Details for: RPL14

Gene ID: 9045

Symbol: RPL14

Ensembl ID: ENSG00000188846

Description: ribosomal protein L14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 663.4339
    Cell Significance Index: -273.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 560.4264
    Cell Significance Index: -264.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 536.7767
    Cell Significance Index: -276.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 37.3554
    Cell Significance Index: -100.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 17.3758
    Cell Significance Index: 443.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.6139
    Cell Significance Index: 592.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 12.5088
    Cell Significance Index: 1277.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.5428
    Cell Significance Index: 147.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 9.9851
    Cell Significance Index: 286.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.8866
    Cell Significance Index: 228.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 9.5410
    Cell Significance Index: 250.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.3807
    Cell Significance Index: 1211.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.7303
    Cell Significance Index: 182.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.6449
    Cell Significance Index: 1187.1800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 8.3540
    Cell Significance Index: 49.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.1945
    Cell Significance Index: 610.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.1511
    Cell Significance Index: 576.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.0597
    Cell Significance Index: 280.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.0137
    Cell Significance Index: 985.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.9574
    Cell Significance Index: 1434.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.7315
    Cell Significance Index: 136.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.3165
    Cell Significance Index: 79.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.1666
    Cell Significance Index: 3168.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.1303
    Cell Significance Index: 332.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.0347
    Cell Significance Index: 829.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.9850
    Cell Significance Index: 3814.6600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.7718
    Cell Significance Index: 41.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.6948
    Cell Significance Index: 196.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.5324
    Cell Significance Index: 421.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 6.3783
    Cell Significance Index: 72.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.1600
    Cell Significance Index: 167.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.1512
    Cell Significance Index: 660.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.3824
    Cell Significance Index: 81.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.2779
    Cell Significance Index: 730.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.0250
    Cell Significance Index: 37.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.0561
    Cell Significance Index: 606.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.8426
    Cell Significance Index: 149.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.7287
    Cell Significance Index: 72.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.5738
    Cell Significance Index: 2323.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.5133
    Cell Significance Index: 1902.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9584
    Cell Significance Index: 182.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9492
    Cell Significance Index: 49.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.8680
    Cell Significance Index: 636.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5240
    Cell Significance Index: 105.1100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2943
    Cell Significance Index: 2.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2293
    Cell Significance Index: 65.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1623
    Cell Significance Index: 58.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1071
    Cell Significance Index: 10.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0651
    Cell Significance Index: -122.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0998
    Cell Significance Index: -73.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1437
    Cell Significance Index: -23.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1454
    Cell Significance Index: -268.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1601
    Cell Significance Index: -18.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1682
    Cell Significance Index: -259.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2118
    Cell Significance Index: -287.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2180
    Cell Significance Index: -122.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2235
    Cell Significance Index: -139.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3340
    Cell Significance Index: -212.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3596
    Cell Significance Index: -22.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3673
    Cell Significance Index: -29.0900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.5006
    Cell Significance Index: -10.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5220
    Cell Significance Index: -236.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5227
    Cell Significance Index: -110.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6378
    Cell Significance Index: -28.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0773
    Cell Significance Index: -123.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2203
    Cell Significance Index: -39.0900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3800
    Cell Significance Index: -23.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.5078
    Cell Significance Index: -95.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.5641
    Cell Significance Index: -9.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.6399
    Cell Significance Index: -238.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.7253
    Cell Significance Index: -28.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.7402
    Cell Significance Index: -97.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.8561
    Cell Significance Index: -65.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.3635
    Cell Significance Index: -163.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.3823
    Cell Significance Index: -59.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.3879
    Cell Significance Index: -143.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.4832
    Cell Significance Index: -258.5600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -3.1217
    Cell Significance Index: -26.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.1613
    Cell Significance Index: -212.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.1794
    Cell Significance Index: -243.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.6024
    Cell Significance Index: -78.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.6299
    Cell Significance Index: -222.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.7820
    Cell Significance Index: -51.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.0576
    Cell Significance Index: -60.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.1594
    Cell Significance Index: -71.2800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -4.3403
    Cell Significance Index: -20.0400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.6535
    Cell Significance Index: -25.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -4.7224
    Cell Significance Index: -126.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.2322
    Cell Significance Index: -154.1100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -5.5013
    Cell Significance Index: -46.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.5927
    Cell Significance Index: -247.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -6.1142
    Cell Significance Index: -72.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.3473
    Cell Significance Index: -233.0100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.3892
    Cell Significance Index: -82.2800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -6.5970
    Cell Significance Index: -40.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -6.7715
    Cell Significance Index: -174.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -6.7982
    Cell Significance Index: -257.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -7.0195
    Cell Significance Index: -229.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -7.1369
    Cell Significance Index: -250.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -7.3416
    Cell Significance Index: -233.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL14 is a small, conserved protein that belongs to the 60S ribosomal protein family. It is encoded by a single gene (ENSG00000188846) and is highly conserved across species, indicating its essential function in eukaryotic cells. RPL14 is a structural constituent of the ribosome, specifically the large subunit, and is involved in the translation elongation process. It interacts with other ribosomal proteins and factors to regulate the translation of messenger RNA (mRNA) into protein. **Pathways and Functions** RPL14 is involved in various cellular processes, including: 1. **Translation elongation**: RPL14 plays a critical role in the translation elongation process, where it interacts with other ribosomal proteins to facilitate the assembly of the ribosome and the translocation of the ribosome along the mRNA. 2. **Regulation of gene expression**: RPL14 is involved in the regulation of gene expression by interacting with transcription factors and other regulatory proteins to control the expression of target genes. 3. **Stress response**: RPL14 is induced in response to stress, starvation, and viral infections, suggesting its role in the cellular response to environmental challenges. 4. **Immune response**: RPL14 is highly expressed in immune cells, including T cells and B cells, indicating its involvement in the immune response. 5. **Cellular differentiation**: RPL14 is expressed in various cell types, including epithelial cells, stem cells, and neural cells, suggesting its role in cellular differentiation and development. **Clinical Significance** RPL14 has been implicated in various diseases and disorders, including: 1. **Influenza**: RPL14 has been shown to be a target of the influenza virus, suggesting its role in viral replication and transcription. 2. **Cancer**: RPL14 has been found to be overexpressed in various types of cancer, including breast and lung cancer, suggesting its potential role in tumorigenesis. 3. **Neurological disorders**: RPL14 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its role in protein synthesis and degradation. 4. **Autoimmune diseases**: RPL14 has been found to be involved in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis, suggesting its role in immune regulation. In conclusion, RPL14 is a critical component of the eukaryotic ribosome, involved in translation elongation, regulation of gene expression, and the response to environmental challenges. Its dysregulation has been implicated in various diseases and disorders, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the role of RPL14 in human health and disease.

Genular Protein ID: 239171415

Symbol: RL14_HUMAN

Name: 60S ribosomal protein L14

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8549859

Title: Identification of trinucleotide repeat-containing genes in human pancreatic islets.

PubMed ID: 8549859

DOI: 10.2337/diab.45.2.157

PubMed ID: 9480843

Title: Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4).

PubMed ID: 9480843

DOI: 10.1006/bbrc.1998.8125

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11401437

Title: A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.

PubMed ID: 11401437

DOI: 10.1006/geno.2000.6470

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 215
  • Mass: 23432
  • Checksum: 4C63DE4FC8E687FE
  • Sequence:
  • MVFRRFVEVG RVAYVSFGPH AGKLVAIVDV IDQNRALVDG PCTQVRRQAM PFKCMQLTDF 
    ILKFPHSAHQ KYVRQAWQKA DINTKWAATR WAKKIEARER KAKMTDFDRF KVMKAKKMRN 
    RIIKNEVKKL QKAALLKASP KKAPGTKGTA AAAAAAAAAK VPAKKITAAS KKAPAQKVPA 
    QKATGQKAAP APKAQKGQKA PAQKAPAPKA SGKKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.