Details for: MAGI1

Gene ID: 9223

Symbol: MAGI1

Ensembl ID: ENSG00000151276

Description: membrane associated guanylate kinase, WW and PDZ domain containing 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 5.97
    Marker Score: 4,497
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 5.23
    Marker Score: 21,791
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 5.09
    Marker Score: 16,674
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.07
    Marker Score: 113,409
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.93
    Marker Score: 4,263
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.83
    Marker Score: 4,282
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.82
    Marker Score: 16,172
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 4.74
    Marker Score: 3,289
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.4
    Marker Score: 4,988
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4.38
    Marker Score: 5,895
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.24
    Marker Score: 19,626
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.21
    Marker Score: 22,596
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 4.2
    Marker Score: 1,535
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 4.16
    Marker Score: 5,033
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.03
    Marker Score: 71,587
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.81
    Marker Score: 2,934
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.81
    Marker Score: 128,608
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.57
    Marker Score: 8,540
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.46
    Marker Score: 1,820
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.44
    Marker Score: 12,245
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.42
    Marker Score: 14,301
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.25
    Marker Score: 950
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.19
    Marker Score: 1,533
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.16
    Marker Score: 1,710
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 3.15
    Marker Score: 907
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.11
    Marker Score: 4,520
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.03
    Marker Score: 2,893
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.97
    Marker Score: 943
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.93
    Marker Score: 1,641
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.91
    Marker Score: 6,690
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.87
    Marker Score: 46,147
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.87
    Marker Score: 57,156
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.81
    Marker Score: 1,636
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.77
    Marker Score: 41,458
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.75
    Marker Score: 6,045
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.74
    Marker Score: 1,604
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.74
    Marker Score: 1,417
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.74
    Marker Score: 20,990
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.74
    Marker Score: 5,267
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.68
    Marker Score: 101,915
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.67
    Marker Score: 57,011
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.65
    Marker Score: 2,862
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.59
    Marker Score: 2,771
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.58
    Marker Score: 10,699
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.57
    Marker Score: 1,077
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.57
    Marker Score: 1,342
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.55
    Marker Score: 7,277
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.53
    Marker Score: 1,512
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.49
    Marker Score: 785
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.48
    Marker Score: 1,631
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.47
    Marker Score: 1,433
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.45
    Marker Score: 90,414
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.43
    Marker Score: 8,620
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.38
    Marker Score: 1,328
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.38
    Marker Score: 863
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.34
    Marker Score: 1,648
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.33
    Marker Score: 8,994
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.31
    Marker Score: 3,877
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.29
    Marker Score: 879
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.21
    Marker Score: 2,440
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20,557
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.18
    Marker Score: 2,260
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.17
    Marker Score: 2,495
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127,023
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.06
    Marker Score: 2,553
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.01
    Marker Score: 1,740
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2
    Marker Score: 20,635
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.97
    Marker Score: 8,015
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.96
    Marker Score: 622
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.96
    Marker Score: 739
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.93
    Marker Score: 528
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.93
    Marker Score: 853
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.92
    Marker Score: 10,304
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18,162
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.91
    Marker Score: 2,700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.87
    Marker Score: 477
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.87
    Marker Score: 2,334
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15,931
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.85
    Marker Score: 1,521
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.82
    Marker Score: 500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.81
    Marker Score: 677
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.76
    Marker Score: 2,126
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.76
    Marker Score: 2,475
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.73
    Marker Score: 458
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.72
    Marker Score: 11,089
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.69
    Marker Score: 2,104
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.68
    Marker Score: 527
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.67
    Marker Score: 3,940
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2,518
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.63
    Marker Score: 906
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.61
    Marker Score: 6,939
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.59
    Marker Score: 785
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.58
    Marker Score: 11,928
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.57
    Marker Score: 8,225
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.56
    Marker Score: 3,913
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.56
    Marker Score: 531
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.53
    Marker Score: 308
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.52
    Marker Score: 2,524
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,122
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.45
    Marker Score: 439

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAGI1 is a 108-kDa protein that belongs to the MAGUK (membrane-associated guanylate kinase) family of proteins. It contains three distinct domains: a WW domain, a PDZ domain, and a guanylate kinase domain. The WW domain is involved in protein-protein interactions, while the PDZ domain mediates the binding of MAGI1 to its target proteins. The guanylate kinase domain is involved in signal transduction and the regulation of cell-cell adhesion. MAGI1 is primarily expressed in epithelial cells, particularly in photoreceptor cells, taste receptor cells, and epithelial cells of the lower respiratory tract. **Pathways and Functions** MAGI1 plays a critical role in regulating cell-cell adhesion and signaling through several pathways: 1. **Adherens Junctions**: MAGI1 interacts with E-cadherin and β-catenin to maintain the integrity of adherens junctions, which are essential for cell-cell adhesion and tissue structure. 2. **Tight Junctions**: MAGI1 also interacts with occludin and claudin to regulate the function of tight junctions, which control the passage of ions and molecules across the epithelial barrier. 3. **Cell Surface Receptor Signaling Pathway**: MAGI1 interacts with various cell surface receptors, including the G protein-coupled receptor (GPCR) family, to regulate signaling and cell migration. 4. **Signal Transduction**: The guanylate kinase domain of MAGI1 is involved in signal transduction, regulating the activity of downstream signaling molecules and influencing cell behavior. **Clinical Significance** Dysregulation of MAGI1 has been implicated in various diseases, including: 1. **Cancer**: Alterations in MAGI1 expression and function have been observed in various cancers, including colorectal, breast, and lung cancer. 2. **Neurological Disorders**: MAGI1 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Epithelial Dysfunctions**: MAGI1 plays a critical role in maintaining epithelial function and integrity, and dysregulation of MAGI1 has been implicated in epithelial dysfunctions, including those seen in inflammatory bowel disease and cystic fibrosis. In conclusion, MAGI1 is a multifunctional protein that plays a critical role in regulating cell-cell adhesion, signaling, and migration. Its dysregulation has been implicated in various diseases, highlighting the importance of MAGI1 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which MAGI1 regulates cellular processes and to explore its therapeutic potential in the treatment of diseases.

Genular Protein ID: 3248722423

Symbol: MAGI1_HUMAN

Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9647739

Title: Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1.

PubMed ID: 9647739

DOI: 10.1006/bbrc.1998.8603

PubMed ID: 11969287

Title: MAGI-1: a widely expressed, alternatively spliced tight junction protein.

PubMed ID: 11969287

DOI: 10.1006/excr.2002.5475

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 9647693

Title: Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.

PubMed ID: 9647693

DOI: 10.1006/mcne.1998.0677

PubMed ID: 9169421

Title: Identification of novel human WW domain-containing proteins by cloning of ligand targets.

PubMed ID: 9169421

DOI: 10.1074/jbc.272.23.14611

PubMed ID: 11168587

Title: Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions.

PubMed ID: 11168587

DOI: 10.1046/j.1365-2443.2000.00385.x

PubMed ID: 12042308

Title: Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.

PubMed ID: 12042308

DOI: 10.1074/jbc.m203072200

PubMed ID: 12773569

Title: JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1.

PubMed ID: 12773569

DOI: 10.1128/mcb.23.12.4267-4282.2003

PubMed ID: 14627983

Title: Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains.

PubMed ID: 14627983

DOI: 10.1038/sj.onc.1206996

PubMed ID: 15317815

Title: PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.

PubMed ID: 15317815

DOI: 10.1074/jbc.m405874200

PubMed ID: 16043488

Title: Angiomotin regulates endothelial cell-cell junctions and cell motility.

PubMed ID: 16043488

DOI: 10.1074/jbc.m503915200

PubMed ID: 16751601

Title: CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin.

PubMed ID: 16751601

DOI: 10.1093/jb/mvj105

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23873930

Title: Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.

PubMed ID: 23873930

DOI: 10.1074/jbc.m113.484683

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24561201

Title: Mislocalization of K+ channels causes the renal salt wasting in EAST/SeSAME syndrome.

PubMed ID: 24561201

DOI: 10.1016/j.febslet.2014.02.024

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1491
  • Mass: 164581
  • Checksum: 4B2EE05243A6FA65
  • Sequence:
  • MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV EAAGLPGGGE 
    GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK AVRQGGRLNK DLRHFLNQRF 
    QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG 
    TYEGNYYGTP KPPSQPVSGK VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE 
    EDDVPEMNSS FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 
    PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV HTEELDSELE 
    LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL EQQQQQQQQQ QQQQQQQQQQ 
    QTEEWTEDHS ALVPPVIPNH PPSNPEPARE VPLQGKPFFT RNPSELKGKF IHTKLRKSSR 
    GFGFTVVGGD EPDEFLQIKS LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ 
    SIPIGASVDL ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 
    KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP MGFGFTIADS 
    PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN QVVDMLVECP KGSEVTLLVQ 
    RGGLPVPKKS PKSQPLERKD SQNSSQHSVS SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ 
    TDSSGQKKPD PFKIWAQSRS MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ 
    DIFLWRKETG FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS 
    HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA SLTEEKRTPQ 
    GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE IRRGENEGFG FVIVSSVSRP 
    EAGTTFAGNA CVAMPHKIGR IIEGSPADRC GKLKVGDRIL AVNGCSITNK SHSDIVNLIK 
    EAGNTVTLRI IPGDESSNAT LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKQESQFEFK 
    APQATQEQDF YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL 
    EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY DPSSDRHGPA TGPQGVPEVR 
    AGPDRRQHPS LESSYPPDLH KSSPHGEKRA HARDPKGSRE YSRQPNEHHT WNGTSRKPDS 
    GACRPKDRAP EGRRDAQAER AAAANGPKRR SPEKRREGTR SADNTLERRE KHEKRRDVSP 
    ERRRERSPTR RRDGSPSRRR RSLERLLEQR RSPERRRGGS PERRAKSTDR RRARSPERRR 
    ERSLDKRNRE DRASHREREE ANLKQDAGRS SRHPPEQRRR PYKECSTDLS I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.