Details for: EED

Gene ID: 8726

Symbol: EED

Ensembl ID: ENSG00000074266

Description: embryonic ectoderm development

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 150.8886
    Cell Significance Index: -23.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.6317
    Cell Significance Index: -24.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 67.1445
    Cell Significance Index: -27.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.3837
    Cell Significance Index: -26.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.8329
    Cell Significance Index: -21.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.5349
    Cell Significance Index: -25.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.1790
    Cell Significance Index: -22.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.6982
    Cell Significance Index: -25.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7276
    Cell Significance Index: -23.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.9837
    Cell Significance Index: -21.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5965
    Cell Significance Index: -26.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8022
    Cell Significance Index: -10.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1510
    Cell Significance Index: 1039.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1169
    Cell Significance Index: 130.1600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0144
    Cell Significance Index: 16.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9337
    Cell Significance Index: 187.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9013
    Cell Significance Index: 98.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8907
    Cell Significance Index: 144.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8891
    Cell Significance Index: 12.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7610
    Cell Significance Index: 20.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7389
    Cell Significance Index: 33.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5576
    Cell Significance Index: 31.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5404
    Cell Significance Index: 28.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5379
    Cell Significance Index: 63.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4626
    Cell Significance Index: 91.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4383
    Cell Significance Index: 157.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4107
    Cell Significance Index: 28.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3863
    Cell Significance Index: 56.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3613
    Cell Significance Index: 10.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3387
    Cell Significance Index: 61.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3253
    Cell Significance Index: 40.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3217
    Cell Significance Index: 6.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2279
    Cell Significance Index: 31.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2136
    Cell Significance Index: 5.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2069
    Cell Significance Index: 20.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1937
    Cell Significance Index: 105.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1806
    Cell Significance Index: 11.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1775
    Cell Significance Index: 11.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1672
    Cell Significance Index: 73.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1632
    Cell Significance Index: 4.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1410
    Cell Significance Index: 6.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1387
    Cell Significance Index: 95.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0808
    Cell Significance Index: 2.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0797
    Cell Significance Index: 6.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0678
    Cell Significance Index: 1.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0528
    Cell Significance Index: 2.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0453
    Cell Significance Index: 8.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0255
    Cell Significance Index: 1.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0240
    Cell Significance Index: 45.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0222
    Cell Significance Index: 2.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0202
    Cell Significance Index: 12.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0095
    Cell Significance Index: 17.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0012
    Cell Significance Index: 1.9100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0111
    Cell Significance Index: -0.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0122
    Cell Significance Index: -16.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0124
    Cell Significance Index: -5.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0182
    Cell Significance Index: -13.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0240
    Cell Significance Index: -0.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0254
    Cell Significance Index: -0.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0282
    Cell Significance Index: -21.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0298
    Cell Significance Index: -22.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0379
    Cell Significance Index: -2.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0443
    Cell Significance Index: -2.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0444
    Cell Significance Index: -25.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0472
    Cell Significance Index: -29.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0596
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0619
    Cell Significance Index: -10.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0673
    Cell Significance Index: -2.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0691
    Cell Significance Index: -19.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0778
    Cell Significance Index: -7.9500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0818
    Cell Significance Index: -1.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0827
    Cell Significance Index: -5.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0898
    Cell Significance Index: -11.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1318
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1367
    Cell Significance Index: -28.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1509
    Cell Significance Index: -2.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1568
    Cell Significance Index: -8.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1610
    Cell Significance Index: -18.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1859
    Cell Significance Index: -5.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1906
    Cell Significance Index: -4.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2002
    Cell Significance Index: -3.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2103
    Cell Significance Index: -15.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2173
    Cell Significance Index: -6.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2246
    Cell Significance Index: -23.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2297
    Cell Significance Index: -6.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2466
    Cell Significance Index: -6.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2562
    Cell Significance Index: -5.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2575
    Cell Significance Index: -3.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2750
    Cell Significance Index: -2.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2840
    Cell Significance Index: -22.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2959
    Cell Significance Index: -6.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3054
    Cell Significance Index: -2.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3366
    Cell Significance Index: -7.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3492
    Cell Significance Index: -21.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3700
    Cell Significance Index: -9.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3740
    Cell Significance Index: -8.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4162
    Cell Significance Index: -21.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4176
    Cell Significance Index: -8.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4177
    Cell Significance Index: -13.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **WD40-domain structure**: EED contains a WD40 domain, a conserved protein motif known for its role in protein-protein interactions and chromatin regulation. 2. **Chromatin remodeling**: EED interacts with chromatin-modifying enzymes, such as histone methyltransferases, to regulate chromatin structure and gene expression. 3. **Regulation of gene expression**: EED influences the expression of various genes, including those involved in embryonic development, cell differentiation, and immune responses. 4. **Significant expression in multiple cell types**: EED is expressed in diverse cell types, including germ cells, neurons, and immune cells, highlighting its broad functional significance. **Pathways and Functions** 1. **Activation of anterior hox genes**: EED regulates the expression of anterior hox genes, which are essential for the development of the hindbrain during early embryogenesis. 2. **Cellular responses to stimuli**: EED participates in cellular responses to various stimuli, including stress and oxidative stress, promoting cellular senescence and survival. 3. **Epigenetic regulation**: EED influences epigenetic regulation of gene expression, interacting with chromatin-modifying enzymes to modulate chromatin structure and gene expression. 4. **Immune responses**: EED is expressed in immune cells, such as immature innate lymphoid cells, and may play a role in regulating immune responses and inflammation. **Clinical Significance** 1. **Developmental disorders**: Mutations in the EED gene have been associated with developmental disorders, such as developmental delay and intellectual disability. 2. **Cancer**: Alterations in EED expression have been linked to cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. 3. **Neurological disorders**: EED expression in neurons and glial cells may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immunological disorders**: EED's role in immune cells may influence the development of immunological disorders, such as autoimmune diseases and inflammatory conditions. In conclusion, the EED gene plays a critical role in regulating chromatin structure, gene expression, and cellular processes, influencing development, immune responses, and disease. Further investigation into the functions and clinical significance of EED is necessary to fully understand its importance in human biology and disease.

Genular Protein ID: 3783385209

Symbol: EED_HUMAN

Name: WD protein associating with integrin cytoplasmic tails 1

UniProtKB Accession Codes:

O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 28 DIP 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 11 EMDB 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 68 PDBsum 68 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9806832

Title: The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation.

PubMed ID: 9806832

DOI: 10.1006/geno.1998.5509

PubMed ID: 9584199

Title: Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.

PubMed ID: 9584199

DOI: 10.1128/mcb.18.6.3586

PubMed ID: 9880543

Title: HEED, the product of the human homolog of the murine eed gene, binds to the matrix protein of HIV-1.

PubMed ID: 9880543

DOI: 10.1074/jbc.274.3.1635

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9765275

Title: The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins.

PubMed ID: 9765275

DOI: 10.1074/jbc.273.42.27459

PubMed ID: 10581039

Title: Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation.

PubMed ID: 10581039

DOI: 10.1038/70602

PubMed ID: 11158321

Title: The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos.

PubMed ID: 11158321

DOI: 10.1128/mcb.21.4.1360-1369.2001

PubMed ID: 12435631

Title: Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.

PubMed ID: 12435631

DOI: 10.1101/gad.1035902

PubMed ID: 12101246

Title: Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins.

PubMed ID: 12101246

DOI: 10.1128/mcb.22.15.5539-5553.2002

PubMed ID: 12351676

Title: Role of histone H3 lysine 27 methylation in Polycomb-group silencing.

PubMed ID: 12351676

DOI: 10.1126/science.1076997

PubMed ID: 14532106

Title: EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.

PubMed ID: 14532106

DOI: 10.1093/emboj/cdg542

PubMed ID: 12649488

Title: Role of histone H3 lysine 27 methylation in X inactivation.

PubMed ID: 12649488

DOI: 10.1126/science.1084274

PubMed ID: 15385962

Title: Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.

PubMed ID: 15385962

DOI: 10.1038/sj.emboj.7600402

PubMed ID: 15231737

Title: Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

PubMed ID: 15231737

DOI: 10.1101/gad.1200204

PubMed ID: 15099518

Title: Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3.

PubMed ID: 15099518

DOI: 10.1016/s1097-2765(04)00185-6

PubMed ID: 15225548

Title: SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

PubMed ID: 15225548

DOI: 10.1016/j.molcel.2004.06.020

PubMed ID: 15684044

Title: Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.

PubMed ID: 15684044

DOI: 10.1073/pnas.0409875102

PubMed ID: 16431907

Title: Substrate preferences of the EZH2 histone methyltransferase complex.

PubMed ID: 16431907

DOI: 10.1074/jbc.m513425200

PubMed ID: 16357870

Title: The Polycomb group protein EZH2 directly controls DNA methylation.

PubMed ID: 16357870

DOI: 10.1038/nature04431

PubMed ID: 17200670

Title: Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.

PubMed ID: 17200670

DOI: 10.1038/ng1950

PubMed ID: 19026781

Title: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

PubMed ID: 19026781

DOI: 10.1016/j.molcel.2008.11.004

PubMed ID: 18086877

Title: Role of hPHF1 in H3K27 methylation and Hox gene silencing.

PubMed ID: 18086877

DOI: 10.1128/mcb.01589-07

PubMed ID: 18285464

Title: Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.

PubMed ID: 18285464

DOI: 10.1128/mcb.02017-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22009739

Title: Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.

PubMed ID: 22009739

DOI: 10.1074/jbc.m111.271064

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20974918

Title: Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).

PubMed ID: 20974918

DOI: 10.1073/pnas.1008937107

PubMed ID: 25787343

Title: A novel mutation in EED associated with overgrowth.

PubMed ID: 25787343

DOI: 10.1038/jhg.2015.26

PubMed ID: 27193220

Title: EED-associated overgrowth in a second male patient.

PubMed ID: 27193220

DOI: 10.1038/jhg.2016.51

PubMed ID: 28475857

Title: Mutations in epigenetic regulation genes are a major cause of overgrowth with intellectual disability.

PubMed ID: 28475857

DOI: 10.1016/j.ajhg.2017.03.010

PubMed ID: 27868325

Title: Novel EED mutation in patient with Weaver syndrome.

PubMed ID: 27868325

DOI: 10.1002/ajmg.a.38055

PubMed ID: 28229514

Title: Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome.

PubMed ID: 28229514

DOI: 10.1002/humu.23200

Sequence Information:

  • Length: 441
  • Mass: 50198
  • Checksum: D2E0A5BA27C0499A
  • Sequence:
    • MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP 
NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR 
VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM 
QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL 
SADYDLLGEK IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS 
TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ 
CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK CTTLTHHKCG AAIRQTSFSR 
DSSILIAVCD DASIWRWDRL R

Genular Protein ID: 2314072117

Symbol: E9PJK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PJK2

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 361
  • Mass: 40635
  • Checksum: B8E21C011F16AA49
  • Sequence:
    • MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP 
NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR 
VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM 
QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL 
SASCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ CDIWYMRFSM DFWQKMLALG 
NQVGKLYVWD LEVEDPHKAK CTTLTHHKCG AAIRQTSFSR DSSILIAVCD DASIWRWDRL 
R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.