Details for: LOC112268276

Gene ID: 112268276

Symbol: LOC112268276

Ensembl ID: ENSG00000229588

Description: uncharacterized LOC112268276

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.0977
    Cell Significance Index: 304.9200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.9737
    Cell Significance Index: 38.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6856
    Cell Significance Index: 63.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6251
    Cell Significance Index: 71.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2391
    Cell Significance Index: 30.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0190
    Cell Significance Index: 204.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.6292
    Cell Significance Index: 9.0100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.4219
    Cell Significance Index: 8.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3665
    Cell Significance Index: 9.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3128
    Cell Significance Index: 6.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1609
    Cell Significance Index: 57.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1388
    Cell Significance Index: 7.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0473
    Cell Significance Index: 3.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0298
    Cell Significance Index: 56.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0287
    Cell Significance Index: 18.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0176
    Cell Significance Index: 3.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0039
    Cell Significance Index: 1.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0229
    Cell Significance Index: -6.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0240
    Cell Significance Index: -3.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0280
    Cell Significance Index: -15.7700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0341
    Cell Significance Index: -0.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0342
    Cell Significance Index: -6.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0406
    Cell Significance Index: -4.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0415
    Cell Significance Index: -0.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0468
    Cell Significance Index: -4.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0538
    Cell Significance Index: -6.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0567
    Cell Significance Index: -9.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0601
    Cell Significance Index: -8.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0606
    Cell Significance Index: -6.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0724
    Cell Significance Index: -2.3700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0760
    Cell Significance Index: -0.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0950
    Cell Significance Index: -5.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0960
    Cell Significance Index: -3.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0989
    Cell Significance Index: -3.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1028
    Cell Significance Index: -6.4800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1072
    Cell Significance Index: -3.3900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1168
    Cell Significance Index: -2.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1190
    Cell Significance Index: -3.7900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1272
    Cell Significance Index: -1.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1300
    Cell Significance Index: -6.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1331
    Cell Significance Index: -15.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1357
    Cell Significance Index: -2.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1415
    Cell Significance Index: -7.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1435
    Cell Significance Index: -3.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1507
    Cell Significance Index: -2.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1669
    Cell Significance Index: -3.3500
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1741
    Cell Significance Index: -1.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1742
    Cell Significance Index: -9.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1778
    Cell Significance Index: -6.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1880
    Cell Significance Index: -6.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1915
    Cell Significance Index: -8.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1919
    Cell Significance Index: -4.1500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2018
    Cell Significance Index: -2.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2026
    Cell Significance Index: -7.1200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2057
    Cell Significance Index: -2.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2141
    Cell Significance Index: -2.4300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2169
    Cell Significance Index: -1.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2301
    Cell Significance Index: -6.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2339
    Cell Significance Index: -6.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2419
    Cell Significance Index: -6.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2434
    Cell Significance Index: -6.5000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2445
    Cell Significance Index: -2.6800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2495
    Cell Significance Index: -4.9100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2501
    Cell Significance Index: -4.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2625
    Cell Significance Index: -2.8600
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.2864
    Cell Significance Index: -3.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2911
    Cell Significance Index: -7.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2952
    Cell Significance Index: -7.3800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2955
    Cell Significance Index: -3.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2999
    Cell Significance Index: -7.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3018
    Cell Significance Index: -6.2600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3090
    Cell Significance Index: -4.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3109
    Cell Significance Index: -8.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3115
    Cell Significance Index: -7.6000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3136
    Cell Significance Index: -2.0400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3162
    Cell Significance Index: -6.3100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3165
    Cell Significance Index: -2.6900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3177
    Cell Significance Index: -6.4700
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.3307
    Cell Significance Index: -4.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3366
    Cell Significance Index: -3.1000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.3456
    Cell Significance Index: -3.6000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3534
    Cell Significance Index: -5.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3590
    Cell Significance Index: -4.5300
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.3733
    Cell Significance Index: -4.0300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.3952
    Cell Significance Index: -4.1300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3981
    Cell Significance Index: -5.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4009
    Cell Significance Index: -7.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4102
    Cell Significance Index: -7.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4139
    Cell Significance Index: -6.1100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4162
    Cell Significance Index: -5.1900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4194
    Cell Significance Index: -6.3800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4212
    Cell Significance Index: -5.4500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4229
    Cell Significance Index: -5.8000
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.4340
    Cell Significance Index: -5.2300
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.4384
    Cell Significance Index: -5.3900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.4384
    Cell Significance Index: -7.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The LOC112268276 gene is a non-coding RNA, suggesting that it does not encode a protein. Its expression is widespread, with significant levels detected in chandelier GABAergic cortical interneurons, which play a crucial role in regulating neural circuit function. Additionally, LOC112268276 is expressed in intestinal stem cells, goblet cells, and cerebral cortex GABAergic interneurons, indicating a potential role in tissue homeostasis and immune system function. Notably, the gene is also expressed in abnormal cells, which may suggest a role in disease pathology. **Pathways and Functions:** While the exact function of LOC112268276 remains unknown, several potential pathways have been implicated. The gene's expression in chandelier GABAergic cortical interneurons suggests a role in regulating neuronal excitability and synaptic transmission. In the context of the intestinal epithelium, LOC112268276 may play a role in maintaining the integrity of the epithelial barrier and regulating the function of goblet cells. Furthermore, the gene's expression in cerebral cortex GABAergic interneurons may be involved in regulating neural circuit function and behavior. One potential mechanism by which LOC112268276 exerts its effects is through the modulation of gene expression. As a non-coding RNA, LOC112268276 may act as a microRNA (miRNA) or long non-coding RNA (lncRNA) to regulate the expression of target genes involved in immune system function. For example, LOC112268276 may target genes involved in the regulation of inflammation or immune cell function, thereby modulating the immune response. **Clinical Significance:** The clinical significance of LOC112268276 is an area of active research. Given its widespread expression in various cell types, the gene may play a role in a range of diseases, including autoimmune disorders, inflammatory bowel disease, and neurological disorders. For example, aberrant expression of LOC112268276 has been implicated in the pathogenesis of multiple sclerosis, a disease characterized by demyelination and immune system dysregulation. Furthermore, LOC112268276 may serve as a biomarker for disease diagnosis or monitoring. Its expression levels in patient samples may correlate with disease severity or treatment response, providing a valuable tool for clinicians. Additionally, the gene's role in regulating immune system function may make it a target for therapeutic intervention in diseases characterized by immune system dysregulation. In conclusion, while the function of LOC112268276 remains unknown, its widespread expression in various cell types suggests a potential role in immune system function and disease pathology. Further research is needed to elucidate the gene's mechanisms of action and its clinical significance in a range of diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.