3-6 intratelencephalic projecting glutamatergic neurons), and epithelial cells (e.g., lens epithelial cells, corneal endothelial cells). 3. **Function:** VAMP4 is involved in various membrane trafficking events, including clathrin-mediated endocytosis, synaptic vesicle endocytosis, and retrograde transport. It facilitates the fusion of vesicles with target membranes, controlling the trafficking of proteins and lipids within cells. **Pathways and Functions:** 1. **Clathrin-mediated endocytosis:** VAMP4 plays a crucial role in regulating clathrin-mediated endocytosis, a process by which cells internalize proteins and lipids from the plasma membrane. 2. **Synaptic vesicle endocytosis:** VAMP4 is involved in the regulation of synaptic vesicle endocytosis, a process that controls the trafficking of neurotransmitters and other signaling molecules within neurons. 3. **Retrograde transport:** VAMP4 facilitates retrograde transport at the trans-Golgi network, a process that regulates the trafficking of proteins and lipids from the Golgi apparatus to the endoplasmic reticulum. 4. **Protein binding:** VAMP4 interacts with various proteins, including SNAP-25, syntaxin, and clathrin, to regulate membrane trafficking events. 5. **Regulation of synaptic vesicle endocytosis:** VAMP4 regulates the fusion of synaptic vesicles with the plasma membrane, controlling the trafficking of neurotransmitters and other signaling molecules within neurons. **Clinical Significance:** Dysregulation of VAMP4 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** Alterations in VAMP4 expression have been linked to neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Immune-mediated disorders:** Dysregulation of VAMP4 has been implicated in immune-mediated disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** VAMP4 has been identified as a potential oncogene, with overexpression associated with cancer progression and metastasis. 4. **Neurodevelopmental disorders:** Alterations in VAMP4 expression have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, VAMP4 plays a crucial role in regulating membrane trafficking events, including clathrin-mediated endocytosis, synaptic vesicle endocytosis, and retrograde transport. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining cellular homeostasis and immune response. Further research is needed to fully elucidate the role of VAMP4 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 616809309

Symbol: VAMP4_HUMAN

Name: Vesicle-associated membrane protein 4

UniProtKB Accession Codes:

O75379 A2IDD8 Q96IY9 Q96J20 Q9UEL7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9553086

Title: Seven novel mammalian SNARE proteins localize to distinct membrane compartments.

PubMed ID: 9553086

DOI: 10.1074/jbc.273.17.10317

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28626000

Title: BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.

PubMed ID: 28626000

DOI: 10.1083/jcb.201702099

Sequence Information:

  • Length: 141
  • Mass: 16397
  • Checksum: 556CC682D26CF91E
  • Sequence:
    • MPPKFKRHLN DDDVTGSVKS ERRNLLEDDS DEEEDFFLRG PSGPRFGPRN DKIKHVQNQV 
DEVIDVMQEN ITKVIERGER LDELQDKSES LSDNATAFSN RSKQLRRQMW WRGCKIKAIM 
ALVAAILLLV IIILIVMKYR T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.