Details for: CD164

Gene ID: 8763

Symbol: CD164

Ensembl ID: ENSG00000135535

Description: CD164 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 407.7271
    Cell Significance Index: -63.4200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 199.8555
    Cell Significance Index: -82.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 184.0379
    Cell Significance Index: -46.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 181.8307
    Cell Significance Index: -73.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 173.5460
    Cell Significance Index: -81.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 156.3808
    Cell Significance Index: -80.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 122.4475
    Cell Significance Index: -82.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 77.9791
    Cell Significance Index: -74.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.6696
    Cell Significance Index: -73.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.4938
    Cell Significance Index: -54.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.1240
    Cell Significance Index: -61.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.5208
    Cell Significance Index: -77.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.9431
    Cell Significance Index: -23.9500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.9722
    Cell Significance Index: 30.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.3608
    Cell Significance Index: 203.3200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.7154
    Cell Significance Index: 29.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9889
    Cell Significance Index: 222.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.7027
    Cell Significance Index: 487.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6283
    Cell Significance Index: 71.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.0837
    Cell Significance Index: 97.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0572
    Cell Significance Index: 252.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9146
    Cell Significance Index: 262.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.8965
    Cell Significance Index: 122.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8664
    Cell Significance Index: 1019.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8055
    Cell Significance Index: 48.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7429
    Cell Significance Index: 79.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6723
    Cell Significance Index: 36.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5353
    Cell Significance Index: 40.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4517
    Cell Significance Index: 236.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4403
    Cell Significance Index: 26.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4394
    Cell Significance Index: 41.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3977
    Cell Significance Index: 72.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3799
    Cell Significance Index: 36.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3161
    Cell Significance Index: 12.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2783
    Cell Significance Index: 165.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2475
    Cell Significance Index: 43.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2353
    Cell Significance Index: 36.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2080
    Cell Significance Index: 154.8600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.1711
    Cell Significance Index: 6.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1060
    Cell Significance Index: 23.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0259
    Cell Significance Index: 101.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0078
    Cell Significance Index: 445.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9210
    Cell Significance Index: 108.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8163
    Cell Significance Index: 161.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5529
    Cell Significance Index: 12.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5411
    Cell Significance Index: 38.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5178
    Cell Significance Index: 103.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4495
    Cell Significance Index: 76.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1812
    Cell Significance Index: 19.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1242
    Cell Significance Index: 1.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1205
    Cell Significance Index: 13.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0963
    Cell Significance Index: 34.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0953
    Cell Significance Index: 1.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0704
    Cell Significance Index: 129.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0630
    Cell Significance Index: 4.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0436
    Cell Significance Index: 30.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0380
    Cell Significance Index: 71.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0235
    Cell Significance Index: 17.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0098
    Cell Significance Index: 7.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0150
    Cell Significance Index: -23.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0179
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0252
    Cell Significance Index: -18.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0295
    Cell Significance Index: -3.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0506
    Cell Significance Index: -68.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0562
    Cell Significance Index: -35.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0573
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0682
    Cell Significance Index: -42.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0996
    Cell Significance Index: -56.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1061
    Cell Significance Index: -48.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1791
    Cell Significance Index: -37.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2011
    Cell Significance Index: -23.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2130
    Cell Significance Index: -61.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2376
    Cell Significance Index: -5.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3638
    Cell Significance Index: -52.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3733
    Cell Significance Index: -19.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3819
    Cell Significance Index: -10.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4239
    Cell Significance Index: -32.5300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4759
    Cell Significance Index: -6.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4861
    Cell Significance Index: -56.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4913
    Cell Significance Index: -13.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5135
    Cell Significance Index: -7.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5136
    Cell Significance Index: -16.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5339
    Cell Significance Index: -13.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5446
    Cell Significance Index: -30.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5688
    Cell Significance Index: -34.1500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5992
    Cell Significance Index: -3.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6642
    Cell Significance Index: -41.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6729
    Cell Significance Index: -35.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6838
    Cell Significance Index: -9.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6971
    Cell Significance Index: -72.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7547
    Cell Significance Index: -14.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8774
    Cell Significance Index: -69.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9371
    Cell Significance Index: -47.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9954
    Cell Significance Index: -61.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0343
    Cell Significance Index: -69.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.0563
    Cell Significance Index: -12.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1922
    Cell Significance Index: -73.0900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.2139
    Cell Significance Index: -8.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2399
    Cell Significance Index: -31.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.3172
    Cell Significance Index: -32.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CD164 is a member of the sialomucin family, characterized by its high expression in epithelial and immune cells. It is highly conserved across species, suggesting its fundamental importance in maintaining tissue homeostasis. The CD164 protein is a glycoprotein that interacts with various cell surface molecules, influencing cell adhesion, migration, and differentiation. **Pathways and Functions:** CD164 is involved in multiple signaling pathways, including: 1. **Cell adhesion:** CD164 interacts with cell surface molecules, such as integrins and selectins, to regulate cell adhesion and migration. 2. **Immune response:** CD164 is expressed on immune cells, including natural killer cells and dendritic cells, and plays a role in regulating immune responses, including cytokine production and antigen presentation. 3. **Endosomal trafficking:** CD164 is involved in regulating endosomal trafficking, influencing the sorting and degradation of endosomal proteins. 4. **Signaling transduction:** CD164 interacts with signaling molecules, such as tyrosine kinases and G-proteins, to regulate cellular responses to external stimuli. **Clinical Significance:** CD164 dysregulation has been implicated in various diseases, including: 1. **Cancer:** CD164 expression is altered in various types of cancer, including colorectal, breast, and lung cancer, suggesting its potential role as a biomarker or therapeutic target. 2. **Autoimmune disorders:** CD164 expression is altered in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, highlighting its potential role in regulating immune responses. 3. **Infectious diseases:** CD164 expression is altered in response to infection, suggesting its potential role in regulating immune responses to pathogens. **Conclusion:** In conclusion, CD164 is a multifaceted gene that plays a crucial role in regulating immune responses, cell adhesion, and development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications. As an expert immunologist, I emphasize the importance of continued investigation into the complexities of CD164, with the ultimate goal of harnessing its potential to improve human health. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms of CD164 signaling and its interactions with other cellular components. 2. The development of CD164-based biomarkers and therapeutic strategies should be pursued to explore its potential in cancer, autoimmune, and infectious diseases. 3. The role of CD164 in tissue development and homeostasis should be further investigated to understand its broader biological significance. By continuing to unravel the mysteries of CD164, we may uncover new avenues for therapeutic intervention and improve our understanding of the intricate relationships between immune responses, cell adhesion, and development.

Genular Protein ID: 1748168175

Symbol: MUC24_HUMAN

Name: Sialomucin core protein 24

UniProtKB Accession Codes:

Q04900 B4DQ85 E1P5E7 E1P5E8 E1P5E9 O95413 Q5JSU6 Q9BPV0 Q9NR26

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 Ensembl 5 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 6 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1478919

Title: A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression.

PubMed ID: 1478919

DOI: 10.1093/oxfordjournals.jbchem.a123948

PubMed ID: 9763543

Title: The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis.

PubMed ID: 9763543

PubMed ID: 10878358

Title: CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor.

PubMed ID: 10878358

DOI: 10.4049/jimmunol.165.2.840

PubMed ID: 11027692

Title: Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn.

PubMed ID: 11027692

DOI: 10.1074/jbc.m007965200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16859559

Title: The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis.

PubMed ID: 16859559

DOI: 10.1186/1471-2407-6-195

PubMed ID: 17077324

Title: Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells.

PubMed ID: 17077324

DOI: 10.1182/blood-2006-05-023028

PubMed ID: 26197441

Title: A novel locus harbouring a functional CD164 nonsense mutation identified in a large Danish family with nonsyndromic hearing impairment.

PubMed ID: 26197441

DOI: 10.1371/journal.pgen.1005386

Sequence Information:

  • Length: 197
  • Mass: 20917
  • Checksum: 4855E02646F4CB35
  • Sequence:
    • MSRLSRSLLW AATCLGVLCV LSADKNTTQH PNVTTLAPIS NVTSAPVTSL PLVTTPAPET 
CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC QVGNTTDFCS VSTATPVPTA 
NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT PTSQPVRKST FDAASFIGGI VLVLGVQAVI 
FFLYKFCKSK ERNYHTL

Genular Protein ID: 3900125154

Symbol: D6R9B4_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6R9B4

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMR 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 163
  • Mass: 17718
  • Checksum: 113613FE35339C5C
  • Sequence:
    • MRKGRKVPMY VPGVLRTYPK AKLEETCEGR NSCVSCFNVS VVNTTCFWIE CKDESYCSHN 
STVSDCQVGN TTDFCSVSTA TPVPTANSTA KPTVQPSPST TSKTVTTSGT TNNTVTPTSQ 
PVRKSTFDAA SFIGGIVLVL GVQAVIFFLY KFCKSKERNY HTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.