Details for: MAGI1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 474.2880
Cell Significance Index: -120.3000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 244.7219
Cell Significance Index: -99.4200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 176.2684
Cell Significance Index: -118.2800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 104.2323
Cell Significance Index: -99.5200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 35.0180
Cell Significance Index: -76.6400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 30.4811
Cell Significance Index: -120.2800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 10.8098
Cell Significance Index: 606.5900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 6.8790
Cell Significance Index: 527.8900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 6.2655
Cell Significance Index: 175.1000 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 5.3702
Cell Significance Index: 47.6700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 5.3541
Cell Significance Index: 329.0900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 5.2250
Cell Significance Index: 125.3100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 4.6867
Cell Significance Index: 1681.0300 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 4.3682
Cell Significance Index: 26.9500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 4.1868
Cell Significance Index: 830.8800 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 3.4048
Cell Significance Index: 48.9700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.1952
Cell Significance Index: 640.9600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.7511
Cell Significance Index: 58.8100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 2.6055
Cell Significance Index: 44.6500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.4371
Cell Significance Index: 1685.6000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.4350
Cell Significance Index: 163.7300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.3779
Cell Significance Index: 1510.2400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.2118
Cell Significance Index: 4164.5000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.8261
Cell Significance Index: 30.7600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.7572
Cell Significance Index: 2705.1700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.6620
Cell Significance Index: 3065.0500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.3369
Cell Significance Index: 38.5200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.7608
Cell Significance Index: 1034.4700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5029
Cell Significance Index: 81.7900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.4965
Cell Significance Index: 3.0000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4912
Cell Significance Index: 88.5400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.4518
Cell Significance Index: 6.6700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3776
Cell Significance Index: 14.3000 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.3721
Cell Significance Index: 1.6200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3525
Cell Significance Index: 43.3500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2802
Cell Significance Index: 252.9700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2775
Cell Significance Index: 125.9600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1616
Cell Significance Index: 71.4400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1536
Cell Significance Index: 16.7100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1481
Cell Significance Index: 5.2100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1164
Cell Significance Index: 5.1500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1124
Cell Significance Index: 61.3800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0967
Cell Significance Index: 4.5100 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.0946
Cell Significance Index: 1.1800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0011
Cell Significance Index: 0.0500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0466
Cell Significance Index: -6.7700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0532
Cell Significance Index: -2.5000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0962
Cell Significance Index: -9.5200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.1024
Cell Significance Index: -19.4900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1039
Cell Significance Index: -76.2100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1089
Cell Significance Index: -80.6600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1355
Cell Significance Index: -84.6100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1515
Cell Significance Index: -114.6600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1869
Cell Significance Index: -105.4100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2456
Cell Significance Index: -25.5700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2694
Cell Significance Index: -46.0000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2778
Cell Significance Index: -38.1500 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.3406
Cell Significance Index: -43.6600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3678
Cell Significance Index: -105.8200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4798
Cell Significance Index: -101.0500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.5274
Cell Significance Index: -31.6700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5775
Cell Significance Index: -16.4800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.5866
Cell Significance Index: -75.7900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5982
Cell Significance Index: -8.8300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6032
Cell Significance Index: -31.6700 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.6251
Cell Significance Index: -7.8900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6394
Cell Significance Index: -73.2600 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.6718
Cell Significance Index: -8.4600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.7252
Cell Significance Index: -84.5100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.7726
Cell Significance Index: -78.9300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.9116
Cell Significance Index: -8.4000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.9149
Cell Significance Index: -104.4300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.9820
Cell Significance Index: -115.8100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.0037
Cell Significance Index: -52.1400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.1037
Cell Significance Index: -57.4900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.1080
Cell Significance Index: -29.6900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.1235
Cell Significance Index: -28.8800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.1688
Cell Significance Index: -87.1100 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -1.3255
Cell Significance Index: -17.1900 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -1.3278
Cell Significance Index: -20.2000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -1.3439
Cell Significance Index: -19.2500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.3734
Cell Significance Index: -108.7700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -1.4043
Cell Significance Index: -99.3200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.5021
Cell Significance Index: -32.8900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.5128
Cell Significance Index: -95.3500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.6011
Cell Significance Index: -51.2800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.7097
Cell Significance Index: -104.8200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.7142
Cell Significance Index: -35.5600 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -1.7337
Cell Significance Index: -18.0600 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -1.7555
Cell Significance Index: -22.5100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.7623
Cell Significance Index: -44.0500 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.7681
Cell Significance Index: -34.9600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.7940
Cell Significance Index: -115.7400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.8156
Cell Significance Index: -44.3000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -2.1641
Cell Significance Index: -45.9300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -2.2585
Cell Significance Index: -48.9300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.5415
Cell Significance Index: -83.2100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.5879
Cell Significance Index: -82.4200 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -2.6875
Cell Significance Index: -35.8500 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -2.7197
Cell Significance Index: -86.0200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3248722423
Symbol: MAGI1_HUMAN
Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9647739
Title: Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1.
PubMed ID: 9647739
PubMed ID: 11969287
Title: MAGI-1: a widely expressed, alternatively spliced tight junction protein.
PubMed ID: 11969287
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 9647693
Title: Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
PubMed ID: 9647693
PubMed ID: 9169421
Title: Identification of novel human WW domain-containing proteins by cloning of ligand targets.
PubMed ID: 9169421
PubMed ID: 11168587
Title: Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions.
PubMed ID: 11168587
PubMed ID: 12042308
Title: Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
PubMed ID: 12042308
PubMed ID: 12773569
Title: JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1.
PubMed ID: 12773569
PubMed ID: 14627983
Title: Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains.
PubMed ID: 14627983
PubMed ID: 15317815
Title: PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.
PubMed ID: 15317815
PubMed ID: 16043488
Title: Angiomotin regulates endothelial cell-cell junctions and cell motility.
PubMed ID: 16043488
PubMed ID: 16751601
Title: CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin.
PubMed ID: 16751601
DOI: 10.1093/jb/mvj105
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23873930
Title: Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.
PubMed ID: 23873930
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24561201
Title: Mislocalization of K+ channels causes the renal salt wasting in EAST/SeSAME syndrome.
PubMed ID: 24561201
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 1491
- Mass: 164581
- Checksum: 4B2EE05243A6FA65
- Sequence:
MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV EAAGLPGGGE GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK AVRQGGRLNK DLRHFLNQRF QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG TYEGNYYGTP KPPSQPVSGK VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE EDDVPEMNSS FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV HTEELDSELE LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL EQQQQQQQQQ QQQQQQQQQQ QTEEWTEDHS ALVPPVIPNH PPSNPEPARE VPLQGKPFFT RNPSELKGKF IHTKLRKSSR GFGFTVVGGD EPDEFLQIKS LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ SIPIGASVDL ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP MGFGFTIADS PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN QVVDMLVECP KGSEVTLLVQ RGGLPVPKKS PKSQPLERKD SQNSSQHSVS SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ TDSSGQKKPD PFKIWAQSRS MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ DIFLWRKETG FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA SLTEEKRTPQ GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE IRRGENEGFG FVIVSSVSRP EAGTTFAGNA CVAMPHKIGR IIEGSPADRC GKLKVGDRIL AVNGCSITNK SHSDIVNLIK EAGNTVTLRI IPGDESSNAT LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKQESQFEFK APQATQEQDF YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY DPSSDRHGPA TGPQGVPEVR AGPDRRQHPS LESSYPPDLH KSSPHGEKRA HARDPKGSRE YSRQPNEHHT WNGTSRKPDS GACRPKDRAP EGRRDAQAER AAAANGPKRR SPEKRREGTR SADNTLERRE KHEKRRDVSP ERRRERSPTR RRDGSPSRRR RSLERLLEQR RSPERRRGGS PERRAKSTDR RRARSPERRR ERSLDKRNRE DRASHREREE ANLKQDAGRS SRHPPEQRRR PYKECSTDLS I
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.