Details for: CTNNAL1

Gene ID: 8727

Symbol: CTNNAL1

Ensembl ID: ENSG00000119326

Description: catenin alpha like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 229.5795
    Cell Significance Index: -35.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 176.7048
    Cell Significance Index: -44.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.5382
    Cell Significance Index: -46.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.3431
    Cell Significance Index: -35.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.5599
    Cell Significance Index: -35.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.2405
    Cell Significance Index: -43.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.3316
    Cell Significance Index: -43.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.7003
    Cell Significance Index: -46.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8093
    Cell Significance Index: -19.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.0619
    Cell Significance Index: 135.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.6622
    Cell Significance Index: 190.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.3017
    Cell Significance Index: 384.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.1063
    Cell Significance Index: 81.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.5426
    Cell Significance Index: 67.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3395
    Cell Significance Index: 63.6800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.0272
    Cell Significance Index: 11.9100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.8865
    Cell Significance Index: 24.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8797
    Cell Significance Index: 305.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8722
    Cell Significance Index: 371.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6525
    Cell Significance Index: 331.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3747
    Cell Significance Index: 77.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2719
    Cell Significance Index: 694.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1605
    Cell Significance Index: 89.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0839
    Cell Significance Index: 31.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9991
    Cell Significance Index: 11.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9737
    Cell Significance Index: 879.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9534
    Cell Significance Index: 103.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8384
    Cell Significance Index: 50.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8054
    Cell Significance Index: 23.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7365
    Cell Significance Index: 101.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6808
    Cell Significance Index: 432.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6054
    Cell Significance Index: 8.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6003
    Cell Significance Index: 215.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5696
    Cell Significance Index: 19.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5423
    Cell Significance Index: 375.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5282
    Cell Significance Index: 233.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4598
    Cell Significance Index: 32.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3569
    Cell Significance Index: 45.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3501
    Cell Significance Index: 15.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3204
    Cell Significance Index: 39.4000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3098
    Cell Significance Index: 5.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2454
    Cell Significance Index: 462.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2390
    Cell Significance Index: 28.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2174
    Cell Significance Index: 3.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2172
    Cell Significance Index: 21.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2168
    Cell Significance Index: 15.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2100
    Cell Significance Index: 387.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2003
    Cell Significance Index: 272.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1780
    Cell Significance Index: 273.9800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1362
    Cell Significance Index: 1.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1079
    Cell Significance Index: 19.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1047
    Cell Significance Index: 17.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0909
    Cell Significance Index: 17.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0899
    Cell Significance Index: 1.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0805
    Cell Significance Index: 36.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0714
    Cell Significance Index: 4.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0709
    Cell Significance Index: 52.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0231
    Cell Significance Index: 0.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0154
    Cell Significance Index: 1.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0059
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0115
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0237
    Cell Significance Index: -14.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0346
    Cell Significance Index: -26.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0371
    Cell Significance Index: -0.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0437
    Cell Significance Index: -5.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0520
    Cell Significance Index: -29.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1126
    Cell Significance Index: -23.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1138
    Cell Significance Index: -13.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1318
    Cell Significance Index: -37.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1403
    Cell Significance Index: -3.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1445
    Cell Significance Index: -8.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1672
    Cell Significance Index: -17.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1862
    Cell Significance Index: -9.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2279
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2287
    Cell Significance Index: -26.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2314
    Cell Significance Index: -10.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2385
    Cell Significance Index: -15.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2527
    Cell Significance Index: -20.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2766
    Cell Significance Index: -8.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3050
    Cell Significance Index: -14.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3221
    Cell Significance Index: -33.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3783
    Cell Significance Index: -8.7400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4026
    Cell Significance Index: -5.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4059
    Cell Significance Index: -25.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4112
    Cell Significance Index: -15.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4117
    Cell Significance Index: -18.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4665
    Cell Significance Index: -11.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4728
    Cell Significance Index: -28.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4821
    Cell Significance Index: -25.3100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5224
    Cell Significance Index: -6.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5242
    Cell Significance Index: -11.1300
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.5452
    Cell Significance Index: -2.7200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5950
    Cell Significance Index: -7.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6438
    Cell Significance Index: -5.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6676
    Cell Significance Index: -13.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7323
    Cell Significance Index: -21.5700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7382
    Cell Significance Index: -4.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7770
    Cell Significance Index: -24.7500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7819
    Cell Significance Index: -8.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CTNNAL1 is a gene that encodes a protein belonging to the catenin family, which is a group of cytoskeletal-associated proteins that play a critical role in maintaining cell-cell adhesion. The CTNNAL1 gene is part of the Wnt signaling pathway, which is a key regulator of cell proliferation, differentiation, and survival. Alpha-catulin, the protein product of CTNNAL1, is a cytoskeletal-associated protein that interacts with beta-catenin, a key component of the Wnt signaling pathway. This interaction regulates the stability and localization of beta-catenin, which in turn modulates gene transcription and cell behavior. **Pathways and Functions:** CTNNAL1 is involved in several key signaling pathways, including: 1. **Wnt signaling pathway**: CTNNAL1 regulates the stability and localization of beta-catenin, which in turn modulates gene transcription and cell behavior. 2. **Cadherin-mediated cell adhesion**: Alpha-catulin interacts with cadherins to regulate cell-cell adhesion and maintain tissue structure. 3. **Cytoskeleton dynamics**: CTNNAL1 regulates the organization and dynamics of the cytoskeleton, which is essential for cell shape, motility, and signaling. 4. **Rho protein signal transduction**: Alpha-catulin interacts with Rho proteins to regulate cell migration, proliferation, and survival. **Clinical Significance:** Dysregulation of CTNNAL1 has been implicated in various diseases, including: 1. **Cancer**: Mutations in CTNNAL1 have been associated with several types of cancer, including colorectal, breast, and ovarian cancer. 2. **Cardiovascular disease**: CTNNAL1 has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 3. **Neurological disorders**: CTNNAL1 has been associated with neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, CTNNAL1 is a complex gene that plays a critical role in maintaining cellular adhesion, structure, and signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of CTNNAL1 and its role in human disease.

Genular Protein ID: 1254336793

Symbol: CTNL1_HUMAN

Name: Alpha-catulin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9806841

Title: Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin.

PubMed ID: 9806841

DOI: 10.1006/geno.1998.5458

PubMed ID: 10542337

Title: Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing.

PubMed ID: 10542337

DOI: 10.1016/s0167-4781(99)00170-0

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12270917

Title: Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation.

PubMed ID: 12270917

DOI: 10.1074/jbc.m202447200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 734
  • Mass: 81896
  • Checksum: 8756237C73AAEA31
  • Sequence:
  • MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT LINHKDNTKK 
    SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI NIACIEAKQA GETIAALTDI 
    TNLNHLESDG QITIFTDKTG VIKAARLLLS SVTKVLLLAD RVVIKQIITS RNKVLATMER 
    LEKVNSFQEF VQIFSQFGNE MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT 
    ASKTCLRHPN CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK 
    MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS TQARMELQQL 
    ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST ATQLAADLLK YHADHVVLKA 
    LKLTGVEGNL EALAEYACKL SEQKEQLVET CRLLRHISGT EPLEITCIHA EETFQVTGQQ 
    IISAAETLTL HPSSKIAKEN LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP 
    KPMKNNANLK SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM 
    SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD DDKLMLLLEI 
    NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL VQLLSLCYKL LKKLQMENNG 
    WVSVTNKDTM DSKT

Genular Protein ID: 1018557309

Symbol: B3KMX6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 734
  • Mass: 81897
  • Checksum: 1EC8BA95ED301F94
  • Sequence:
  • MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT LINHKDNTKK 
    SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI NIACIEAKQA GETIAALTDI 
    TNLNHLESDG QITIFTDKTG VIKAARLLLS SVTKVLLLAD RVVIKQIITS RNKVLATMER 
    LEKVNSFQEF VQIFSQFGNE MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT 
    ASKTCLRHPN CESAHKDKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK 
    MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS TQARMELQQL 
    ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST ATQLAADLLK YHADHVVLKA 
    LKLTGVEGNL EALAEYACKL SEQKEQLVET CRLLRHISGT EPLEITCIHA EETFQVTGQQ 
    IISAAETLTL HPSSKIAKEN LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP 
    KPMKNNANLK SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM 
    SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD DDKLMLLLEI 
    NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL VQLLSLCYKL LKKLQMENNG 
    WVSVTNKDTM DSKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.