Details for: STX11

Gene ID: 8676

Symbol: STX11

Ensembl ID: ENSG00000135604

Description: syntaxin 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.6050
    Cell Significance Index: -11.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.1528
    Cell Significance Index: -11.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.6302
    Cell Significance Index: -12.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.6835
    Cell Significance Index: -13.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.7115
    Cell Significance Index: -13.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.8544
    Cell Significance Index: -12.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.7796
    Cell Significance Index: 88.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5168
    Cell Significance Index: -12.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.4166
    Cell Significance Index: 60.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.3795
    Cell Significance Index: -10.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1677
    Cell Significance Index: -12.5000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.8459
    Cell Significance Index: 18.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.5893
    Cell Significance Index: 40.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0196
    Cell Significance Index: -4.4200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.4030
    Cell Significance Index: 4.1700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.0401
    Cell Significance Index: 7.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8692
    Cell Significance Index: 45.1500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.8655
    Cell Significance Index: 12.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5691
    Cell Significance Index: 108.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4318
    Cell Significance Index: 32.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4125
    Cell Significance Index: 11.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3966
    Cell Significance Index: 18.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3590
    Cell Significance Index: 21.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3309
    Cell Significance Index: 39.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2829
    Cell Significance Index: 3.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2316
    Cell Significance Index: 29.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2036
    Cell Significance Index: 22.1500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1485
    Cell Significance Index: 1.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1417
    Cell Significance Index: 17.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1128
    Cell Significance Index: 101.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1035
    Cell Significance Index: 3.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0863
    Cell Significance Index: 9.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0794
    Cell Significance Index: 7.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0757
    Cell Significance Index: 12.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0740
    Cell Significance Index: 5.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0435
    Cell Significance Index: 7.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0423
    Cell Significance Index: 3.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0196
    Cell Significance Index: 8.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0176
    Cell Significance Index: 0.3800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0033
    Cell Significance Index: 0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0021
    Cell Significance Index: 1.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0036
    Cell Significance Index: -2.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0065
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0074
    Cell Significance Index: -1.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0081
    Cell Significance Index: -12.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0082
    Cell Significance Index: -0.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0093
    Cell Significance Index: -6.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0105
    Cell Significance Index: -0.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0105
    Cell Significance Index: -5.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0107
    Cell Significance Index: -14.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0108
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0111
    Cell Significance Index: -6.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0148
    Cell Significance Index: -0.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0202
    Cell Significance Index: -12.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0209
    Cell Significance Index: -1.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0219
    Cell Significance Index: -2.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0219
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0242
    Cell Significance Index: -5.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0292
    Cell Significance Index: -13.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0295
    Cell Significance Index: -8.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0340
    Cell Significance Index: -12.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0344
    Cell Significance Index: -0.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0385
    Cell Significance Index: -4.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0387
    Cell Significance Index: -1.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0401
    Cell Significance Index: -7.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0459
    Cell Significance Index: -2.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0539
    Cell Significance Index: -10.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0577
    Cell Significance Index: -1.5400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0627
    Cell Significance Index: -0.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0632
    Cell Significance Index: -9.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0792
    Cell Significance Index: -10.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0871
    Cell Significance Index: -6.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0929
    Cell Significance Index: -10.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1059
    Cell Significance Index: -5.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1066
    Cell Significance Index: -2.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1079
    Cell Significance Index: -6.9600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1125
    Cell Significance Index: -4.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1161
    Cell Significance Index: -12.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1359
    Cell Significance Index: -2.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1410
    Cell Significance Index: -3.9400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1557
    Cell Significance Index: -2.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1630
    Cell Significance Index: -5.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1902
    Cell Significance Index: -11.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1907
    Cell Significance Index: -12.8200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1922
    Cell Significance Index: -2.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2052
    Cell Significance Index: -1.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2244
    Cell Significance Index: -13.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2256
    Cell Significance Index: -8.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2384
    Cell Significance Index: -13.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2530
    Cell Significance Index: -11.8000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2670
    Cell Significance Index: -5.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2779
    Cell Significance Index: -12.2900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2861
    Cell Significance Index: -6.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2873
    Cell Significance Index: -4.3300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2998
    Cell Significance Index: -1.8500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3173
    Cell Significance Index: -1.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3235
    Cell Significance Index: -12.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** STX11 is a small, soluble protein that belongs to the syntaxin family, which is characterized by a conserved SNARE motif (Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor). STX11 is specifically expressed in various cell types, including classical and non-classical monocytes, which are key players in the innate immune response. It is also expressed in vascular lymphangioblasts, skeletal muscle satellite stem cells, and cardiac endothelial cells, highlighting its role in tissue development and maintenance. STX11 is involved in the regulation of membrane fusion and exocytosis, particularly in the context of synaptic vesicle formation and vesicle docking and fusion. **Pathways and Functions** STX11 is involved in several key pathways, including: 1. **Endomembrane system**: STX11 plays a crucial role in the regulation of membrane fusion and exocytosis within the endomembrane system, including the Golgi apparatus and the plasma membrane. 2. **Exocytosis**: STX11 is involved in the regulation of vesicle docking and fusion, which is essential for the release of neurotransmitters and other molecules from synaptic vesicles. 3. **Intracellular protein transport**: STX11 is involved in the regulation of protein transport between the Golgi apparatus and the plasma membrane, which is essential for cell signaling and protein secretion. 4. **Membrane fusion**: STX11 plays a crucial role in the regulation of membrane fusion, particularly in the context of synaptic vesicle formation and vesicle docking and fusion. **Clinical Significance** STX11 has been implicated in several diseases, including: 1. **Immunodeficiency disorders**: Mutations in the STX11 gene have been associated with immunodeficiency disorders, including chronic granulomatous disease (CGD) and X-linked lymphoproliferative disease (XLP). 2. **Neurological disorders**: STX11 has been implicated in the development of neurological disorders, including autism spectrum disorder (ASD) and schizophrenia. 3. **Cancer**: STX11 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer, highlighting its potential role in tumorigenesis. 4. **Infectious diseases**: STX11 has been implicated in the regulation of immune responses to infectious diseases, including tuberculosis and HIV. In conclusion, STX11 is a critical regulator of membrane fusion and exocytosis, and its dysregulation has been implicated in several diseases. Further studies are needed to fully elucidate the role of STX11 in human disease and to develop therapeutic strategies for its manipulation.

Genular Protein ID: 1185859683

Symbol: STX11_HUMAN

Name: Syntaxin-11

UniProtKB Accession Codes:

O75558 E1P598 O75378 O95148 Q5TCL6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 GO 13 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9571206

Title: Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain.

PubMed ID: 9571206

DOI: 10.1006/bbrc.1998.8490

PubMed ID: 9553086

Title: Seven novel mammalian SNARE proteins localize to distinct membrane compartments.

PubMed ID: 9553086

DOI: 10.1074/jbc.273.17.10317

PubMed ID: 10036234

Title: Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network.

PubMed ID: 10036234

DOI: 10.1242/jcs.112.6.845

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15703195

Title: Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11.

PubMed ID: 15703195

DOI: 10.1093/hmg/ddi076

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 287
  • Mass: 33196
  • Checksum: 18E8B43BA987D891
  • Sequence:
    • MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD IQDENQLLVA 
DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI HCKLRAMKEL SEAAEAQHGP 
HSAVARISRA QYNALTLTFQ RAMHDYNQAE MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM 
FEQGKWDVFS ENLLADVKGA RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD 
TLNVIELNVQ KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.