Details for: CCN6

Gene ID: 8838

Symbol: CCN6

Ensembl ID: ENSG00000112761

Description: cellular communication network factor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.6247
    Cell Significance Index: 61.9600
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.7581
    Cell Significance Index: 6.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1204
    Cell Significance Index: 83.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0809
    Cell Significance Index: 1.7300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0744
    Cell Significance Index: 0.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0700
    Cell Significance Index: 7.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0689
    Cell Significance Index: 4.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0544
    Cell Significance Index: 24.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0455
    Cell Significance Index: 0.7800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0454
    Cell Significance Index: 0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0407
    Cell Significance Index: 8.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0248
    Cell Significance Index: 1.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0222
    Cell Significance Index: 1.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0038
    Cell Significance Index: 0.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0028
    Cell Significance Index: 0.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0004
    Cell Significance Index: 0.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0002
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0016
    Cell Significance Index: -0.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -0.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0022
    Cell Significance Index: -0.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0034
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0036
    Cell Significance Index: -2.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0050
    Cell Significance Index: -0.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0056
    Cell Significance Index: -1.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0057
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0103
    Cell Significance Index: -1.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0104
    Cell Significance Index: -1.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0115
    Cell Significance Index: -2.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0126
    Cell Significance Index: -1.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0140
    Cell Significance Index: -0.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0155
    Cell Significance Index: -2.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0157
    Cell Significance Index: -2.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0188
    Cell Significance Index: -0.8300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0227
    Cell Significance Index: -0.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0246
    Cell Significance Index: -1.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0248
    Cell Significance Index: -0.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0259
    Cell Significance Index: -1.5900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0268
    Cell Significance Index: -0.2600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0285
    Cell Significance Index: -0.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0285
    Cell Significance Index: -1.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0292
    Cell Significance Index: -2.3200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0347
    Cell Significance Index: -0.4800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0360
    Cell Significance Index: -1.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0406
    Cell Significance Index: -2.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0410
    Cell Significance Index: -2.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0410
    Cell Significance Index: -0.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0430
    Cell Significance Index: -1.5800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0432
    Cell Significance Index: -1.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0434
    Cell Significance Index: -2.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0455
    Cell Significance Index: -1.1700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0469
    Cell Significance Index: -1.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0470
    Cell Significance Index: -2.1300
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0476
    Cell Significance Index: -0.5100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0505
    Cell Significance Index: -0.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0549
    Cell Significance Index: -1.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0567
    Cell Significance Index: -1.9700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0577
    Cell Significance Index: -0.7700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0610
    Cell Significance Index: -0.7700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0642
    Cell Significance Index: -0.8800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0658
    Cell Significance Index: -0.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0683
    Cell Significance Index: -1.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0689
    Cell Significance Index: -3.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0708
    Cell Significance Index: -2.4800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0709
    Cell Significance Index: -1.0600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0719
    Cell Significance Index: -0.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0728
    Cell Significance Index: -1.0800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0729
    Cell Significance Index: -1.2000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0735
    Cell Significance Index: -0.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0740
    Cell Significance Index: -2.6000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0744
    Cell Significance Index: -0.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0751
    Cell Significance Index: -2.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0754
    Cell Significance Index: -1.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0760
    Cell Significance Index: -2.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0773
    Cell Significance Index: -1.0000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0778
    Cell Significance Index: -0.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0779
    Cell Significance Index: -1.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0802
    Cell Significance Index: -2.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0819
    Cell Significance Index: -0.8900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0878
    Cell Significance Index: -1.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0880
    Cell Significance Index: -2.1100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0896
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0905
    Cell Significance Index: -1.1400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0920
    Cell Significance Index: -0.8900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0921
    Cell Significance Index: -0.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0951
    Cell Significance Index: -1.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0953
    Cell Significance Index: -2.8000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0960
    Cell Significance Index: -1.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0970
    Cell Significance Index: -2.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0971
    Cell Significance Index: -2.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0984
    Cell Significance Index: -2.8200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1004
    Cell Significance Index: -0.9500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1006
    Cell Significance Index: -0.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression**: CCN6 is widely expressed in various cell types, including erythrocytes, endothelial cells, hematopoietic stem cells, megakaryocyte-erythroid progenitor cells, pancreatic cells, goblet cells, and neurons. 2. **Heparin and Integrin Binding**: CCN6 interacts with heparin and integrins, which are essential for cell-cell and cell-extracellular matrix interactions. 3. **Regulation of Angiogenesis and Cell Proliferation**: CCN6 negatively regulates angiogenesis and cell population proliferation, suggesting its role in maintaining tissue architecture and preventing excessive cell growth. 4. **Cell Differentiation and Survival**: CCN6 positively regulates cell differentiation and is involved in maintaining mitochondrial membrane potential, suggesting its role in promoting cell survival and reducing oxidative stress. **Pathways and Functions:** 1. **Cell-Cell Signaling**: CCN6 participates in cell-cell signaling pathways, including the regulation of cell adhesion and migration. 2. **Extracellular Matrix Regulation**: CCN6 interacts with extracellular matrix components, influencing cell adhesion and migration. 3. **Growth Factor Activity**: CCN6 modulates growth factor activity, influencing cell proliferation and differentiation. 4. **Mitochondrial Regulation**: CCN6 regulates mitochondrial membrane potential, influencing cell survival and proliferation. 5. **Reactive Oxygen Species Biosynthesis**: CCN6 is involved in regulating reactive oxygen species biosynthesis, which is essential for maintaining cellular homeostasis. **Clinical Significance:** 1. **Cancer**: CCN6's role in regulating cell proliferation and differentiation makes it a potential target for cancer therapy. 2. **Angiogenesis Disorders**: CCN6's involvement in angiogenesis regulation suggests its potential as a therapeutic target for conditions characterized by abnormal angiogenesis, such as cancer and diabetic retinopathy. 3. **Neurological Disorders**: CCN6's expression in neurons and its role in regulating cell differentiation and survival make it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Wound Healing**: CCN6's involvement in regulating cell adhesion and migration suggests its potential as a therapeutic target for improving wound healing. In conclusion, CCN6 is a multifunctional gene that plays a crucial role in regulating various cellular processes, including cell-cell signaling, cell adhesion, and angiogenesis regulation. Its involvement in multiple signaling pathways highlights its importance in maintaining tissue homeostasis and regulating cellular behavior. Further research is necessary to fully elucidate CCN6's role in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 3372963816

Symbol: CCN6_HUMAN

Name: Cellular communication network factor 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9843955

Title: WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.

PubMed ID: 9843955

DOI: 10.1073/pnas.95.25.14717

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27252383

Title: CCN6 regulates mitochondrial function.

PubMed ID: 27252383

DOI: 10.1242/jcs.186247

PubMed ID: 10471507

Title: Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia.

PubMed ID: 10471507

DOI: 10.1038/12699

PubMed ID: 16152649

Title: Molecular study of WISP3 in nine families originating from the Middle-East and presenting with progressive pseudorheumatoid dysplasia: identification of two novel mutations, and description of a founder effect.

PubMed ID: 16152649

DOI: 10.1002/ajmg.a.30906

PubMed ID: 19064006

Title: Identification of novel mutations in WISP3 gene in two unrelated Chinese families with progressive pseudorheumatoid dysplasia.

PubMed ID: 19064006

DOI: 10.1016/j.bone.2008.11.005

PubMed ID: 22987568

Title: Analysis of the WISP3 gene in Indian families with progressive pseudorheumatoid dysplasia.

PubMed ID: 22987568

DOI: 10.1002/ajmg.a.35620

PubMed ID: 22685593

Title: Novel and recurrent mutations of WISP3 in two Chinese families with progressive pseudorheumatoid dysplasia.

PubMed ID: 22685593

DOI: 10.1371/journal.pone.0038643

PubMed ID: 25988854

Title: Novel and recurrent mutations in WISP3 and an atypical phenotype.

PubMed ID: 25988854

DOI: 10.1002/ajmg.a.37164

PubMed ID: 25794430

Title: A novel compound WISP3 mutation in a Chinese family with progressive pseudorheumatoid dysplasia.

PubMed ID: 25794430

DOI: 10.1016/j.gene.2015.03.029

PubMed ID: 25738435

Title: Identification of a mutation in the WISP3 gene in three unrelated families with progressive pseudorheumatoid dysplasia.

PubMed ID: 25738435

DOI: 10.3892/mmr.2015.3430

PubMed ID: 27436824

Title: WISP3 mutational analysis in Indian patients diagnosed with progressive pseudorheumatoid dysplasia and report of a novel mutation at p.Y198.

PubMed ID: 27436824

DOI: 10.1302/2046-3758.57.2000520

PubMed ID: 29092958

Title: WISP3 mutation associated with pseudorheumatoid dysplasia.

PubMed ID: 29092958

DOI: 10.1101/mcs.a001990

Sequence Information:

  • Length: 354
  • Mass: 39293
  • Checksum: 67F48D0D5C2F5EE3
  • Sequence:
  • MQGLLFSTLL LAGLAQFCCR VQGTGPLDTT PEGRPGEVSD APQRKQFCHW PCKCPQQKPR 
    CPPGVSLVRD GCGCCKICAK QPGEICNEAD LCDPHKGLYC DYSVDRPRYE TGVCAYLVAV 
    GCEFNQVHYH NGQVFQPNPL FSCLCVSGAI GCTPLFIPKL AGSHCSGAKG GKKSDQSNCS 
    LEPLLQQLST SYKTMPAYRN LPLIWKKKCL VQATKWTPCS RTCGMGISNR VTNENSNCEM 
    RKEKRLCYIQ PCDSNILKTI KIPKGKTCQP TFQLSKAEKF VFSGCSSTQS YKPTFCGICL 
    DKRCCIPNKS KMITIQFDCP NEGSFKWKML WITSCVCQRN CREPGDIFSE LKIL

Genular Protein ID: 1484707699

Symbol: I6L968_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 219
  • Mass: 23559
  • Checksum: E45AE160B0320A44
  • Sequence:
  • MQGLLFSTLL LAGLAQFCCR VQGTGPLDTT PEGRPGEVSD APQRKQFCHW PCKCPHQKPR 
    CPPGVSLVRD GCGCCKICAK QPGEICNEAD LCDPHKGLYC DYSVDRPRYE TGVCAYLVAV 
    GCEFNQVHYH NGQVFQPNPL FSCLCVSGAI GCTPLFIPKL AGSHCSGAKG GKKSDQSNCS 
    LEPLLQQLST SYKTMPDVCQ ASNLLPALRS LNCCLPSSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.