Details for: SAP30

Gene ID: 8819

Symbol: SAP30

Ensembl ID: ENSG00000164105

Description: Sin3A associated protein 30

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 182.1335
    Cell Significance Index: -28.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 110.6672
    Cell Significance Index: -28.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.0113
    Cell Significance Index: -24.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.6509
    Cell Significance Index: -24.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.8208
    Cell Significance Index: -29.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7956
    Cell Significance Index: -28.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4834
    Cell Significance Index: -29.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3200
    Cell Significance Index: -16.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2297
    Cell Significance Index: -4.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7629
    Cell Significance Index: 113.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6074
    Cell Significance Index: 187.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4989
    Cell Significance Index: 148.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0624
    Cell Significance Index: 63.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0605
    Cell Significance Index: 115.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0394
    Cell Significance Index: 938.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7795
    Cell Significance Index: 126.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5263
    Cell Significance Index: 72.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4815
    Cell Significance Index: 33.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4109
    Cell Significance Index: 82.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3326
    Cell Significance Index: 147.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3246
    Cell Significance Index: 177.2800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.2832
    Cell Significance Index: 1.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2790
    Cell Significance Index: 3.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2184
    Cell Significance Index: 151.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1928
    Cell Significance Index: 8.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1750
    Cell Significance Index: 22.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1726
    Cell Significance Index: 2.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1324
    Cell Significance Index: 8.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1083
    Cell Significance Index: 38.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0844
    Cell Significance Index: 16.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0817
    Cell Significance Index: 5.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0370
    Cell Significance Index: 4.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0285
    Cell Significance Index: 5.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0242
    Cell Significance Index: 37.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0165
    Cell Significance Index: 31.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0079
    Cell Significance Index: 4.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0032
    Cell Significance Index: 4.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0010
    Cell Significance Index: 0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0269
    Cell Significance Index: -12.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0286
    Cell Significance Index: -0.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0292
    Cell Significance Index: -2.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0315
    Cell Significance Index: -23.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0379
    Cell Significance Index: -28.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0427
    Cell Significance Index: -6.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0431
    Cell Significance Index: -31.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0541
    Cell Significance Index: -30.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0641
    Cell Significance Index: -12.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0684
    Cell Significance Index: -42.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0688
    Cell Significance Index: -3.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0730
    Cell Significance Index: -3.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0743
    Cell Significance Index: -21.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0770
    Cell Significance Index: -3.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0812
    Cell Significance Index: -1.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0960
    Cell Significance Index: -2.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1098
    Cell Significance Index: -12.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1348
    Cell Significance Index: -7.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1364
    Cell Significance Index: -6.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1369
    Cell Significance Index: -4.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1552
    Cell Significance Index: -20.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1715
    Cell Significance Index: -29.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1742
    Cell Significance Index: -5.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1761
    Cell Significance Index: -37.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1811
    Cell Significance Index: -5.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1871
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2365
    Cell Significance Index: -27.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2614
    Cell Significance Index: -27.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2734
    Cell Significance Index: -20.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2841
    Cell Significance Index: -7.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2873
    Cell Significance Index: -6.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2964
    Cell Significance Index: -22.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3065
    Cell Significance Index: -10.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3091
    Cell Significance Index: -6.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3109
    Cell Significance Index: -12.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3178
    Cell Significance Index: -16.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3280
    Cell Significance Index: -25.9800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3360
    Cell Significance Index: -2.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3571
    Cell Significance Index: -18.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3598
    Cell Significance Index: -24.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4015
    Cell Significance Index: -17.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4511
    Cell Significance Index: -7.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4571
    Cell Significance Index: -11.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4629
    Cell Significance Index: -17.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4766
    Cell Significance Index: -11.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4984
    Cell Significance Index: -30.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5118
    Cell Significance Index: -9.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.5541
    Cell Significance Index: -8.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5997
    Cell Significance Index: -15.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6393
    Cell Significance Index: -6.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6528
    Cell Significance Index: -22.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6636
    Cell Significance Index: -17.7200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7057
    Cell Significance Index: -12.4700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7351
    Cell Significance Index: -23.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7404
    Cell Significance Index: -15.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7561
    Cell Significance Index: -24.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7652
    Cell Significance Index: -28.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7957
    Cell Significance Index: -26.0500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8052
    Cell Significance Index: -10.0400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.8058
    Cell Significance Index: -5.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8070
    Cell Significance Index: -13.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SAP30 is a 32-kDa protein that is highly conserved across species, with a high degree of similarity to other histone deacetylase complex subunits. It is characterized by its ability to interact with histone deacetylases (HDACs) and other chromatin-modifying enzymes, facilitating the negative regulation of transcription and epigenetic modifications. SAP30 is also involved in the regulation of stem cell population maintenance, suggesting its role in maintaining cellular homeostasis and preventing aberrant cell proliferation. **Pathways and Functions:** SAP30 is involved in various signaling pathways, including: 1. **Chromatin modifying enzymes:** SAP30 interacts with HDACs to regulate the acetylation of histones, leading to the suppression of transcription and the promotion of gene silencing. 2. **Epigenetic regulation of gene expression:** SAP30 is involved in the negative regulation of transcription by RNA polymerase II, as well as the regulation of stem cell population maintenance. 3. **Infectious disease:** SAP30 has been implicated in the regulation of viral infections, including SARS-CoV, suggesting its potential as a therapeutic target for infectious diseases. 4. **Immune function:** SAP30 is expressed in immune cells, including macrophages and T cells, and is involved in the regulation of immune responses, including the suppression of inflammatory responses. **Clinical Significance:** SAP30 has been implicated in various diseases, including: 1. **Cancer:** SAP30 has been shown to be overexpressed in certain types of cancer, including breast cancer and colon cancer, suggesting its potential as a diagnostic biomarker or therapeutic target. 2. **Neurological disorders:** SAP30 has been implicated in the regulation of neuronal function and has been associated with neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases:** SAP30 has been shown to play a role in the regulation of viral infections, including SARS-CoV, suggesting its potential as a therapeutic target for infectious diseases. **Potential Therapeutics:** Given its role in regulating epigenetic processes and immune function, SAP30 has potential as a therapeutic target for various diseases, including: 1. **Cancer:** Inhibition of SAP30 activity could lead to the suppression of tumor growth and the promotion of cancer cell death. 2. **Infectious diseases:** Inhibition of SAP30 activity could lead to the suppression of viral infections and the promotion of immune responses. 3. **Neurological disorders:** Inhibition of SAP30 activity could lead to the promotion of neuronal function and the suppression of disease progression in neurological disorders. In conclusion, SAP30 is a complex gene that plays a critical role in regulating epigenetic processes, gene expression, and immune function. Its involvement in various diseases, including cancer, neurological disorders, and infectious diseases, highlights its potential as a therapeutic target. Further research is needed to fully understand the mechanisms of SAP30 and its potential applications in human disease.

Genular Protein ID: 77721416

Symbol: SAP30_HUMAN

Name: Histone deacetylase complex subunit SAP30

UniProtKB Accession Codes:

O75446 D3DP38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 CarbonylDB 1 ComplexPortal 3 DIP 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9651585

Title: SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.

PubMed ID: 9651585

DOI: 10.1016/s1097-2765(00)80102-1

PubMed ID: 9702189

Title: SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.

PubMed ID: 9702189

DOI: 10.1016/s1097-2765(00)80111-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 15496587

Title: HTRP -- an immediate-early gene product induced by HSV1 infection in human embryo fibroblasts, is involved in cellular co-repressors.

PubMed ID: 15496587

DOI: 10.1093/jb/mvh108

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21221920

Title: Transcriptional regulation by HSV-1 induced HTRP via acetylation system.

PubMed ID: 21221920

DOI: 10.1007/s12250-010-3147-8

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 19223330

Title: Solution structure of a novel zinc finger motif in the SAP30 polypeptide of the Sin3 corepressor complex and its potential role in nucleic acid recognition.

PubMed ID: 19223330

DOI: 10.1093/nar/gkp051

Sequence Information:

  • Length: 220
  • Mass: 23306
  • Checksum: FF84E06B17AFCAC2
  • Sequence:
    • MNGFTPDEMS RGGDAAAAVA AVVAAAAAAA SAGNGTGAGT GAEVPGAGAV SAAGPPGAAG 
PGPGQLCCLR EDGERCGRAA GNASFSKRIQ KSISQKKVKI ELDKSARHLY ICDYHKNLIQ 
SVRNRRKRKG SDDDGGDSPV QDIDTPEVDL YQLQVNTLRR YKRHFKLPTR PGLNKAQLVE 
IVGCHFRSIP VNEKDTLTYF IYSVKNDKNK SDLKVDSGVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.