Details for: CBFA2T2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 370.2139
Cell Significance Index: -57.5900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 226.0654
Cell Significance Index: -57.3400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 123.3260
Cell Significance Index: -58.2300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 46.8995
Cell Significance Index: -57.8300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.2619
Cell Significance Index: -51.6000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 17.0110
Cell Significance Index: -37.2300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.1650
Cell Significance Index: -49.6500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.7439
Cell Significance Index: -58.1800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.8959
Cell Significance Index: 574.7000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.8107
Cell Significance Index: 157.7200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.5406
Cell Significance Index: 71.0000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.4910
Cell Significance Index: 499.6900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.0769
Cell Significance Index: 744.9600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.0296
Cell Significance Index: 136.4700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.6288
Cell Significance Index: 125.0000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.4282
Cell Significance Index: 987.8100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.4244
Cell Significance Index: 34.1600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.3780
Cell Significance Index: 84.7000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.2667
Cell Significance Index: 56.0300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.2628
Cell Significance Index: 32.4600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.2520
Cell Significance Index: 47.4100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.2027
Cell Significance Index: 34.3200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.1787
Cell Significance Index: 14.6200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9800
Cell Significance Index: 159.3800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.9587
Cell Significance Index: 111.7300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9455
Cell Significance Index: 12.9000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9092
Cell Significance Index: 98.9000 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.7209
Cell Significance Index: 14.0700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.6306
Cell Significance Index: 13.4800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6235
Cell Significance Index: 28.2600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6148
Cell Significance Index: 17.7200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5568
Cell Significance Index: 33.4300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.4973
Cell Significance Index: 10.8900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4658
Cell Significance Index: 29.3600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3905
Cell Significance Index: 352.6100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3819
Cell Significance Index: 26.4100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3784
Cell Significance Index: 712.3900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3509
Cell Significance Index: 43.1500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3422
Cell Significance Index: 61.6800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2181
Cell Significance Index: 138.5200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1914
Cell Significance Index: 3.2800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1816
Cell Significance Index: 82.4200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1757
Cell Significance Index: 270.4700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1670
Cell Significance Index: 308.0100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1540
Cell Significance Index: 29.3000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1535
Cell Significance Index: 1.8300 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.1447
Cell Significance Index: 1.4600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1425
Cell Significance Index: 77.8000 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1069
Cell Significance Index: 1.5400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1018
Cell Significance Index: 138.3600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0948
Cell Significance Index: 41.9100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0588
Cell Significance Index: 2.0700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0392
Cell Significance Index: 3.8800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0146
Cell Significance Index: -0.3900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0250
Cell Significance Index: -3.6400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0300
Cell Significance Index: -22.2100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0521
Cell Significance Index: -32.5100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0523
Cell Significance Index: -38.3600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0639
Cell Significance Index: -8.7700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0693
Cell Significance Index: -39.1100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0755
Cell Significance Index: -57.1200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1089
Cell Significance Index: -18.5900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1371
Cell Significance Index: -28.8800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1680
Cell Significance Index: -48.3300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1735
Cell Significance Index: -22.2400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2529
Cell Significance Index: -29.8200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2612
Cell Significance Index: -26.6900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2980
Cell Significance Index: -15.4800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.3097
Cell Significance Index: -40.0100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3200
Cell Significance Index: -16.8000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3451
Cell Significance Index: -35.9300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3643
Cell Significance Index: -41.5800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3719
Cell Significance Index: -17.4800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3813
Cell Significance Index: -17.7800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3973
Cell Significance Index: -45.5200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4146
Cell Significance Index: -8.8300 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.4884
Cell Significance Index: -6.8300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5028
Cell Significance Index: -37.4700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5295
Cell Significance Index: -34.1600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.5767
Cell Significance Index: -14.0700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5798
Cell Significance Index: -8.5600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5917
Cell Significance Index: -18.9500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5919
Cell Significance Index: -41.8600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6085
Cell Significance Index: -48.1900 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.6714
Cell Significance Index: -5.9600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6905
Cell Significance Index: -17.2600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7041
Cell Significance Index: -43.1700 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.7226
Cell Significance Index: -9.0100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.7378
Cell Significance Index: -15.6600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7438
Cell Significance Index: -23.6900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7773
Cell Significance Index: -25.4500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.7860
Cell Significance Index: -13.1600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.7948
Cell Significance Index: -15.7200 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: -0.8299
Cell Significance Index: -5.1200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.8528
Cell Significance Index: -44.4200 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.9009
Cell Significance Index: -11.3700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.9016
Cell Significance Index: -18.1000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.9232
Cell Significance Index: -32.0800 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.9641
Cell Significance Index: -16.6700 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -1.0003
Cell Significance Index: -10.4200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1813931262
Symbol: MTG8R_HUMAN
Name: Protein CBFA2T2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9787195
Title: EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias.
PubMed ID: 9787195
PubMed ID: 9447981
Title: The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.
PubMed ID: 9447981
DOI: 10.1128/mcb.18.2.846
PubMed ID: 10675041
Title: Structure and expression pattern of a human MTG8/ETO family gene, MTGR1.
PubMed ID: 10675041
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9790752
Title: CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.
PubMed ID: 9790752
PubMed ID: 12242670
Title: The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies.
PubMed ID: 12242670
PubMed ID: 14703694
Title: Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins.
PubMed ID: 14703694
PubMed ID: 12559562
PubMed ID: 15203199
Title: The MTG proteins: chromatin repression players with a passion for networking.
PubMed ID: 15203199
PubMed ID: 16616331
Title: The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.
PubMed ID: 16616331
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20520637
Title: CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia.
PubMed ID: 20520637
DOI: 10.1038/leu.2010.106
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23251453
Title: Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.
PubMed ID: 23251453
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26115422
Title: PAX5 alterations in genetically unclassified childhood Precursor B-cell acute lymphoblastic leukaemia.
PubMed ID: 26115422
DOI: 10.1111/bjh.13543
PubMed ID: 27281218
Title: Co-repressor CBFA2T2 regulates pluripotency and germline development.
PubMed ID: 27281218
DOI: 10.1038/nature18004
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
Sequence Information:
- Length: 604
- Mass: 67133
- Checksum: 1E55618844908169
- Sequence:
MAKESGISLK EIQVLARQWK VGPEKRVPAM PGSPVEVKIQ SRSSPPTMPP LPPINPGGPR PVSFTPTALS NGINHSPPTL NGAPSPPQRF SNGPASSTSS ALTNQQLPAT CGARQLSKLK RFLTTLQQFG NDISPEIGEK VRTLVLALVN STVTIEEFHC KLQEATNFPL RPFVIPFLKA NLPLLQRELL HCARAAKQTP SQYLAQHEHL LLNTSIASPA DSSELLMEVH GNGKRPSPER REENSFDRDT IAPEPPAKRV CTISPAPRHS PALTVPLMNP GGQFHPTPPP LQHYTLEDIA TSHLYREPNK MLEHREVRDR HHSLGLNGGY QDELVDHRLT EREWADEWKH LDHALNCIME MVEKTRRSMA VLRRCQESDR EELNYWKRRY NENTELRKTG TELVSRQHSP GSADSLSNDS QREFNSRPGT GYVPVEFWKK TEEAVNKVKI QAMSEVQKAV AEAEQKAFEV IATERARMEQ TIADVKRQAA EDAFLVINEQ EESTENCWNC GRKASETCSG CNIARYCGSF CQHKDWERHH RLCGQNLHGQ SPHGQGRPLL PVGRGSSARS ADCSVPSPAL DKTSATTSRS STPASVTAID TNGL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.