Details for: RNGTT

Gene ID: 8732

Symbol: RNGTT

Ensembl ID: ENSG00000111880

Description: RNA guanylyltransferase and 5'-phosphatase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 265.3248
    Cell Significance Index: -41.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 162.5116
    Cell Significance Index: -41.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.8996
    Cell Significance Index: -43.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.7615
    Cell Significance Index: -36.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.8531
    Cell Significance Index: -36.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.3970
    Cell Significance Index: -42.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.3498
    Cell Significance Index: -41.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.6742
    Cell Significance Index: -25.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8184
    Cell Significance Index: -42.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.6011
    Cell Significance Index: 145.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3614
    Cell Significance Index: 468.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2800
    Cell Significance Index: 457.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0009
    Cell Significance Index: 717.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.8730
    Cell Significance Index: 44.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8101
    Cell Significance Index: 344.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6199
    Cell Significance Index: 1120.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6010
    Cell Significance Index: 98.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.4269
    Cell Significance Index: 30.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3910
    Cell Significance Index: 34.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2664
    Cell Significance Index: 47.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2109
    Cell Significance Index: 33.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1797
    Cell Significance Index: 52.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1423
    Cell Significance Index: 76.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0774
    Cell Significance Index: 82.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0417
    Cell Significance Index: 22.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9870
    Cell Significance Index: 25.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9804
    Cell Significance Index: 115.6200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.9556
    Cell Significance Index: 9.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9438
    Cell Significance Index: 852.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8037
    Cell Significance Index: 22.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6943
    Cell Significance Index: 13.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6535
    Cell Significance Index: 8.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6047
    Cell Significance Index: 98.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4932
    Cell Significance Index: 53.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3019
    Cell Significance Index: 29.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2369
    Cell Significance Index: 4.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2192
    Cell Significance Index: 6.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2128
    Cell Significance Index: 400.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1972
    Cell Significance Index: 35.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1664
    Cell Significance Index: 20.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1655
    Cell Significance Index: 105.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1262
    Cell Significance Index: 57.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1186
    Cell Significance Index: 8.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1162
    Cell Significance Index: 178.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1152
    Cell Significance Index: 5.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0917
    Cell Significance Index: 169.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0864
    Cell Significance Index: 47.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0501
    Cell Significance Index: 3.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0404
    Cell Significance Index: 17.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0403
    Cell Significance Index: 0.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0284
    Cell Significance Index: 38.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0143
    Cell Significance Index: 0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0139
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0231
    Cell Significance Index: -14.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0248
    Cell Significance Index: -18.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0306
    Cell Significance Index: -4.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0441
    Cell Significance Index: -32.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0535
    Cell Significance Index: -7.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0549
    Cell Significance Index: -41.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0630
    Cell Significance Index: -35.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0637
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0973
    Cell Significance Index: -16.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1202
    Cell Significance Index: -34.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1329
    Cell Significance Index: -27.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1841
    Cell Significance Index: -21.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2104
    Cell Significance Index: -26.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2183
    Cell Significance Index: -25.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2189
    Cell Significance Index: -22.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2497
    Cell Significance Index: -25.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2534
    Cell Significance Index: -32.7400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2563
    Cell Significance Index: -2.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2654
    Cell Significance Index: -17.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2849
    Cell Significance Index: -14.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2898
    Cell Significance Index: -5.7300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3050
    Cell Significance Index: -4.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3083
    Cell Significance Index: -14.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3758
    Cell Significance Index: -10.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3852
    Cell Significance Index: -27.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3863
    Cell Significance Index: -5.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3913
    Cell Significance Index: -29.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3938
    Cell Significance Index: -44.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4113
    Cell Significance Index: -8.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4119
    Cell Significance Index: -21.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4459
    Cell Significance Index: -14.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4482
    Cell Significance Index: -14.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4640
    Cell Significance Index: -6.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4708
    Cell Significance Index: -21.9500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4772
    Cell Significance Index: -5.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4919
    Cell Significance Index: -38.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5219
    Cell Significance Index: -11.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5373
    Cell Significance Index: -11.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5377
    Cell Significance Index: -28.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5594
    Cell Significance Index: -11.2300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5752
    Cell Significance Index: -7.4600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5795
    Cell Significance Index: -7.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5990
    Cell Significance Index: -10.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6028
    Cell Significance Index: -36.9600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6553
    Cell Significance Index: -15.9900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6687
    Cell Significance Index: -8.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNGTT is a dual-function enzyme that possesses both guanylyltransferase and 5'-phosphatase activities. The guanylyltransferase activity is responsible for the addition of a guanine nucleotide to the 5' end of mRNA, a process essential for mRNA capping and stability. The 5'-phosphatase activity, on the other hand, removes the 5' phosphate group from mRNA, which is necessary for the initiation of translation. RNGTT is also involved in the regulation of gene expression, where it can influence the levels of mRNA and protein production. **Pathways and Functions:** RNGTT is involved in several key pathways, including: 1. **7-methylguanosine mRNA capping:** RNGTT is responsible for the addition of a 7-methylguanosine cap to mRNA, which protects it from degradation and regulates its translation. 2. **ATP binding:** RNGTT interacts with ATP, which is necessary for the guanylyltransferase activity. 3. **Dephosphorylation:** RNGTT possesses 5'-phosphatase activity, which removes the 5' phosphate group from mRNA, initiating translation. 4. **Gene expression (transcription):** RNGTT influences gene expression by regulating the levels of mRNA and protein production. 5. **GTP binding:** RNGTT interacts with GTP, which is necessary for its guanylyltransferase activity. 6. **HIV life cycle:** RNGTT is required for the transcription of the HIV genome, making it a critical target for antiviral therapies. **Clinical Significance:** RNGTT has significant clinical implications, particularly in the context of HIV infection. As a key enzyme in the HIV life cycle, RNGTT is a potential target for antiviral therapies. Additionally, RNGTT's role in regulating gene expression and mRNA processing makes it a promising candidate for the treatment of various diseases, including cancer and neurological disorders. In conclusion, RNGTT is a complex gene that plays a crucial role in RNA processing and the regulation of gene expression. Its involvement in the HIV life cycle and its potential as a therapeutic target make it an important area of research. Further study of RNGTT is necessary to fully understand its mechanisms and to explore its clinical applications. **Significantly expressed cells:** RNGTT is highly expressed in various cell types, including: 1. **GABAergic cortical interneurons:** RNGTT is highly expressed in these cells, which are involved in regulating neural activity. 2. **Purkinje cells:** RNGTT is also expressed in Purkinje cells, which are responsible for motor coordination and balance. 3. **Corneal epithelial cells:** RNGTT is expressed in these cells, which form the outermost layer of the cornea. 4. **Lamp5 GABAergic cortical interneurons:** RNGTT is also expressed in these cells, which are involved in regulating neural activity. 5. **Vip GABAergic cortical interneurons:** RNGTT is expressed in these cells, which are involved in regulating neural activity. 6. **Sst GABAergic cortical interneurons:** RNGTT is also expressed in these cells, which are involved in regulating neural activity. 7. **Caudal ganglionic eminence derived GABAergic cortical interneurons:** RNGTT is expressed in these cells, which are involved in regulating neural activity. 8. **Near-projecting glutamatergic cortical neuron:** RNGTT is expressed in these cells, which are involved in regulating neural activity. 9. **Astrocyte of the cerebral cortex:** RNGTT is expressed in these cells, which are involved in regulating neural activity and supporting neurons. In summary, RNGTT is a complex gene that plays a crucial role in RNA processing and the regulation of gene expression. Its involvement in the HIV life cycle and its potential as a therapeutic target make it an important area of research. Further study of RNGTT is necessary to fully understand its mechanisms and to explore its clinical applications.

Genular Protein ID: 289427441

Symbol: MCE1_HUMAN

Name: mRNA-capping enzyme

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9371772

Title: Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II.

PubMed ID: 9371772

DOI: 10.1073/pnas.94.24.12898

PubMed ID: 9512541

Title: Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme.

PubMed ID: 9512541

DOI: 10.1093/nar/26.7.1700

PubMed ID: 9473487

Title: Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme.

PubMed ID: 9473487

DOI: 10.1006/bbrc.1997.8038

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9705270

Title: Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes.

PubMed ID: 9705270

DOI: 10.1074/jbc.273.34.21443

PubMed ID: 10421630

Title: Transcription elongation factor hSPT5 stimulates mRNA capping.

PubMed ID: 10421630

DOI: 10.1101/gad.13.14.1774

PubMed ID: 11278368

Title: HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA.

PubMed ID: 11278368

DOI: 10.1074/jbc.m007901200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21636784

Title: Structure of the guanylyltransferase domain of human mRNA capping enzyme.

PubMed ID: 21636784

DOI: 10.1073/pnas.1106610108

Sequence Information:

  • Length: 597
  • Mass: 68557
  • Checksum: 51CEEC1B190603DE
  • Sequence:
  • MAHNKIPPRW LNCPRRGQPV AGRFLPLKTM LGPRYDSQVA EENRFHPSML SNYLKSLKVK 
    MGLLVDLTNT SRFYDRNDIE KEGIKYIKLQ CKGHGECPTT ENTETFIRLC ERFNERNPPE 
    LIGVHCTHGF NRTGFLICAF LVEKMDWSIE AAVATFAQAR PPGIYKGDYL KELFRRYGDI 
    EEAPPPPLLP DWCFEDDEDE DEDEDGKKES EPGSSASFGK RRKERLKLGA IFLEGVTVKG 
    VTQVTTQPKL GEVQQKCHQF CGWEGSGFPG AQPVSMDKQN IKLLDLKPYK VSWKADGTRY 
    MMLIDGTNEV FMIDRDNSVF HVSNLEFPFR KDLRMHLSNT LLDGEMIIDR VNGQAVPRYL 
    IYDIIKFNSQ PVGDCDFNVR LQCIEREIIS PRHEKMKTGL IDKTQEPFSV RNKPFFDICT 
    SRKLLEGNFA KEVSHEMDGL IFQPTGKYKP GRCDDILKWK PPSLNSVDFR LKITRMGGEG 
    LLPQNVGLLY VGGYERPFAQ IKVTKELKQY DNKIIECKFE NNSWVFMRQR TDKSFPNAYN 
    TAMAVCNSIS NPVTKEMLFE FIDRCTAASQ GQKRKHHLDP DTELMPPPPP KRPRPLT

Genular Protein ID: 3833194659

Symbol: Q7Z3R6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 84
  • Mass: 9831
  • Checksum: B95D7143094A6874
  • Sequence:
  • VTKELKQYDN KIIECKFENN SWVFMRQRTD KSFPNAYNTA MAVCNSISNP VTKEMLFEFI 
    DRCTAASQGQ KRKHHLDPDT ELMP

Genular Protein ID: 1419018888

Symbol: B4DSJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 514
  • Mass: 59084
  • Checksum: 0A8320011E1B96FF
  • Sequence:
  • MGLLVDLTNT SRFYDRNDIE KEGIKYIKLQ CKGHGECPTT ENTETFIRLC ERFNERNPPE 
    LIGVHCTHGF NRTGFLICAF LVEKMDWSIE AAVATFAQAR PPGIYKGDYL KELFRRYGDI 
    EEAPPPPLLP DWCFEDDEDE DEDEDGKKES EPGSSASFGK RRKERLKLGA IFLEGVTVKG 
    VTQVTTQPKL GEVQQKCHQF CGWEGSGFPG AQPVSMDKQN IKLLDLKPYK VSWKADGTRY 
    MMLIDGTNEV FMIDRDNSVF HVSNLEFPFR KDLRMHLSNT LLDGEMIIDR VNGQAVPRYL 
    IYDIIKFNSQ PVGDCDFNVR LQCIEREIIS PRHEKMKTGL IDKTQEPFSV RNKPFFDICT 
    SRKKYKPGRC DDILKWKPPS LNSVDFRLKI TRMGGEGLLP QNVGLLYVGG YERPFAQIKV 
    TKELKQYDNK IIECKFENNS WVFMRQRTDK SFPNAYNTAM AVCNSISNPV TKEMLFEFID 
    RCTAASQGQK RKHHLDPDTE LMPPPPPKRP RPLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.