FGF18 | ENSG00000156427 | NCBI 8817

Details for: FGF18

Gene ID: 8817

Symbol: FGF18

Ensembl ID: ENSG00000156427

Description: fibroblast growth factor 18

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3b ligand binding and activation
(R-HSA-190371)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-HSA-5658623)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Anatomical structure morphogenesis
(GO:0009653)
Angiogenesis
(GO:0001525)
Cell-cell signaling
(GO:0007267)
Cell population proliferation
(GO:0008283)
Chondrocyte development
(GO:0002063)
Cytoplasm
(GO:0005737)
Endochondral ossification
(GO:0001958)
Erk1 and erk2 cascade
(GO:0070371)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Intramembranous ossification
(GO:0001957)
Lung development
(GO:0030324)
Neurogenesis
(GO:0022008)
Nucleolus
(GO:0005730)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chondrocyte differentiation
(GO:0032332)
Positive regulation of endothelial cell chemotaxis to fibroblast growth factor
(GO:2000546)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030949)
Regulation of cell migration
(GO:0030334)
Regulation of endothelial cell proliferation
(GO:0001936)
Regulation of sprouting angiogenesis
(GO:1903670)
Signal transduction
(GO:0007165)
Type 1 fibroblast growth factor receptor binding
(GO:0005105)
Type 2 fibroblast growth factor receptor binding
(GO:0005111)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 40.4384
Cell Significance Index: -6.2900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 24.6409
Cell Significance Index: -6.2500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 1.5940
Cell Significance Index: -6.2900
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.1550
Cell Significance Index: 630.7500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.0189
Cell Significance Index: -2.2300
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.9801
Cell Significance Index: 23.7400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5392
Cell Significance Index: 102.6100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4451
Cell Significance Index: 26.7200
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.3050
Cell Significance Index: 1.3500
Cell Name: chondroblast (CL0000058)
Fold Change: 0.2504
Cell Significance Index: 1.4700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2356
Cell Significance Index: 25.6300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1891
Cell Significance Index: 8.5700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1887
Cell Significance Index: 3.9500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1708
Cell Significance Index: 4.9200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1699
Cell Significance Index: 3.6800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1230
Cell Significance Index: 8.5100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1165
Cell Significance Index: 105.2400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1156
Cell Significance Index: 11.4400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0902
Cell Significance Index: 14.6800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0826
Cell Significance Index: 1.7600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0706
Cell Significance Index: 5.4200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0657
Cell Significance Index: 13.0400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0569
Cell Significance Index: 11.4200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0544
Cell Significance Index: 6.9700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0528
Cell Significance Index: 23.3400
Cell Name: keratocyte (CL0002363)
Fold Change: 0.0397
Cell Significance Index: 0.6300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0324
Cell Significance Index: 0.8100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0229
Cell Significance Index: 0.4800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0186
Cell Significance Index: 0.2800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0175
Cell Significance Index: 2.0400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0137
Cell Significance Index: 0.4800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0016
Cell Significance Index: -2.9600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0023
Cell Significance Index: -0.8200
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0027
Cell Significance Index: -0.0400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0028
Cell Significance Index: -0.3500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0036
Cell Significance Index: -6.6400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0044
Cell Significance Index: -6.7900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0045
Cell Significance Index: -6.0700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0071
Cell Significance Index: -5.2400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0075
Cell Significance Index: -5.7100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0079
Cell Significance Index: -5.0200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0082
Cell Significance Index: -1.4700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0083
Cell Significance Index: -6.1200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0103
Cell Significance Index: -0.6300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0108
Cell Significance Index: -6.1000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0117
Cell Significance Index: -5.3300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0120
Cell Significance Index: -3.4400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0122
Cell Significance Index: -0.8600
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0123
Cell Significance Index: -0.1900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0147
Cell Significance Index: -0.4700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0175
Cell Significance Index: -0.2500
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0187
Cell Significance Index: -0.9500
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0188
Cell Significance Index: -0.4000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0190
Cell Significance Index: -2.6100
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.0198
Cell Significance Index: -0.2100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0211
Cell Significance Index: -2.7200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0217
Cell Significance Index: -1.0100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0222
Cell Significance Index: -3.2300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0304
Cell Significance Index: -6.4100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0308
Cell Significance Index: -5.2600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0330
Cell Significance Index: -0.4500
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0348
Cell Significance Index: -0.6800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0396
Cell Significance Index: -1.8600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0408
Cell Significance Index: -1.1700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0490
Cell Significance Index: -5.0100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0510
Cell Significance Index: -2.6500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0534
Cell Significance Index: -6.1200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0566
Cell Significance Index: -6.6800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0598
Cell Significance Index: -6.2300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0630
Cell Significance Index: -1.7600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0652
Cell Significance Index: -2.8400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0774
Cell Significance Index: -5.7700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0776
Cell Significance Index: -5.2200
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0800
Cell Significance Index: -1.1100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0801
Cell Significance Index: -2.0600
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.0809
Cell Significance Index: -0.7800
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0812
Cell Significance Index: -1.1400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0844
Cell Significance Index: -5.3200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0867
Cell Significance Index: -5.3300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0871
Cell Significance Index: -4.8900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0891
Cell Significance Index: -5.7500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0920
Cell Significance Index: -4.8300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1019
Cell Significance Index: -2.7300
Cell Name: peg cell (CL4033014)
Fold Change: -0.1030
Cell Significance Index: -2.3800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1106
Cell Significance Index: -1.1500
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1107
Cell Significance Index: -1.4200
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1208
Cell Significance Index: -1.7000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1216
Cell Significance Index: -5.3800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1315
Cell Significance Index: -1.4300
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.1335
Cell Significance Index: -1.9200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1341
Cell Significance Index: -4.6600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1402
Cell Significance Index: -4.9100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1403
Cell Significance Index: -2.4800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1410
Cell Significance Index: -5.1800
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1417
Cell Significance Index: -0.9600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1444
Cell Significance Index: -1.6400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1450
Cell Significance Index: -5.4900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1454
Cell Significance Index: -4.7600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1498
Cell Significance Index: -4.7700
Cell Name: myometrial cell (CL0002366)
Fold Change: -0.1511
Cell Significance Index: -1.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FGF18 is a secreted protein with a molecular weight of approximately 20 kDa. It is expressed in a variety of cell types, including retinal bipolar neurons, retinal rod cells, kidney proximal convoluted tubule epithelial cells, and cardiac endothelial cells. FGF18 is involved in the regulation of angiogenesis, a process essential for the formation of new blood vessels from pre-existing ones. It also plays a role in the regulation of cell migration, proliferation, and differentiation in various tissues. **Pathways and Functions** The FGF18- FGFR axis is involved in several signaling pathways, including: 1. **Angiogenesis**: FGF18 promotes the formation of new blood vessels by inducing the expression of vascular endothelial growth factor (VEGF) and other angiogenic factors. 2. **Cell proliferation and differentiation**: FGF18 regulates the proliferation and differentiation of cells in various tissues, including the cardiovascular system, nervous system, and immune system. 3. **Cell migration**: FGF18 promotes the migration of cells, including endothelial cells, fibroblasts, and immune cells. 4. **Inflammation**: FGF18 has anti-inflammatory properties and can regulate the expression of pro-inflammatory cytokines. **Clinical Significance** FGF18 has been implicated in various diseases, including: 1. **Cancer**: FGF18 has been shown to promote the growth and metastasis of certain types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular disease**: FGF18 has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 3. **Neurological disorders**: FGF18 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Immune system disorders**: FGF18 has been implicated in the development of immune system disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, FGF18 is a multifunctional protein that plays a crucial role in various biological processes, including angiogenesis, cell proliferation, differentiation, and migration. Its dysregulation has been implicated in various diseases, highlighting the importance of FGF18 in human health and disease. **Future Directions** Further research is needed to fully understand the mechanisms by which FGF18 regulates various biological processes and its role in human disease. Potential therapeutic strategies may include the development of FGF18-targeting therapies to treat diseases characterized by FGF18 dysregulation, such as cancer and cardiovascular disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 18

Genular Protein ID: 256828093

Symbol: FGF18_HUMAN

Name: Fibroblast growth factor 18

UniProtKB Accession Codes:

O76093 D3DQL7 Q6UWF1

Database IDs:

Citations:

PubMed ID: 9742123

Title: FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation.

PubMed ID: 9742123

DOI: 10.1128/mcb.18.10.6063

PubMed ID: 9660775

Title: Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18.

PubMed ID: 9660775

DOI: 10.1074/jbc.273.29.18161

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

Sequence Information:

Length: 207
Mass: 23989
Checksum: 57F69E7B30181500
Sequence:

MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR 
TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP 
DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK 
GQPELQKPFK YTTVTKRSRR IRPTHPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF18

Associated with

Cells (max top 100)

Other Information

FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. PubMed ID: 9742123

Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. PubMed ID: 9660775

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617