CTNNAL1 | ENSG00000119326 | NCBI 8727

Details for: CTNNAL1

Gene ID: 8727

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CTNNAL1

Ensembl ID: ENSG00000119326

Description: catenin alpha like 1

Cell Significance Landscape

Display Count:

Associated with

Actin filament binding
(GO:0051015)
Cadherin binding
(GO:0045296)
Cell adhesion
(GO:0007155)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Rho protein signal transduction
(GO:0007266)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

pulmonary artery endothelial cell CL1001568

CSI 34.84

rCSI 47.4%

PRS 77.06
retinal pigment epithelial cell CL0002586

CSI 33.98

rCSI 67.47%

PRS 62.72
keratinocyte CL0000312

CSI 24.06

rCSI 20.17%

PRS 69.62
placental villous trophoblast CL2000060

CSI 17.96

rCSI 27.75%

PRS 64.15
lung secretory cell CL1000272

CSI 16.83

rCSI 41.67%

PRS 64.22
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 14.15

rCSI 34.39%

PRS 45.52
stromal cell of ovary CL0002132

CSI 13.45

rCSI 36.96%

PRS 77.25
enteroglial cell CL4040002

CSI 11.69

rCSI 61.46%

PRS 70.21
near-projecting glutamatergic cortical neuron CL4023012

CSI 10.9

rCSI 41.19%

PRS 47.7
extravillous trophoblast CL0008036

CSI 8.75

rCSI 10.82%

PRS 62.44
L6b glutamatergic cortical neuron CL4023038

CSI 8.44

rCSI 26.39%

PRS 48.77
vein endothelial cell of respiratory system CL4033008

CSI 7.82

rCSI 53.67%

PRS 77.57
myofibroblast cell CL0000186

CSI 6.9

rCSI 9.56%

PRS 65.87
blood vessel endothelial cell CL0000071

CSI 6.68

rCSI 13.86%

PRS 62.77
glandular epithelial cell CL0000150

CSI 6.54

rCSI 17.22%

PRS 82.49
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 6.43

rCSI 10.99%

PRS 82.61
pro-B cell CL0000826

CSI 6.39

rCSI 5.29%

PRS 68.11
astrocyte of the cerebral cortex CL0002605

CSI 5.92

rCSI 13.27%

PRS 47.7
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 5.85

rCSI 34.46%

PRS 48.23
endothelial cell of uterus CL0009095

CSI 5.83

rCSI 42.61%

PRS 80.36
ionocyte CL0005006

CSI 5.77

rCSI 6.19%

PRS 65.6
pulmonary ionocyte CL0017000

CSI 5.49

rCSI 6.68%

PRS 73.12
podocyte CL0000653

CSI 5.48

rCSI 24.33%

PRS 65.6
ciliated epithelial cell CL0000067

CSI 5.45

rCSI 4.79%

PRS 53.62
skin fibroblast CL0002620

CSI 5.34

rCSI 4.6%

PRS 70.32
basal cell of prostate epithelium CL0002341

CSI 5.14

rCSI 14.88%

PRS 76.65
cerebral cortex endothelial cell CL1001602

CSI 4.94

rCSI 8.54%

PRS 55.96
secretory cell CL0000151

CSI 4.92

rCSI 5.14%

PRS 65.9
interstitial cell of Cajal CL0002088

CSI 4.82

rCSI 6.14%

PRS 71.84
glioblast CL0000030

CSI 4.8

rCSI 7.65%

PRS 57.94
intestine goblet cell CL0019031

CSI 4.76

rCSI 4.23%

PRS 63.51
peripheral nervous system neuron CL2000032

CSI 4.53

rCSI 6.17%

PRS 57.13
melanocyte CL0000148

CSI 4.46

rCSI 3.31%

PRS 58.43
basal cell of epidermis CL0002187

CSI 4.35

rCSI 7.72%

PRS 38.5
hepatic stellate cell CL0000632

CSI 4.34

rCSI 16.24%

PRS 57.56
respiratory basal cell CL0002633

CSI 4.18

rCSI 4.33%

PRS 71.42
ependymal cell CL0000065

CSI 4.17

rCSI 8.46%

PRS 44.43
Mueller cell CL0000636

CSI 4.05

rCSI 9.25%

PRS 57.34
promyelocyte CL0000836

CSI 3.91

rCSI 5.64%

PRS 74.44
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 3.9

rCSI 12.01%

PRS 73.28
vein endothelial cell CL0002543

CSI 3.73

rCSI 10.17%

PRS 81.44
duct epithelial cell CL0000068

CSI 3.58

rCSI 5.24%

PRS 70.64
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 3.58

rCSI 16.42%

PRS 75.21
medium spiny neuron CL1001474

CSI 3.52

rCSI 30.29%

PRS 52.82
goblet cell CL0000160

CSI 3.51

rCSI 3.32%

PRS 64.82
pancreatic ductal cell CL0002079

CSI 3.51

rCSI 6.84%

PRS 68.65
Schwann cell CL0002573

CSI 3.47

rCSI 9.87%

PRS 63.35
pancreatic D cell CL0000173

CSI 3.44

rCSI 3.39%

PRS 68.54
pulmonary capillary endothelial cell CL4028001

CSI 3.44

rCSI 6.56%

PRS 79.81
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 3.36

rCSI 4.76%

PRS 62.02
renal alpha-intercalated cell CL0005011

CSI 3.35

rCSI 4.48%

PRS 74.32
retinal blood vessel endothelial cell CL0002585

CSI 3.25

rCSI 5.19%

PRS 69.87
colon epithelial cell CL0011108

CSI 3.24

rCSI 3.39%

PRS 62.14
basal-myoepithelial cell of mammary gland CL0002324

CSI 3.23

rCSI 6.11%

PRS 82.57
granulocyte monocyte progenitor cell CL0000557

CSI 3.21

rCSI 2.78%

PRS 70.69
retinal rod cell CL0000604

CSI 3.19

rCSI 5.63%

PRS 62.3
epithelial cell CL0000066

CSI 3.17

rCSI 4.87%

PRS 59.95
epithelial cell of lung CL0000082

CSI 3.16

rCSI 2.62%

PRS 65.19
fibroblast of lung CL0002553

CSI 3.13

rCSI 2.91%

PRS 66.37
parietal epithelial cell CL1000452

CSI 3.12

rCSI 8.34%

PRS 56.58
interneuron CL0000099

CSI 3.08

rCSI 6.18%

PRS 54.67
pancreatic A cell CL0000171

CSI 3.06

rCSI 3.21%

PRS 69.27
neuroblast (sensu Vertebrata) CL0000031

CSI 3.05

rCSI 3.92%

PRS 62.6
mesodermal cell CL0000222

CSI 3.05

rCSI 3.66%

PRS 63.82
club cell CL0000158

CSI 3.04

rCSI 4.46%

PRS 61.02
primitive red blood cell CL0002355

CSI 2.99

rCSI 16.11%

PRS 76.87
dopaminergic neuron CL0000700

CSI 2.99

rCSI 16.87%

PRS 50.72
radial glial cell CL0000681

CSI 2.96

rCSI 4.11%

PRS 64.21
inhibitory interneuron CL0000498

CSI 2.91

rCSI 6.71%

PRS 54.26
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 2.9

rCSI 3.35%

PRS 58.57
lung neuroendocrine cell CL1000223

CSI 2.9

rCSI 4.29%

PRS 70.97
pvalb GABAergic cortical interneuron CL4023018

CSI 2.89

rCSI 3.6%

PRS 45.19
VIP GABAergic cortical interneuron CL4023016

CSI 2.86

rCSI 3.42%

PRS 46.81
ciliated cell CL0000064

CSI 2.83

rCSI 4.58%

PRS 61.88
erythrocyte CL0000232

CSI 2.83

rCSI 6.41%

PRS 68.83
common myeloid progenitor CL0000049

CSI 2.81

rCSI 2.27%

PRS 67.43
stem cell CL0000034

CSI 2.8

rCSI 2.7%

PRS 56.74
enteroendocrine cell CL0000164

CSI 2.79

rCSI 3.81%

PRS 66.86
neural crest cell CL0011012

CSI 2.72

rCSI 2.15%

PRS 52.56
bronchus fibroblast of lung CL2000093

CSI 2.7

rCSI 2.19%

PRS 65.96
perivascular cell CL4033054

CSI 2.66

rCSI 3.64%

PRS 71.51
lung endothelial cell CL1001567

CSI 2.65

rCSI 6.17%

PRS 82.44
nasal mucosa goblet cell CL0002480

CSI 2.62

rCSI 3.04%

PRS 72.71
endocardial cell CL0002350

CSI 2.6

rCSI 12.46%

PRS 63.71
fallopian tube secretory epithelial cell CL4030006

CSI 2.58

rCSI 2.49%

PRS 65.4
luminal cell of prostate epithelium CL0002340

CSI 2.56

rCSI 13.77%

PRS 76.68
renal principal cell CL0005009

CSI 2.49

rCSI 6.46%

PRS 68.75
epithelial cell of lower respiratory tract CL0002632

CSI 2.45

rCSI 1.9%

PRS 68.4
muscle cell CL0000187

CSI 2.42

rCSI 4.97%

PRS 82.01
kidney connecting tubule epithelial cell CL1000768

CSI 2.36

rCSI 6%

PRS 55.13
adipocyte CL0000136

CSI 2.36

rCSI 3.03%

PRS 57.67
multi-ciliated epithelial cell CL0005012

CSI 2.35

rCSI 2.35%

PRS 59.09
acinar cell CL0000622

CSI 2.33

rCSI 3.42%

PRS 77.05
enteroendocrine cell of small intestine CL0009006

CSI 2.31

rCSI 5.08%

PRS 77.37
enteric smooth muscle cell CL0002504

CSI 2.29

rCSI 3.27%

PRS 67.61
sst GABAergic cortical interneuron CL4023017

CSI 2.29

rCSI 2.95%

PRS 48.31
intrahepatic cholangiocyte CL0002538

CSI 2.28

rCSI 5.48%

PRS 74.55
lung ciliated cell CL1000271

CSI 2.28

rCSI 2.64%

PRS 56.16
transit amplifying cell of colon CL0009011

CSI 2.24

rCSI 2.63%

PRS 67.79
hepatocyte CL0000182

CSI 2.22

rCSI 3.97%

PRS 65.06

direct pathway medium spiny neuron CL4023026

CSI 0.2

rCSI 4.5%

PRS 46.1%
indirect pathway medium spiny neuron CL4023029

CSI 0.2

rCSI 4.9%

PRS 46.9%
epithelial cell of urethra CL1000296

CSI 0.2

rCSI 5.6%

PRS 80.4%
mesenchymal stem cell CL0000134

CSI 0.2

rCSI 2.6%

PRS 76.8%
bronchiolar smooth muscle cell CL4033017

CSI 0.3

rCSI 4.3%

PRS 80.4%
central nervous system neuron CL2000029

CSI 0.5

rCSI 3.3%

PRS 52.2%
regular ventricular cardiac myocyte CL0002131

CSI 0.5

rCSI 3.0%

PRS 57.4%
pluripotent stem cell CL0002248

CSI 0.5

rCSI 16.1%

PRS 83.5%
endothelial cell of placenta CL0009092

CSI 0.5

rCSI 2.7%

PRS 76.5%
H2 horizontal cell CL0004218

CSI 0.5

rCSI 2.7%

PRS 62.4%
erythroblast CL0000765

CSI 0.6

rCSI 1.5%

PRS 76.1%
vasa recta ascending limb cell CL1001131

CSI 0.8

rCSI 3.4%

PRS 80.2%
cardiac blood vessel endothelial cell CL0010006

CSI 0.8

rCSI 5.3%

PRS 57.5%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.8

rCSI 2.4%

PRS 51.2%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.8

rCSI 8.4%

PRS 63.5%
epithelial cell of nephron CL1000449

CSI 0.8

rCSI 7.5%

PRS 92.4%
Hofbauer cell CL3000001

CSI 0.8

rCSI 1.5%

PRS 76.0%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.8

rCSI 2.7%

PRS 52.5%
pancreatic acinar cell CL0002064

CSI 0.9

rCSI 1.1%

PRS 72.0%
mesenchymal cell CL0008019

CSI 0.9

rCSI 2.2%

PRS 59.6%
microcirculation associated smooth muscle cell CL0008035

CSI 0.9

rCSI 2.5%

PRS 66.7%
mammary gland epithelial cell CL0002327

CSI 0.9

rCSI 3.2%

PRS 77.5%
blood vessel smooth muscle cell CL0019018

CSI 0.9

rCSI 7.4%

PRS 59.1%
type EC enteroendocrine cell CL0000577

CSI 1.0

rCSI 3.4%

PRS 73.4%
prostate gland microvascular endothelial cell CL2000059

CSI 1.0

rCSI 23.5%

PRS 81.5%
ON midget ganglion cell CL4033046

CSI 1.0

rCSI 20.3%

PRS 56.2%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 1.0

rCSI 2.4%

PRS 52.8%
sncg GABAergic cortical interneuron CL4023015

CSI 1.0

rCSI 1.6%

PRS 49.0%
melanocyte of skin CL1000458

CSI 1.0

rCSI 1.4%

PRS 35.2%
paneth cell of epithelium of small intestine CL1000343

CSI 1.1

rCSI 3.0%

PRS 75.9%
retinal ganglion cell CL0000740

CSI 1.1

rCSI 2.4%

PRS 51.6%
syncytiotrophoblast cell CL0000525

CSI 1.1

rCSI 3.1%

PRS 77.6%
intestinal crypt stem cell of small intestine CL0009017

CSI 1.1

rCSI 2.9%

PRS 72.4%
GABAergic neuron CL0000617

CSI 1.1

rCSI 3.7%

PRS 50.5%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 1.1

rCSI 4.1%

PRS 45.4%
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 1.3

rCSI 2.7%

PRS 53.3%
tracheobronchial smooth muscle cell CL0019019

CSI 1.3

rCSI 2.2%

PRS 73.7%
keratocyte CL0002363

CSI 1.3

rCSI 3.1%

PRS 72.6%
erythroid progenitor cell CL0000038

CSI 1.3

rCSI 7.4%

PRS 74.3%
cardiac neuron CL0010022

CSI 1.3

rCSI 4.1%

PRS 62.8%
glutamatergic neuron CL0000679

CSI 1.3

rCSI 2.7%

PRS 55.4%
renal interstitial pericyte CL1001318

CSI 1.3

rCSI 3.7%

PRS 60.9%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 1.3

rCSI 3.0%

PRS 61.5%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.3

rCSI 2.7%

PRS 82.2%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.4

rCSI 1.2%

PRS 62.7%
type B pancreatic cell CL0000169

CSI 1.4

rCSI 3.1%

PRS 63.9%
regular atrial cardiac myocyte CL0002129

CSI 1.4

rCSI 4.5%

PRS 63.4%
alveolar adventitial fibroblast CL4028006

CSI 1.4

rCSI 2.2%

PRS 68.2%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.4

rCSI 2.6%

PRS 46.1%
large pre-B-II cell CL0000957

CSI 1.5

rCSI 4.1%

PRS 76.2%
platelet CL0000233

CSI 1.5

rCSI 6.0%

PRS 67.5%
endothelial cell of venule CL1000414

CSI 1.5

rCSI 12.9%

PRS 80.4%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.5

rCSI 3.8%

PRS 60.7%
luminal epithelial cell of mammary gland CL0002326

CSI 1.5

rCSI 2.7%

PRS 79.7%
fraction A pre-pro B cell CL0002045

CSI 1.6

rCSI 1.8%

PRS 82.9%
kidney epithelial cell CL0002518

CSI 1.6

rCSI 3.0%

PRS 84.1%
tendon cell CL0000388

CSI 1.6

rCSI 4.2%

PRS 79.1%
neural progenitor cell CL0011020

CSI 1.6

rCSI 7.2%

PRS 55.6%
brain vascular cell CL4023072

CSI 1.7

rCSI 17.3%

PRS 59.5%
retinal cone cell CL0000573

CSI 1.7

rCSI 2.7%

PRS 55.2%
erythroid lineage cell CL0000764

CSI 1.7

rCSI 10.8%

PRS 81.7%
basal cell CL0000646

CSI 1.7

rCSI 2.3%

PRS 65.8%
megakaryocyte CL0000556

CSI 1.7

rCSI 7.5%

PRS 76.8%
BEST4+ enteroycte CL4030026

CSI 1.8

rCSI 2.2%

PRS 67.4%
small intestine goblet cell CL1000495

CSI 1.8

rCSI 3.9%

PRS 73.2%
adventitial cell CL0002503

CSI 1.8

rCSI 4.2%

PRS 73.6%
cardiac endothelial cell CL0010008

CSI 1.8

rCSI 7.2%

PRS 64.8%
GABAergic amacrine cell CL4030027

CSI 1.8

rCSI 6.2%

PRS 54.1%
cardiac muscle cell CL0000746

CSI 1.8

rCSI 2.6%

PRS 55.2%
suprabasal keratinocyte CL4033013

CSI 1.8

rCSI 3.0%

PRS 34.4%
chondrocyte CL0000138

CSI 1.8

rCSI 2.9%

PRS 58.2%
enterocyte CL0000584

CSI 1.9

rCSI 3.0%

PRS 68.2%
OFF midget ganglion cell CL4033047

CSI 1.9

rCSI 39.0%

PRS 57.6%
glial cell CL0000125

CSI 1.9

rCSI 7.4%

PRS 56.2%
mucous neck cell CL0000651

CSI 1.9

rCSI 2.8%

PRS 75.7%
lamp5 GABAergic cortical interneuron CL4023011

CSI 2.0

rCSI 3.3%

PRS 47.1%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 2.0

rCSI 3.6%

PRS 57.2%
vascular associated smooth muscle cell CL0000359

CSI 2.0

rCSI 6.5%

PRS 65.3%
respiratory hillock cell CL4030023

CSI 2.0

rCSI 3.6%

PRS 78.4%
conjunctival epithelial cell CL1000432

CSI 2.1

rCSI 3.1%

PRS 66.4%
choroid plexus epithelial cell CL0000706

CSI 2.1

rCSI 3.4%

PRS 54.7%
lung microvascular endothelial cell CL2000016

CSI 2.1

rCSI 40.1%

PRS 79.6%
retina horizontal cell CL0000745

CSI 2.1

rCSI 3.2%

PRS 62.0%
myoepithelial cell CL0000185

CSI 2.1

rCSI 5.3%

PRS 73.2%
alveolar type 1 fibroblast cell CL4028004

CSI 2.1

rCSI 2.3%

PRS 69.4%
renal beta-intercalated cell CL0002201

CSI 2.1

rCSI 5.1%

PRS 66.1%
vascular leptomeningeal cell CL4023051

CSI 2.2

rCSI 3.8%

PRS 57.9%
hepatocyte CL0000182

CSI 2.2

rCSI 4.0%

PRS 65.1%
transit amplifying cell of colon CL0009011

CSI 2.2

rCSI 2.6%

PRS 67.8%
lung ciliated cell CL1000271

CSI 2.3

rCSI 2.6%

PRS 56.2%
intrahepatic cholangiocyte CL0002538

CSI 2.3

rCSI 5.5%

PRS 74.6%
sst GABAergic cortical interneuron CL4023017

CSI 2.3

rCSI 3.0%

PRS 48.3%
enteric smooth muscle cell CL0002504

CSI 2.3

rCSI 3.3%

PRS 67.6%
enteroendocrine cell of small intestine CL0009006

CSI 2.3

rCSI 5.1%

PRS 77.4%
acinar cell CL0000622

CSI 2.3

rCSI 3.4%

PRS 77.1%
multi-ciliated epithelial cell CL0005012

CSI 2.4

rCSI 2.4%

PRS 59.1%
adipocyte CL0000136

CSI 2.4

rCSI 3.0%

PRS 57.7%
kidney connecting tubule epithelial cell CL1000768

CSI 2.4

rCSI 6.0%

PRS 55.1%
muscle cell CL0000187

CSI 2.4

rCSI 5.0%

PRS 82.0%
epithelial cell of lower respiratory tract CL0002632

CSI 2.5

rCSI 1.9%

PRS 68.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CTNNAL1](/details-gene/8727), or catenin alpha like 1, encodes the protein alpha-catulin, which is homologous to alpha-catenin ([Link](https://doi.org/10.1006/geno.1998.5458)). Functionally, [CTNNAL1](/details-gene/8727) is implicated in cell adhesion and cytoskeletal organization through its ability to bind actin filaments and cadherins. **Overall**, expression data reveals its highest significance in barrier-forming cells, particularly endothelial and epithelial lineages such as [pulmonary artery endothelial cell](/details-cell/CL1001568) and [retinal pigment epithelial cell](/details-cell/CL0002586). This suggests a primary role in maintaining the structural integrity of tissues by linking cell-cell adhesion complexes to the intracellular actin cytoskeleton. ## Cellular Roles and Expression Landscape The expression profile of [CTNNAL1](/details-gene/8727) highlights its importance in cells that form structural and physiological barriers. **Overall**, it is a highly significant gene in endothelial cells, with top scores in [pulmonary artery endothelial cell](/details-cell/CL1001568) (CSI: 34.84) and also featuring prominently in [vein endothelial cell of respiratory system](/details-cell/CL4033008) and general [blood vessel endothelial cell](/details-cell/CL0000071). This points to a crucial function in maintaining vascular integrity. Similarly, [CTNNAL1](/details-gene/8727) is a key marker in multiple epithelial cell types, including [retinal pigment epithelial cell](/details-cell/CL0002586) (CSI: 33.98) and [keratinocyte](/details-cell/CL0000312) (CSI: 24.06), which are critical for forming protective layers in the eye and skin, respectively. Its significance in trophoblastic cells, such as [placental villous trophoblast](/details-cell/CL2000060) and [extravillous trophoblast](/details-cell/CL0008036), suggests a role in the formation and maintenance of the placental barrier. Beyond these barrier tissues, [CTNNAL1](/details-gene/8727) also shows notable significance in several glutamatergic neuron subtypes, such as [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040), indicating a potential, albeit less dominant, role in neuronal adhesion or cytoskeletal dynamics at the synapse. Its expression in [myofibroblast cell](/details-cell/CL0000186) is consistent with a function in regulating contractile actin structures. ## Pathways and Molecular Function The molecular functions of [CTNNAL1](/details-gene/8727) are centered around its role as a scaffold protein that connects cell adhesion molecules to the cytoskeleton. Gene Ontology annotations confirm its participation in [cell adhesion](/details-cell/GO:0007155), facilitated by its molecular ability for [cadherin binding](/details-cell/GO:0045296) at the [plasma membrane](/details-cell/GO:0005886). Once associated with adhesion complexes, it links them to the intracellular [cytoskeleton](/details-cell/GO:0005856) through its [actin filament binding](/details-cell/GO:0051015) capacity. Furthermore, [CTNNAL1](/details-gene/8727) is involved in [Rho protein signal transduction](/details-cell/GO:0007266), a key pathway regulating cytoskeletal dynamics, cell migration, and proliferation. This is supported by evidence showing that alpha-catulin can associate with the Lbc Rho guanine nucleotide exchange factor, thereby promoting the activation of serum response factor (SRF), a downstream effector of Rho signaling ([Link](https://doi.org/10.1074/jbc.m202447200)). This dual role in both stable adhesion and dynamic signaling suggests [CTNNAL1](/details-gene/8727) is a key integrator of extracellular cues and intracellular responses. ## Research Directions The widespread and high-level expression of [CTNNAL1](/details-gene/8727) in various barrier-forming cells presents several avenues for future research, particularly concerning its role in disease pathogenesis. ### Proposed Hypotheses 1. **Role in Vascular Permeability:** Given its high significance in multiple endothelial cell types and its function in cell adhesion, it is hypothesized that downregulation or dysfunction of [CTNNAL1](/details-gene/8727) is a key event in the loss of vascular barrier integrity during inflammatory conditions such as sepsis or acute respiratory distress syndrome (ARDS). 2. **Function in Epithelial Barrier Pathologies:** The high expression of [CTNNAL1](/details-gene/8727) in [keratinocyte](/details-cell/CL0000312) and [retinal pigment epithelial cell](/details-cell/CL0002586) suggests that mutations or altered expression of this gene could contribute to skin blistering diseases or retinal degenerative disorders characterized by a compromised epithelial barrier. 3. **Involvement in Cancer Cell Invasion:** Through its role in [Rho protein signal transduction](/details-cell/GO:0007266) and cell adhesion, [CTNNAL1](/details-gene/8727) may play a context-dependent role in cancer. It could either suppress metastasis by stabilizing cell-cell adhesion or promote invasion by mediating dynamic cytoskeletal changes, depending on the cellular context and post-translational modifications. ### Experimental Approach To test the hypothesis that [CTNNAL1](/details-gene/8727) is a critical regulator of vascular barrier integrity (Hypothesis 1), a targeted experiment could be performed. CRISPR-Cas9 could be used to knock out [CTNNAL1](/details-gene/8727) in primary human pulmonary artery endothelial cells ([pulmonary artery endothelial cell](/details-cell/CL1001568)). These cells would be grown into a confluent monolayer on a Transwell insert, and barrier function would be quantified by measuring transendothelial electrical resistance (TEER) and the paracellular flux of fluorescently-labeled dextran. The monolayer would then be challenged with an inflammatory stimulus, such as TNF-alpha or LPS, to determine if the loss of [CTNNAL1](/details-gene/8727) exacerbates the breakdown of the endothelial barrier compared to wild-type controls. ### Therapeutic Potential As an intracellular scaffolding protein, [CTNNAL1](/details-gene/8727) is not a conventional drug target. Direct inhibition or activation would be challenging. However, given its role in mediating cell adhesion and Rho signaling, it could be considered a potential target for modulating disease processes involving barrier dysfunction or cell migration. For example, in cancers where its expression is linked to metastasis, developing small molecules that disrupt its specific protein-protein interactions (e.g., its binding to RhoGEFs) could represent a novel therapeutic strategy to inhibit cancer cell invasion. Conversely, in diseases of vascular leakage, strategies aimed at stabilizing [CTNNAL1](/details-gene/8727) function or expression could be explored to enhance barrier integrity.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Alpha-catulin
B3KMX6_HUMAN

Genular Protein ID: 1254336793

Symbol: CTNL1_HUMAN

Name: Alpha-catulin

UniProtKB Accession Codes:

Q9UBT7 B5BU47 O76084 Q53FQ2 Q5JTQ7 Q5JTQ8 Q9Y401

Database IDs:

Citations:

PubMed ID: 9806841

Title: Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin.

PubMed ID: 9806841

DOI: 10.1006/geno.1998.5458

PubMed ID: 10542337

Title: Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing.

PubMed ID: 10542337

DOI: 10.1016/s0167-4781(99)00170-0

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12270917

Title: Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation.

PubMed ID: 12270917

DOI: 10.1074/jbc.m202447200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 734
Mass: 81896
Checksum: 8756237C73AAEA31
Sequence:

MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT LINHKDNTKK 
SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI NIACIEAKQA GETIAALTDI 
TNLNHLESDG QITIFTDKTG VIKAARLLLS SVTKVLLLAD RVVIKQIITS RNKVLATMER 
LEKVNSFQEF VQIFSQFGNE MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT 
ASKTCLRHPN CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK 
MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS TQARMELQQL 
ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST ATQLAADLLK YHADHVVLKA 
LKLTGVEGNL EALAEYACKL SEQKEQLVET CRLLRHISGT EPLEITCIHA EETFQVTGQQ 
IISAAETLTL HPSSKIAKEN LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP 
KPMKNNANLK SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM 
SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD DDKLMLLLEI 
NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL VQLLSLCYKL LKKLQMENNG 
WVSVTNKDTM DSKT

Genular Protein ID: 1018557309

Symbol: B3KMX6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KMX6

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

Length: 734
Mass: 81897
Checksum: 1EC8BA95ED301F94
Sequence:

MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT LINHKDNTKK 
SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI NIACIEAKQA GETIAALTDI 
TNLNHLESDG QITIFTDKTG VIKAARLLLS SVTKVLLLAD RVVIKQIITS RNKVLATMER 
LEKVNSFQEF VQIFSQFGNE MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT 
ASKTCLRHPN CESAHKDKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK 
MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS TQARMELQQL 
ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST ATQLAADLLK YHADHVVLKA 
LKLTGVEGNL EALAEYACKL SEQKEQLVET CRLLRHISGT EPLEITCIHA EETFQVTGQQ 
IISAAETLTL HPSSKIAKEN LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP 
KPMKNNANLK SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM 
SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD DDKLMLLLEI 
NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL VQLLSLCYKL LKKLQMENNG 
WVSVTNKDTM DSKT

Details for: CTNNAL1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. PubMed ID: 9806841

Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing. PubMed ID: 10542337

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. PubMed ID: 12270917

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039