Details for: PLXNA4

Gene ID: 91584

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PLXNA4

Ensembl ID: ENSG00000221866

Description: plexin A4

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • VIP GABAergic cortical interneuron CL4023016
    CSI 49.96
    rCSI 59.67%
    PRS 85.65
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 48.78
    rCSI 60.68%
    PRS 83.54
  • adipocyte CL0000136
    CSI 38.42
    rCSI 49.33%
    PRS 88.33
  • sncg GABAergic cortical interneuron CL4023015
    CSI 30.75
    rCSI 49.46%
    PRS 86.52
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 24.44
    rCSI 59.4%
    PRS 83.73
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 22.6
    rCSI 39.92%
    PRS 85.1
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 21.09
    rCSI 65.96%
    PRS 88.16
  • epicardial adipocyte CL1000309
    CSI 19.39
    rCSI 63.09%
    PRS 92.54
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 19.01
    rCSI 41.24%
    PRS 85.61
  • interneuron CL0000099
    CSI 17.24
    rCSI 34.61%
    PRS 90.49
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 16.48
    rCSI 62.28%
    PRS 85.74
  • retinal bipolar neuron CL0000748
    CSI 16.14
    rCSI 30.22%
    PRS 88.61
  • sst GABAergic cortical interneuron CL4023017
    CSI 15.69
    rCSI 20.23%
    PRS 86.6
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 15.1
    rCSI 54.35%
    PRS 83.98
  • neuron CL0000540
    CSI 14.89
    rCSI 39.65%
    PRS 84.68
  • progenitor cell CL0011026
    CSI 14.69
    rCSI 31.25%
    PRS 89.06
  • inhibitory interneuron CL0000498
    CSI 13.03
    rCSI 30.08%
    PRS 87.97
  • OFFx cell CL4033036
    CSI 12.97
    rCSI 61.04%
    PRS 85.73
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 12.51
    rCSI 21.01%
    PRS 85.79
  • cerebral cortex neuron CL0010012
    CSI 12.42
    rCSI 50.62%
    PRS 88.73
  • Mueller cell CL0000636
    CSI 11.85
    rCSI 27.05%
    PRS 89.89
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 11.59
    rCSI 14.87%
    PRS 91.47
  • subcutaneous adipocyte CL0002521
    CSI 11.55
    rCSI 59.15%
    PRS 95.7
  • neural cell CL0002319
    CSI 11.49
    rCSI 43.35%
    PRS 83.45
  • tracheobronchial smooth muscle cell CL0019019
    CSI 11.45
    rCSI 20.19%
    PRS 96.31
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 10.16
    rCSI 33.4%
    PRS 85.74
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 10.12
    rCSI 24.21%
    PRS 86.79
  • retinal cone cell CL0000573
    CSI 10.01
    rCSI 16.12%
    PRS 88.41
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 9.65
    rCSI 11.15%
    PRS 88.49
  • alveolar type 1 fibroblast cell CL4028004
    CSI 8.93
    rCSI 9.78%
    PRS 95.67
  • hepatic stellate cell CL0000632
    CSI 8.72
    rCSI 32.67%
    PRS 91.97
  • glutamatergic neuron CL0000679
    CSI 8.6
    rCSI 17.67%
    PRS 85.23
  • GABAergic amacrine cell CL4030027
    CSI 8.55
    rCSI 29.3%
    PRS 84.61
  • endocardial cell CL0002350
    CSI 8.28
    rCSI 39.65%
    PRS 92.19
  • cardiac muscle cell CL0000746
    CSI 8.24
    rCSI 11.82%
    PRS 88.31
  • neural crest cell CL0011012
    CSI 8.07
    rCSI 6.38%
    PRS 89.94
  • cardiac neuron CL0010022
    CSI 7.97
    rCSI 25.49%
    PRS 93.75
  • flat midget bipolar cell CL4033033
    CSI 7.47
    rCSI 53.43%
    PRS 86.28
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 7.37
    rCSI 43.37%
    PRS 86.02
  • fibroblast of lung CL0002553
    CSI 7.3
    rCSI 6.8%
    PRS 95.62
  • central nervous system neuron CL2000029
    CSI 7.3
    rCSI 53.65%
    PRS 89.03
  • diffuse bipolar 3a cell CL4033029
    CSI 7.29
    rCSI 49.63%
    PRS 87.48
  • astrocyte of the cerebral cortex CL0002605
    CSI 7.25
    rCSI 16.25%
    PRS 85.77
  • GABAergic neuron CL0000617
    CSI 7.02
    rCSI 23.51%
    PRS 84.13
  • alveolar adventitial fibroblast CL4028006
    CSI 6.86
    rCSI 10.83%
    PRS 95.38
  • diffuse bipolar 3b cell CL4033030
    CSI 6.4
    rCSI 42.46%
    PRS 89.08
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 6.31
    rCSI 16.3%
    PRS 92.89
  • neural progenitor cell CL0011020
    CSI 6.09
    rCSI 26.8%
    PRS 85.71
  • Schwann cell CL0002573
    CSI 6.03
    rCSI 17.15%
    PRS 91.77
  • dopaminergic neuron CL0000700
    CSI 5.78
    rCSI 32.65%
    PRS 86.54
  • vascular leptomeningeal cell CL4023051
    CSI 5.64
    rCSI 9.89%
    PRS 92.5
  • chondrocyte CL0000138
    CSI 5.5
    rCSI 8.75%
    PRS 91.35
  • cardiac endothelial cell CL0010008
    CSI 5.5
    rCSI 22.17%
    PRS 95.09
  • cerebellar granule cell CL0001031
    CSI 5.36
    rCSI 7.88%
    PRS 90.94
  • L6b glutamatergic cortical neuron CL4023038
    CSI 5.36
    rCSI 16.75%
    PRS 86.63
  • regular atrial cardiac myocyte CL0002129
    CSI 5.28
    rCSI 17%
    PRS 91.48
  • serotonergic neuron CL0000850
    CSI 5.13
    rCSI 22.91%
    PRS 82.88
  • diffuse bipolar 2 cell CL4033028
    CSI 4.91
    rCSI 38.07%
    PRS 88
  • macroglial cell CL0000126
    CSI 4.54
    rCSI 11.68%
    PRS 91.2
  • cerebral cortex endothelial cell CL1001602
    CSI 4.37
    rCSI 7.56%
    PRS 91.18
  • diffuse bipolar 1 cell CL4033027
    CSI 4.15
    rCSI 31.17%
    PRS 85
  • medium spiny neuron CL1001474
    CSI 3.97
    rCSI 34.16%
    PRS 88.65
  • mesenchymal stem cell of adipose tissue CL0002570
    CSI 3.87
    rCSI 21.55%
    PRS 95.78
  • mesothelial cell CL0000077
    CSI 3.86
    rCSI 15.08%
    PRS 83.04
  • podocyte CL0000653
    CSI 3.8
    rCSI 16.87%
    PRS 94.43
  • basket cell CL0000118
    CSI 3.79
    rCSI 23.77%
    PRS 78.37
  • cardiac blood vessel endothelial cell CL0010006
    CSI 3.45
    rCSI 24.38%
    PRS 90.08
  • OFF-bipolar cell CL0000750
    CSI 3.23
    rCSI 4.41%
    PRS 92.53
  • stromal cell of ovary CL0002132
    CSI 3
    rCSI 8.25%
    PRS 96.29
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.95
    rCSI 18.42%
    PRS 89.68
  • cerebral cortex pyramidal neuron CL4023111
    CSI 2.66
    rCSI 16.41%
    PRS 93.87
  • direct pathway medium spiny neuron CL4023026
    CSI 2.57
    rCSI 61.41%
    PRS 83.45
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.54
    rCSI 61.21%
    PRS 83.31
  • S cone cell CL0003050
    CSI 2.51
    rCSI 11.03%
    PRS 91.06
  • enteroglial cell CL4040002
    CSI 2
    rCSI 10.51%
    PRS 94.51
  • peripheral nervous system neuron CL2000032
    CSI 1.99
    rCSI 2.71%
    PRS 89.75
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 1.91
    rCSI 3.47%
    PRS 90.21
  • stromal cell CL0000499
    CSI 1.73
    rCSI 4.86%
    PRS 91.89
  • midbrain dopaminergic neuron CL2000097
    CSI 1.62
    rCSI 10.38%
    PRS 89.06
  • amacrine cell CL0000561
    CSI 1.56
    rCSI 4.52%
    PRS 88.3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [PLXNA4](/details-gene/91584), or Plexin A4, is a protein-coding gene located on chromosome 7q32.3. As a member of the plexin family, it functions as a transmembrane receptor for semaphorin signaling molecules. Its primary role is in nervous system development, where it is critically involved in processes such as [axon guidance](/details-go/GO:0007411) ([R-HSA-422475](https://reactome.org/content/detail/R-HSA-422475)), synapse assembly, and the morphogenesis of multiple cranial nerves. Expression data strongly corroborates this function, revealing high significance in a wide array of neuronal cell types, particularly diverse subtypes of cortical [interneurons](/details-cell/CL0000099) and glutamatergic [neurons](/details-cell/CL0000540). The gene was initially characterized as part of large-scale cDNA sequencing projects aimed at identifying novel human proteins ([Link](https://doi.org/10.1038/ng1285), [Link](https://doi.org/10.1101/gr.1293003)). ## Cellular Roles and Expression Landscape The expression profile of [PLXNA4](/details-gene/91584) highlights its profound importance in the central nervous system. **Overall**, the gene shows the highest significance in various subtypes of inhibitory cortical interneurons, including [VIP GABAergic cortical interneurons](/details-cell/CL4023016) (CSI: 49.96), [pvalb GABAergic cortical interneurons](/details-cell/CL4023018) (CSI: 48.78), and [sncg GABAergic cortical interneurons](/details-cell/CL4023015) (CSI: 30.75). This suggests a pivotal role for [PLXNA4](/details-gene/91584) in establishing the complex circuitry of the cerebral cortex by guiding the migration and integration of these diverse inhibitory cells. In addition to interneurons, [PLXNA4](/details-gene/91584) is also a significant marker in excitatory glutamatergic [neurons](/details-cell/CL0000540), such as [L2/3-6 intratelencephalic projecting glutamatergic neurons](/details-cell/CL4023040) (CSI: 24.44) and [L5 extratelencephalic projecting glutamatergic cortical neurons](/details-cell/CL4023041) (CSI: 15.10). Its expression in these projection [neurons](/details-cell/CL0000540) is consistent with its function in mediating long-range axon guidance cues during brain development. Interestingly, outside of the nervous system, [PLXNA4](/details-gene/91584) demonstrates high significance in [adipocytes](/details-cell/CL0000136) (CSI: 38.42), including [epicardial adipocytes](/details-cell/CL1000309) (CSI: 19.39). This suggests a potential, less-characterized role for plexin-semaphorin signaling in adipose tissue biology, which could involve processes such as adipogenesis, metabolic regulation, or tissue vascularization. ## Pathways and Molecular Function The molecular functions of [PLXNA4](/details-gene/91584) are centered on its role as a [semaphorin receptor](/details-go/GO:0017154), positioning it as a key mediator of the [semaphorin-plexin signaling pathway](/details-go/GO:0071526). This pathway is fundamental to [nervous system development](/details-reactome/R-HSA-9675108), and annotations confirm the involvement of [PLXNA4](/details-gene/91584) in numerous related biological processes. These include [axon guidance](/details-go/GO:0007411), [motor neuron axon guidance](/details-go/GO:0008045), [synapse assembly](/details-go/GO:0007416), and the morphogenesis of several cranial nerves, such as the trigeminal ([GO:0021637](https://www.ebi.ac.uk/QuickGO/term/GO:0021637)) and vagus ([GO:0021644](https://www.ebi.ac.uk/QuickGO/term/GO:0021644)) nerves. Functionally, activation of the [PLXNA4](/details-gene/91584) receptor by semaphorin ligands typically initiates intracellular signaling cascades that lead to cytoskeletal rearrangements, resulting in cellular responses like chemorepulsion ([GO:0021793](https://www.ebi.ac.uk/QuickGO/term/GO:0021793)) and the [negative regulation of cell adhesion](/details-go/GO:0007162). Reactome pathways further detail these mechanisms, implicating [PLXNA4](/details-gene/91584) in [Sema3A-Plexin repulsion signaling](/details-reactome/R-HSA-399955) and [other semaphorin interactions](/details-reactome/R-HSA-416700), which collectively regulate axon extension and cell migration. The gene product is primarily localized to the [plasma membrane](/details-go/GO:0005886) as part of the [semaphorin receptor complex](/details-go/GO:0002116). ## Research Directions Based on its well-defined role in neurodevelopment and its intriguing expression in non-neuronal cells, several research avenues for [PLXNA4](/details-gene/91584) can be proposed. 1. **Hypothesis 1:** The high significance of [PLXNA4](/details-gene/91584) across multiple, distinct cortical [interneuron](/details-cell/CL0000099) subtypes suggests that it plays a crucial role in the subtype-specific laminar positioning and synaptic targeting of these cells. Different expression levels of [PLXNA4](/details-gene/91584) may fine-tune their responsiveness to semaphorin gradients within the developing cortex, thereby ensuring the proper assembly of inhibitory microcircuits. 2. **Hypothesis 2:** The significant expression of [PLXNA4](/details-gene/91584) in [adipocytes](/details-cell/CL0000136) indicates a role in metabolic regulation or adipose tissue homeostasis. [PLXNA4](/details-gene/91584) signaling could mediate cell-cell communication within adipose tissue, potentially regulating adipogenesis, lipolysis, or the angiogenic remodeling that accompanies adipose tissue expansion. **Experimental Proposal:** To test the second hypothesis regarding the function of [PLXNA4](/details-gene/91584) in adipocytes, a loss-of-function study could be performed. Human pre-adipocyte cell lines (e.g., SGBS) could be transduced with lentiviral vectors carrying shRNA or a CRISPR-Cas9 system to stably knock down or knock out [PLXNA4](/details-gene/91584). Following selection, control and knockout cells would be induced to differentiate into mature [adipocytes](/details-cell/CL0000136). The impact on adipogenesis would be quantified by measuring lipid accumulation via Oil Red O staining and assessing the expression of key adipogenic transcription factors (e.g., PPARG, CEBPA) and mature adipocyte markers (e.g., ADIPOQ, FABP4) using qPCR and Western blotting. **Therapeutic Potential:** As a cell surface receptor with a primary role in developmental signaling, [PLXNA4](/details-gene/91584) presents potential therapeutic opportunities. In the context of neurological disorders, such as spinal cord injury or neurodegenerative diseases, modulating [PLXNA4](/details-gene/91584) activity could be a strategy to inhibit repulsive cues and promote axonal regeneration. Conversely, in diseases characterized by pathological cell migration or angiogenesis, such as cancer, inhibiting [PLXNA4](/details-gene/91584) could disrupt these processes. Given its expression on the plasma membrane, it is an accessible target for biologic therapies like monoclonal antibodies or antibody-drug conjugates, as well as small molecules designed to modulate its intracellular signaling activity.

Genular Protein ID: 2427315469

Symbol: PLXA4_HUMAN

Name: Plexin-A4

UniProtKB Accession Codes:

Q9HCM2 A4D1N6 E9PAM2 Q6UWC6 Q6ZW89 Q8N969 Q8ND00 Q8NEN3 Q9NTD4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 6 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 5 RefSeq 5 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

Sequence Information:

  • Length: 1894
  • Mass: 212455
  • Checksum: 7B45C8929C5847DF
  • Sequence:
    • MKAMPWNWTC LLSHLLMVGM GSSTLLTRQP APLSQKQRSF VTFRGEPAEG FNHLVVDERT 
GHIYLGAVNR IYKLSSDLKV LVTHETGPDE DNPKCYPPRI VQTCNEPLTT TNNVNKMLLI 
DYKENRLIAC GSLYQGICKL LRLEDLFKLG EPYHKKEHYL SGVNESGSVF GVIVSYSNLD 
DKLFIATAVD GKPEYFPTIS SRKLTKNSEA DGMFAYVFHD EFVASMIKIP SDTFTIIPDF 
DIYYVYGFSS GNFVYFLTLQ PEMVSPPGST TKEQVYTSKL VRLCKEDTAF NSYVEVPIGC 
ERSGVEYRLL QAAYLSKAGA VLGRTLGVHP DDDLLFTVFS KGQKRKMKSL DESALCIFIL 
KQINDRIKER LQSCYRGEGT LDLAWLKVKD IPCSSALLTI DDNFCGLDMN APLGVSDMVR 
GIPVFTEDRD RMTSVIAYVY KNHSLAFVGT KSGKLKKIRV DGPRGNALQY ETVQVVDPGP 
VLRDMAFSKD HEQLYIMSER QLTRVPVESC GQYQSCGECL GSGDPHCGWC VLHNTCTRKE 
RCERSKEPRR FASEMKQCVR LTVHPNNISV SQYNVLLVLE TYNVPELSAG VNCTFEDLSE 
MDGLVVGNQI QCYSPAAKEV PRIITENGDH HVVQLQLKSK ETGMTFASTS FVFYNCSVHN 
SCLSCVESPY RCHWCKYRHV CTHDPKTCSF QEGRVKLPED CPQLLRVDKI LVPVEVIKPI 
TLKAKNLPQP QSGQRGYECI LNIQGSEQRV PALRFNSSSV QCQNTSYSYE GMEINNLPVE 
LTVVWNGHFN IDNPAQNKVH LYKCGAMRES CGLCLKADPD FACGWCQGPG QCTLRQHCPA 
QESQWLELSG AKSKCTNPRI TEIIPVTGPR EGGTKVTIRG ENLGLEFRDI ASHVKVAGVE 
CSPLVDGYIP AEQIVCEMGE AKPSQHAGFV EICVAVCRPE FMARSSQLYY FMTLTLSDLK 
PSRGPMSGGT QVTITGTNLN AGSNVVVMFG KQPCLFHRRS PSYIVCNTTS SDEVLEMKVS 
VQVDRAKIHQ DLVFQYVEDP TIVRIEPEWS IVSGNTPIAV WGTHLDLIQN PQIRAKHGGK 
EHINICEVLN ATEMTCQAPA LALGPDHQSD LTERPEEFGF ILDNVQSLLI LNKTNFTYYP 
NPVFEAFGPS GILELKPGTP IILKGKNLIP PVAGGNVKLN YTVLVGEKPC TVTVSDVQLL 
CESPNLIGRH KVMARVGGME YSPGMVYIAP DSPLSLPAIV SIAVAGGLLI IFIVAVLIAY 
KRKSRESDLT LKRLQMQMDN LESRVALECK EAFAELQTDI HELTSDLDGA GIPFLDYRTY 
TMRVLFPGIE DHPVLRDLEV PGYRQERVEK GLKLFAQLIN NKVFLLSFIR TLESQRSFSM 
RDRGNVASLI MTVLQSKLEY ATDVLKQLLA DLIDKNLESK NHPKLLLRRT ESVAEKMLTN 
WFTFLLYKFL KECAGEPLFS LFCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIDYKTL 
VLSCVSPDNA NSPEVPVKIL NCDTITQVKE KILDAIFKNV PCSHRPKAAD MDLEWRQGSG 
ARMILQDEDI TTKIENDWKR LNTLAHYQVP DGSVVALVSK QVTAYNAVNN STVSRTSASK 
YENMIRYTGS PDSLRSRTPM ITPDLESGVK MWHLVKNHEH GDQKEGDRGS KMVSEIYLTR 
LLATKGTLQK FVDDLFETIF STAHRGSALP LAIKYMFDFL DEQADKHGIH DPHVRHTWKS 
NCLPLRFWVN MIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY 
AKDIPSYKNW VERYYSDIGK MPAISDQDMN AYLAEQSRMH MNEFNTMSAL SEIFSYVGKY 
SEEILGPLDH DDQCGKQKLA YKLEQVITLM SLDS