Details for: CD164

Gene ID: 8763

Symbol: CD164

Ensembl ID: ENSG00000135535

Description: CD164 molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.91
    Marker Score: 3,933
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.71
    Marker Score: 2,905
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.01
    Marker Score: 8,313
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.76
    Marker Score: 693
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.73
    Marker Score: 7,980
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.73
    Marker Score: 8,579
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.68
    Marker Score: 23,288
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.66
    Marker Score: 1,151
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.66
    Marker Score: 16,973
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.65
    Marker Score: 10,223
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.62
    Marker Score: 2,999
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.62
    Marker Score: 2,512
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.62
    Marker Score: 67,010
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.61
    Marker Score: 6,579
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6
    Marker Score: 88,546
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.53
    Marker Score: 2,527
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.47
    Marker Score: 1,204
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.44
    Marker Score: 5,559
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.43
    Marker Score: 11,640
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.41
    Marker Score: 83,568
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.4
    Marker Score: 2,559
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.39
    Marker Score: 27,774
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.39
    Marker Score: 1,880
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.35
    Marker Score: 810
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.34
    Marker Score: 130,978
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.32
    Marker Score: 10,009
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.31
    Marker Score: 3,274
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.3
    Marker Score: 4,067
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.29
    Marker Score: 547
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.28
    Marker Score: 7,835
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.27
    Marker Score: 980
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.25
    Marker Score: 3,733
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.25
    Marker Score: 7,977
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.22
    Marker Score: 3,263
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.21
    Marker Score: 21,906
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.2
    Marker Score: 1,470
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.2
    Marker Score: 4,129
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.19
    Marker Score: 1,278
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.19
    Marker Score: 1,494
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.19
    Marker Score: 1,571
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.18
    Marker Score: 1,035
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.17
    Marker Score: 1,236
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.16
    Marker Score: 5,796
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.15
    Marker Score: 1,149
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.13
    Marker Score: 1,540
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.12
    Marker Score: 672
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.12
    Marker Score: 8,333
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.12
    Marker Score: 5,174
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.11
    Marker Score: 4,787
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.11
    Marker Score: 4,404
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.11
    Marker Score: 21,366
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 2.1
    Marker Score: 588
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.1
    Marker Score: 3,234
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.1
    Marker Score: 13,661
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.09
    Marker Score: 779
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.07
    Marker Score: 6,526
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.07
    Marker Score: 844
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.07
    Marker Score: 1,843
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.06
    Marker Score: 1,137
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.06
    Marker Score: 2,909
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.05
    Marker Score: 2,075
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.04
    Marker Score: 712
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.04
    Marker Score: 1,277
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.03
    Marker Score: 17,531
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.03
    Marker Score: 1,052
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.03
    Marker Score: 809
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.01
    Marker Score: 441
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.01
    Marker Score: 2,129
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.01
    Marker Score: 533
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.01
    Marker Score: 5,008
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.01
    Marker Score: 755
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2
    Marker Score: 494
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2
    Marker Score: 12,144
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.99
    Marker Score: 728
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.99
    Marker Score: 12,736
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.99
    Marker Score: 2,857
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.98
    Marker Score: 573
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.98
    Marker Score: 4,709
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.98
    Marker Score: 3,618
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.98
    Marker Score: 3,763
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.98
    Marker Score: 890
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.97
    Marker Score: 1,307
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.96
    Marker Score: 916
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.96
    Marker Score: 516
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.95
    Marker Score: 553
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.95
    Marker Score: 481
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.94
    Marker Score: 1,415
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.93
    Marker Score: 1,869
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.93
    Marker Score: 4,546
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.93
    Marker Score: 3,515
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.93
    Marker Score: 2,969
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.92
    Marker Score: 3,748
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.92
    Marker Score: 2,249
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.92
    Marker Score: 2,087
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.92
    Marker Score: 2,366
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.92
    Marker Score: 3,141
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.91
    Marker Score: 438
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.91
    Marker Score: 2,025
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.91
    Marker Score: 799
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.9
    Marker Score: 3,317

Other Information

**Key Characteristics:** CD164 is a member of the sialomucin family, characterized by its high expression in epithelial and immune cells. It is highly conserved across species, suggesting its fundamental importance in maintaining tissue homeostasis. The CD164 protein is a glycoprotein that interacts with various cell surface molecules, influencing cell adhesion, migration, and differentiation. **Pathways and Functions:** CD164 is involved in multiple signaling pathways, including: 1. **Cell adhesion:** CD164 interacts with cell surface molecules, such as integrins and selectins, to regulate cell adhesion and migration. 2. **Immune response:** CD164 is expressed on immune cells, including natural killer cells and dendritic cells, and plays a role in regulating immune responses, including cytokine production and antigen presentation. 3. **Endosomal trafficking:** CD164 is involved in regulating endosomal trafficking, influencing the sorting and degradation of endosomal proteins. 4. **Signaling transduction:** CD164 interacts with signaling molecules, such as tyrosine kinases and G-proteins, to regulate cellular responses to external stimuli. **Clinical Significance:** CD164 dysregulation has been implicated in various diseases, including: 1. **Cancer:** CD164 expression is altered in various types of cancer, including colorectal, breast, and lung cancer, suggesting its potential role as a biomarker or therapeutic target. 2. **Autoimmune disorders:** CD164 expression is altered in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, highlighting its potential role in regulating immune responses. 3. **Infectious diseases:** CD164 expression is altered in response to infection, suggesting its potential role in regulating immune responses to pathogens. **Conclusion:** In conclusion, CD164 is a multifaceted gene that plays a crucial role in regulating immune responses, cell adhesion, and development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications. As an expert immunologist, I emphasize the importance of continued investigation into the complexities of CD164, with the ultimate goal of harnessing its potential to improve human health. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms of CD164 signaling and its interactions with other cellular components. 2. The development of CD164-based biomarkers and therapeutic strategies should be pursued to explore its potential in cancer, autoimmune, and infectious diseases. 3. The role of CD164 in tissue development and homeostasis should be further investigated to understand its broader biological significance. By continuing to unravel the mysteries of CD164, we may uncover new avenues for therapeutic intervention and improve our understanding of the intricate relationships between immune responses, cell adhesion, and development.

Genular Protein ID: 1748168175

Symbol: MUC24_HUMAN

Name: Sialomucin core protein 24

UniProtKB Accession Codes:

Q04900 B4DQ85 E1P5E7 E1P5E8 E1P5E9 O95413 Q5JSU6 Q9BPV0 Q9NR26

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 Ensembl 5 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 6 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1478919

Title: A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression.

PubMed ID: 1478919

DOI: 10.1093/oxfordjournals.jbchem.a123948

PubMed ID: 9763543

Title: The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis.

PubMed ID: 9763543

PubMed ID: 10878358

Title: CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor.

PubMed ID: 10878358

DOI: 10.4049/jimmunol.165.2.840

PubMed ID: 11027692

Title: Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn.

PubMed ID: 11027692

DOI: 10.1074/jbc.m007965200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16859559

Title: The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis.

PubMed ID: 16859559

DOI: 10.1186/1471-2407-6-195

PubMed ID: 17077324

Title: Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells.

PubMed ID: 17077324

DOI: 10.1182/blood-2006-05-023028

PubMed ID: 26197441

Title: A novel locus harbouring a functional CD164 nonsense mutation identified in a large Danish family with nonsyndromic hearing impairment.

PubMed ID: 26197441

DOI: 10.1371/journal.pgen.1005386

Sequence Information:

  • Length: 197
  • Mass: 20917
  • Checksum: 4855E02646F4CB35
  • Sequence:
    • MSRLSRSLLW AATCLGVLCV LSADKNTTQH PNVTTLAPIS NVTSAPVTSL PLVTTPAPET 
CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC QVGNTTDFCS VSTATPVPTA 
NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT PTSQPVRKST FDAASFIGGI VLVLGVQAVI 
FFLYKFCKSK ERNYHTL

Genular Protein ID: 3900125154

Symbol: D6R9B4_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6R9B4

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMR 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 163
  • Mass: 17718
  • Checksum: 113613FE35339C5C
  • Sequence:
    • MRKGRKVPMY VPGVLRTYPK AKLEETCEGR NSCVSCFNVS VVNTTCFWIE CKDESYCSHN 
STVSDCQVGN TTDFCSVSTA TPVPTANSTA KPTVQPSPST TSKTVTTSGT TNNTVTPTSQ 
PVRKSTFDAA SFIGGIVLVL GVQAVIFFLY KFCKSKERNY HTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.