Details for: CCN6
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 3.6247
Cell Significance Index: 61.9600 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.7581
Cell Significance Index: 6.8800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1204
Cell Significance Index: 83.3000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.0809
Cell Significance Index: 1.7300 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.0744
Cell Significance Index: 0.7600 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0700
Cell Significance Index: 7.1600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0689
Cell Significance Index: 4.8700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0544
Cell Significance Index: 24.0300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0455
Cell Significance Index: 0.7800 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.0454
Cell Significance Index: 0.7200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.0407
Cell Significance Index: 8.5700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0248
Cell Significance Index: 1.2500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0222
Cell Significance Index: 1.4000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0038
Cell Significance Index: 0.2800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0028
Cell Significance Index: 0.0400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0004
Cell Significance Index: 0.3200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0002
Cell Significance Index: 0.1400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0001
Cell Significance Index: -0.0800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0013
Cell Significance Index: -2.4900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0016
Cell Significance Index: -0.1200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0018
Cell Significance Index: -0.9600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0020
Cell Significance Index: -3.7100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0021
Cell Significance Index: -3.2000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0022
Cell Significance Index: -0.7900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0023
Cell Significance Index: -1.2900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0027
Cell Significance Index: -3.6800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0034
Cell Significance Index: -0.0500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0036
Cell Significance Index: -2.2800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0047
Cell Significance Index: -3.5800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0050
Cell Significance Index: -0.9100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0056
Cell Significance Index: -1.1300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0057
Cell Significance Index: -2.5900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0103
Cell Significance Index: -1.1800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0104
Cell Significance Index: -1.2800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0115
Cell Significance Index: -2.2900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0126
Cell Significance Index: -1.6300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0140
Cell Significance Index: -0.3800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0155
Cell Significance Index: -2.2500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0157
Cell Significance Index: -2.1500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0188
Cell Significance Index: -0.8300 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0195
Cell Significance Index: -0.2300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0227
Cell Significance Index: -0.8600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0246
Cell Significance Index: -1.2800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0248
Cell Significance Index: -0.7300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0259
Cell Significance Index: -1.5900 - Cell Name: osteoblast (CL0000062)
Fold Change: -0.0268
Cell Significance Index: -0.2600 - Cell Name: microglial cell (CL0000129)
Fold Change: -0.0285
Cell Significance Index: -0.3400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0285
Cell Significance Index: -1.3300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0292
Cell Significance Index: -2.3200 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0347
Cell Significance Index: -0.4800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0360
Cell Significance Index: -1.4800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0406
Cell Significance Index: -2.2800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0410
Cell Significance Index: -2.7600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0410
Cell Significance Index: -0.6900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0430
Cell Significance Index: -1.5800 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0432
Cell Significance Index: -1.0800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0434
Cell Significance Index: -2.0400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0455
Cell Significance Index: -1.1700 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0469
Cell Significance Index: -1.1700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0470
Cell Significance Index: -2.1300 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: -0.0476
Cell Significance Index: -0.5100 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.0505
Cell Significance Index: -0.8100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0549
Cell Significance Index: -1.1500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0567
Cell Significance Index: -1.9700 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0577
Cell Significance Index: -0.7700 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0610
Cell Significance Index: -0.7700 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0642
Cell Significance Index: -0.8800 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0658
Cell Significance Index: -0.8500 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0683
Cell Significance Index: -1.7400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0689
Cell Significance Index: -3.0000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0708
Cell Significance Index: -2.4800 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0709
Cell Significance Index: -1.0600 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0719
Cell Significance Index: -0.9700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0728
Cell Significance Index: -1.0800 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0729
Cell Significance Index: -1.2000 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0735
Cell Significance Index: -0.6300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0740
Cell Significance Index: -2.6000 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0744
Cell Significance Index: -0.7700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0751
Cell Significance Index: -2.4600 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0754
Cell Significance Index: -1.3000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0760
Cell Significance Index: -2.4200 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0773
Cell Significance Index: -1.0000 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.0778
Cell Significance Index: -0.8900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0779
Cell Significance Index: -1.5200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0802
Cell Significance Index: -2.3100 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0819
Cell Significance Index: -0.8900 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.0878
Cell Significance Index: -1.1500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0880
Cell Significance Index: -2.1100 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.0896
Cell Significance Index: -0.9900 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0905
Cell Significance Index: -1.1400 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0920
Cell Significance Index: -0.8900 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.0921
Cell Significance Index: -0.5700 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0951
Cell Significance Index: -1.5400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0953
Cell Significance Index: -2.8000 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0960
Cell Significance Index: -1.2800 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0970
Cell Significance Index: -2.4200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0971
Cell Significance Index: -2.0600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0984
Cell Significance Index: -2.8200 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.1004
Cell Significance Index: -0.9500 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.1006
Cell Significance Index: -0.9700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3372963816
Symbol: CCN6_HUMAN
Name: Cellular communication network factor 6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9843955
Title: WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.
PubMed ID: 9843955
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 27252383
PubMed ID: 10471507
Title: Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia.
PubMed ID: 10471507
DOI: 10.1038/12699
PubMed ID: 16152649
Title: Molecular study of WISP3 in nine families originating from the Middle-East and presenting with progressive pseudorheumatoid dysplasia: identification of two novel mutations, and description of a founder effect.
PubMed ID: 16152649
DOI: 10.1002/ajmg.a.30906
PubMed ID: 19064006
Title: Identification of novel mutations in WISP3 gene in two unrelated Chinese families with progressive pseudorheumatoid dysplasia.
PubMed ID: 19064006
PubMed ID: 22987568
Title: Analysis of the WISP3 gene in Indian families with progressive pseudorheumatoid dysplasia.
PubMed ID: 22987568
DOI: 10.1002/ajmg.a.35620
PubMed ID: 22685593
Title: Novel and recurrent mutations of WISP3 in two Chinese families with progressive pseudorheumatoid dysplasia.
PubMed ID: 22685593
PubMed ID: 25988854
Title: Novel and recurrent mutations in WISP3 and an atypical phenotype.
PubMed ID: 25988854
DOI: 10.1002/ajmg.a.37164
PubMed ID: 25794430
Title: A novel compound WISP3 mutation in a Chinese family with progressive pseudorheumatoid dysplasia.
PubMed ID: 25794430
PubMed ID: 25738435
Title: Identification of a mutation in the WISP3 gene in three unrelated families with progressive pseudorheumatoid dysplasia.
PubMed ID: 25738435
PubMed ID: 27436824
Title: WISP3 mutational analysis in Indian patients diagnosed with progressive pseudorheumatoid dysplasia and report of a novel mutation at p.Y198.
PubMed ID: 27436824
PubMed ID: 29092958
Title: WISP3 mutation associated with pseudorheumatoid dysplasia.
PubMed ID: 29092958
DOI: 10.1101/mcs.a001990
Sequence Information:
- Length: 354
- Mass: 39293
- Checksum: 67F48D0D5C2F5EE3
- Sequence:
MQGLLFSTLL LAGLAQFCCR VQGTGPLDTT PEGRPGEVSD APQRKQFCHW PCKCPQQKPR CPPGVSLVRD GCGCCKICAK QPGEICNEAD LCDPHKGLYC DYSVDRPRYE TGVCAYLVAV GCEFNQVHYH NGQVFQPNPL FSCLCVSGAI GCTPLFIPKL AGSHCSGAKG GKKSDQSNCS LEPLLQQLST SYKTMPAYRN LPLIWKKKCL VQATKWTPCS RTCGMGISNR VTNENSNCEM RKEKRLCYIQ PCDSNILKTI KIPKGKTCQP TFQLSKAEKF VFSGCSSTQS YKPTFCGICL DKRCCIPNKS KMITIQFDCP NEGSFKWKML WITSCVCQRN CREPGDIFSE LKIL
Genular Protein ID: 1484707699
Symbol: I6L968_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 219
- Mass: 23559
- Checksum: E45AE160B0320A44
- Sequence:
MQGLLFSTLL LAGLAQFCCR VQGTGPLDTT PEGRPGEVSD APQRKQFCHW PCKCPHQKPR CPPGVSLVRD GCGCCKICAK QPGEICNEAD LCDPHKGLYC DYSVDRPRYE TGVCAYLVAV GCEFNQVHYH NGQVFQPNPL FSCLCVSGAI GCTPLFIPKL AGSHCSGAKG GKKSDQSNCS LEPLLQQLST SYKTMPDVCQ ASNLLPALRS LNCCLPSSL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.