Details for: URI1

Gene ID: 8725

Symbol: URI1

Ensembl ID: ENSG00000105176

Description: URI1 prefoldin like chaperone

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 405.6055
    Cell Significance Index: -63.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 235.4093
    Cell Significance Index: -59.7100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 166.7688
    Cell Significance Index: -68.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 141.7640
    Cell Significance Index: -66.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 132.4038
    Cell Significance Index: -53.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 121.5820
    Cell Significance Index: -62.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 99.8924
    Cell Significance Index: -67.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.8844
    Cell Significance Index: -54.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.3133
    Cell Significance Index: -64.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.1180
    Cell Significance Index: -61.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.0929
    Cell Significance Index: -52.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.5533
    Cell Significance Index: -65.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.0456
    Cell Significance Index: -30.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.4389
    Cell Significance Index: 136.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0951
    Cell Significance Index: 415.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9240
    Cell Significance Index: 26.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9216
    Cell Significance Index: 385.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8530
    Cell Significance Index: 113.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8222
    Cell Significance Index: 328.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6925
    Cell Significance Index: 47.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6864
    Cell Significance Index: 604.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6232
    Cell Significance Index: 199.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5607
    Cell Significance Index: 42.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4698
    Cell Significance Index: 35.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.3094
    Cell Significance Index: 35.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2547
    Cell Significance Index: 33.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2093
    Cell Significance Index: 166.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0501
    Cell Significance Index: 48.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0192
    Cell Significance Index: 704.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9571
    Cell Significance Index: 49.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8689
    Cell Significance Index: 66.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7953
    Cell Significance Index: 434.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7842
    Cell Significance Index: 346.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7016
    Cell Significance Index: 49.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6433
    Cell Significance Index: 29.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5907
    Cell Significance Index: 5.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5192
    Cell Significance Index: 33.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4536
    Cell Significance Index: 21.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4139
    Cell Significance Index: 10.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3343
    Cell Significance Index: 14.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3061
    Cell Significance Index: 11.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3030
    Cell Significance Index: 39.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2402
    Cell Significance Index: 15.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2125
    Cell Significance Index: 134.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2080
    Cell Significance Index: 15.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1724
    Cell Significance Index: 324.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1711
    Cell Significance Index: 3.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1544
    Cell Significance Index: 10.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1515
    Cell Significance Index: 3.5000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1338
    Cell Significance Index: 1.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1165
    Cell Significance Index: 14.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1058
    Cell Significance Index: 162.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0997
    Cell Significance Index: 183.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0979
    Cell Significance Index: 2.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0881
    Cell Significance Index: 40.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0874
    Cell Significance Index: 14.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0743
    Cell Significance Index: 12.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0700
    Cell Significance Index: 1.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0676
    Cell Significance Index: 12.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0351
    Cell Significance Index: 47.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0245
    Cell Significance Index: 22.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0244
    Cell Significance Index: 1.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0142
    Cell Significance Index: 10.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0182
    Cell Significance Index: -1.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0248
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0595
    Cell Significance Index: -44.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0618
    Cell Significance Index: -46.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0919
    Cell Significance Index: -1.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1044
    Cell Significance Index: -58.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1206
    Cell Significance Index: -75.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1422
    Cell Significance Index: -16.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1971
    Cell Significance Index: -56.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2002
    Cell Significance Index: -29.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2076
    Cell Significance Index: -21.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3189
    Cell Significance Index: -37.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3290
    Cell Significance Index: -69.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3507
    Cell Significance Index: -4.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3780
    Cell Significance Index: -9.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3907
    Cell Significance Index: -44.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3909
    Cell Significance Index: -13.7400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4346
    Cell Significance Index: -3.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5216
    Cell Significance Index: -11.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5296
    Cell Significance Index: -55.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5559
    Cell Significance Index: -44.0300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5571
    Cell Significance Index: -8.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5847
    Cell Significance Index: -16.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6871
    Cell Significance Index: -11.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7468
    Cell Significance Index: -12.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7537
    Cell Significance Index: -39.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7803
    Cell Significance Index: -11.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8587
    Cell Significance Index: -22.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9307
    Cell Significance Index: -32.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9335
    Cell Significance Index: -20.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9807
    Cell Significance Index: -20.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0508
    Cell Significance Index: -33.6600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.0654
    Cell Significance Index: -13.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0821
    Cell Significance Index: -30.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0955
    Cell Significance Index: -23.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0971
    Cell Significance Index: -67.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** URI1 is a prefoldin like chaperone, which suggests its involvement in protein folding and stabilization. Its ability to interact with various proteins, including RPB5, highlights its role in regulating cellular processes. URI1's significant expression in different cell types indicates its widespread involvement in maintaining cellular homeostasis. **Pathways and Functions:** URI1 is involved in several cellular pathways, including: 1. **Cellular response to growth factor stimulus**: URI1 regulates the response to growth factors, which is crucial for cellular growth and proliferation. 2. **Cellular response to steroid hormone stimulus**: URI1 interacts with steroid hormones, which play a significant role in regulating gene expression and cellular homeostasis. 3. **Negative regulation of intrinsic apoptotic signaling pathway**: URI1 inhibits the intrinsic apoptotic signaling pathway, which is essential for preventing excessive cell death. 4. **Negative regulation of phosphatase activity**: URI1 regulates phosphatase activity, which is crucial for maintaining cellular homeostasis and preventing aberrant signaling. 5. **Negative regulation of transcription by RNA polymerase II**: URI1 inhibits transcription by RNA polymerase II, which is essential for regulating gene expression and cellular homeostasis. 6. **Phosphatase inhibitor activity**: URI1 inhibits phosphatase activity, which is crucial for maintaining cellular homeostasis and preventing aberrant signaling. 7. **Protein binding**: URI1 interacts with various proteins, including RPB5, which highlights its role in regulating cellular processes. **Clinical Significance:** URI1's involvement in various cellular pathways makes it a potential therapeutic target for various diseases, including: 1. **Cancer**: URI1's role in regulating cell growth and proliferation makes it a potential target for cancer therapy. 2. **Neurological disorders**: URI1's involvement in regulating neuronal function and survival makes it a potential target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular disease**: URI1's role in regulating cardiac function and survival makes it a potential target for cardiovascular disease therapy. In conclusion, URI1 is a crucial gene that plays a significant role in maintaining cellular homeostasis. Its involvement in various cellular pathways makes it a potential therapeutic target for various diseases. Further research is needed to fully understand the role of URI1 in human health and disease.

Genular Protein ID: 2125629863

Symbol: RMP_HUMAN

Name: Unconventional prefoldin RPB5 interactor 1

UniProtKB Accession Codes:

O94763 A8K805 H7BY42 Q8TC23 Q9UNU3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9878255

Title: Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease.

PubMed ID: 9878255

DOI: 10.1006/geno.1998.5609

PubMed ID: 9819440

Title: RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein.

PubMed ID: 9819440

DOI: 10.1128/mcb.18.12.7546

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12737519

Title: Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP).

PubMed ID: 12737519

DOI: 10.1038/sj.cr.7290155

PubMed ID: 14615539

Title: Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.

PubMed ID: 14615539

DOI: 10.1126/science.1088401

PubMed ID: 15367675

Title: Subcellular localization of RPB5-mediating protein and its putative functional partner.

PubMed ID: 15367675

DOI: 10.1128/mcb.24.19.8556-8566.2004

PubMed ID: 17936702

Title: S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.

PubMed ID: 17936702

DOI: 10.1016/j.molcel.2007.08.010

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21397856

Title: URI is an oncogene amplified in ovarian cancer cells and is required for their survival.

PubMed ID: 21397856

DOI: 10.1016/j.ccr.2011.01.019

PubMed ID: 21730289

Title: Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP.

PubMed ID: 21730289

DOI: 10.1128/mcb.05429-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28561026

Title: R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

PubMed ID: 28561026

DOI: 10.1038/ncomms15615

PubMed ID: 31738558

Title: Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.

PubMed ID: 31738558

DOI: 10.1021/acs.jproteome.9b00599

Sequence Information:

  • Length: 535
  • Mass: 59832
  • Checksum: DBB046A392E3C752
  • Sequence:
    • MEAPTVETPP DPSPPSAPAP ALVPLRAPDV ARLREEQEKV VTNCQERIQH WKKVDNDYNA 
LRERLSTLPD KLSYNIMVPF GPFAFMPGKL VHTNEVTVLL GDNWFAKCSA KQAVGLVEHR 
KEHVRKTIDD LKKVMKNFES RVEFTEDLQK MSDAAGDIVD IREEIKCDFE FKAKHRIAHK 
PHSKPKTSDI FEADIANDVK SKDLLADKEL WARLEELERQ EELLGELDSK PDTVIANGED 
TTSSEEEKED RNTNVNAMHQ VTDSHTPCHK DVASSEPFSG QVNSQLNCSV NGSSSYHSDD 
DDDDDDDDDD DNIDDDDGDN DHEALGVGDN SIPTIYFSHT VEPKRVRINT GKNTTLKFSE 
KKEEAKRKRK NSTGSGHSAQ ELPTIRTPAD IYRAFVDVVN GEYVPRKSIL KSRSRENSVC 
SDTSESSAAE FDDRRGVLRS ISCEEATCSD TSESILEEEP QENQKKLLPL SVTPEAFSGT 
VIEKEFVSPS LTPPPAIAHP ALPTIPERKE VLLEASEETG KRVSKFKAAR LQQKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.